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113Cd-1H hetero TOCSY: A method for determining metal-protein connectivities

Gardner, K. H. & Coleman, J. E., Nov 1 1994, In : Journal of biomolecular NMR. 4, 6, p. 761-774 14 p.

Research output: Contribution to journalArticle

17 Scopus citations

1H and 15N assignments and secondary structure of the Src SH3 domain

Yu, H., Rosen, M. K. & Schreiber, S. L., Jun 7 1993, In : FEBS Letters. 324, 1, p. 87-92 6 p.

Research output: Contribution to journalArticle

48 Scopus citations
37 Scopus citations

A Bacterial Effector Mimics a Host HSP90 Client to Undermine Immunity

Lopez, V. A., Park, B. C., Nowak, D., Sreelatha, A., Zembek, P., Fernandez, J., Servage, K. A., Gradowski, M., Hennig, J., Tomchick, D. R., Pawłowski, K., Krzymowska, M. & Tagliabracci, V. S., Sep 19 2019, In : Cell. 179, 1, p. 205-218.e21

Research output: Contribution to journalArticle

6 Scopus citations

A broken α-helix in folded α-synuclein

Chandra, S., Chen, X., Rizo-Rey, J., Jahn, R. & Südhof, T. C., Apr 25 2003, In : Journal of Biological Chemistry. 278, 17, p. 15313-15318 6 p.

Research output: Contribution to journalArticle

339 Scopus citations

Absence of TLR11 in Mice Does Not Confer Susceptibility to Salmonella Typhi

Song, J., Wilhelm, C. L., Wangdi, T., Maira-Litran, T., Lee, S. J., Raetz, M., Sturge, C. R., Mirpuri, J., Pei, J., Grishin, N. V., McSorley, S. J., Gewirtz, A. T., Bäumler, A. J., Pier, G. B., Galán, J. E. & Yarovinsky, F., Feb 25 2016, In : Cell. 164, 5, p. 827-828 2 p.

Research output: Contribution to journalArticle

9 Scopus citations

Acidic region tyrosines provide access points for allosteric activation of the autoinhibited Vav1 Db1 homology domain

Amarasinghe, G. K. & Rosen, M. K., Nov 22 2005, In : Biochemistry. 44, 46, p. 15257-15268 12 p.

Research output: Contribution to journalArticle

26 Scopus citations

A Complexin/Synaptotagmin 1 Switch Controls Fast Synaptic Vesicle Exocytosis

Tang, J., Maximov, A., Shin, O. H., Dai, H., Rizo-Rey, J. & Südhof, T. C., Sep 22 2006, In : Cell. 126, 6, p. 1175-1187 13 p.

Research output: Contribution to journalArticle

315 Scopus citations

A composition-dependent molecular clutch between T cell signaling condensates and actin

Ditlev, J. A., Vega, A. R., Köster, D. V., Su, X., Tani, T., Lakoduk, A. M., Vale, R. D., Mayor, S., Jaqaman, K. & Rosen, M. K., Jul 2019, In : eLife. 8, e42695.

Research output: Contribution to journalArticle

Open Access
8 Scopus citations

A comprehensive update of the sequence and structure classification of kinases

Cheek, S., Ginalski, K., Zhang, H. & Grishin, N. V., Mar 16 2005, In : BMC Structural Biology. 5, 6.

Research output: Contribution to journalArticle

93 Scopus citations

A conformational switch in syntaxin during exocytosis: Role of munc18

Dulubova, I., Sugita, S., Hill, S., Hosaka, M., Fernandez, I., Südhof, T. C. & Rizo-Rey, J., Aug 16 1999, In : EMBO Journal. 18, 16, p. 4372-4382 11 p.

Research output: Contribution to journalArticle

499 Scopus citations

A conformational switch in the Piccolo C2A domain regulated by alternative splicing

Garcia, J., Gerber, S. H., Sugita, S., Südhof, T. C. & Rizo-Rey, J., Jan 1 2004, In : Nature Structural and Molecular Biology. 11, 1, p. 45-53 9 p.

Research output: Contribution to journalArticle

69 Scopus citations

A conserved amphipathic helix in WASP/scar proteins is essential for activation of Arp2/3 complex

Panchal, S. C., Kaiser, D. A., Torres, E., Pollard, T. D. & Rosen, M. K., Aug 1 2003, In : Nature Structural Biology. 10, 8, p. 591-598 8 p.

Research output: Contribution to journalArticle

118 Scopus citations

A conserved glutamine plays a central role in LOV domain signal transmission and Its duration

Nash, A. I., Ko, W. H., Harper, S. M. & Gardner, K. H., Dec 30 2008, In : Biochemistry. 47, 52, p. 13842-13849 8 p.

