Research Output

2020

Absolute proteomic quantification reveals design principles of sperm flagellar chemosensation

Trötschel, C., Hamzeh, H., Alvarez, L., Pascal, R., Lavryk, F., Bönigk, W., Körschen, H. G., Müller, A., Poetsch, A., Rennhack, A., Gui, L., Nicastro, D., Strünker, T., Seifert, R. & Kaupp, U. B., Feb 17 2020, In : EMBO Journal. 39, 4, e102723.

Research output: Contribution to journalArticle

Open Access

A genomic perspective on the taxonomy of the subtribe Carcharodina (Lepidoptera: Hesperiidae: Carcharodini)

Zhang, J., Brockmann, E., Cong, Q., Shen, J. & Grishin, N. V., Mar 5 2020, In : Zootaxa. 4748, 1, p. 182-194 13 p.

Research output: Contribution to journalArticle

Open Access

A lytic polysaccharide monooxygenase-like protein functions in fungal copper import and meningitis

Garcia-Santamarina, S., Probst, C., Festa, R. A., Ding, C., Smith, A. D., Conklin, S. E., Brander, S., Kinch, L. N., Grishin, N. V., Franz, K. J., Riggs-Gelasco, P., Lo Leggio, L., Johansen, K. S. & Thiele, D. J., Mar 1 2020, In : Nature chemical biology. 16, 3, p. 337-344 8 p.

Research output: Contribution to journalArticle

1 Scopus citations

A Phosphorylated Intermediate in the Activation of WNK Kinases

Akella, R., Drozdz, M. A., Humphreys, J. M., Jiou, J., Durbacz, M. Z., Mohammed, Z. J., He, H., Liwocha, J., Sekulski, K. & Goldsmith, E. J., May 12 2020, In : Biochemistry. 59, 18, p. 1747-1755 9 p.

Research output: Contribution to journalArticle

CLASPs at a glance

Lawrence, E. J., Zanic, M. & Rice, L. M., Apr 2020, In : Journal of cell science. 133, 8, jcs243097.

Research output: Contribution to journalArticle

Open Access

Cryo-EM structure of the PlexinC1/A39R complex reveals inter-domain interactions critical for ligand-induced activation

Kuo, Y. C., Chen, H., Shang, G., Uchikawa, E., Tian, H., Bai, X. C. & Zhang, X., Dec 1 2020, In : Nature communications. 11, 1, 1953.

Research output: Contribution to journalArticle

Open Access

Cryo-EM Structures of Human Drosha and DGCR8 in Complex with Primary MicroRNA

Partin, A. C., Zhang, K., Jeong, B. C., Herrell, E., Li, S., Chiu, W. & Nam, Y., May 7 2020, In : Molecular cell. 78, 3, p. 411-422.e4

Research output: Contribution to journalArticle

Fast and Robust Quantification of Detergent Micellization Thermodynamics from Isothermal Titration Calorimetry

Tso, S. C., Mahler, F., Höring, J., Keller, S. & Brautigam, C. A., Jan 1 2020, (Accepted/In press) In : Analytical chemistry.

Research output: Contribution to journalArticle

Insights into allosteric control of microtubule dynamics from a buried β-tubulin mutation that causes faster growth and slower shrinkage

Ye, X., Kim, T., Geyer, E. A. & Rice, L. M., Jan 1 2020, (Accepted/In press) In : Protein Science.

Research output: Contribution to journalArticle

In situ structure determination at nanometer resolution using TYGRESS

Song, K., Shang, Z., Fu, X., Lou, X., Grigorieff, N. & Nicastro, D., Feb 1 2020, In : Nature methods. 17, 2, p. 201-208 8 p.

Research output: Contribution to journalArticle

1 Scopus citations

Novel MscL agonists that allow multiple antibiotics cytoplasmic access activate the channel through a common binding site

Wray, R., Wang, J., Iscla, I. & Blount, P., Jan 1 2020, In : PloS one. 15, 1, e0228153.

