Research Output 1979 2019

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2014
30 Citations (Scopus)

Extracellular architecture of the SYG-1/SYG-2 adhesion complex instructs synaptogenesis

Özkan, E., Chia, P. H., Wang, R. R., Goriatcheva, N., Borek, D., Otwinowski, Z., Walz, T., Shen, K. & Garcia, K. C., Jan 30 2014, In : Cell. 156, 3, p. 482-494 13 p.

Research output: Contribution to journalArticle

Cell Adhesion Molecules
Synapses
Adhesion
Geometry
Kidney
39 Citations (Scopus)

Full-length structure of a monomeric histidine kinase reveals basis for sensory regulation

Rivera-Cancel, G., Ko, W. H., Tomchick, D. R., Correa, F. & Gardner, K. H., Dec 16 2014, In : Proceedings of the National Academy of Sciences of the United States of America. 111, 50, p. 17839-17844 6 p.

Research output: Contribution to journalArticle

Dimerization
Light
Adenosine Triphosphate
Histidine
Sphingomonadaceae
8 Citations (Scopus)

Haemophilus ducreyi Hfq contributes to virulence gene regulation as cells enter stationary phase

Gangaiah, D., Labandeira, M., Zhang, X., Fortney, K. R., Ellinger, S., Zwickl, B., Baker, B., Liu, Y., Janowicz, D. M., Katz, B. P., Brautigam, C. A., Munson, R. S., Hansen, E. J. & Spinola, S. M., Feb 11 2014, In : mBio. 5, 1, e01081-13.

Research output: Contribution to journalArticle

Haemophilus ducreyi
Virulence
Genes
Down-Regulation
Sigma Factor
9 Citations (Scopus)
Borrelia burgdorferi
Genetic Promoter Regions
DNA
Sigma Factor
Spirochaetales
7 Citations (Scopus)

Identification of an outer membrane lipoprotein involved in nasopharyngeal colonization by Moraxella catarrhalis in an animal model

Wang, W., Joslin, S. N., Pybus, C., Evans, A. S., Lichaa, F., Brautigam, C. A. & Hansen, E. J., 2014, In : Infection and Immunity. 82, 6, p. 2287-2299 13 p.

Research output: Contribution to journalArticle

Moraxella (Branhamella) catarrhalis
Lipoproteins
Animal Models
Membranes
Proteins
15 Citations (Scopus)

Identification of lysine residues in the Borrelia burgdorferi DbpA adhesin required for murine infection

Fortune, D. E., Lin, Y. P., Deka, R. K., Groshong, A. M., Moore, B. P., Hagman, K. E., Leong, J. M., Tomchick, D. R. & Blevins, J. S., 2014, In : Infection and Immunity. 82, 8, p. 3186-3198 13 p.

Research output: Contribution to journalArticle

Decorin
Lysine
Staphylococcal Protein A
Carrier Proteins
Infection
119 Citations (Scopus)

Initiation of translation by cricket paralysis virus IRES requires its translocation in the ribosome

Fernández, I. S., Bai, X. C., Murshudov, G., Scheres, S. H. W. & Ramakrishnan, V., May 8 2014, In : Cell. 157, 4, p. 823-831 9 p.

Research output: Contribution to journalArticle

Gryllidae
Ribosomes
Viruses
Paralysis
Messenger RNA
41 Citations (Scopus)

In silico derived small molecules bind the filovirus VP35 protein and inhibit its polymerase cofactor activity

Brown, C. S., Lee, M. S., Leung, D. W., Wang, T., Xu, W., Luthra, P., Anantpadma, M., Shabman, R. S., Melito, L. M., Macmillan, K. S., Borek, D. M., Otwinowski, Z., Ramanan, P., Stubbs, A. J., Peterson, D. S., Binning, J. M., Tonelli, M., Olson, M. A., Davey, R. A., Ready, J. M. & 2 others, Basler, C. F. & Amarasinghe, G. K., May 15 2014, In : Journal of Molecular Biology. 426, 10, p. 2045-2058 14 p.

