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2016

The human SKA complex drives the metaphase-anaphase cell cycle transition by recruiting protein phosphatase 1 to kinetochores

Sivakumar, S., Janczyk, P., Qu, Q., Brautigam, C. A., Stukenberg, P. T., Yu, H. & Gorbsky, G. J., Mar 16 2016, In : eLife. 5, MARCH2016, e12902.

Research output: Contribution to journalArticle

36 Scopus citations

The Penaincisalia amatista species-group (Lepidoptera: Lycaenidae, Eumaeini) in Colombia, insights from mtDNA barcodes and the description of a new species

Prieto, C., Grishin, N. V., Hausmann, A. & Lorenc-Brudecka, J., Mar 3 2016, In : Systematics and Biodiversity. 14, 2, p. 171-183 13 p.

Research output: Contribution to journalArticle

3 Scopus citations

The Sac3 TPR-like region in the Saccharomyces cerevisiae TREX-2 complex is more extensive but independent of the CID region

Aibara, S., Bai, X. C. & Stewart, M., Sep 1 2016, In : Journal of Structural Biology. 195, 3, p. 316-324 9 p.

Research output: Contribution to journalArticle

2 Scopus citations

The Tp0684 (MglB-2) lipoprotein of treponema pallidum: A glucose-binding protein with divergent topology

Brautigam, C. A., Deka, R. K., Liu, W. Z. & Norgard, M. V., Aug 1 2016, In : PLoS One. 11, 8, e0161022.

Research output: Contribution to journalArticle

6 Scopus citations

TLR4/MD-2 activation by a synthetic agonist with no similarity to LPS

Wang, Y., Su, L., Morin, M. D., Jones, B. T., Whitby, L. R., Surakattula, M. M. R. P., Huang, H., Shi, H., Choi, J. H., Wang, K. W., Moresco, E. M. Y., Berger, M., Zhan, X., Zhang, H., Boger, D. L. & Beutler, B., Feb 16 2016, In : Proceedings of the National Academy of Sciences of the United States of America. 113, 7, p. E884-E893

Research output: Contribution to journalArticle

56 Scopus citations
2015

A long-duration dihydroorotate dehydrogenase inhibitor (DSM265) for prevention and treatment of malaria

Phillips, M. A., Lotharius, J., Marsh, K., White, J., Dayan, A., White, K. L., Njoroge, J. W., El Mazouni, F., Lao, Y., Kokkonda, S., Tomchick, D. R., Deng, X., Laird, T., Bhatia, S. N., March, S., Ng, C. L., Fidock, D. A., Wittlin, S., Lafuente-Monasterio, M., Benito, F. J. G. & 33 others, Alonso, L. M. S., Martinez, M. S., Jimenez-Diaz, M. B., Bazaga, S. F., Angulo-Barturen, I., Haselden, J. N., Louttit, J., Cui, Y., Sridhar, A., Zeeman, A. M., Kocken, C., Sauerwein, R., Dechering, K., Avery, V. M., Duffy, S., Delves, M., Sinden, R., Ruecker, A., Wickham, K. S., Rochford, R., Gahagen, J., Iyer, L., Riccio, E., Mirsalis, J., Bathhurst, I., Rueckle, T., Ding, X., Campo, B., Leroy, D., Rogers, M. J., Rathod, P. K., Burrows, J. N. & Charman, S. A., Jul 15 2015, In : Science translational medicine. 7, 296, aaa6645.

Research output: Contribution to journalArticle

126 Scopus citations

A Moraxella catarrhalis two-component signal transduction system necessary for growth in liquid media affects production of two lysozyme inhibitors

Joslin, S. N., Pybus, C., Labandeira-Rey, M., Evans, A. S., Attia, A. S., Brautigam, C. A. & Hansen, E. J., Jan 1 2015, In : Infection and immunity. 83, 1, p. 146-160 15 p.

