Research Output 1979 2019

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2016
9 Citations (Scopus)

Karyopherin-β2 Recognition of a PY-NLS Variant that Lacks the Proline-Tyrosine Motif

Soniat, M. & Chook, Y. M., Oct 4 2016, In : Structure. 24, 10, p. 1802-1809 8 p.

Research output: Contribution to journalArticle

Karyopherins
Nuclear Localization Signals
Proline
Tyrosine
Epitopes
9 Citations (Scopus)

Ligand-induced growth and compaction of CD36 nanoclusters enriched in Fyn induces Fyn signaling

Githaka, J. M., Vega, A. R., Baird, M. A., Davidson, M. W., Jaqaman, K. & Touret, N., 2016, In : Journal of Cell Science. 129, 22, p. 4175-4189 15 p.

Research output: Contribution to journalArticle

Thrombospondin 1
Ligands
Cluster Analysis
Growth
Angiogenesis Inducing Agents

May I check your cap?

Geyer, E. A., Majumdar, S. & Rice, L. M., Apr 6 2016, In : eLife. 5, APRIL2016, e15570.

Research output: Contribution to journalArticle

Microtubules
Growth
10 Citations (Scopus)
Flavoproteins
Periplasm
Protein Transport
Flavin Mononucleotide
FAD pyrophosphatase
33 Citations (Scopus)

Next-generation XPO1 inhibitor shows improved efficacy and in vivo tolerability in hematological malignancies

Hing, Z. A., Fung, H. Y. J., Ranganathan, P., Mitchell, S., El-Gamal, D., Woyach, J. A., Williams, K., Goettl, V. M., Smith, J., Yu, X., Meng, X., Sun, Q., Cagatay, T., Lehman, A. M., Lucas, D. M., Baloglu, E., Shacham, S., Kauffman, M. G., Byrd, J. C., Chook, Y. M. & 2 others, Garzon, R. & Lapalombella, R., Jun 21 2016, (Accepted/In press) In : Leukemia.

Research output: Contribution to journalArticle

Hematologic Neoplasms
Cell Nucleus Active Transport
B-Cell Chronic Lymphocytic Leukemia
Acute Myeloid Leukemia
Tumor Suppressor Proteins
33 Citations (Scopus)

On the acquisition and analysis of microscale thermophoresis data

Scheuermann, T. H., Padrick, S. B., Gardner, K. H. & Brautigam, C. A., Mar 1 2016, In : Analytical Biochemistry. 496, p. 79-83 5 p.

Research output: Contribution to journalArticle

Thermophoresis
Practice Guidelines
Proteins
Lasers
Coloring Agents
12 Citations (Scopus)

Pathogenic C9ORF72 Antisense Repeat RNA Forms a Double Helix with Tandem C: C Mismatches

Dodd, D. W., Tomchick, D. R., Corey, D. R. & Gagnon, K. T., Mar 8 2016, In : Biochemistry. 55, 9, p. 1283-1286 4 p.

Research output: Contribution to journalArticle

Antisense RNA
RNA
Amyotrophic Lateral Sclerosis
Molecular Pathology
Introns
182 Citations (Scopus)

Phase separation of signaling molecules promotes T cell receptor signal transduction

Su, X., A. Ditlev, J., Hui, E., Xing, W., Banjade, S., Okrut, J., King, D. S., Taunton, J., Rosen, M. K. & Vale, R. D., Apr 7 2016, (Accepted/In press) In : Science. p. 1-8 8 p.

Research output: Contribution to journalArticle

T-Cell Antigen Receptor
Actins
Signal Transduction
Jurkat Cells
Cell Surface Receptors
15 Citations (Scopus)

Phosphorylation of spore coat proteins by a family of atypical protein kinases

Nguyen, K. B., Sreelatha, A., Durrant, E. S., Lopez-Garrido, J., Muszewska, A., Dudkiewicz, M., Grynberg, M., Yee, S., Pogliano, K., Tomchick, D. R., Pawłowski, K., Dixon, J. E. & Tagliabracci, V. S., Jun 21 2016, In : Proceedings of the National Academy of Sciences of the United States of America. 113, 25, p. E3482-E3491

Research output: Contribution to journalArticle

Capsid Proteins
Spores
Protein Kinases
Phosphorylation
Germination
13 Citations (Scopus)

Phylogeny Reconstruction with Alignment-Free Method That Corrects for Horizontal Gene Transfer

Bromberg, R., Grishin, N. V. & Otwinowski, Z., Jun 1 2016, In : PLoS Computational Biology. 12, 6, e1004985.