Research output: Contribution to journalArticle

Viral Proteins
Computer Simulation
Ebolavirus
Nucleoproteins
Proteins
98 Citations (Scopus)

In situ selectivity profiling and crystal structure of SML-8-73-1, an active site inhibitor of oncogenic K-Ras G12C

Hunter, J. C., Gurbani, D., Ficarro, S. B., Carrasco, M. A., Lim, S. M., Choi, H. G., Xie, T., Marto, J. A., Chen, Z., Gray, N. S. & Westover, K. D., 2014, In : Proceedings of the National Academy of Sciences of the United States of America. 111, 24, p. 8895-8900 6 p.

Research output: Contribution to journalArticle

Guanine Nucleotides
Catalytic Domain
ras Proteins
ras Genes
Guanosine Triphosphate
62 Citations (Scopus)

Local F-actin network links synapse formation and axon branching

Chia, P. H., Chen, B., Li, P., Rosen, M. K. & Shen, K., 2014, In : Cell. 156, 1-2, p. 208-220 13 p.

Research output: Contribution to journalArticle

Synapses
Axons
Actins
Actin Cytoskeleton
Cell Adhesion Molecules
41 Citations (Scopus)

LocNES: A computational tool for locating classical NESs in CRM1 cargo proteins

Xu, D., Marquis, K., Pei, J., Fu, S. C., Caʇatay, T., Grishin, N. V. & Chook, Y. M., Nov 5 2014, In : Bioinformatics. 31, 9, p. 1357-1365 9 p.

Research output: Contribution to journalArticle

Nuclear Export Signals
Peptides
Proteins
Protein
Nuclear Proteins
7 Citations (Scopus)

Measurement of the temperature of the resting rotor in analytical ultracentrifugation

Ghirlando, R., Zhao, H., Balbo, A., Piszczek, G., Curth, U., Brautigam, C. A. & Schuck, P., Aug 1 2014, In : Analytical Biochemistry. 458, p. 37-39 3 p.

Research output: Contribution to journalArticle

Ultracentrifugation
Rotors
Temperature
Hydrodynamics
Vacuum
509 Citations (Scopus)

Mixed Lineage Kinase Domain-like Protein MLKL Causes Necrotic Membrane Disruption upon Phosphorylation by RIP3

Wang, H., Sun, L., Su, L., Rizo-Rey, J., Liu, L., Wang, L. F., Wang, F. S. & Wang, X., Apr 10 2014, In : Molecular Cell. 54, 1, p. 133-146 14 p.

Research output: Contribution to journalArticle

Phosphotransferases
Phosphorylation
Membranes
Chemical and Drug Induced Liver Injury
Intracellular Membranes
116 Citations (Scopus)

Molecular architecture of the 40S · eIF1 · eIF3 translation initiation complex

Erzberger, J. P., Stengel, F., Pellarin, R., Zhang, S., Schaefer, T., Aylett, C. H. S., Cimermančič, P., Boehringer, D., Sali, A., Aebersold, R. & Ban, N., Aug 28 2014, In : Cell. 158, 5, p. 1123-1135 13 p.

Research output: Contribution to journalArticle

Eukaryotic Small Ribosome Subunits
Multiprotein Complexes
Peptide Initiation Factors
Hepatitis C
Yeast
14 Citations (Scopus)

Mutation of mouse Samd4 causes leanness, myopathy, uncoupled mitochondrial respiration, and dysregulated mTORC1 signaling

Chen, Z., Holland, W., Shelton, J. M., Ali, A., Zhan, X., Won, S., Tomisato, W., Liu, C., Li, X., Moresco, E. M. Y. & Beutler, B., May 20 2014, In : Proceedings of the National Academy of Sciences of the United States of America. 111, 20, p. 7367-7372 6 p.

Research output: Contribution to journalArticle

Mitochondrial Myopathies
Thinness
Respiration
Mutation
Proteins
123 Citations (Scopus)

Phase transitions of multivalent proteins can promote clustering of membrane receptors

Banjade, S. & Rosen, M. K., 2014, In : eLife. 3

Research output: Contribution to journalArticle

Phase Transition
Cluster Analysis
Phase transitions
Membranes
Proteins
39 Citations (Scopus)

Re-examining how complexin inhibits neurotransmitter release: SNARE complex insertion or electrostatic hindrance?

Trimbuch, T., Xu, J., Flaherty, D., Tomchick, D. R., Rizo-Rey, J. & Rosenmund, C., May 8 2014, In : eLife. 2014, 3, e02391.

