Biomedical Engineering

Research output

Research output per year 2004 2021 2022 2023 2024 2024

• 54 Article
• 4 Comment/debate
• 4 Review article
• 2 Letter
• 4 More
  • 1 Conference contribution
  • 1 Conference article
  • 1 Editorial
  • 1 Short survey

Research output per year

Research output per year

Search results

• 2024

  Automated segmentation of phases, steps, and tasks in laparoscopic cholecystectomy using deep learning

  Hegde, S. R., Namazi, B., Iyengar, N., Cao, S., Desir, A., Marques, C., Mahnken, H., Dumas, R. P. & Sankaranarayanan, G., Jan 2024, In: Surgical endoscopy. 38, 1, p. 158-170 13 p.

  Research output: Contribution to journal › Article › peer-review

  • Deep Learning 100%
  • Laparoscopic Cholecystectomy 82%
  • Datasets 28%
  • Bile 18%
  • Hemorrhage 11%
  1 Scopus citations

• Beyond synthetic aperture focusing: deconvolution-based elevation resolution enhancement using simulated point spread function for linear array-based three-dimensional photoacoustic imaging

  Tang, Y., Lesniak, W. G., Gao, S., Wu, Y., Pomper, M. G. & Zhang, H. K., Mar 1 2024, In: Biomedical Optics Express. 15, 3, p. 1847-1860 14 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • synthetic apertures 100%
  • Three-Dimensional Imaging 92%
  • linear arrays 88%
  • point spread functions 84%
  • augmentation 47%

• Comparison of Multiple Segmentation Methods for Volumetric Delineation of Primary Prostate Cancer with Prostate-Specific Membrane Antigen-Targeted ¹⁸F-DCFPyL PET/CT

  Wang, F., Liu, C., Vidal, I., Mana-Ay, M., Voter, A. F., Solnes, L. B., Ross, A. E., Gafita, A., Schaeffer, E. M., Bivalacqua, T. J., Pienta, K. J., Pomper, M. G., Lodge, M. A., Song, D. Y., Oldan, J. D., Allaf, M. E., De Marzo, A. M., Sheikhbahaei, S., Gorin, M. A. & Rowe, S. P., Jan 1 2024, In: Journal of Nuclear Medicine. 65, 1, p. 87-93 7 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • 2-(3-(1-carboxy-5-((6-fluoropyridine-3-carbonyl)amino)pentyl)ureido)pentanedioic acid 100%
  • Prostate-Specific Antigen 51%
  • Tumor Burden 47%
  • Prostatic Neoplasms 39%
  • Membranes 29%

• Deep Semisupervised Transfer Learning for Fully Automated Whole-Body Tumor Quantification and Prognosis of Cancer on PET/CT

  Leung, K. H., Rowe, S. P., Sadaghiani, M. S., Leal, J. P., Mena, E., Choyke, P. L., Du, Y. & Pomper, M. G., 2024, In: Journal of Nuclear Medicine. 65, 4, p. 643-650 8 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

• Determining topical product bioequivalence with stimulated Raman scattering microscopy

  Iliopoulos, F., Tu, D., Pence, I. J., Li, X., Ghosh, P., Luke, M. C., Raney, S. G., Rantou, E. & Evans, C. L., Mar 2024, In: Journal of Controlled Release. 367, p. 864-876 13 p.

  Research output: Contribution to journal › Article › peer-review

  • Nonlinear Optical Microscopy 100%
  • Therapeutic Equivalency 74%
  • Bioavailability 42%
  • Skin 32%
  • Drug 30%

• Development of New CD38 Targeted Peptides for Cancer Imaging

  Zheleznyak, A., Tang, R., Duncan, K., Manion, B., Liang, K., Xu, B., Vanover, A., Ghai, A., Prior, J., Lees, S., Achilefu, S., Kelly, K. & Shokeen, M., 2024, (Accepted/In press) In: Molecular Imaging and Biology.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Multiple Myeloma 100%
  • 1-(1,3-carboxypropyl)-4,7-carboxymethyl-1,4,7-triazacyclononane 81%
  • Peptides 64%
  • Positron-Emission Tomography 40%
  • Radiopharmaceuticals 34%

• Editor's Note: Eph-B2/Ephrin-B2 Interaction Plays a Major Role in the Adhesion and Proliferation of Waldenstrom's Macroglobulinemia

  Azab, F., Azab, A. K., Maiso, P., Calimeri, T., Flores, L., Liu, Y., Quang, P., Roccaro, A. M., Sacco, A., Ngo, H. T., Zhang, Y., Morgan, B. L., Carrasco, R. D. & Ghobrial, I. M., Feb 15 2024, In: Clinical Cancer Research. 30, 4, p. 920 1 p.

