Research Output 1979 2019

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Article
1993
167 Citations (Scopus)
Chorismate Mutase
Bacillus subtilis
Catalytic Domain
Water
Enzymes
66 Citations (Scopus)

Membrane-bound conformation of a signal peptide: A transferred nuclear overhauser effect analysis

Wang, Z., Jones, J. D., Rizo-Rey, J. & Gierasch, L. M., 1993, In : Biochemistry®. 32, 50, p. 13991-13999 9 p.

Research output: Contribution to journalArticle

Protein Sorting Signals
Conformations
Membranes
Peptides
Lipid bilayers
53 Citations (Scopus)

Sequential assignment and structure determination of spider toxin ω-aga-IVB 1,2

Yu, H., Rosen, M. K., Saccomano, N. A., Phillips, D., Volkmann, R. A. & Schreiber, S. L., 1993, In : Biochemistry®. 32, 48, p. 13123-13129 7 p.

Research output: Contribution to journalArticle

Spiders
Nuclear magnetic resonance
P-Type Calcium Channels
Proteins
Molecules
27 Citations (Scopus)

Simultaneous incorporations of two anticancer drugs into DNA: The structures of formaldehyde-cross-linked adducts of daunorubicin-d(CG(araC)GCG) and doxorubicin-d(CA(araC)GTG) complexes at high resolution

Zhang, H., Gao, Y. G., Van Der Marel, G. A., Van Boom, J. H. & Wang, A. H. J., May 15 1993, In : Journal of Biological Chemistry. 268, 14, p. 10095-10101 7 p.

Research output: Contribution to journalArticle

Daunorubicin
Doxorubicin
Formaldehyde
DNA
Pharmaceutical Preparations
1766 Citations (Scopus)

Three-dimensional structure of myosin subfragment-1: A molecular motor

Rayment, I., Rypniewski, W. R., Schmidt-Bäse, K., Smith, R., Tomchick, D. R., Benning, M. M., Winkelmann, D. A., Wesenberg, G. & Holden, H. M., Jul 2 1993, In : Science. 261, 5117, p. 50-58 9 p.

Research output: Contribution to journalArticle

Myosin Subfragments
Myosins
Molecular Structure
Actins
Nucleotides
1992
37 Citations (Scopus)

Conformational analysis of a highly potent, constrained gonadotropin-releasing hormone antagonist. 1. Nuclear magnetic resonance

Rizo-Rey, J., Koerber, S. C., Bienstock, R. J., Rivier, J., Hagler, A. T. & Gierasch, L. M., 1992, In : Journal of the American Chemical Society. 114, 8, p. 2852-2859 8 p.

Research output: Contribution to journalArticle

Hormone Antagonists
Gonadotropin-Releasing Hormone
Magnetic Resonance Spectroscopy
Nuclear magnetic resonance
Conformations
38 Citations (Scopus)

Conformational analysis of a highly potent, constrained gonadotropin-releasing hormone antagonist. 2. Molecular dynamics simulations

Rizo-Rey, J., Koerber, S. C., Bienstock, R. J., Rivier, J., Gierasch, L. M. & Hagler, A. T., 1992, In : Journal of the American Chemical Society. 114, 8, p. 2860-2871 12 p.

Research output: Contribution to journalArticle

Hormone Antagonists
Molecular Dynamics Simulation
Gonadotropin-Releasing Hormone
Molecular dynamics
Nuclear magnetic resonance
356 Citations (Scopus)

Constrained peptides: Models of bioactive peptides and protein substructures

Rizo-Rey, J. & Gierasch, L. M., 1992, In : Annual Review of Biochemistry. 61, p. 387-418 32 p.

Research output: Contribution to journalArticle

Molecular Sequence Data
Melanocyte-Stimulating Hormones
Protein folding
Tachykinins
Cyclic Peptides
19 Citations (Scopus)

Impact of a micellar environment on the conformations of two cyclic pentapeptides

Bruch, M. D., Rizo-Rey, J. & Gierasch, L. M., Dec 1992, In : Biopolymers. 32, 12, p. 1741-1754 14 p.