Research output: Contribution to journalArticle

Open Access

PCRM1exportome: Database of predicted CRM1-dependent Nuclear Export Signal (NES) motifs in cancer-related genes

Lee, Y., Baumhardt, J. M., Pei, J., Chook, Y. M. & Grishin, N. V., Feb 1 2020, In : Bioinformatics. 36, 3, p. 961-963 3 p.

Research output: Contribution to journalArticle

Recent advances suggest increased influence of selective pressure in allostery

Bhat, A. S., Dustin Schaeffer, R., Kinch, L., Medvedev, K. E. & Grishin, N. V., Jun 2020, In : Current Opinion in Structural Biology. 62, p. 183-188 6 p.

Research output: Contribution to journalReview article

RUVBL1/RUVBL2 ATPase Activity Drives PAQosome Maturation, DNA Replication and Radioresistance in Lung Cancer

Yenerall, P., Das, A. K., Wang, S., Kollipara, R. K., Li, L. S., Villalobos, P., Flaming, J., Lin, Y. F., Huffman, K., Timmons, B. C., Gilbreath, C., Sonavane, R., Kinch, L. N., Rodriguez-Canales, J., Moran, C., Behrens, C., Hirasawa, M., Takata, T., Murakami, R., Iwanaga, K. & 6 others, Chen, B. P. C., Grishin, N. V., Raj, G. V., Wistuba, I. I., Minna, J. D. & Kittler, R., Jan 16 2020, In : Cell Chemical Biology. 27, 1, p. 105-121.e14

Research output: Contribution to journalArticle

1 Scopus citations

Speciation in North American Junonia from a genomic perspective

Cong, Q., Zhang, J., Shen, J., Cao, X., Brévignon, C. & Grishin, N. V., Jan 1 2020, (Accepted/In press) In : Systematic Entomology.

Research output: Contribution to journalArticle

Strategies for Engineering and Rewiring Kinase Regulation

McCormick, J. W., Pincus, D., Resnekov, O. & Reynolds, K. A., Mar 2020, In : Trends in biochemical sciences. 45, 3, p. 259-271 13 p.

Research output: Contribution to journalReview article

Synaptotagmin-1 and Doc2b Exhibit Distinct Membrane-Remodeling Mechanisms

Sorkin, R., Marchetti, M., Logtenberg, E., Piontek, M. C., Kerklingh, E., Brand, G., Voleti, R., Rizo, J., Roos, W. H., Groffen, A. J. & Wuite, G. J. L., Feb 4 2020, In : Biophysical journal. 118, 3, p. 643-656 14 p.

Research output: Contribution to journalArticle

The mitogenome of a malagasy butterfly malaza fastuosus (Mabille, 1884) recovered from the holotype collected over 140 years ago adds support for a new subfamily of hesperiidae (lepidoptera)

Zhang, J., Lees, D. C., Shen, J., Cong, Q., Huertas, B., Martin, G. & Grishin, N. V., Jan 1 2020, In : Genome. 63, 4, p. 195-202 8 p.

Research output: Contribution to journalArticle

Open Access
2019

A Bacterial Effector Mimics a Host HSP90 Client to Undermine Immunity

Lopez, V. A., Park, B. C., Nowak, D., Sreelatha, A., Zembek, P., Fernandez, J., Servage, K. A., Gradowski, M., Hennig, J., Tomchick, D. R., Pawłowski, K., Krzymowska, M. & Tagliabracci, V. S., Sep 19 2019, In : Cell. 179, 1, p. 205-218.e21

Research output: Contribution to journalArticle

3 Scopus citations

A composition-dependent molecular clutch between T cell signaling condensates and actin

Ditlev, J. A., Vega, A. R., Köster, D. V., Su, X., Tani, T., Lakoduk, A. M., Vale, R. D., Mayor, S., Jaqaman, K. & Rosen, M. K., Jul 3 2019, In : eLife. 8