Research output: Contribution to journalArticle

Gene transfer
Horizontal Gene Transfer
gene transfer
Phylogeny
phylogeny
25 Citations (Scopus)

Preparation and characterization of stable α-synuclein lipoprotein particles

Eichmann, C., Campioni, S., Kowal, J., Maslennikov, I., Gerez, J., Liu, X., Verasdonck, J., Nespovitaya, N., Choe, S., Meier, B. H., Picotti, P., Rizo-Rey, J., Stahlberg, H. & Riek, R., Apr 15 2016, In : Journal of Biological Chemistry. 291, 16, p. 8516-8527 12 p.

Research output: Contribution to journalArticle

Synucleins
Lipoproteins
HDL Lipoproteins
Phospholipids
Magnetic Resonance Spectroscopy
4 Citations (Scopus)

Proteomics analysis reveals previously uncharacterized virulence factors in vibrio proteolyticus

Ray, A., Kinch, L. N., De Souza Santos, M., Grishin, N. V., Orth, K. & Salomon, D., Jul 1 2016, In : mBio. 7, 4, e01077-16.

Research output: Contribution to journalArticle

Vibrio
Virulence Factors
Proteomics
Leukocidins
Virulence
13 Citations (Scopus)

Recognition elements in the histone H3 and H4 tails for seven different importins

Soniat, M., Caǧatay, T. & Chook, Y. M., Sep 30 2016, In : Journal of Biological Chemistry. 291, 40, p. 21171-21183 13 p.

Research output: Contribution to journalArticle

Karyopherins
Histones
Lysine
Histone Chaperones
Acetylation
11 Citations (Scopus)

Relief of autoinhibition by conformational switch explains enzyme activation by a catalytically dead paralog

Volkov, O. A., Kinch, L., Ariagno, C., Deng, X., Zhong, S., Grishin, N., Tomchick, D. R., Chen, Z. & Phillips, M. A., Dec 15 2016, In : eLife. 5, DECEMBER2016, e20198.

Research output: Contribution to journalArticle

Enzyme Activation
Chemical activation
Switches
Enzymes
Adenosylmethionine Decarboxylase
143 Citations (Scopus)

Sequence Determinants of Intracellular Phase Separation by Complex Coacervation of a Disordered Protein

Pak, C. W., Kosno, M., Holehouse, A. S., Padrick, S. B., Mittal, A., Ali, R., Yunus, A. A., Liu, D. R., Pappu, R. V. & Rosen, M. K., Jul 7 2016, In : Molecular Cell. 63, 1, p. 72-85 14 p.

Research output: Contribution to journalArticle

Proteins
Intrinsically Disordered Proteins
Mutagenesis
Organelles
Amino Acids
4 Citations (Scopus)

Sequence-specific assignment of methyl groups from the neuronal SNARE complex using lanthanide-induced pseudocontact shifts

Pan, Y. Z., Quade, B., Brewer, K. D., Szabo, M., Swarbrick, J. D., Graham, B. & Rizo, J., Dec 1 2016, In : Journal of Biomolecular NMR. 66, 4, p. 281-293 13 p.

Research output: Contribution to journalArticle

SNARE Proteins
Lanthanoid Series Elements
Syntaxin 1
R-SNARE Proteins
Synaptotagmin I
21 Citations (Scopus)

Speciation in Cloudless Sulphurs Gleaned from Complete Genomes

Cong, Q., Shen, J., Warren, A. D., Borek, D., Otwinowski, Z. & Grishin, N. V., Mar 30 2016, In : Genome Biology and Evolution. 8, 3, p. 915-931 17 p.