Research output: Contribution to journalArticle

SNARE Proteins
Accessories
Static Electricity
R-SNARE Proteins
Neurotransmitter Agents
202 Citations (Scopus)

Regulation of microtubule motors by tubulin isotypes and post-translational modifications

Sirajuddin, M., Rice, L. M. & Vale, R. D., 2014, In : Nature Cell Biology. 16, 4, p. 335-344 10 p.

Research output: Contribution to journalArticle

Post Translational Protein Processing
Tubulin
Microtubules
Kinesin
Microtubule-Associated Proteins
75 Citations (Scopus)

Retromer binding to FAM21 and the WASH complex is perturbed by the Parkinson disease-linked VPS35(D620N) mutation

McGough, I. J., Steinberg, F., Jia, D., Barbuti, P. A., McMillan, K. J., Heesom, K. J., Whone, A. L., Caldwell, M. A., Billadeau, D. D., Rosen, M. K. & Cullen, P. J., Jul 21 2014, In : Current Biology. 24, 14, p. 1670-1676 7 p.

Research output: Contribution to journalArticle

Wiskott-Aldrich Syndrome
Parkinson disease
endosomes
Endosomes
Parkinson Disease
8 Citations (Scopus)
Phosphate Transport Proteins
Borrelia burgdorferi
ATP-Binding Cassette Transporters
Lipoproteins
Phosphates
23 Citations (Scopus)

Structure and Ca2+-binding properties of the tandem C 2 Domains of E-Syt2

Xu, J., Bacaj, T., Zhou, A., Tomchick, D. R., Südhof, T. C. & Rizo-Rey, J., Feb 4 2014, In : Structure. 22, 2, p. 269-280 12 p.

Research output: Contribution to journalArticle

Synaptotagmins
Fungal Proteins
Endoplasmic Reticulum
Mammals
Magnetic Resonance Spectroscopy
61 Citations (Scopus)

Structure of cohesin subcomplex pinpoints direct shugoshin-Wapl antagonism in centromeric cohesion

Hara, K., Zheng, G., Qu, Q., Liu, H., Ouyang, Z., Chen, Z., Tomchick, D. R. & Yu, H., Jan 1 2014, In : Nature Structural and Molecular Biology. 21, 10, p. 864-870 7 p.

Research output: Contribution to journalArticle

Separase
Prophase
Chromosome Segregation
Anaphase
Chromatids
3 Citations (Scopus)

Structure of the effector-binding domain of deoxyribonucleoside regulator DeoR from Bacillus subtilis

Škerlová, J., Fábry, M., Hubálek, M., Otwinowski, Z. & Řezáčová, P., Sep 1 2014, In : FEBS Journal. 281, 18, p. 4280-4292 13 p.

Research output: Contribution to journalArticle

Deoxyribonucleosides
Bacilli
Bacillus subtilis
Deoxyribose
Schiff Bases
128 Citations (Scopus)

Structure of the large ribosomal subunit from human mitochondria

Brown, A., Amunts, A., Bai, X. C., Sugimoto, Y., Edwards, P. C., Murshudov, G., Scheres, S. H. W. & Ramakrishnan, V., Nov 7 2014, In : Science. 346, 6210, p. 718-722 5 p.

Research output: Contribution to journalArticle

Large Ribosome Subunits
Transfer RNA
Mitochondria
RNA, Transfer, Val
Mitochondrial Diseases
273 Citations (Scopus)

Structure of the yeast mitochondrial

Amunts, A., Brown, A., Bai, X. C., Llácer, J. L., Hussain, T., Emsley, P., Long, F., Murshudov, G., Scheres, S. H. W. & Ramakrishnan, V., Jan 1 2014, In : Science. 343, 6178, p. 1485-1489 5 p.