  Research output: Contribution to journal › Editorial › peer-review

  Open Access

• Prognostic Performance of RECIP 1.0 Based on [18F]PSMA-1007 PET in Prostate Cancer Patients Treated with [177Lu]Lu-PSMA I&T

  Hartrampf, P. E., Hüttmann, T., Seitz, A. K., Kübler, H., Serfling, S. E., Higuchi, T., Schlötelburg, W., Michalski, K., Gafita, A., Rowe, S. P., Pomper, M. G., Buck, A. K. & Werner, R. A., 2024, In: Journal of Nuclear Medicine. 65, 4, p. 560-565 6 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

• Sprayable Hydrogel Sealant for Gastrointestinal Wound Shielding

  Muñoz Taboada, G., Dahis, D., Dosta, P., Edelman, E. & Artzi, N., 2024, (Accepted/In press) In: Advanced Materials.

  Research output: Contribution to journal › Article › peer-review

  Open Access

• The development of a deep learning model for automated segmentation of the robotic pancreaticojejunostomy

  Al Abbas, A. I., Namazi, B., Radi, I., Alterio, R., Abreu, A. A., Rail, B., Polanco, P. M., Zeh, H. J., Hogg, M. E., Zureikat, A. H. & Sankaranarayanan, G., 2024, (Accepted/In press) In: Surgical endoscopy.

  Research output: Contribution to journal › Article › peer-review

  • Pancreaticojejunostomy 100%
  • Deep Learning 92%
  • Robotics 70%
  • Pancreaticoduodenectomy 31%
  • Pancreatic Fistula 17%

• Validity and reliability evidence support task-specific metrics for laparoscopic fundoplication

  Desir, A., Marques, C., Farah, E., R. Hegde, S., Holcomb, C., Scott, D. J. & Sankaranarayanan, G., Apr 2024, In: Surgical endoscopy. 38, 4, p. 2219-2230 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Hiatal Hernia 100%
  • Fundoplication 99%
  • Herniorrhaphy 88%
  • Reproducibility of Results 69%
  • Virtual Reality 38%
• 2023

  A Comprehensive Analysis of Cerebellar Volumes in the 22q11.2 Deletion Syndrome

  Schmitt, J. E., DeBevits, J. J., Roalf, D. R., Ruparel, K., Gallagher, R. S., Gur, R. C., Alexander-Bloch, A., Eom, T. Y., Alam, S., Steinberg, J., Akers, W., Khairy, K., Crowley, T. B., Emanuel, B., Zakharenko, S. S., McDonald-McGinn, D. M. & Gur, R. E., Jan 2023, In: Biological Psychiatry: Cognitive Neuroscience and Neuroimaging. 8, 1, p. 79-90 12 p.

  Research output: Contribution to journal › Article › peer-review

  • DiGeorge Syndrome 100%
  • Cerebellum 24%
  • Frontal Lobe 17%
  • Psychotic Disorders 16%
  • Linear Models 14%
  4 Scopus citations

• Adapting to a Robotic Era: The Transferability of Open and Laparoscopic Skills to Robotic Surgery

  Farah, E., Abreu, A. A., Rail, B., Radi, I., Sankaranarayanan, G., Scott, D. J., Zeh, H. & Polanco, P. M., Dec 2023, In: Journal of Surgical Education. 80, 12, p. 1868-1876 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Robotics 100%
  • surgery 98%
  • Mandrillus 19%
  • resident 18%
  • Curriculum 15%

• Advances in vaginal bioengineering: Applications, techniques, and needs

  Buchanan, L. M., Domingo, M. J. E., White, S. E., Vanoven, T. N., Karbasion, N., Bersi, M. R., Pence, I. J., Florian-Rodriguez, M. & Miller, K. S., Jan 2023, In: Current Research in Physiology. 6, 100111.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

• Baseline performance in a robotic virtual reality platform predicts rate of skill acquisition in a proficiency-based curriculum: a cohort study of surgical trainees

  Abreu, A. A., Rail, B., Farah, E., Alterio, R. E., Scott, D. J., Sankaranarayanan, G., Zeh, H. J. & Polanco, P. M., Nov 2023, In: Surgical endoscopy. 37, 11, p. 8804-8809 6 p.