Research output: Contribution to journalArticle

68 Scopus citations

Actin cytoskeleton reorganization by syk regulates fcγ receptor responsiveness by increasing its lateral mobility and clustering

Jaumouillé, V., Farkash, Y., Jaqaman, K., Das, R., Lowell, C. A. & Grinstein, S., Jun 9 2014, In : Developmental Cell. 29, 5, p. 534-546 13 p.

Research output: Contribution to journalArticle

56 Scopus citations

Actin is an evolutionarily-conserved damage-associated molecular pattern that signals tissue injury in Drosophila melanogaster

Srinivasan, N., Gordon, O., Ahrens, S., Franz, A., Deddouche, S., Chakravarty, P., Phillips, D., Yunus, A. A., Rosen, M. K., Valente, R. S., Teixeira, L., Thompson, B., Dionne, M. S., Wood, W. & Reis e Sousa, C., Nov 22 2016, In : eLife. 5, NOVEMBER2016, e19662.

Research output: Contribution to journalArticle

23 Scopus citations

Activated RhoA binds to the Pleckstrin Homology (PH) domain of PDZ-RhoGEF, a potential site for autoregulation

Chen, Z., Medina, F., Liu, M. Y., Thomas, C., Sprang, S. R. & Sternweis, P. C., Jul 2 2010, In : Journal of Biological Chemistry. 285, 27, p. 21070-21081 12 p.

Research output: Contribution to journalArticle

38 Scopus citations

Activated RhoA is a positive feedback regulator of the Lbc family of Rho guanine nucleotide exchange factor proteins

Medina, F., Carter, A. M., Dada, O., Gutowski, S., Hadas, J., Chen, Z. & Sternweis, P. C., Apr 19 2013, In : Journal of Biological Chemistry. 288, 16, p. 11325-11333 9 p.

Research output: Contribution to journalArticle

27 Scopus citations

Activating WASP mutations associated with X-linked neutropenia result in enhanced actin polymerization, altered cytoskeletal responses, and genomic instability in lymphocytes

Westerberg, L. S., Meelu, P., Baptista, M., Eston, M. A., Adamovich, D. A., Cotta-de-Almeida, V., Seed, B., Rosen, M. K., Vandenberghe, P., Thrasher, A. J., Klein, C., Alt, F. W. & Snapper, S. B., Jun 7 2010, In : Journal of Experimental Medicine. 207, 6, p. 1145-1152 8 p.

Research output: Contribution to journalArticle

37 Scopus citations

Activation mechanism of the insulin receptor revealed by cryo-EM structure of the fully liganded receptor-ligand complex

Uchikawa, E., Choi, E., Shang, G., Yu, H. & Xiao-Chen, B., Aug 2019, In : eLife. 8, e48630.

Research output: Contribution to journalArticle

Open Access
11 Scopus citations

Activation of p115-RhoGEF requires direct association of Gα13and the Dbl homology domain

Chen, Z., Guo, L., Hadas, J., Gutowski, S., Sprang, S. R. & Sternweis, P. C., Jul 20 2012, In : Journal of Biological Chemistry. 287, 30, p. 25490-25500 11 p.

Research output: Contribution to journalArticle

27 Scopus citations

Activation of the DExD/H-box protein Dbp5 by the nuclear-pore protein Gle1 and its coactivator InsP6 is required for mRNA export

Weirich, C. S., Erzberger, J. P., Flick, J. S., Berger, J. M., Thorner, J. & Weis, K., Jul 1 2006, In : Nature cell biology. 8, 7, p. 668-676 9 p.

Research output: Contribution to journalArticle

187 Scopus citations

Active nuclear import and passive nuclear export are the primary determinants of TDP-43 localization

Pinarbasi, E. S., Caǧatay, T., Fung, H. Y. J., Li, Y. C., Chook, Y. M. & Thomas, P. J., Dec 1 2018, In : Scientific Reports. 8, 1, 7083.

Research output: Contribution to journalArticle

21 Scopus citations

Adaptation of an enzyme to regulatory function: Structure of Bacillus subtilis PyrR, a pyr RNA-binding attenuation protein and uracil phosphoribosyltransferase

Tomchick, D. R., Turner, R. J., Switzer, R. L. & Smith, J. L., Mar 15 1998, In : Structure. 6, 3, p. 337-350 14 p.