Research output: Contribution to journalArticle

Sulfur
sulfur
genome
Genome
phenotype
26 Citations (Scopus)

Structural and mechanistic insights into regulation of the retromer coat by TBC1d5

Jia, D., Zhang, J. S., Li, F., Wang, J., Deng, Z., White, M. A., Osborne, D. G., Phillips-Krawczak, C., Gomez, T. S., Li, H., Singla, A., Burstein, E., Billadeau, D. D. & Rosen, M. K., Nov 9 2016, In : Nature Communications. 7, 13305.

Research output: Contribution to journalArticle

GTPase-Activating Proteins
proteins
Sorting Nexins
time measurement
membranes
55 Citations (Scopus)

Structure and ligand-binding mechanism of the human OX1 and OX2 orexin receptors

Yin, J., Babaoglu, K., Brautigam, C. A., Clark, L., Shao, Z., Scheuermann, T. H., Harrell, C. M., Gotter, A. L., Roecker, A. J., Winrow, C. J., Renger, J. J., Coleman, P. J. & Rosenbaum, D. M., Mar 7 2016, (Accepted/In press) In : Nature Structural and Molecular Biology.

Research output: Contribution to journalArticle

Orexin Receptors
Ligands
Neuropeptides
Mammals
Sleep
12 Citations (Scopus)

Synthesis and Biological Evaluation of Kibdelone C and Its Simplified Derivatives

Rujirawanich, J., Kim, S., Ma, A. J., Butler, J. R., Wang, Y., Wang, C., Rosen, M., Posner, B., Nijhawanc, D. & Ready, J. M., Aug 24 2016, In : Journal of the American Chemical Society. 138, 33, p. 10561-10570 10 p.

Research output: Contribution to journalArticle

Biological Products
Actins
Polycyclic Compounds
Derivatives
Enantiomers
1 Citation (Scopus)

Taking a look at the calibration of a CCD detector with a fiber-optic taper

Alkire, R. W., Rotella, F. J., Duke, N. E. C., Otwinowski, Z. & Borek, D., 2016, In : Journal of Applied Crystallography. 49, p. 415-425 11 p.

Research output: Contribution to journalArticle

Charge coupled devices
Fiber optics
Calibration
Detectors
Photons
181 Citations (Scopus)

Targeting renal cell carcinoma with a HIF-2 antagonist

Chen, W., Hill, H., Christie, A., Kim, M. S., Holloman, E., Pavia-Jimenez, A., Homayoun, F., Ma, Y., Patel, N., Yell, P., Hao, G., Yousuf, Q., Joyce, A., Pedrosa, I., Geiger, H., Zhang, H., Chang, J., Gardner, K. H., Bruick, R. K., Reeves, C. & 14 others, Hwang, T. H., Courtney, K., Frenkel, E., Sun, X., Zojwalla, N., Wong, T., Rizzi, J. P., Wallace, E. M., Josey, J. A., Xie, Y., Xie, X. J., Kapur, P., McKay, R. M. & Brugarolas, J., 2016, In : Nature. 539, 7627, p. 112-117 6 p.

Research output: Contribution to journalArticle

Renal Cell Carcinoma
Neoplasms
Carcinogenesis
Genetic Suppression
Mutation
30 Citations (Scopus)

Tetrahydro-2-naphthyl and 2-Indanyl Triazolopyrimidines Targeting Plasmodium falciparum Dihydroorotate Dehydrogenase Display Potent and Selective Antimalarial Activity

Kokkonda, S., Deng, X., White, K. L., Coteron, J. M., Marco, M., De Las Heras, L., White, J., El Mazouni, F., Tomchick, D. R., Manjalanagara, K., Rudra, K. R., Chen, G., Morizzi, J., Ryan, E., Kaminsky, W., Leroy, D., Martínez-Martínez, M. S., Jimenez-Diaz, M. B., Bazaga, S. F., Angulo-Barturen, I. & 6 others, Waterson, D., Burrows, J. N., Matthews, D., Charman, S. A., Phillips, M. A. & Rathod, P. K., Jun 9 2016, In : Journal of Medicinal Chemistry. 59, 11, p. 5416-5431 16 p.

Research output: Contribution to journalArticle

Antimalarials
Plasmodium falciparum
Malaria
Halogens
SCID Mice
43 Citations (Scopus)

The Central domain of RyR1 is the transducer for long-range allosteric gating of channel opening

Bai, X. C., Yan, Z., Wu, J., Li, Z. & Yan, N., Sep 1 2016, In : Cell Research. 26, 9, p. 995-1006 12 p.