Research output: Contribution to journalArticle

Mitochondria
Yeasts
Cryoelectron Microscopy
Tocopherols
Ribosomes

Structure of the yeast mitochondrial large ribosomal subunit

Amunts, A., Brown, A., Bai, X. C., Llácer, J. L., Hussain, T., Emsley, P., Long, F., Murshudov, G., Scheres, S. H. W. & Ramakrishnan, V., Jan 1 2014, In : Microscopy and Microanalysis. 20, 3, p. 1252-1253 2 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)

Substrate-Specific Activation of the Mitotic Kinase Bub1 through Intramolecular Autophosphorylation and Kinetochore Targeting

Lin, Z., Jia, L., Tomchick, D. R., Luo, X. & Yu, H., Nov 4 2014, In : Structure. 22, 11, p. 1616-1627 12 p.

Research output: Contribution to journalArticle

Kinetochores
Phosphotransferases
Phosphorylation
Anaphase-Promoting Complex-Cyclosome
Chromosome Segregation
99 Citations (Scopus)

The contribution of αβ-tubulin curvature to microtubule dynamics

Brouhard, G. J. & Rice, L. M., 2014, In : Journal of Cell Biology. 207, 3, p. 323-334 12 p.

Research output: Contribution to journalArticle

Tubulin
Microtubules
Axoneme
Microtubule Proteins
Spindle Apparatus
106 Citations (Scopus)

The cytosolic DNA sensor cGAS forms an oligomeric complex with DNA and undergoes switch-like conformational changes in the activation loop

Zhang, X., Wu, J., Du, F., Xu, H., Sun, L., Chen, Z., Brautigam, C. A., Zhang, X. & Chen, Z., Feb 13 2014, In : Cell Reports. 6, 3, p. 421-430 10 p.

Research output: Contribution to journalArticle

Chemical activation
Switches
DNA
Sensors
GMP synthase (glutamine-hydrolyzing)
6 Citations (Scopus)

The haemophilus ducreyi lspa1 protein inhibits phagocytosis by using a new mechanism involving Activation of C-terminal src kinase

Dodd, D. A., Worth, R. G., Rosen, M. K., Grinstein, S., van Oers, N. S. C. & Hansen, E. J., May 20 2014, In : mBio. 5, 3

Research output: Contribution to journalArticle

src-Family Kinases
Phagocytosis
Tyrosine
Haemophilus ducreyi
Chancroid
119 Citations (Scopus)

The WAVE regulatory complex links diverse receptors to the actin cytoskeleton

Chen, B., Brinkmann, K., Chen, Z., Pak, C. W., Liao, Y., Shi, S., Henry, L., Grishin, N. V., Bogdan, S. & Rosen, M. K., 2014, In : Cell. 156, 1-2, p. 195-207 13 p.

Research output: Contribution to journalArticle

Actin Cytoskeleton
Actins
Membrane Proteins
Actin-Related Protein 2-3 Complex
Ligands
184 Citations (Scopus)

Three-dimensional structure of human γ-secretase

Lu, P., Bai, X. C., Ma, D., Xie, T., Yan, C., Sun, L., Yang, G., Zhao, Y., Zhou, R., Scheres, S. H. W. & Shi, Y., Aug 14 2014, In : Nature. 512, 7513, p. 166-170 5 p.

Research output: Contribution to journalArticle

Amyloid Precursor Protein Secretases
Peptide Hydrolases
Presenilin-1
Amyloid beta-Protein Precursor
Amyloid
15 Citations (Scopus)

Transportin acts to regulate mitotic assembly events by target binding rather than Ran sequestration

Bernis, C., Swift-Taylor, B., Nord, M., Carmona, S., Chook, Y. M. & Forbes, D. J., Apr 1 2014, In : Molecular Biology of the Cell. 25, 7, p. 992-1009 18 p.

Research output: Contribution to journalArticle

Karyopherins
Chromatin
Nuclear Pore
Kinetochores
Nuclear Pore Complex Proteins
2013
26 Citations (Scopus)

Activated RhoA is a positive feedback regulator of the Lbc family of Rho guanine nucleotide exchange factor proteins

Medina, F., Carter, A. M., Dada, O., Gutowski, S., Hadas, J., Chen, Z. & Sternweis, P. C., Apr 19 2013, In : Journal of Biological Chemistry. 288, 16, p. 11325-11333 9 p.