Research output: Contribution to journalArticle

4 Scopus citations

A multilaboratory comparison of calibration accuracy and the performance of external references in analytical ultracentrifugation

Zhao, H., Ghirlando, R., Alfonso, C., Arisaka, F., Attali, I., Bain, D. L., Bakhtina, M. M., Becker, D. F., Bedwell, G. J., Bekdemir, A., Besong, T. M. D., Birck, C., Brautigam, C. A., Brennerman, W., Byron, O., Bzowska, A., Chaires, J. B., Chaton, C. T., Cölfen, H., Connaghan, K. D. & 100 others, Crowley, K. A., Curth, U., Daviter, T., Dean, W. L., Díez, A. I., Ebel, C., Eckert, D. M., Eisele, L. E., Eisenstein, E., England, P., Escalante, C., Fagan, J. A., Fairman, R., Finn, R. M., Fischle, W., García De La Torre, J., Gor, J., Gustafsson, H., Hall, D., Harding, S. E., Hernández Cifre, J. G., Herr, A. B., Howell, E. E., Isaac, R. S., Jao, S. C., Jose, D., Kim, S. J., Kokona, B., Kornblatt, J. A., Kosek, D., Krayukhina, E., Krzizike, D., Kusznir, E. A., Kwon, H., Larson, A., Laue, T. M., Roy, A. L., Leech, A. P., Lilie, H., Luger, K., Luque-Ortega, J. R., Ma, J., May, C. A., Maynard, E. L., Modrak-Wojcik, A., Mok, Y. F., Mücke, N., Nagel-Steger, L., Narlikar, G. J., Noda, M., Nourse, A., Obsil, T., Park, C. K., Park, J. K., Pawelek, P. D., Perdue, E. E., Perkins, S. J., Perugini, M. A., Peterson, C. L., Peverelli, M. G., Piszczek, G., Prag, G., Prevelige, P. E., Raynal, B. D. E., Rezabkova, L., Richter, K., Ringel, A. E., Rosenberg, R., Rowe, A. J., Rufer, A. C., Scott, D. J., Seravalli, J. G., Solovyova, A. S., Song, R., Staunton, D., Stoddard, C., Stott, K., Strauss, H. M., Streicher, W. W., Sumida, J. P., Swygert, S. G., Szczepanowski, R. H., Tessmer, I., Toth, R. T., Tripathy, A., Uchiyama, S., Uebel, S. F. W., Unzai, S., Gruber, A. V., Von Hippel, P. H., Wandrey, C., Wang, S. H., Weitzel, S. E., Wielgus-Kutrowska, B., Wolberger, C., Wolff, M., Wright, E., Wu, Y. S., Wubben, J. M. & Schuck, P., May 21 2015, In : PloS one. 10, 5, e0126420.

Research output: Contribution to journalArticle

42 Scopus citations

A mutation uncouples the tubulin conformational and GTPase cycles, revealing allosteric control of microtubule dynamics

Geyer, E. A., Burns, A., Lalonde, B. A., Ye, X., Piedra, F. A., Huffaker, T. C. & Rice, L. M., Oct 6 2015, In : eLife. 4, OCTOBER2015, e10113.

Research output: Contribution to journalArticle

44 Scopus citations

An atomic structure of human γ-secretase

Bai, X. C., Yan, C., Yang, G., Lu, P., Ma, D., Sun, L., Zhou, R., Scheres, S. H. W. & Shi, Y., Sep 10 2015, In : Nature. 525, 7568, p. 212-217 6 p.

Research output: Contribution to journalArticle

290 Scopus citations

An intrinsically disordered peptide from ebola virus VP35 controls viral RNA synthesis by modulating nucleoprotein-RNA interactions

Leung, D. W., Borek, D., Luthra, P., Binning, J. M., Anantpadma, M., Liu, G., Harvey, I. B., Su, Z., Endlich-Frazier, A., Pan, J., Shabman, R. S., Chiu, W., Davey, R. A., Otwinowski, Z., Basler, C. F. & Amarasinghe, G. K., Apr 21 2015, In : Cell Reports. 11, 3, p. 376-389 14 p.

Research output: Contribution to journalArticle

73 Scopus citations

Anomalous diffusion in neutral evolution of model proteins

Nelson, E. D. & Grishin, N. V., Jun 1 2015, In : Physical Review E - Statistical, Nonlinear, and Soft Matter Physics. 91, 6, 060701.

Research output: Contribution to journalArticle

2 Scopus citations

A Single Kinase Generates the Majority of the Secreted Phosphoproteome

Tagliabracci, V. S., Wiley, S. E., Guo, X., Kinch, L. N., Durrant, E., Wen, J., Xiao, J., Cui, J., Nguyen, K. B., Engel, J. L., Coon, J. J., Grishin, N., Pinna, L. A., Pagliarini, D. J. & Dixon, J. E., Jun 20 2015, In : Cell. 161, 7, p. 1619-1632 14 p.