Research output: Contribution to journalArticle

Peptides
Conformations
Micelles
Isomers
Sodium dodecyl sulfate
44 Citations (Scopus)

Molecular Recognition of Immunophilins and Immunophilin-Ligand Complexes

Schreiber, S. L., Lui, J., Albers, M. W., Rosen, M. K., Standaert, R. F., Wandless, T. J. & Somers, P. K., Mar 27 1992, In : Tetrahedron. 48, 13, p. 2545-2558 14 p.

Research output: Contribution to journalArticle

Immunophilins
Molecular recognition
Ligands
Signal transduction
Signal Transduction
172 Citations (Scopus)

Natural products as probes of cellular function: Studies of immunophilins

Rosen, M. K. & Schreiber, S. L., Apr 1992, In : Angewandte Chemie (International Edition in English). 31, 4, p. 384-400 17 p.

Research output: Contribution to journalArticle

Immunophilins
Biological Products
Cytology
Proteins
Signal transduction
5 Citations (Scopus)

Reversible protection of lysine to facilitate the purification of protected peptide segments

Rizo, J., Albericio, F., Giralt, E. & Pedroso, E., Jan 14 1992, In : Tetrahedron Letters. 33, 3, p. 397-400 4 p.

Research output: Contribution to journalArticle

Lysine
Amines
Purification
Peptides
Impurities
89 Citations (Scopus)

Roles of potassium ions, acetyl and l-glyceryl groups in native gellan double helix: an X-ray study

Chandrasekaran, R., Radha, A. & Thailambal, V. G., Feb 7 1992, In : Carbohydrate Research. 224, C, p. 1-17 17 p.

Research output: Contribution to journalArticle

Potassium
X-Rays
Ions
X rays
Substitution reactions
272 Citations (Scopus)

Solution structure of the SH3 domain of Src and identification of its ligand-binding site

Yu, H., Rosen, M. K., Shin, T. B., Seidel-Dugan, C., Brugge, J. S. & Schreiber, S. L., Dec 4 1992, In : Science. 258, 5088, p. 1665-1668 4 p.

Research output: Contribution to journalArticle

src Homology Domains
Binding Sites
Ligands
Aromatic Amino Acids
Proline
29 Citations (Scopus)

Structure of poly d(A) · poly d(T)

Chandrasekaran, R. & Radha, A., 1992, In : Journal of Biomolecular Structure and Dynamics. 10, 1, p. 153-168 16 p.

Research output: Contribution to journalArticle

Hydrogen
X-Rays
B-Form DNA
Thymine
DNA
8 Citations (Scopus)
Cyclophilins
Calcineurin
Cyclosporine
Conformations
Ligands
1991

Crystallization and preliminary X-ray analysis of nerve growth factor from Vipera lebetina

Joachimiak, A., Giel, M., Otwinowski, Z., Arumae, U., Siigur, J., Saarma, M., Sigler, P. B. & Barciszewski, J., Mar 1 1991, In : Journal of Crystal Growth. 110, 1-2, p. 214-219 6 p.

Research output: Contribution to journalArticle

X ray analysis
nerves
Nerve Growth Factor
Crystallization
crystallization
1128 Citations (Scopus)

Crystallographic analysis of the interaction of the glucocorticoid receptor with DNA

Luisi, B. F., Xu, W. X., Otwinowski, Z., Freedman, L. P., Yamamoto, K. R. & Sigler, P. B., Aug 8 1991, In : Nature. 352, 6335, p. 497-505 9 p.

Research output: Contribution to journalArticle

Glucocorticoid Receptors
DNA
Consensus Sequence
Base Pairing
3 Citations (Scopus)

Crystal structure of bee-venom phospholipase A2: Correction [10]

Scott, D. L., Otwinowski, Z., Gelb, M. H. & Sigler, P. B., 1991, In : Science. 252, 5007, p. 764 1 p.

Research output: Contribution to journalArticle

Molecular Sequence Data
Bee Venoms
Crystallography
Phospholipases A
Phospholipases A2
62 Citations (Scopus)

Escherichia coli aspartate carbamoyltransferase: The probing of crystal structure analysis via site-specific mutagenesis

Stevens, R. C., Chook, Y. M., Cho, C. Y., Lipscomb, W. N. & Kantrowitz, E. R., 1991, In : Protein Engineering. 4, 4, p. 391-408 18 p.