Research output: Contribution to journalArticle

Open Access
58 Scopus citations

A distinct inhibitory mechanism of the V-ATPase by Vibrio VopQ revealed by cryo-EM

Peng, W., Casey, A. K., Fernandez, J., Carpinone, E. M., Servage, K. A., Chen, Z., Li, Y., Tomchick, D. R., Starai, V. J. & Orth, K., Jun 1 2020, In : Nature Structural and Molecular Biology. 27, 6, p. 589-597 9 p.

Research output: Contribution to journalArticle

A Dual-H-NOX Signaling System in Saccharophagus degradans

Guo, Y., Cooper, M. M., Bromberg, R. & Marletta, M. A., Nov 27 2018, In : Biochemistry. 57, 47, p. 6570-6580 11 p.

Research output: Contribution to journalArticle

A large kindred with X-linked neutropenia with an I294T mutation of the Wiskott-Aldrich syndrome gene

Beel, K., Cotter, M. M., Blatny, J., Bond, J., Lucas, G., Green, F., Vanduppen, V., Leung, D. W., Rooney, S., Smith, O. P., Rosen, M. K. & Vandenberghe, P., Jan 1 2009, In : British Journal of Haematology. 144, 1, p. 120-126 7 p.

Research output: Contribution to journalArticle

64 Scopus citations

A Legionella effector kinase is activated by host inositol hexakisphosphate

Sreelatha, A., Nolan, C., Park, B. C., Pawłowski, K., Tomchick, D. R. & Tagliabracci, V. S., May 1 2020, In : Journal of Biological Chemistry. 295, 18, p. 6214-6224 11 p.

Research output: Contribution to journalArticle

Allosteric inhibition of hypoxia inducible factor-2 with small molecules

Scheuermann, T. H., Li, Q., Ma, H. W., Key, J., Zhang, L., Chen, R., Garcia, J. A., Naidoo, J., Longgood, J., Frantz, D. E., Tambar, U. K., Gardner, K. H. & Bruick, R. K., Apr 1 2013, In : Nature chemical biology. 9, 4, p. 271-276 6 p.

Research output: Contribution to journalArticle

141 Scopus citations

Allosteric Modulation of Grb2 Recruitment to the Intrinsically Disordered Scaffold Protein, LAT, by Remote Site Phosphorylation

Huang, W. Y. C., Ditlev, J. A., Chiang, H. K., Rosen, M. K. & Groves, J. T., Dec 13 2017, In : Journal of the American Chemical Society. 139, 49, p. 18009-18015 7 p.

Research output: Contribution to journalArticle

5 Scopus citations

A long-duration dihydroorotate dehydrogenase inhibitor (DSM265) for prevention and treatment of malaria

Phillips, M. A., Lotharius, J., Marsh, K., White, J., Dayan, A., White, K. L., Njoroge, J. W., El Mazouni, F., Lao, Y., Kokkonda, S., Tomchick, D. R., Deng, X., Laird, T., Bhatia, S. N., March, S., Ng, C. L., Fidock, D. A., Wittlin, S., Lafuente-Monasterio, M., Benito, F. J. G. & 33 others, Alonso, L. M. S., Martinez, M. S., Jimenez-Diaz, M. B., Bazaga, S. F., Angulo-Barturen, I., Haselden, J. N., Louttit, J., Cui, Y., Sridhar, A., Zeeman, A. M., Kocken, C., Sauerwein, R., Dechering, K., Avery, V. M., Duffy, S., Delves, M., Sinden, R., Ruecker, A., Wickham, K. S., Rochford, R., Gahagen, J., Iyer, L., Riccio, E., Mirsalis, J., Bathhurst, I., Rueckle, T., Ding, X., Campo, B., Leroy, D., Rogers, M. J., Rathod, P. K., Burrows, J. N. & Charman, S. A., Jul 15 2015, In : Science translational medicine. 7, 296, aaa6645.

Research output: Contribution to journalArticle

126 Scopus citations

A minimal domain responsible for Munc13 activity

Basu, J., Shen, N., Dulubova, I., Lu, J., Guan, R., Guryev, O., Grishin, N. V., Rosenmund, C. & Rizo-Rey, J., Nov 29 2005, In : Nature Structural and Molecular Biology. 12, 11, p. 1017-1018 2 p.

Research output: Contribution to journalArticle

124 Scopus citations

A Moraxella catarrhalis two-component signal transduction system necessary for growth in liquid media affects production of two lysozyme inhibitors

Joslin, S. N., Pybus, C., Labandeira-Rey, M., Evans, A. S., Attia, A. S., Brautigam, C. A. & Hansen, E. J., Jan 1 2015, In : Infection and immunity. 83, 1, p. 146-160 15 p.