  Research output: Contribution to journal › Article › peer-review

  • Virtual Reality 100%
  • Robotics 86%
  • Curriculum 80%
  • Internship and Residency 68%
  • Cohort Studies 56%
  1 Scopus citations

• Erratum: Endogenous Cyclin D1 Promotes the Rate of Onset and Magnitude of Mitogenic Signaling via Akt1 Ser473 Phosphorylation (Cell Reports (2020) 32(11), (S2211124720311402), (10.1016/j.celrep.2020.108151))

  Chen, K., Jiao, X., Di Rocco, A., Shen, D., Xu, S., Ertel, A., Yu, Z., Di Sante, G., Wang, M., Li, Z., Pestell, T. G., Casimiro, M. C., Skordalakes, E., Achilefu, S. & Pestell, R. G., Jun 27 2023, In: Cell Reports. 42, 6, 112595.

  Research output: Contribution to journal › Comment/debate › peer-review

  Open Access

  • Cyclin D1 100%
  • Error 69%
  • Phosphorylation 63%
  • Confusion 50%
  • Emotions 36%

• E-selectin-targeting lipid nanoparticles improve therapeutic efficacy and reduce side effects of bortezomib in multiple myeloma

  Maksimos, M., Muz, B., Magnani, J. L. & Azab, A. K., Dec 2023, In: Blood Cancer Journal. 13, 1, 48.

  Research output: Contribution to journal › Letter › peer-review

  Open Access

• Fatty acid binding proteins in multiple myeloma

  Diedrich, C., Maksimos, M. & Azab, A. K., Aug 2023, In: Trends in Molecular Medicine. 29, 8, p. 584-585 2 p.

  Research output: Contribution to journal › Short survey › peer-review

  • Fatty Acid-Binding Proteins 100%
  • Multiple Myeloma 75%
  • Proteasome Inhibitors 30%
  • Protein Transport 28%
  • Proteasome Endopeptidase Complex 26%
  1 Scopus citations

• Gold nanoparticle-enhanced X-ray microtomography of the rodent reveals region-specific cerebrospinal fluid circulation in the brain

  Pan, S., Yang, P. H., DeFreitas, D., Ramagiri, S., Bayguinov, P. O., Hacker, C. D., Snyder, A. Z., Wilborn, J., Huang, H., Koller, G. M., Raval, D. K., Halupnik, G. L., Sviben, S., Achilefu, S., Tang, R., Haller, G., Quirk, J. D., Fitzpatrick, J. A. J., Esakky, P. & Strahle, J. M., Dec 2023, In: Nature communications. 14, 1, 453.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • cerebrospinal fluid 100%
  • rodents 95%
  • X-Ray Microtomography 88%
  • Cord 83%
  • Gold 68%
  5 Scopus citations

• Identification of hyperoxidized PRDX3 as a ferroptosis marker reveals ferroptotic damage in chronic liver diseases

  Cui, S., Ghai, A., Deng, Y., Li, S., Zhang, R., Egbulefu, C., Liang, G., Achilefu, S. & Ye, J., Nov 2 2023, In: Molecular cell. 83, 21, p. 3931-3939.e5

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Peroxiredoxin III 100%
  • Ferroptosis 89%
  • Liver Diseases 47%
  • Chronic Disease 42%
  • Sulfinic Acids 15%
  10 Scopus citations

• Objective metrics for hand-sewn bowel anastomoses can differentiate novice from expert surgeons

  Sankaranarayanan, G., Parker, L. M., Khan, A., Dials, J., Demirel, D., Halic, T., Crawford, A., Kruger, U., De, S. & Fleshman, J. W., Feb 2023, In: Surgical endoscopy. 37, 2, p. 1282-1292 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Least-Squares Analysis 100%
  • Hand 67%
  • Surgeons 63%
  • Colorectal Surgery 54%
  • Virtual Reality 54%
  1 Scopus citations