Research output: Contribution to journalArticle

115 Scopus citations

Atomic structure of the apoptosome: Mechanism of cytochrome c- and dATP-mediated activation of Apaf-1

Zhou, M., Li, Y., Hu, Q., Bai, X. C., Huang, W., Yan, C., Scheres, S. H. W. & Shi, Y., Nov 15 2015, In : Genes and Development. 29, 22, p. 2349-2361 13 p.

Research output: Contribution to journalArticle

88 Scopus citations

C2H2 zinc finger proteins of the SP/KLF, Wilms tumor, EGR, Huckebein, and Klumpfuss families in metazoans and beyond

Pei, J. & Grishin, N. V., Nov 15 2015, In : Gene. 573, 1, p. 91-99 9 p., 40812.

Research output: Contribution to journalArticle

8 Scopus citations

ChSeq: A database of chameleon sequences

Li, W., Kinch, L. N., Karplus, P. A. & Grishin, N. V., Jul 1 2015, In : Protein Science. 24, 7, p. 1075-1086 12 p.

Research output: Contribution to journalArticle

24 Scopus citations

Coiled-coil coactivators play a structural role mediating interactions in hypoxia-inducible factor heterodimerization

Guo, Y., Scheuermann, T. H., Partch, C. L., Tomchick, D. R. & Gardner, K. H., Mar 20 2015, In : Journal of Biological Chemistry. 290, 12, p. 7707-7721 15 p.

Research output: Contribution to journalArticle

13 Scopus citations

Conserved interdomain linker promotes phase separation of the multivalent adaptor protein Nck

Banjade, S., Wu, Q., Mittal, A., Peeples, W. B., Pappu, R. V. & Rosen, M. K., Nov 24 2015, In : Proceedings of the National Academy of Sciences of the United States of America. 112, 47, p. E6426-E6435

Research output: Contribution to journalArticle

55 Scopus citations

Crystal structure of the human OX2 orexin receptor bound to the insomnia drug suvorexant

Yin, J., Mobarec, J. C., Kolb, P. & Rosenbaum, D. M., Mar 12 2015, In : Nature. 519, 7542, p. 247-250 4 p.

Research output: Contribution to journalArticle

126 Scopus citations
13 Scopus citations

Disruption of Wnt/β-catenin signaling and telomeric shortening are inextricable consequences of tankyrase inhibition in human cells

Kulak, O., Chen, H., Holohan, B., Wu, X., He, H., Borek, D., Otwinowski, Z., Yamaguchi, K., Garofalo, L. A., Ma, Z., Wright, W., Chen, C., Shay, J. W., Zhang, X. & Lum, L., 2015, In : Molecular and Cellular Biology. 35, 14, p. 2425-2435 11 p.

Research output: Contribution to journalArticle

35 Scopus citations

Domain-Swapping Switch Point in Ste20 Protein Kinase SPAK

Taylor, C. A., Juang, Y. C., Earnest, S., Sengupta, S., Goldsmith, E. J. & Cobb, M. H., Jul 24 2015, In : Biochemistry. 54, 32, p. 5063-5071 9 p.

Research output: Contribution to journalArticle

10 Scopus citations

Dynamic binding mode of a Synaptotagmin-1-SNARE complex in solution

Brewer, K. D., Bacaj, T., Cavalli, A., Camilloni, C., Swarbrick, J. D., Liu, J., Zhou, A., Zhou, P., Barlow, N., Xu, J., Seven, A. B., Prinslow, E. A., Voleti, R., Häussinger, D., Bonvin, A. M. J. J., Tomchick, D. R., Vendruscolo, M., Graham, B., Südhof, T. C. & Rizo-Rey, J., Jul 9 2015, In : Nature Structural and Molecular Biology. 22, 7, p. 555-564 10 p.

Research output: Contribution to journalArticle

73 Scopus citations
17 Scopus citations

Evolutionary conservation of complexins: From choanoflagellates to mice

Yang, X., Pei, J., Kaeser-Woo, Y. J., Bacaj, T., Grishin, N. V. & Südhof, T. C., Oct 1 2015, In : EMBO Reports. 16, 10, p. 1308-1317 10 p.

Research output: Contribution to journalArticle

15 Scopus citations

Fitting two- and three-site binding models to isothermal titration calorimetric data

Brautigam, C. A., Apr 1 2015, In : Methods. 76, p. 124-136 13 p.

Research output: Contribution to journalArticle

29 Scopus citations

Formation and Maturation of Phase-Separated Liquid Droplets by RNA-Binding Proteins

Lin, Y., Protter, D. S. W., Rosen, M. K. & Parker, R., Oct 15 2015, In : Molecular cell. 60, 2, p. 208-219 12 p.