Research output: Contribution to journalArticle

Molecular Sequence Data
Aspartate Carbamoyltransferase
Mutagenesis
Protein Conformation
Crystallography
32 Citations (Scopus)

FK506 and Rapamycin Binding to FKBP: Common Elements in Immunophilin-Ligand Complexation

Wandless, T. J., Michnick, S. W., Rosen, M. K., Karplus, M. & Schreiber, S. L., Mar 13 1991, In : Journal of the American Chemical Society. 113, 6, p. 2339-2341 3 p.

Research output: Contribution to journalArticle

58 Citations (Scopus)

Immunophilin-ligand complexes as probes of intracellular signaling pathways

Schreiber, S. L., Liu, J., Albers, M. W., Karmacharya, R., Koh, E., Martin, P. K., Rosen, M. K., Standaert, R. F. & Wandless, T. J., 1991, In : Transplantation Proceedings. 23, 6, p. 2839-2844 6 p.

Research output: Contribution to journalArticle

46 Citations (Scopus)

Proton and nitrogen sequential assignments and secondary structure determination of the human FK506 and rapamycin binding protein

Rosen, M. K., Michnick, S. W., Karplus, M. & Schreiber, S. L., 1991, In : Biochemistry. 30, 19, p. 4774-4789 16 p.

Research output: Contribution to journalArticle

Tacrolimus Binding Proteins
Amides
Protons
Nitrogen
Tacrolimus
258 Citations (Scopus)

Solution structure of FKBP, a rotamase enzyme and receptor for FK506 and rapamycin

Michnick, S. W., Rosen, M. K., Wandless, T. J., Karplus, M. & Schreiber, S. L., May 10 1991, In : Science. 252, 5007, p. 836-839 4 p.

Research output: Contribution to journalArticle

Tacrolimus Binding Proteins
Tacrolimus
Sirolimus
Enzymes
Immunophilins
52 Citations (Scopus)

Structure of the binuclear metal-binding site in the GAL4 transcription factor

Gardner, K. H., Pan, T., Narula, S., Rivera, E. & Coleman, J. E., 1991, In : Biochemistry. 30, 47, p. 11292-11302 11 p.

Research output: Contribution to journalArticle

Metal ions
Transcription Factors
Metals
Binding Sites
Peptides
7 Citations (Scopus)

Study of receptor-ligand interactions through receptor labeling and isotope-edited NMR

Rosen, M. K., Michnick, S. W., Wandless, T. J. & Schreiber, S. L., 1991, In : Journal of Organic Chemistry. 56, 22, p. 6262-6264 3 p.

Research output: Contribution to journalArticle

Isotopes
Labeling
Nuclear magnetic resonance
Ligands
Experiments
1990
294 Citations (Scopus)

Crystal structure of bee-venom phospholipase A2 in a complex with a transition-state analogue

Scott, D. L., Otwinowski, Z., Gelb, M. H. & Sigler, P. B., Dec 14 1990, In : Science. 250, 4987, p. 1563-1566 4 p.

Research output: Contribution to journalArticle

Bee Venoms
Phospholipases A2
Organophosphonates
Phospholipases
Enzymes
272 Citations (Scopus)

Crystal structure of cobra-venom phospholipase A2 in a complex with a transition-state analogue

White, S. P., Scott, D. L., Otwinowski, Z., Gelb, M. H. & Sigler, P. B., Dec 14 1990, In : Science. 250, 4987, p. 1560-1563 4 p.

Research output: Contribution to journalArticle

Cobra Venoms
Phospholipases A2
Catalysis
Bee Venoms
Elapidae
96 Citations (Scopus)

Cyclic pentapeptides as models for reverse turns: Determination of the equilibrium distribution between type I and type II conformations of Pro-Asn and Pro-Ala β-turns

Stradley, S. J., Rizo-Rey, J., Bruch, M. D., Stroup, A. N. & Gierasch, L. M., 1990, In : Biopolymers. 29, 1, p. 263-287 25 p.