• Passive, active and endogenous organ-targeted lipid and polymer nanoparticles for delivery of genetic drugs

  Dilliard, S. A. & Siegwart, D. J., Apr 2023, In: Nature Reviews Materials. 8, 4, p. 282-300 19 p.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  • Nucleic acids 100%
  • Lipids 91%
  • Nanoparticles 67%
  • Nucleic Acid 57%
  • Polymers 49%
  87 Scopus citations

• Resting-state functional connectivity-based parcellation of the human dentate nucleus: new findings and clinical relevance

  Kulkarni, M., Kent, J. S., Park, K., Guell, X. & Anteraper, S., Sep 2023, In: Brain Structure and Function. 228, 7, p. 1799-1810 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Cerebellar Nuclei 100%
  • Signal-To-Noise Ratio 22%
  • Seeds 19%
  • Cerebellum 17%
  • Neuroimaging 17%
  1 Scopus citations

• The interactive medical simulation toolkit (iMSTK): an open source platform for surgical simulation

  Moore, J., Scheirich, H., Jadhav, S., Enquobahrie, A., Paniagua, B., Wilson, A., Bray, A., Sankaranarayanan, G. & Clipp, R. B., 2023, In: Frontiers in Virtual Reality. 4, 1130156.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Tissue 100%
  • Biopsy 76%
  • Surgery 59%
  • Hydrodynamics 50%
  • Visualization 45%
  1 Scopus citations

• The interplay of quaternary ammonium lipid structure and protein corona on lung-specific mRNA delivery by selective organ targeting (SORT) nanoparticles

  Dilliard, S. A., Sun, Y., Brown, M. O., Sung, Y. C., Chatterjee, S., Farbiak, L., Vaidya, A., Lian, X., Wang, X., Lemoff, A. & Siegwart, D. J., Sep 2023, In: Journal of Controlled Release. 361, p. 361-372 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Protein Corona 100%
  • Messenger RNA 78%
  • Ammonium Compounds 75%
  • Nanoparticles 52%
  • Ammonium 46%
  10 Scopus citations

• What are essential laparoscopic skills these days? Results of the SAGES Fundamentals of Laparoscopic Surgery (FLS) Committee technical skills survey

  Seymour, N. E., Nepomnayshy, D., De, S., Banks, E., Breitkopf, D. M., Campagna, R., Gomez-Garibello, C., Green, I., Jacobsen, G., Korndorffer, J. R., Minasi, J., Okrainec, A., Matthew Ritter, E., Sankaranarayanan, G., Schwaitzberg, S., Soper, N. J., Vassiliou, M., Wagner, M. & Zevin, B., Oct 2023, In: Surgical endoscopy. 37, 10, p. 7676-7685 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Laparoscopy 100%
  • Surgeons 77%
  • Certification 21%
  • Laparoscopes 12%
  • Internship and Residency 9%
• 2022

  Ablation of VLA4 in multiple myeloma cells redirects tumor spread and prolongs survival

  Hathi, D., Chanswangphuwana, C., Cho, N., Fontana, F., Maji, D., Ritchey, J., O’Neal, J., Ghai, A., Duncan, K., Akers, W. J., Fiala, M., Vij, R., DiPersio, J. F., Rettig, M. & Shokeen, M., Dec 2022, In: Scientific reports. 12, 1, 30.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Multiple Myeloma 100%
  • Survival 56%
  • cyanine dye 5 52%
  • Neoplasms 32%
  • Bone Marrow Cells 31%
  12 Scopus citations

• ALL-090 Highly Effective Combination of FLT3 and BCL2 Inhibitors in a Preclinical Model of Lineage Ambiguous Leukemia

  Montefiori, L., lacobucci, I., Budhraja, A., Moore, J., Baskin, R., DeVries, R., Backhaus, E., Johnson, M., Akers, W., Chepyala, D., Mehr, C., Seth, A., Mead, P., Opferman, J. & Mullighan, C., Oct 2022, In: Clinical Lymphoma, Myeloma and Leukemia. 22, p. S193-S194

  Research output: Contribution to journal › Article › peer-review

  • gilteritinib 100%
  • Leukemia 98%
  • venetoclax 79%
  • Animals 15%
  • Therapeutics 14%