Research output: Contribution to journalArticle

Ryanodine Receptor Calcium Release Channel
Transducers
Excitation Contraction Coupling
Skeletal Muscle
S 6
13 Citations (Scopus)

The complete mitochondrial genome of Lerema accius and its phylogenetic implications

Cong, Q. & Grishin, N. V., 2016, In : PeerJ. 2016, 1, e1546.

Research output: Contribution to journalArticle

Lepidoptera
Mitochondrial Genome
Genes
phylogeny
Genome
7 Citations (Scopus)

The complete mitogenome of Achalarus lyciades (Lepidoptera: Hesperiidae)

Shen, J., Cong, Q. & Grishin, N. V., 2016, In : Mitochondrial DNA Part B: Resources. 1, 1, p. 581-583 3 p.

Research output: Contribution to journalArticle

Lepidoptera
Transfer RNA
Butterflies
Gene Order
Mitochondrial Genome
31 Citations (Scopus)

The human SKA complex drives the metaphase-anaphase cell cycle transition by recruiting protein phosphatase 1 to kinetochores

Sivakumar, S., Janczyk, P., Qu, Q., Brautigam, C. A., Stukenberg, P. T., Yu, H. & Gorbsky, G. J., Mar 16 2016, In : eLife. 5, MARCH2016, e12902.

Research output: Contribution to journalArticle

Protein Phosphatase 1
Kinetochores
Anaphase
Metaphase
Cell Cycle
3 Citations (Scopus)

The Penaincisalia amatista species-group (Lepidoptera: Lycaenidae, Eumaeini) in Colombia, insights from mtDNA barcodes and the description of a new species

Prieto, C., Grishin, N. V., Hausmann, A. & Lorenc-Brudecka, J., Mar 3 2016, In : Systematics and Biodiversity. 14, 2, p. 171-183 13 p.

Research output: Contribution to journalArticle

Celosia
Lycaenidae
barcoding
DNA barcoding
Colombia
1 Citation (Scopus)

The Sac3 TPR-like region in the Saccharomyces cerevisiae TREX-2 complex is more extensive but independent of the CID region

Aibara, S., Bai, X. C. & Stewart, M., Sep 1 2016, In : Journal of Structural Biology. 195, 3, p. 316-324 9 p.

Research output: Contribution to journalArticle

Saccharomyces cerevisiae
X Ray Crystallography
Sf9 Cells
Cell Nucleus Active Transport
Baculoviridae
6 Citations (Scopus)

The Tp0684 (MglB-2) lipoprotein of treponema pallidum: A glucose-binding protein with divergent topology

Brautigam, C. A., Deka, R. K., Liu, W. Z. & Norgard, M. V., Aug 1 2016, In : PLoS One. 11, 8, e0161022.

Research output: Contribution to journalArticle

Treponema pallidum
lipoproteins
topology
Lipoproteins
binding proteins
47 Citations (Scopus)

TLR4/MD-2 activation by a synthetic agonist with no similarity to LPS

Wang, Y., Su, L., Morin, M. D., Jones, B. T., Whitby, L. R., Surakattula, M. M. R. P., Huang, H., Shi, H., Choi, J. H., Wang, K. W., Moresco, E. M. Y., Berger, M., Zhan, X., Zhang, H., Boger, D. L. & Beutler, B., Feb 16 2016, In : Proceedings of the National Academy of Sciences of the United States of America. 113, 7, p. E884-E893

Research output: Contribution to journalArticle

Lipopolysaccharides
Lipid A
Ligands
Peptidomimetics
Toll-Like Receptor 4
2015
110 Citations (Scopus)

A long-duration dihydroorotate dehydrogenase inhibitor (DSM265) for prevention and treatment of malaria