Research output: Contribution to journalArticle

Peptides
Conformations
Chirality
Molecular Dynamics Simulation
Molecular dynamics
177 Citations (Scopus)

Inhibition of FKBP rotamase activity by immunosuppressant FK506: Twisted amide surrogate

Rosen, M. K., Standaert, R. F., Galat, A., Nakatsuka, M. & Schreiber, S. L., May 18 1990, In : Science. 248, 4957, p. 863-866 4 p.

Research output: Contribution to journalArticle

Tacrolimus Binding Proteins
Tacrolimus
Immunosuppressive Agents
Amides
Cyclophilins
638 Citations (Scopus)

Interfacial catalysis: The mechanism of phospholipase A2

Scott, D. L., White, S. P., Otwinowski, Z., Yuan, W., Gelb, M. H. & Sigler, P. B., Dec 14 1990, In : Science. 250, 4987, p. 1541-1546 6 p.

Research output: Contribution to journalArticle

Cobra Venoms
Phospholipases A2
Catalysis
Bee Venoms
Enzymes
1 Citation (Scopus)

Transcription factor TFIIIA stimulates DNA supercoiling promoted by a fractionated cell-free extract from Xenopus laevis

Sekiguchi, J. A. M., Cole, A. D., Gardner, K. H. & Kmiec, E. B., 1990, In : European Journal of Biochemistry. 192, 2, p. 311-320 10 p.

Research output: Contribution to journalArticle

Transcription Factor TFIIIA
Xenopus laevis
Cell Extracts
DNA
Teniposide
31 Citations (Scopus)

π-Complexes of alkenes to trivalent aluminum

Chey, J., Choe, H. S., Chook, Y. M., Jensen, E., Seida, P. R. & Francl, M. M., 1990, In : Organometallics. 9, 9, p. 2430-2436 7 p.

Research output: Contribution to journalArticle

Alkenes
Aluminum
alkenes
ethylene
aluminum
1989
5 Citations (Scopus)

Crystal and molecular structure of tetraethyl-ammonium bis (stilbene 1,2-dithiolato) nickelate(III)

Rajalakshmi, A., Radha, A., Seshasayee, M., Kuppusamy, P. & Manoharan, P. T., 1989, In : Zeitschrift fur Kristallographie - New Crystal Structures. 187, 1-2, p. 159-164 6 p.

Research output: Contribution to journalArticle

Stilbenes
stilbene
Ammonium Compounds
Molecular structure
molecular structure
11 Citations (Scopus)

Structure of the beta-form of poly d(A).poly d(U).

Chandrasekaran, R., Radha, A., Park, H. S. & Arnott, S., Jun 1989, In : Journal of biomolecular structure & dynamics. 6, 6, p. 1203-1215 13 p.

Research output: Contribution to journalArticle

Poly T
B-Form DNA
Poly U
Base Pairing
Salts
1988
759 Citations (Scopus)

Crystal structure of trp represser/operator complex at atomic resolution

Otwinowski, Z., Schevitz, R. W., Zhang, R. G., Lawson, C. L., Joachimiak, A., Marmorstein, R. Q., Luisi, B. F. & Sigler, P. B., 1988, In : Nature. 335, 6188, p. 321-329 9 p.

Research output: Contribution to journalArticle

Hydrogen
Phosphates
Water
DNA
E coli TRPR protein
1 Citation (Scopus)

Erratum: Crystal structure of trp represser/operator complex at atomic resolution (Nature (1988) 335 (321-329))

Otwinowski, Z., Schevitz, R. W., Zhang, R. G., Lawson, C. L., Joachimiak, A., Marmorstein, R. Q., Luisi, B. F. & Sigler, P. B., 1988, In : Nature. 335, 6193, p. 837 1 p.

Research output: Contribution to journalArticle

123 Citations (Scopus)

Flexibility of the DNA-binding domains of trp repressor

Lawson, C. L., Zhang, R., Schevitz, R. W., Otwinowski, Z., Joachimiak, A. & Sigler, P. B., 1988, In : Proteins: Structure, Function and Genetics. 3, 1, p. 18-31 14 p.