Research output: Contribution to journalArticle

4 Scopus citations

AMP-activated protein kinase-regulated phosphorylation and acetylation of importin α1: Involvement in the nuclear import of RNA-binding protein HuR

Wang, W., Yang, X., Kawai, T., De Silanes, I. L., Mazan-Mamczarz, K., Chen, P., Yuh, M. C., Quensel, C., Köhler, M. & Gorospe, M., Nov 12 2004, In : Journal of Biological Chemistry. 279, 46, p. 48376-48388 13 p.

Research output: Contribution to journalArticle

100 Scopus citations

A multi-faceted analysis of RutD reveals a novel family of α/β hydrolases

Knapik, A. A., Petkowski, J. J., Otwinowski, Z., Cymborowski, M. T., Cooper, D. R., Majorek, K. A., Chruszcz, M., Krajewska, W. M. & Minor, W., Oct 1 2012, In : Proteins: Structure, Function and Bioinformatics. 80, 10, p. 2359-2368 10 p.

Research output: Contribution to journalArticle

5 Scopus citations

A multilaboratory comparison of calibration accuracy and the performance of external references in analytical ultracentrifugation

Zhao, H., Ghirlando, R., Alfonso, C., Arisaka, F., Attali, I., Bain, D. L., Bakhtina, M. M., Becker, D. F., Bedwell, G. J., Bekdemir, A., Besong, T. M. D., Birck, C., Brautigam, C. A., Brennerman, W., Byron, O., Bzowska, A., Chaires, J. B., Chaton, C. T., Cölfen, H., Connaghan, K. D. & 100 others, Crowley, K. A., Curth, U., Daviter, T., Dean, W. L., Díez, A. I., Ebel, C., Eckert, D. M., Eisele, L. E., Eisenstein, E., England, P., Escalante, C., Fagan, J. A., Fairman, R., Finn, R. M., Fischle, W., García De La Torre, J., Gor, J., Gustafsson, H., Hall, D., Harding, S. E., Hernández Cifre, J. G., Herr, A. B., Howell, E. E., Isaac, R. S., Jao, S. C., Jose, D., Kim, S. J., Kokona, B., Kornblatt, J. A., Kosek, D., Krayukhina, E., Krzizike, D., Kusznir, E. A., Kwon, H., Larson, A., Laue, T. M., Roy, A. L., Leech, A. P., Lilie, H., Luger, K., Luque-Ortega, J. R., Ma, J., May, C. A., Maynard, E. L., Modrak-Wojcik, A., Mok, Y. F., Mücke, N., Nagel-Steger, L., Narlikar, G. J., Noda, M., Nourse, A., Obsil, T., Park, C. K., Park, J. K., Pawelek, P. D., Perdue, E. E., Perkins, S. J., Perugini, M. A., Peterson, C. L., Peverelli, M. G., Piszczek, G., Prag, G., Prevelige, P. E., Raynal, B. D. E., Rezabkova, L., Richter, K., Ringel, A. E., Rosenberg, R., Rowe, A. J., Rufer, A. C., Scott, D. J., Seravalli, J. G., Solovyova, A. S., Song, R., Staunton, D., Stoddard, C., Stott, K., Strauss, H. M., Streicher, W. W., Sumida, J. P., Swygert, S. G., Szczepanowski, R. H., Tessmer, I., Toth, R. T., Tripathy, A., Uchiyama, S., Uebel, S. F. W., Unzai, S., Gruber, A. V., Von Hippel, P. H., Wandrey, C., Wang, S. H., Weitzel, S. E., Wielgus-Kutrowska, B., Wolberger, C., Wolff, M., Wright, E., Wu, Y. S., Wubben, J. M. & Schuck, P., May 21 2015, In : PloS one. 10, 5, e0126420.

Research output: Contribution to journalArticle

42 Scopus citations

A Munc13/RIM/Rab3 tripartite complex: From priming to plasticity?

Dulubova, I., Lou, X., Lu, J., Huryeva, I., Alam, A., Schneggenburger, R., Südhof, T. C. & Rizo-Rey, J., Aug 17 2005, In : EMBO Journal. 24, 16, p. 2839-2850 12 p.

Research output: Contribution to journalArticle

155 Scopus citations

A mutation uncouples the tubulin conformational and GTPase cycles, revealing allosteric control of microtubule dynamics

Geyer, E. A., Burns, A., Lalonde, B. A., Ye, X., Piedra, F. A., Huffaker, T. C. & Rice, L. M., Oct 6 2015, In : eLife. 4, OCTOBER2015, e10113.