Phillips, M. A., Lotharius, J., Marsh, K., White, J., Dayan, A., White, K. L., Njoroge, J. W., El Mazouni, F., Lao, Y., Kokkonda, S., Tomchick, D. R., Deng, X., Laird, T., Bhatia, S. N., March, S., Ng, C. L., Fidock, D. A., Wittlin, S., Lafuente-Monasterio, M., Benito, F. J. G. & 33 others, Alonso, L. M. S., Martinez, M. S., Jimenez-Diaz, M. B., Bazaga, S. F., Angulo-Barturen, I., Haselden, J. N., Louttit, J., Cui, Y., Sridhar, A., Zeeman, A. M., Kocken, C., Sauerwein, R., Dechering, K., Avery, V. M., Duffy, S., Delves, M., Sinden, R., Ruecker, A., Wickham, K. S., Rochford, R., Gahagen, J., Iyer, L., Riccio, E., Mirsalis, J., Bathhurst, I., Rueckle, T., Ding, X., Campo, B., Leroy, D., Rogers, M. J., Rathod, P. K., Burrows, J. N. & Charman, S. A., Jul 15 2015, In : Science Translational Medicine. 7, 296, aaa6645.

Research output: Contribution to journalArticle

Malaria
Parasites
Drug Combinations
Therapeutics
Liver
4 Citations (Scopus)

A Moraxella catarrhalis two-component signal transduction system necessary for growth in liquid media affects production of two lysozyme inhibitors

Joslin, S. N., Pybus, C., Labandeira-Rey, M., Evans, A. S., Attia, A. S., Brautigam, C. A. & Hansen, E. J., 2015, In : Infection and Immunity. 83, 1, p. 146-160 15 p.

Research output: Contribution to journalArticle

Moraxella (Branhamella) catarrhalis
Muramidase
Signal Transduction
Growth
Nasopharynx
36 Citations (Scopus)

A multilaboratory comparison of calibration accuracy and the performance of external references in analytical ultracentrifugation

Zhao, H., Ghirlando, R., Alfonso, C., Arisaka, F., Attali, I., Bain, D. L., Bakhtina, M. M., Becker, D. F., Bedwell, G. J., Bekdemir, A., Besong, T. M. D., Birck, C., Brautigam, C. A., Brennerman, W., Byron, O., Bzowska, A., Chaires, J. B., Chaton, C. T., Cölfen, H., Connaghan, K. D. & 100 others, Crowley, K. A., Curth, U., Daviter, T., Dean, W. L., Díez, A. I., Ebel, C., Eckert, D. M., Eisele, L. E., Eisenstein, E., England, P., Escalante, C., Fagan, J. A., Fairman, R., Finn, R. M., Fischle, W., García De La Torre, J., Gor, J., Gustafsson, H., Hall, D., Harding, S. E., Hernández Cifre, J. G., Herr, A. B., Howell, E. E., Isaac, R. S., Jao, S. C., Jose, D., Kim, S. J., Kokona, B., Kornblatt, J. A., Kosek, D., Krayukhina, E., Krzizike, D., Kusznir, E. A., Kwon, H., Larson, A., Laue, T. M., Roy, A. L., Leech, A. P., Lilie, H., Luger, K., Luque-Ortega, J. R., Ma, J., May, C. A., Maynard, E. L., Modrak-Wojcik, A., Mok, Y. F., Mücke, N., Nagel-Steger, L., Narlikar, G. J., Noda, M., Nourse, A., Obsil, T., Park, C. K., Park, J. K., Pawelek, P. D., Perdue, E. E., Perkins, S. J., Perugini, M. A., Peterson, C. L., Peverelli, M. G., Piszczek, G., Prag, G., Prevelige, P. E., Raynal, B. D. E., Rezabkova, L., Richter, K., Ringel, A. E., Rosenberg, R., Rowe, A. J., Rufer, A. C., Scott, D. J., Seravalli, J. G., Solovyova, A. S., Song, R., Staunton, D., Stoddard, C., Stott, K., Strauss, H. M., Streicher, W. W., Sumida, J. P., Swygert, S. G., Szczepanowski, R. H., Tessmer, I., Toth, R. T., Tripathy, A., Uchiyama, S., Uebel, S. F. W., Unzai, S., Gruber, A. V., Von Hippel, P. H., Wandrey, C., Wang, S. H., Weitzel, S. E., Wielgus-Kutrowska, B., Wolberger, C., Wolff, M., Wright, E., Wu, Y. S., Wubben, J. M. & Schuck, P., May 21 2015, In : PLoS One. 10, 5, e0126420.