Research output: Contribution to journalArticle

Open Access
6 Scopus citations

Agonist Selectivity and Ion Permeation in the α3β4 Ganglionic Nicotinic Receptor

Gharpure, A., Teng, J., Zhuang, Y., Noviello, C. M., Walsh, R. M., Cabuco, R., Howard, R. J., Zaveri, N. T., Lindahl, E. & Hibbs, R. E., Nov 6 2019, In : Neuron. 104, 3, p. 501-511.e6

Research output: Contribution to journalArticle

6 Scopus citations

And three's a party: lysosomes, lipid droplets, and the ER in lipid trafficking and cell homeostasis

Henne, M., Aug 2019, In : Current Opinion in Cell Biology. 59, p. 40-49 10 p.

Research output: Contribution to journalReview article

Open Access
5 Scopus citations

An improved yeast surface display platform for the screening of nanobody immune libraries

Uchański, T., Zögg, T., Yin, J., Yuan, D., Wohlkönig, A., Fischer, B., Rosenbaum, D. M., Kobilka, B. K., Pardon, E. & Steyaert, J., Dec 1 2019, In : Scientific reports. 9, 1, 382.

Research output: Contribution to journalArticle

4 Scopus citations

Assessing predictions on fitness effects of missense variants in calmodulin

Zhang, J., Kinch, L. N., Cong, Q., Katsonis, P., Lichtarge, O., Savojardo, C., Babbi, G., Martelli, P. L., Capriotti, E., Casadio, R., Garg, A., Pal, D., Weile, J., Sun, S., Verby, M., Roth, F. P. & Grishin, N. V., Jan 1 2019, (Accepted/In press) In : Human Mutation.

Research output: Contribution to journalArticle

2 Scopus citations

A Two-Enzyme Adaptive Unit within Bacterial Folate Metabolism

Schober, A. F., Mathis, A. D., Ingle, C., Park, J. O., Chen, L., Rabinowitz, J. D., Junier, I., Rivoire, O. & Reynolds, K. A., Jun 11 2019, In : Cell Reports. 27, 11, p. 3359-3370.e7

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Bacterial pseudokinase catalyzes protein polyglutamylation to inhibit the SidE-family ubiquitin ligases

Black, M. H., Osinski, A., Gradowski, M., Servage, K. A., Pawłowski, K., Tomchick, D. R. & Tagliabracci, V. S., May 24 2019, In : Science (New York, N.Y.). 364, 6442, p. 787-792 6 p.

Research output: Contribution to journalArticle

Bridges between Antimalarials and Synaptic Transmission

Kim, J. J. & Hibbs, R. E., Feb 20 2019, In : Neuron. 101, 4, p. 546-547 2 p.

Research output: Contribution to journalShort survey

CAKUT and Autonomic Dysfunction Caused by Acetylcholine Receptor Mutations

Mann, N., Kause, F., Henze, E. K., Gharpure, A., Shril, S., Connaughton, D. M., Nakayama, M., Klämbt, V., Majmundar, A. J., Wu, C. H. W., Kolvenbach, C. M., Dai, R., Chen, J., van der Ven, A. T., Ityel, H., Tooley, M. J., Kari, J. A., Bownass, L., El Desoky, S., De Franco, E. & 13 others, Shalaby, M., Tasic, V., Bauer, S. B., Lee, R. S., Beckel, J. M., Yu, W., Mane, S. M., Lifton, R. P., Reutter, H., Ellard, S., Hibbs, R. E., Kawate, T. & Hildebrandt, F., Dec 5 2019, In : American Journal of Human Genetics. 105, 6, p. 1286-1293 8 p.

Research output: Contribution to journalArticle

CASP13 target classification into tertiary structure prediction categories

Kinch, L. N., Kryshtafovych, A., Monastyrskyy, B. & Grishin, N. V., Jan 1 2019, In : Proteins: Structure, Function and Bioinformatics.