Research output: Contribution to journalArticle

494 Scopus citations

High-precision, automated integration of multiple isothermal titration calorimetric thermograms: New features of NITPIC

Scheuermann, T. H. & Brautigam, C. A., Apr 1 2015, In : Methods. 76, p. 87-98 12 p.

Research output: Contribution to journalArticle

54 Scopus citations
9 Scopus citations

Isoform-Selective and Stereoselective Inhibition of Hypoxia Inducible Factor-2

Scheuermann, T. H., Stroud, D., Sleet, C. E., Bayeh, L., Shokri, C., Wang, H., Caldwell, C. G., Longgood, J., MacMillan, J. B., Bruick, R. K., Gardner, K. H. & Tambar, U. K., Jul 30 2015, In : Journal of Medicinal Chemistry. 58, 15, p. 5930-5941 12 p.

Research output: Contribution to journalArticle

32 Scopus citations

KDM4/JMJD2 Histone Demethylase Inhibitors Block Prostate Tumor Growth by Suppressing the Expression of AR and BMYB-Regulated Genes

Duan, L., Rai, G., Roggero, C., Zhang, Q. J., Wei, Q., Ma, S. H., Zhou, Y., Santoyo, J., Martinez, E. D., Xiao, G., Raj, G., Jadhav, A., Simeonov, A., Maloney, D. J., Rizo-Rey, J., Hsieh, J-T. & Liu, Z-P., Sep 17 2015, In : Chemistry and Biology. 22, 9, p. 1185-1196 12 p.

Research output: Contribution to journalArticle

31 Scopus citations

Large-scale determination of previously unsolved protein structures using evolutionary information

Ovchinnikov, S., Kinch, L., Park, H., Liao, Y., Pei, J., Kim, D. E., Kamisetty, H., Grishin, N. V. & Baker, D., Sep 3 2015, In : eLife. 4, September, e09248.

Research output: Contribution to journalArticle

125 Scopus citations

Ligand-induced folding of a two-component signaling receiver domain

Ocasio, V. J., Corrêa, F. & Gardner, K. H., Feb 17 2015, In : Biochemistry. 54, 6, p. 1353-1363 11 p.

Research output: Contribution to journalArticle

12 Scopus citations

LocNES: A computational tool for locating classical NESs in CRM1 cargo proteins

Xu, D., Marquis, K., Pei, J., Fu, S. C., Caʇatay, T., Grishin, N. V. & Chook, Y. M., 2015, In : Bioinformatics. 31, 9, p. 1357-1365 9 p.

Research output: Contribution to journalArticle

52 Scopus citations

Manual classification strategies in the ECOD database

Cheng, H., Liao, Y., Schaeffer, R. D. & Grishin, N. V., Jul 1 2015, In : Proteins: Structure, Function and Bioinformatics. 83, 7, p. 1238-1251 14 p.

Research output: Contribution to journalArticle

18 Scopus citations

Methyl labeling and TROSY NMR spectroscopy of proteins expressed in the eukaryote Pichia pastoris

Clark, L., Zahm, J. A., Ali, R., Kukula, M., Bian, L., Patrie, S. M., Gardner, K. H., Rosen, M. & Rosenbaum, D. M., May 30 2015, (Accepted/In press) In : Journal of Biomolecular NMR.

Research output: Contribution to journalArticle

29 Scopus citations

Nuclear export inhibitors avert progression in preclinical models of inflammatory demyelination

Haines, J. D., Herbin, O., De La Hera, B., Vidaurre, O. G., Moy, G. A., Sun, Q., Fung, H. Y. J., Albrecht, S., Alexandropoulos, K., McCauley, D., Chook, Y. M., Kuhlmann, T., Kidd, G. J., Shacham, S. & Casaccia, P., Apr 28 2015, In : Nature neuroscience. 18, 4, p. 511-520 10 p.

Research output: Contribution to journalArticle

37 Scopus citations

Nuclear localization signals for four distinct Karyopherin-β nuclear import systems

Soniat, M. & Chook, Y. M., Jun 15 2015, In : Biochemical Journal. 468, 3, p. 353-362 10 p.