Research output: Contribution to journalArticle

Rho Guanine Nucleotide Exchange Factors
GTP Phosphohydrolases
Feedback
Proteins
Pleckstrin Homology Domains
128 Citations (Scopus)

Allosteric inhibition of hypoxia inducible factor-2 with small molecules

Scheuermann, T. H., Li, Q., Ma, H. W., Key, J., Zhang, L., Chen, R., Garcia, J. A., Naidoo, J., Longgood, J., Frantz, D. E., Tambar, U. K., Gardner, K. H. & Bruick, R. K., Apr 2013, In : Nature Chemical Biology. 9, 4, p. 271-276 6 p.

Research output: Contribution to journalArticle

Hypoxia-Inducible Factor 1
Ligands
Transcription Factors
Cell Hypoxia
Renal Cell Carcinoma
17 Citations (Scopus)

Analysis of SNARE complex/synaptotagmin-1 interactions by one-dimensional NMR spectroscopy

Zhou, A., Brewer, K. D. & Rizo-Rey, J., May 21 2013, In : Biochemistry. 52, 20, p. 3446-3456 11 p.

Research output: Contribution to journalArticle

Synaptotagmin I
SNARE Proteins
Nuclear magnetic resonance spectroscopy
Magnetic Resonance Spectroscopy
Membrane Fusion
101 Citations (Scopus)

Antileukemic activity of nuclear export inhibitors that spare normal hematopoietic cells

Etchin, J., Sun, Q., Kentsis, A., Farmer, A., Zhang, Z. C., Sanda, T., Mansour, M. R., Barcelo, C., McCauley, D., Kauffman, M., Shacham, S., Christie, A. L., Kung, A. L., Rodig, S. J., Chook, Y. M. & Look, A. T., Jan 2013, In : Leukemia. 27, 1, p. 66-74 9 p.

Research output: Contribution to journalArticle

Cell Nucleus Active Transport
Nuclear Export Signals
Acute Myeloid Leukemia
Myeloid Cells
Digital Libraries
135 Citations (Scopus)

A small molecule modulates Jumonji histone demethylase activity and selectively inhibits cancer growth.

Wang, L., Chang, J., Varghese, D., Dellinger, M., Kumar, S., Best, A. M., Ruiz, J., Bruick, R., Peña-Llopis, S., Xu, J., Babinski, D. J., Frantz, D. E., Brekken, R. A., Quinn, A. M., Simeonov, A., Easmon, J. & Martinez, E. D., 2013, In : Nature Communications. 4, 2035.

Research output: Contribution to journalArticle

Histone Demethylases
inhibitors
tumors
cancer
Molecules
29 Citations (Scopus)

Blue light-induced dimerization of a bacterial LOV-HTH DNA-binding protein

Zoltowski, B. D., Motta-Mena, L. B. & Gardner, K. H., Sep 24 2013, In : Biochemistry. 52, 38, p. 6653-6661 9 p.

Research output: Contribution to journalArticle

Dimerization
DNA-Binding Proteins
Oxygen
Light
DNA
21 Citations (Scopus)

Blue light regulated two-component systems: Enzymatic and functional analyses of light-oxygen-voltage (LOV)-histidine kinases and downstream response regulators

Correa, F., Ko, W. H., Ocasio, V., Bogomolni, R. A. & Gardner, K. H., Jul 9 2013, In : Biochemistry. 52, 27, p. 4656-4666 11 p.

Research output: Contribution to journalArticle

Histidine
Phosphotransferases
Oxygen
Light
Electric potential
9 Citations (Scopus)

Crystal structure of human Karyopherin β2 bound to the PY-NLS of Saccharomyces cerevisiae Nab2

Soniat, M., Sampathkumar, P., Collett, G., Gizzi, A. S., Banu, R. N., Bhosle, R. C., Chamala, S., Chowdhury, S., Fiser, A., Glenn, A. S., Hammonds, J., Hillerich, B., Khafizov, K., Love, J. D., Matikainen, B., Seidel, R. D., Toro, R., Rajesh Kumar, P., Bonanno, J. B., Chook, Y. M. & 1 others, Almo, S. C., Jun 2013, In : Journal of Structural and Functional Genomics. 14, 2, p. 31-35 5 p.