Research output: Contribution to journalArticle

6 Scopus citations

Cerebellar ataxia disease-associated Snx14 promotes lipid droplet growth at ER-droplet contacts

Datta, S., Liu, Y., Hariri, H., Bowerman, J. & Henne, W. M., Jan 1 2019, In : Journal of Cell Biology. 218, 4, p. 1335-1351 17 p.

Research output: Contribution to journalArticle

Open Access
19 Scopus citations

Chemical and structural analysis of a photoactive vertebrate cryptochrome from pigeon

Zoltowski, B. D., Chelliah, Y., Wickramaratne, A., Jarocha, L., Karki, N., Xu, W., Mouritsen, H., Hore, P. J., Hibbs, R. E., Green, C. B. & Takahashi, J. S., Sep 24 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 39, p. 19449-19457 9 p.

Research output: Contribution to journalArticle

Open Access
6 Scopus citations

Classification of the human phox homology (PX) domains based on their phosphoinositide binding specificities

Chandra, M., Chin, Y. K. Y., Mas, C., Feathers, J. R., Paul, B., Datta, S., Chen, K. E., Jia, X., Yang, Z., Norwood, S. J., Mohanty, B., Bugarcic, A., Teasdale, R. D., Henne, W. M., Mobli, M. & Collins, B. M., Dec 1 2019, In : Nature communications. 10, 1, 1528.

Research output: Contribution to journalArticle

Open Access
13 Scopus citations

Combined blockade of activating ERBB2 mutations and ER results in synthetic lethality of ERþ/HER2 mutant breast cancer

Croessmann, S., Formisano, L., Kinch, L. N., Gonzalez-Ericsson, P. I., Sudhan, D. R., Nagy, R. J., Mathew, A., Bernicker, E. H., Cristofanilli, M., He, J., Cutler, R. E., Lalani, A. S., Miller, V. A., Lanman, R. B., Grishin, N. V. & Arteaga, C. L., Jan 1 2019, In : Clinical Cancer Research. 25, 1, p. 277-289 13 p.

Research output: Contribution to journalArticle

10 Scopus citations
Open Access

Cryo-EM analyses reveal the common mechanism and diversification in the activation of RET by different ligands

Li, J., Shang, G., Chen, Y. J., Brautigam, C. A., Liou, J., Zhang, X. & Bai, X. C., Sep 2019, In : eLife. 8, e47650.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Cryo-EM structures of STING reveal its mechanism of activation by cyclic GMP–AMP

Shang, G., Zhang, C., Chen, Z., Bai, X. & Zhang, X., Mar 21 2019, In : Nature. 567, 7748, p. 389-393 5 p.

Research output: Contribution to journalLetter

32 Scopus citations

Cryo-EM structures of the human cation-chloride cotransporter KCC1

Liu, S., Chang, S., Han, B., Xu, L., Zhang, M., Zhao, C., Yang, W., Wang, F., Li, J., Delpire, E., Ye, S., Bai, X. C. & Guo, J., Oct 25 2019, In : Science. 366, 6464, p. 505-508 4 p.

Research output: Contribution to journalArticle

4 Scopus citations
1 Scopus citations

Direct observation of individual tubulin dimers binding to growing microtubules

Mickolajczyk, K. J., Geyer, E. A., Kim, T., Rice, L. M. & Hancock, W. O., Apr 9 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 15, p. 7314-7322 9 p.

Research output: Contribution to journalArticle

9 Scopus citations

Divergent kinase regulates membrane ultrastructure of the Toxoplasma parasitophorous vacuole

Beraki, T., Hu, X., Broncel, M., Young, J. C., O'Shaughnessy, W. J., Borek, D., Treeck, M. & Reese, M. L., Jan 1 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 13, p. 6361-6370 10 p.