• An End-To-End Pipeline for Fully Automatic Morphological Quantification of Mouse Brain Structures From MRI Imagery

  Alam, S., Eom, T. Y., Steinberg, J., Ackerman, D., Schmitt, J. E., Akers, W. J., Zakharenko, S. S. & Khairy, K., 2022, In: Frontiers in Bioinformatics. 2, 865443.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Magnetic Resonance Image 100%
  • Imagery 89%
  • Mouse 77%
  • Pipeline 70%
  • Quantification 67%
  1 Scopus citations

• An mTORC1 to HRI signaling axis promotes cytotoxicity of proteasome inhibitors in multiple myeloma

  Darawshi, O., Muz, B., Naamat, S. G., Praveen, B., Mahameed, M., Goldberg, K., Dipta, P., Shmuel, M., Forno, F., Boukeileh, S., Pahima, H., Hermann, J., Raab, M. S., Poos, A. M., Weinhold, N., Rosenbluh, C., Gatt, M. E., Palm, W., Azab, A. K. & Tirosh, B., Nov 2022, In: Cell Death and Disease. 13, 11, 969.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Mechanistic Target of Rapamycin Complex 1 100%
  • Proteasome Inhibitors 95%
  • Multiple Myeloma 78%
  • In Vitro Techniques 6%
  • Hypoxia 5%
  3 Scopus citations

• Copper-Catalyzed Covalent Dimerization of Near-Infrared Fluorescent Cyanine Dyes: Synergistic Enhancement of Photoacoustic Signals for Molecular Imaging of Tumors

  Maji, D., Oh, D., Gautam, K. S., Zhou, M., Zhang, H., Kao, J., Giblin, D., Smith, M., Lim, J., Lee, S., Kang, Y., Kim, W. J., Kim, C. & Achilefu, S., Jan 2022, In: Analysis and Sensing. 2, 1, e202100065.

  Research output: Contribution to journal › Comment/debate › peer-review

  Open Access

  • Cypate 100%
  • Molecular imaging 85%
  • Dimerization 81%
  • Photoacoustic effect 76%
  • Cyanine Dye 60%
  5 Scopus citations

• Disrupting off-target Cas9 activity in the liver

  Dilliard, S. A. & Siegwart, D. J., Feb 2022, In: Nature Biomedical Engineering. 6, 2, p. 106-107 2 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  2 Scopus citations

• Enhancing CRISPR/Cas gene editing through modulating cellular mechanical properties for cancer therapy

  Zhang, D., Wang, G., Yu, X., Wei, T., Farbiak, L., Johnson, L. T., Taylor, A. M., Xu, J., Hong, Y., Zhu, H. & Siegwart, D. J., Jul 2022, In: Nature Nanotechnology. 17, 7, p. 777-787 11 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • editing 100%
  • genes 80%
  • Tumors 70%
  • tumors 65%
  • Genes 65%
  85 Scopus citations

• In vivo CRISPR screening identifies BAZ2 chromatin remodelers as druggable regulators of mammalian liver regeneration

  Jia, Y., Li, L., Lin, Y. H., Gopal, P., Shen, S., Zhou, K., Yu, X., Sharma, T., Zhang, Y., Siegwart, D. J., Ready, J. M. & Zhu, H., Mar 3 2022, In: Cell Stem Cell. 29, 3, p. 372-385.e8

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Liver Regeneration 100%
  • Clustered Regularly Interspaced Short Palindromic Repeats 93%
  • Chromatin 71%
  • Regeneration 68%
  • 1-(1-(3-(methylsulfonyl)phenyl)-7-propoxyindolizin-3-yl)ethanone 39%
  11 Scopus citations

• Lipid Nanoparticle (LNP) Chemistry Can Endow Unique in Vivo RNA Delivery Fates within the Liver That Alter Therapeutic Outcomes in a Cancer Model

  Johnson, L. T., Zhang, D., Zhou, K., Lee, S. M., Liu, S., Dilliard, S. A., Farbiak, L., Chatterjee, S., Lin, Y. H. & Siegwart, D. J., Nov 7 2022, In: Molecular Pharmaceutics. 19, 11, p. 3973-3986 14 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Nanoparticles 100%
  • RNA 78%
  • Lipid 77%
  • Lipids 73%
  • Chemistry 65%
  16 Scopus citations