Research output: Contribution to journalArticle

44 Scopus citations
76 Scopus citations

Analyses of the stability and function of three surface mutants (R82C, K69H, and L32R) of the gene V protein from Ff phage by X-ray crystallography

Su, S., Gao, Y. G., Zhang, H., Terwilliger, T. C. & Wang, A. H. J., Apr 1 1997, In : Protein Science. 6, 4, p. 771-780 10 p.

Research output: Contribution to journalArticle

9 Scopus citations

Analysis of asymmetry in lipid and content mixing assays with reconstituted proteoliposomes containing the neuronal SNAREs

Pan, Y. Z., Liu, X. & Rizo, J., Dec 1 2020, In : Scientific reports. 10, 1, 2907.

Research output: Contribution to journalArticle

Open Access

Analysis of a yeast SNARE complex reveals remarkable similarity to the neuronal SNARE complex and a novel function for the C terminus of the SNAP- 25 homolog, Sec9

Rossi, G., Salminen, A., Rice, L. M., Brünger, A. T. & Brennwald, P., Jun 27 1997, In : Journal of Biological Chemistry. 272, 26, p. 16610-16617 8 p.

Research output: Contribution to journalArticle

83 Scopus citations

Analysis of SNARE complex/synaptotagmin-1 interactions by one-dimensional NMR spectroscopy

Zhou, A., Brewer, K. D. & Rizo-Rey, J., May 21 2013, In : Biochemistry. 52, 20, p. 3446-3456 11 p.

Research output: Contribution to journalArticle

17 Scopus citations

An atomic structure of human γ-secretase

Bai, X. C., Yan, C., Yang, G., Lu, P., Ma, D., Sun, L., Zhou, R., Scheres, S. H. W. & Shi, Y., Sep 10 2015, In : Nature. 525, 7568, p. 212-217 6 p.

Research output: Contribution to journalArticle

290 Scopus citations

An efficient routine for computing symmetric real spherical harmonics for high orders of expansion

Kudlicki, A., Rowicka, M., Gilski, M. & Otwinowski, Z., Jun 1 2005, In : Journal of Applied Crystallography. 38, 3, p. 501-504 4 p.

Research output: Contribution to journalArticle

4 Scopus citations

A new generation of crystallographic validation tools for the Protein Data Bank

Read, R. J., Adams, P. D., Arendall, W. B., Brunger, A. T., Emsley, P., Joosten, R. P., Kleywegt, G. J., Krissinel, E. B., Lütteke, T., Otwinowski, Z., Perrakis, A., Richardson, J. S., Sheffler, W. H., Smith, J. L., Tickle, I. J., Vriend, G. & Zwart, P. H., Oct 12 2011, In : Structure. 19, 10, p. 1395-1412 18 p.

Research output: Contribution to journalArticle

287 Scopus citations

A new species of Oeneis from Alaska, United States, with notes on the Oeneis chryxus complex (Lepidoptera: Nymphalidae: Satyrinae)

Warren, A. D., Nakahara, S., Lukhtanov, V. A., Daly, K. M., Ferris, C. D., Grishin, N. V., Cesanek, M. & Pelham, J. P., 2016, In : Journal of Research on the Lepidoptera. 49, 1, p. 1-20 20 p.

Research output: Contribution to journalArticle

2 Scopus citations

An improved yeast surface display platform for the screening of nanobody immune libraries

Uchański, T., Zögg, T., Yin, J., Yuan, D., Wohlkönig, A., Fischer, B., Rosenbaum, D. M., Kobilka, B. K., Pardon, E. & Steyaert, J., Dec 1 2019, In : Scientific reports. 9, 1, 382.

Research output: Contribution to journalArticle

5 Scopus citations

An intrinsically disordered peptide from ebola virus VP35 controls viral RNA synthesis by modulating nucleoprotein-RNA interactions

Leung, D. W., Borek, D., Luthra, P., Binning, J. M., Anantpadma, M., Liu, G., Harvey, I. B., Su, Z., Endlich-Frazier, A., Pan, J., Shabman, R. S., Chiu, W., Davey, R. A., Otwinowski, Z., Basler, C. F. & Amarasinghe, G. K., Apr 21 2015, In : Cell Reports. 11, 3, p. 376-389 14 p.

Research output: Contribution to journalArticle

73 Scopus citations

An isolated CLASP TOG domain suppresses microtubule catastrophe and promotes rescue

Majumdar, S., Kim, T., Chen, Z., Munyoki, S., Tso, S. C., Brautigam, C. A. & Rice, L. M., Jun 1 2018, In : Molecular biology of the cell. 29, 11, p. 1359-1375 17 p.

Research output: Contribution to journalArticle

9 Scopus citations