Research output: Contribution to journalArticle

Tryptophan
Ligands
Crystals
Conformations
DNA
13 Citations (Scopus)
Carbon Monoxide
Electrons
Pair Bond
synthesis
Ligands
12 Citations (Scopus)

Use of polar picolyl protecting groups in peptide synthesis

Rizo-Rey, J., Albericio, F., Romero, G., García-Echeverría, C., Claret, J., Muller, C., Giralt, E. & Pedroso, E., 1988, In : Journal of Organic Chemistry. 53, 22, p. 5386-5389 4 p.

Research output: Contribution to journalArticle

Glutamates
Threonine
Serine
Purification
Peptides
1987
27 Citations (Scopus)

Facing up to membranes: Structure/function relationships in phospholipases

Achari, A., Scott, D., Barlow, P., Vidal, J. C., Otwinowski, Z., Brunie, S. & Sigler, P. B., 1987, In : Cold Spring Harbor Symposia on Quantitative Biology. 52, p. 441-452 12 p.

Research output: Contribution to journalArticle

structure-activity relationships
phospholipases
214 Citations (Scopus)

The crystal structure of trp aporepressor at 1.8 Å shows how binding tryptophan enhances DNA affinity

Zhang, R. G., Joachimiak, A., Lawson, C. L., Schevitz, R. W., Otwinowski, Z. & Sigler, P. B., 1987, In : Nature. 327, 6123, p. 591-597 7 p.

Research output: Contribution to journalArticle

Tryptophan
Reading
Head
DNA
E coli TRPR protein
1985
10 Citations (Scopus)
Bond length
Molecular structure
Hydrogen bonds
molecular structure
Carbon
263 Citations (Scopus)

The three-dimensional structure of trp repressor

Schevitz, R. W., Otwinowski, Z., Joachimiak, A., Lawson, C. L. & Sigler, P. B., 1985, In : Nature. 317, 6040, p. 782-786 5 p.

Research output: Contribution to journalArticle

Helix-Turn-Helix Motifs
Tryptophan
Escherichia coli
DNA
Proteins
1984
93 Citations (Scopus)

Application of gel-phase 13c-nmr to monitor solid phase peptide synthesis

Giralt, E., Rizo-Rey, J. & Pedroso, E., 1984, In : Tetrahedron. 40, 20, p. 4141-4152 12 p.

Research output: Contribution to journalArticle

Solid-Phase Synthesis Techniques
divinyl benzene
Gels
Polystyrenes
Nuclear magnetic resonance
3 Citations (Scopus)

Crystal and molecular structure of hexa(antipyrine)cadmium(II) Perchlorate, [(C11H12ON2)6CD]2+ [FORMULA OMITTED]

Mahadevan, C., Radha, A. & Seshasayee, M., 1984, In : Zeitschrift fur Kristallographie - New Crystal Structures. 169, 1-4, p. 159-163 5 p.

Research output: Contribution to journalArticle

Antipyrine
perchlorates
Cadmium
cadmium
Molecular structure
1979
5 Citations (Scopus)

Multiplicity of charged particles π- interactions on nuclei at 40 GeV/c

Abrosimov, A. T., Bellini, G., Chernenko, L. P., Di Corato, M., Drondina, G. I., Frabetti, P. L., Ivanshin, Y. I., Laurikainen, P., Litkin, L. K., Lobanova, V. P., Meroni, E., Michelletti, S., Moiseenko, V. A., Nikanorov, V. I., Otwinowski, S., Otwinowski, Z., Palombo, F., Pernicka, M., Pisarev, A. F., Rancoita, P. G. & 10 others, Sala, S., Sychkov, S. I., Szeptycka, M., Tjapkin, A. A., Vasilevski, I. M., Vegni, G., Vishevskaja, K. P., Vishnjakov, V. V., Wojcik, W. & Zaimidoroga, O. A., Oct 8 1979, In : Nuclear Physics, Section B. 158, 1, p. 11-28 18 p.

Research output: Contribution to journalArticle

particle interactions
charged particles
nuclei
spark chambers
protons