• Lipid nanoparticle chemistry determines how nucleoside base modifications alter mRNA delivery

  Melamed, J. R., Hajj, K. A., Chaudhary, N., Strelkova, D., Arral, M. L., Pardi, N., Alameh, M. G., Miller, J. B., Farbiak, L., Siegwart, D. J., Weissman, D. & Whitehead, K. A., Jan 2022, In: Journal of Controlled Release. 341, p. 206-214 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Nucleosides 100%
  • Nucleoside 87%
  • Nanoparticles 83%
  • Lipid 65%
  • Lipids 61%
  26 Scopus citations

• Next-Generation Diprovocims with Potent Human and Murine TLR1/TLR2 Agonist Activity That Activate the Innate and Adaptive Immune Response

  Yang, M. H., Russell, J. L., Mifune, Y., Wang, Y., Shi, H., Moresco, E. M. Y., Siegwart, D. J., Beutler, B. & Boger, D. L., Jul 14 2022, In: Journal of Medicinal Chemistry. 65, 13, p. 9230-9252 23 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Toll Like Receptor Agonist 100%
  • Adjuvant 59%
  • Toll-Like Receptors 52%
  • Adaptive Immunity 49%
  • Agonist 46%
  3 Scopus citations

• Optimization of phospholipid chemistry for improved lipid nanoparticle (LNP) delivery of messenger RNA (mRNA)

  Álvarez-Benedicto, E., Farbiak, L., Márquez Ramírez, M., Wang, X., Johnson, L. T., Mian, O., Guerrero, E. D. & Siegwart, D. J., Jan 21 2022, In: Biomaterials Science. 10, 2, p. 549-559 11 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Phospholipids 100%
  • Messenger RNA 87%
  • Lipids 83%
  • Nanoparticles 61%
  • Phospholipid 51%
  54 Scopus citations

• Proton magnetic resonance spectroscopy detects cerebral metabolic derangement in a mouse model of brain coenzyme a deficiency

  Li, Y., Steinberg, J., Coleman, Z., Wang, S., Subramanian, C., Li, Y., Patay, Z., Akers, W., Rock, C. O., Jackowski, S. & Bagga, P., Dec 2022, In: Journal of Translational Medicine. 20, 1, 103.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • 4-boronic acid benzophenone 86%
  • Coenzymes 79%
  • Coenzyme A 76%
  • Proton Magnetic Resonance Spectroscopy 72%
  • Coenzyme 66%
  3 Scopus citations
• 2021

  All-In-One Dendrimer-Based Lipid Nanoparticles Enable Precise HDR-Mediated Gene Editing In Vivo

  Farbiak, L., Cheng, Q., Wei, T., Álvarez-Benedicto, E., Johnson, L. T., Lee, S. & Siegwart, D. J., Jul 28 2021, In: Advanced Materials. 33, 30, 2006619.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Dendrimers 100%
  • Lipids 74%
  • Nanoparticles 54%
  • Genes 53%
  • Repair 45%
  50 Scopus citations

• A Systematic Study of Unsaturation in Lipid Nanoparticles Leads to Improved mRNA Transfection In Vivo

  Lee, S. M., Cheng, Q., Yu, X., Liu, S., Johnson, L. T. & Siegwart, D. J., Mar 8 2021, In: Angewandte Chemie - International Edition. 60, 11, p. 5848-5853 6 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Messenger RNA 100%
  • Lipids 95%
  • Nanoparticles 70%
  • Lipid 49%
  • Nanoparticle 35%
  56 Scopus citations

• Detection of cold stress in plants using fluorescence lifetime imaging (Flim)

  Peng, O., Akers, W. & Berezin, M. Y., 2021, In: Current Analytical Chemistry. 17, 3, p. 317-327 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Fluorescence Lifetime 100%
  • High Throughput Screening 51%
  • Fluorescence Decay 27%
  • Fluorescence Intensity 21%
  • Leaf Like Crystal 20%
  3 Scopus citations

• Hydrophobic optimization of functional poly(Tpae-co-suberoyl chloride) for extrahepatic mrna delivery following intravenous administration