Research output: Contribution to journalArticle

Karyopherins
Nuclear Localization Signals
Yeast
Saccharomyces cerevisiae
Crystal structure
52 Citations (Scopus)

Development of inhibitors of the PAS-B domain of the HIF-2α transcription factor

Rogers, J. L., Bayeh, L., Scheuermann, T. H., Longgood, J., Key, J., Naidoo, J., Melito, L., Shokri, C., Frantz, D. E., Bruick, R. K., Gardner, K. H., MacMillan, J. B. & Tambar, U. K., 2013, In : Journal of Medicinal Chemistry. 56, 4, p. 1739-1747 9 p.

Research output: Contribution to journalArticle

Transcription Factors
X Ray Crystallography
Structure-Activity Relationship
endothelial PAS domain-containing protein 1
Neoplasms
28 Citations (Scopus)

Effectors of animal and plant pathogens use a common domain to bind host phosphoinositides.

Salomon, D., Guo, Y., Kinch, L. N., Grishin, N. V., Gardner, K. H. & Orth, K., 2013, In : Nature Communications. 4, 2973.

Research output: Contribution to journalArticle

effectors
pathogens
Pathogens
Phosphatidylinositols
animals
1 Citation (Scopus)

Erratum: A small molecule modulates Jumonji histone demethylase activity and selectively inhibits cancer growth (Nature Communications (2013) 4 (2035) Doi:10.1038/ncomms3035)

Wang, L., Chang, J., Varghese, D., Dellinger, M., Kumar, S., Best, A. M., Ruiz, J., Bruick, R., Penã-Llopis, S., Xu, J., Babinski, D. J., Frantz, D. E., Brekken, R. A., Quinn, A. M., Simeonov, A., Easmon, J. & Martinez, E. D., 2013, In : Nature Communications. 4, 2639.

Research output: Contribution to journalArticle

26 Citations (Scopus)

Evidence for an ABC-type riboflavin transporter system in pathogenic spirochetes

Deka, R. K., Brautigam, C. A., Biddy, B. A., Liu, W. Z. & Norgard, M. V., 2013, In : mBio. 4, 1

Research output: Contribution to journalArticle

Spirochaetales
ATP-Binding Cassette Transporters
Riboflavin
Treponema pallidum
Globus Pallidus

Evidence for an ABC-type riboflavin transporter system in pathogenic spirochetes.

Deka, R. K., Brautigam, C. A., Biddy, B. A., Liu, W. Z. & Norgard, M. V., 2013, In : mBio. 4, 1

Research output: Contribution to journalArticle

Spirochaetales
ATP-Binding Cassette Transporters
Riboflavin
Treponema pallidum
Ligands
19 Citations (Scopus)

Identification of patterns in diffraction intensities affected by radiation exposure

Borek, D., Dauter, Z. & Otwinowski, Z., 2013, In : Journal of Synchrotron Radiation. 20, 1, p. 37-48 12 p.

Research output: Contribution to journalArticle

radiation dosage
Diffraction
Radiation
radiation
diffraction
42 Citations (Scopus)

Improving the thermal, radial, and temporal accuracy of the analytical ultracentrifuge through external references

Ghirlando, R., Balbo, A., Piszczek, G., Brown, P. H., Lewis, M. S., Brautigam, C. A., Schuck, P. & Zhao, H., 2013, In : Analytical Biochemistry. 440, 1, p. 81-95 15 p.

Research output: Contribution to journalArticle

Sedimentation
Calibration
Hot Temperature
Temperature
Hydrodynamics
82 Citations (Scopus)

Molecular architecture of a eukaryotic translational initiation complex

Fernández, I. S., Bai, X. C., Hussain, T., Kelley, A. C., Lorsch, J. R., Ramakrishnan, V. & Scheres, S. H. W., Jan 1 2013, In : Science. 342, 6160, 1240585.

Research output: Contribution to journalArticle

RNA, Transfer, Met
Large Ribosome Subunits
Small Ribosome Subunits
Cryoelectron Microscopy
Peptide Initiation Factors
10 Citations (Scopus)

Multi-Signal Sedimentation Velocity Analysis with Mass Conservation for Determining the Stoichiometry of Protein Complexes

Brautigam, C. A., Padrick, S. B. & Schuck, P., May 16 2013, In : PLoS One. 8, 5, e62694.

Research output: Contribution to journalArticle

ultracentrifugation
Ultracentrifugation
stoichiometry
Sedimentation
Stoichiometry