Research output: Contribution to journalArticle

ultracentrifugation
Ultracentrifugation
Calibration
bovine serum albumin
Bovine Serum Albumin
38 Citations (Scopus)

A mutation uncouples the tubulin conformational and GTPase cycles, revealing allosteric control of microtubule dynamics

Geyer, E. A., Burns, A., Lalonde, B. A., Ye, X., Piedra, F. A., Huffaker, T. C. & Rice, L. M., Oct 6 2015, In : eLife. 4, OCTOBER2015, e10113.

Research output: Contribution to journalArticle

GTP Phosphohydrolases
Tubulin
Microtubules
Mutation
Conformations
258 Citations (Scopus)

An atomic structure of human γ-secretase

Bai, X. C., Yan, C., Yang, G., Lu, P., Ma, D., Sun, L., Zhou, R., Scheres, S. H. W. & Shi, Y., Sep 10 2015, In : Nature. 525, 7568, p. 212-217 6 p.

Research output: Contribution to journalArticle

Presenilin-1
Amyloid Precursor Protein Secretases
Catalytic Domain
Alzheimer Disease
Cryoelectron Microscopy
68 Citations (Scopus)

An intrinsically disordered peptide from ebola virus VP35 controls viral RNA synthesis by modulating nucleoprotein-RNA interactions

Leung, D. W., Borek, D., Luthra, P., Binning, J. M., Anantpadma, M., Liu, G., Harvey, I. B., Su, Z., Endlich-Frazier, A., Pan, J., Shabman, R. S., Chiu, W., Davey, R. A., Otwinowski, Z., Basler, C. F. & Amarasinghe, G. K., Apr 21 2015, In : Cell Reports. 11, 3, p. 376-389 14 p.

Research output: Contribution to journalArticle

Nucleoproteins
Viral RNA
RNA
Peptides
Ebolavirus
2 Citations (Scopus)

Anomalous diffusion in neutral evolution of model proteins

Nelson, E. D. & Grishin, N. V., Jun 1 2015, In : Physical Review E - Statistical, Nonlinear, and Soft Matter Physics. 91, 6, 060701.

Research output: Contribution to journalArticle

Anomalous Diffusion
Structural Change
proteins
Protein
Power Law
97 Citations (Scopus)

A Single Kinase Generates the Majority of the Secreted Phosphoproteome

Tagliabracci, V. S., Wiley, S. E., Guo, X., Kinch, L. N., Durrant, E., Wen, J., Xiao, J., Cui, J., Nguyen, K. B., Engel, J. L., Coon, J. J., Grishin, N., Pinna, L. A., Pagliarini, D. J. & Dixon, J. E., Jun 20 2015, In : Cell. 161, 7, p. 1619-1632 14 p.

Research output: Contribution to journalArticle

Phosphotransferases
Phosphoproteins
Substrates
Clustered Regularly Interspaced Short Palindromic Repeats
Biomineralization
79 Citations (Scopus)

Atomic structure of the apoptosome: Mechanism of cytochrome c- and dATP-mediated activation of Apaf-1

Zhou, M., Li, Y., Hu, Q., Bai, X. C., Huang, W., Yan, C., Scheres, S. H. W. & Shi, Y., Nov 15 2015, In : Genes and Development. 29, 22, p. 2349-2361 13 p.

Research output: Contribution to journalArticle

Apoptotic Protease-Activating Factor 1
Apoptosomes
Cytochromes c
Cryoelectron Microscopy
Caspases
3 Citations (Scopus)

Biocalorimetry

Chaires, J. B., Hansen, L. D., Keller, S., Brautigam, C. A., Zhao, H. & Schuck, P., Apr 1 2015, In : Methods. 76, p. 1-2 2 p.

Research output: Contribution to journalArticle

Calorimetry
Thermodynamics
3 Citations (Scopus)

C2H2 zinc finger proteins of the SP/KLF, Wilms tumor, EGR, Huckebein, and Klumpfuss families in metazoans and beyond

Pei, J. & Grishin, N. V., Nov 15 2015, In : Gene. 573, 1, p. 91-99 9 p., 40812.