  Yu, X., Liu, S., Cheng, Q., Lee, S. M., Wei, T., Wang, X., Siegwart, D. J., Zhang, D., Farbiak, L. & Johnson, L. T., Nov 2021, In: Pharmaceutics. 13, 11, 1914.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Messenger RNA 100%
  • Chlorides 80%
  • Intravenous Administration 71%
  • Chloride 44%
  • A 17 25%
  6 Scopus citations

• Membrane-destabilizing ionizable phospholipids for organ-selective mRNA delivery and CRISPR–Cas gene editing

  Liu, S., Cheng, Q., Wei, T., Yu, X., Johnson, L. T., Farbiak, L. & Siegwart, D. J., May 2021, In: Nature Materials. 20, 5, p. 701-710 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Phospholipids 100%
  • editing 90%
  • Messenger RNA 87%
  • genes 72%
  • Lipids 69%
  269 Scopus citations

• Next-generation humanized patient-derived xenograft mouse model for pre-clinical antibody studies in neuroblastoma

  Nguyen, R., Patel, A. G., Griffiths, L. M., Dapper, J., Stewart, E. A., Houston, J., Johnson, M., Akers, W. J., Furman, W. L. & Dyer, M. A., Mar 2021, In: Cancer Immunology, Immunotherapy. 70, 3, p. 721-732 12 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Neuroblastoma 100%
  • Heterografts 90%
  • Natural Killer Cells 77%
  • Clinical Studies 69%
  • Antibodies 55%
  16 Scopus citations

• On the mechanism of tissue-specific mRNA delivery by selective organ targeting nanoparticles

  Dilliard, S. A., Cheng, Q. & Siegwart, D. J., Dec 28 2021, In: Proceedings of the National Academy of Sciences of the United States of America. 118, 52, e2109256118.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Nanoparticles 100%
  • Messenger RNA 64%
  • Lipids 24%
  • Liver 19%
  • RNA Editing 17%
  264 Scopus citations

• Recent advances in the targeted fluorescent probes for the detection of metastatic bone cancer

  Wu, P., Siegwart, D. J. & Xiong, H., Aug 2021, In: Science China Chemistry. 64, 8, p. 1283-1296 14 p.

  Research output: Contribution to journal › Review article › peer-review

  • Fluorescent Probe 100%
  • Probe 43%
  • Molecular Probe 42%
  • Ligand 15%
  7 Scopus citations

• Selection of hyperspectral endmember extraction algorithm for tumor delineation in animal models

  Mishra, D., Wang, J., Wang, S. T., Cao, Q., Hurbon, H., Akers, W. & Berezin, M. Y., 2021, In: Optics InfoBase Conference Papers. OF2E.2.

  Research output: Contribution to journal › Conference article › peer-review

  • Tumors 100%
  • Animals 94%
  • Imaging techniques 74%
  • Application 30%

• Targeting the spliceosome through RBM39 degradation results in exceptional responses in high-risk neuroblastoma models

  Singh, S., Quarni, W., Goralski, M., Wan, S., Jin, H., van de Velde, L. A., Fang, J., Wu, Q., Abu-Zaid, A., Wang, T., Singh, R., Craft, D., Fan, Y., Confer, T., Johnson, M., Akers, W. J., Wang, R., Murray, P. J., Thomas, P. G., Nijhawan, D., & 2 othersDavidoff, A. M. & Yang, J., Nov 2021, In: Science Advances. 7, 47, eabj5405.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • N-(3-chloro-7-indolyl)-1,4-benzenedisulphonamide 100%
  • Spliceosomes 92%
  • Neuroblastoma 67%
  • RNA Splicing Factors 22%
  • Ubiquitin-Protein Ligases 19%
  22 Scopus citations

• TRIM7 inhibits enterovirus replication and promotes emergence of a viral variant with increased pathogenicity

  Fan, W., Mar, K. B., Sari, L., Gaszek, I. K., Cheng, Q., Evers, B. M., Shelton, J. M., Wight-Carter, M., Siegwart, D. J., Lin, M. M. & Schoggins, J. W., Jun 24 2021, In: Cell. 184, 13, p. 3410-3425.e17

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Enterovirus 100%
  • Effector 94%
  • Virulence 75%
  • Mutation 73%
  • 2C helicase 64%
  33 Scopus citations