Research output: Contribution to journalArticle

Open Access
6 Scopus citations

Drosophila Snazarus Regulates a Lipid Droplet Population at Plasma Membrane-Droplet Contacts in Adipocytes

Ugrankar, R., Bowerman, J., Hariri, H., Chandra, M., Chen, K., Bossanyi, M. F., Datta, S., Rogers, S., Eckert, K. M., Dias do Vale, G., Victoria, A., Fresquez, J., McDonald, J. G., Jean, S., Collins, B. M. & Henne, W. M., Sep 9 2019, In : Developmental Cell. 50, 5, p. 557-572.e5

Research output: Contribution to journalArticle

3 Scopus citations

ECOD: Identification of distant homology among multidomain and transmembrane domain proteins

Schaeffer, R. D., Kinch, L., Medvedev, K. E., Pei, J., Cheng, H. & Grishin, N., Jun 21 2019, In : BMC Molecular and Cell Biology. 20, 1, 18.

Research output: Contribution to journalArticle

Open Access

Effector Specificity Mechanisms of Rab35 GTPase

Kuo, Y. C. & Zhang, X., May 7 2019, In : Structure. 27, 5, p. 725-727 3 p.

Research output: Contribution to journalShort survey

Enhanced Sample Handling for Analytical Ultracentrifugation with 3D-Printed Centerpieces

To, S. C., Brautigam, C. A., Chaturvedi, S. K., Bollard, M. T., Krynitsky, J., Kakareka, J. W., Pohida, T. J., Zhao, H. & Schuck, P., May 7 2019, In : Analytical chemistry. 91, 9, p. 5866-5873 8 p.

Research output: Contribution to journalArticle

2 Scopus citations

FAP57/WDR65 targets assembly of a subset of inner arm dyneins and connects to regulatory hubs in cilia

Lin, J., Le, T. V., Augspurger, K., Tritschler, D., Bower, R., Fu, G., Perrone, C., O'Toole, E. T., VanderWaal Mills, K., Dymek, E., Smith, E., Nicastro, D. & Porter, M. E., Oct 1 2019, In : Molecular biology of the cell. 30, 21, p. 2659-2680 22 p.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

FISIK: Framework for the Inference of In Situ Interaction Kinetics from Single-Molecule Imaging Data

de Oliveira, L. R. & Jaqaman, K., Jan 1 2019, (Accepted/In press) In : Biophysical Journal.

Research output: Contribution to journalArticle

Functional analysis of rossmann-like domains reveals convergent evolution of topology and reaction pathways

Medvedevid, K. E., Kinch, L. N., Schaeffer, R. D. & Grishin, N. V., Dec 23 2019, In : PLoS Computational Biology. 15, 12, e1007569.

Research output: Contribution to journalArticle

Open Access

Functional Assessment of Lipoyltransferase-1 Deficiency in Cells, Mice, and Humans

Ni, M., Solmonson, A., Pan, C., Yang, C., Li, D., Notzon, A., Cai, L., Guevara, G., Zacharias, L. G., Faubert, B., Vu, H. S., Jiang, L., Ko, B., Morales, N. M., Pei, J., Vale, G., Rakheja, D., Grishin, N. V., McDonald, J. G., Gotway, G. K. & 3 others, McNutt, M. C., Pascual, J. M. & DeBerardinis, R. J., Apr 30 2019, In : Cell Reports. 27, 5, p. 1376-1386.e6

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Functional divergence caused by mutations in an energetic hotspot in ERK2

Taylor, C. A., Cormier, K. W., Keenan, S. E., Earnest, S., Stippec, S., Wichaidit, C., Juang, Y. C., Wang, J., Shvartsman, S. Y., Goldsmith, E. J. & Cobb, M. H., Jul 30 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 31, p. 15514-15523 10 p.

Research output: Contribution to journalArticle

Open Access
4 Scopus citations

Genomes of skipper butterflies reveal extensive convergence of wing patterns

Li, W., Cong, Q., Shen, J., Zhang, J., Hallwachs, W., Janzen, D. H. & Grishin, N. V., Jan 1 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 13, p. 6232-6237 6 p.

Research output: Contribution to journalArticle

Open Access
15 Scopus citations