Research output: Contribution to journalArticle

Wilms Tumor
Growth
Proteins
Ctenophora
Mesomycetozoea
22 Citations (Scopus)

ChSeq: A database of chameleon sequences

Li, W., Kinch, L. N., Karplus, P. A. & Grishin, N. V., Jul 1 2015, In : Protein Science. 24, 7, p. 1075-1086 12 p.

Research output: Contribution to journalArticle

Lizards
Databases
Proteins
Plasticity
Conformations
12 Citations (Scopus)

Coiled-coil coactivators play a structural role mediating interactions in hypoxia-inducible factor heterodimerization

Guo, Y., Scheuermann, T. H., Partch, C. L., Tomchick, D. R. & Gardner, K. H., Mar 20 2015, In : Journal of Biological Chemistry. 290, 12, p. 7707-7721 15 p.

Research output: Contribution to journalArticle

Aryl Hydrocarbon Receptor Nuclear Translocator
Transcription
CREB-Binding Protein
Crystallography
Transcriptional Activation
47 Citations (Scopus)

Conserved interdomain linker promotes phase separation of the multivalent adaptor protein Nck

Banjade, S., Wu, Q., Mittal, A., Peeples, W. B., Pappu, R. V. & Rosen, M. K., Nov 24 2015, In : Proceedings of the National Academy of Sciences of the United States of America. 112, 47, p. E6426-E6435

Research output: Contribution to journalArticle

Neuronal Wiskott-Aldrich Syndrome Protein
Proteins
Phosphotyrosine
src Homology Domains
Membranes
112 Citations (Scopus)

Crystal structure of the human OX2 orexin receptor bound to the insomnia drug suvorexant

Yin, J., Mobarec, J. C., Kolb, P. & Rosenbaum, D. M., Mar 12 2015, In : Nature. 519, 7542, p. 247-250 4 p.

Research output: Contribution to journalArticle

Orexin Receptors
Sleep Initiation and Maintenance Disorders
G-Protein-Coupled Receptors
Pharmaceutical Preparations
Cataplexy
13 Citations (Scopus)
Trypanosoma brucei brucei
Growth
Proteins
Biosynthesis
Polyamines
32 Citations (Scopus)

Disruption of Wnt/β-catenin signaling and telomeric shortening are inextricable consequences of tankyrase inhibition in human cells

Kulak, O., Chen, H., Holohan, B., Wu, X., He, H., Borek, D., Otwinowski, Z., Yamaguchi, K., Garofalo, L. A., Ma, Z., Wright, W., Chen, C., Shay, J. W., Zhang, X. & Lum, L., 2015, In : Molecular and Cellular Biology. 35, 14, p. 2425-2435 11 p.

Research output: Contribution to journalArticle

Tankyrases
Catenins
Telomere Homeostasis
Telomere
Porcupines
9 Citations (Scopus)

Domain-Swapping Switch Point in Ste20 Protein Kinase SPAK

Taylor, C. A., Juang, Y. C., Earnest, S., Sengupta, S., Goldsmith, E. J. & Cobb, M. H., Jul 24 2015, In : Biochemistry. 54, 32, p. 5063-5071 9 p.

Research output: Contribution to journalArticle

Protein Kinases
Phosphotransferases
Switches
Chemical activation
Phosphorylation
68 Citations (Scopus)

Dynamic binding mode of a Synaptotagmin-1-SNARE complex in solution

Brewer, K. D., Bacaj, T., Cavalli, A., Camilloni, C., Swarbrick, J. D., Liu, J., Zhou, A., Zhou, P., Barlow, N., Xu, J., Seven, A. B., Prinslow, E. A., Voleti, R., Häussinger, D., Bonvin, A. M. J. J., Tomchick, D. R., Vendruscolo, M., Graham, B., Südhof, T. C. & Rizo-Rey, J., Jul 9 2015, In : Nature Structural and Molecular Biology. 22, 7, p. 555-564 10 p.

Research output: Contribution to journalArticle

Synaptotagmin I
SNARE Proteins
Syntaxin 1
Vesicle-Associated Membrane Protein 1
Lanthanoid Series Elements