Research output: Contribution to journalArticle

63 Scopus citations

Real-time resolution of point mutations that cause phenovariance in mice

Wang, T., Zhan, X., Bua, C. H., Lyona, S., Pratta, D., Hildebrand, S., Choi, J. H., Zhang, Z., Zeng, M., Wang, K. W., Turer, E. E., Chen, Z., Zhang Ph.D., D-W., Yue, T., Wang, Y., Shi, H-X., Wang, J., Sun, L., SoRelle, J., McAlpine, W. & 28 others, Hutchins, N., Zhan, X., Fin, M., Gobert, R., Quan, J., Kreutzer, M., Arnett, S., Hawkins, K., Leach, A., Tate, C., Daniel, C., Reyna, C., Prince, L., Davis, S., Purrington, J., Bearden, R., Weatherly, J., White, D., Russell, J. L., Sun, Q., Tang, M., Li, X., Scott, L., Moresco, E. M. Y., McInerney, G. M., Karlsson Hedestam, G. B., Xie, Y. & Beutler, B. A., Feb 3 2015, In : Proceedings of the National Academy of Sciences of the United States of America. 112, 5, p. E440-E449

Research output: Contribution to journalArticle

36 Scopus citations

Refinement by shifting secondary structure elements improves sequence alignments

Tong, J., Pei, J., Otwinowski, Z. & Grishin, N. V., Mar 1 2015, In : Proteins: Structure, Function and Bioinformatics. 83, 3, p. 411-427 17 p.

Research output: Contribution to journalArticle

2 Scopus citations

Sampling the conformational space of the catalytic subunit of human g-secretase

Bai, X. C., Rajendra, E., Yang, G., Shi, Y. & Scheres, S. H. W., Dec 1 2015, In : eLife. 4, December2015, e11182.

Research output: Contribution to journalArticle

266 Scopus citations
6 Scopus citations

Sensitivity-Enhanced NMR Reveals Alterations in Protein Structure by Cellular Milieus

Frederick, K. K., Michaelis, V. K., Corzilius, B., Ong, T. C., Jacavone, A. C., Griffin, R. G. & Lindquist, S., Oct 22 2015, In : Cell. 163, 3, p. 620-628 9 p.

Research output: Contribution to journalArticle

74 Scopus citations

SFESA: A web server for pairwise alignment refinement by secondary structure shifts

Tong, J., Pei, J. & Grishin, N. V., Sep 3 2015, In : BMC Bioinformatics. 16, 1, 282.

Research output: Contribution to journalArticle

Skipper genome sheds light on unique phenotypic traits and phylogeny

Cong, Q., Borek, D., Otwinowski, Z. & Grishin, N. V., Aug 27 2015, In : BMC Genomics. 16, 1, 639.

Research output: Contribution to journalArticle

23 Scopus citations

Structural Basis and IP6 Requirement for Pds5-Dependent Cohesin Dynamics

Ouyang, Z., Zheng, G., Tomchick, D. R., Luo, X. & Yu, H., Nov 16 2015, (Accepted/In press) In : Molecular Cell.

Research output: Contribution to journalArticle

54 Scopus citations

Structural determinants of nuclear export signal orientation in binding to exportin CRM1

Fung, H. Y. J., Fu, S. C., Brautigam, C. A. & Chook, Y. M., Sep 8 2015, In : eLife. 4, September 2015, e10034.

Research output: Contribution to journalArticle

33 Scopus citations

Structural organization of nuclear lamins A, C, B1, and B2 revealed by superresolution microscopy

Shimia, T., Kittisopikul, M., Tran, J., Goldman, A. E., Adam, S. A., Zheng, Y., Jaqaman, K. & Goldman, R. D., Nov 5 2015, In : Molecular Biology of the Cell. 26, 22, p. 4075-4086 12 p.

Research output: Contribution to journalArticle

75 Scopus citations

Structure of a Yeast 40S-eIF1-eIF1A-eIF3-eIF3j initiation complex

Aylett, C. H. S., Boehringer, D., Erzberger, J. P., Schaefer, T. & Ban, N., Mar 6 2015, In : Nature Structural and Molecular Biology. 22, 3, p. 269-271 3 p.

Research output: Contribution to journalArticle

56 Scopus citations

Structure of the apoptosome: Mechanistic insights into activation of an initiator caspase from Drosophila

Pang, Y., Bai, X. C., Yan, C., Hao, Q., Chen, Z., Wang, J. W., Scheres, S. H. W. & Shi, Y., Jan 1 2015, In : Genes and Development. 29, 3, p. 277-287 11 p.

Research output: Contribution to journalArticle

31 Scopus citations