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2015

Structure of the rabbit ryanodine receptor RyR1 at near-atomic resolution

Yan, Z., Bai, X. C., Yan, C., Wu, J., Li, Z., Xie, T., Peng, W., Yin, C. C., Li, X., Scheres, S. H. W., Shi, Y. & Yan, N., Jan 1 2015, In : Nature. 517, 7532, p. 50-55 6 p.

Research output: Contribution to journalArticle

254 Scopus citations

Syntaxin opening by the MUN domain underlies the function of Munc13 in synaptic-vesicle priming

Yang, X., Wang, S., Sheng, Y., Zhang, M., Zou, W., Wu, L., Kang, L., Rizo-Rey, J., Zhang, R., Xu, T. & Ma, C., Jul 9 2015, In : Nature Structural and Molecular Biology. 22, 7, p. 547-554 8 p.

Research output: Contribution to journalArticle

67 Scopus citations

The architecture of the spliceosomal U4/U6.U5 tri-snRNP

Nguyen, T. H. D., Galej, W. P., Bai, X. C., Savva, C. G., Newman, A. J., Scheres, S. H. W. & Nagai, K., Jul 1 2015, In : Nature. 523, 7558, p. 47-52 6 p.

Research output: Contribution to journalArticle

128 Scopus citations

The Cdc20-binding Phe box of the spindle checkpoint protein BubR1 maintains the mitotic checkpoint complex during mitosis

Diaz-Martinez, L. A., Tian, W., Li, B., Warrington, R., Jia, L., Brautigam, C. A., Luo, X. & Yu, H., Jan 23 2015, In : Journal of Biological Chemistry. 290, 4, p. 2431-2443 13 p.

Research output: Contribution to journalArticle

33 Scopus citations

The complete mitochondrial genome of Papilio glaucus and its phylogenetic implications

Shen, J., Cong, Q. & Grishin, N. V., Sep 1 2015, In : Meta Gene. 5, p. 68-83 16 p.

Research output: Contribution to journalArticle

13 Scopus citations

The Synaptic Vesicle Release Machinery

Rizo-Rey, J. & Xu, J., Jun 22 2015, In : Annual Review of Biophysics. 44, p. 339-367 29 p.

Research output: Contribution to journalArticle

146 Scopus citations

Tiger Swallowtail Genome Reveals Mechanisms for Speciation and Caterpillar Chemical Defense

Cong, Q., Borek, D., Otwinowski, Z. & Grishin, N. V., Feb 17 2015, In : Cell Reports. 10, 6, p. 910-919 10 p.

Research output: Contribution to journalArticle

51 Scopus citations

Type VI Secretion System Toxins Horizontally Shared between Marine Bacteria

Salomon, D., Klimko, J. A., Trudgian, D. C., Kinch, L. N., Grishin, N. V., Mirzaei, H. & Orth, K., Aug 1 2015, In : PLoS pathogens. 11, 8, e1005128.

Research output: Contribution to journalArticle

28 Scopus citations

Using homology relations within a database markedly boosts protein sequence similarity search

Tong, J., Sadreyev, R. I., Pei, J., Kinch, L. N. & Grishin, N. V., Jun 2 2015, In : Proceedings of the National Academy of Sciences of the United States of America. 112, 22, p. 7003-7008 6 p.

Research output: Contribution to journalArticle

4 Scopus citations
2014

Actin cytoskeleton reorganization by syk regulates fcγ receptor responsiveness by increasing its lateral mobility and clustering

Jaumouillé, V., Farkash, Y., Jaqaman, K., Das, R., Lowell, C. A. & Grinstein, S., Jun 9 2014, In : Developmental Cell. 29, 5, p. 534-546 13 p.

Research output: Contribution to journalArticle

56 Scopus citations

An optogenetic gene expression system with rapid activation and deactivation kinetics

Motta-Mena, L. B., Reade, A., Mallory, M. J., Glantz, S., Weiner, O. D., Lynch, K. W. & Gardner, K. H., Mar 2014, In : Nature chemical biology. 10, 3, p. 196-202 7 p.

Research output: Contribution to journalArticle

153 Scopus citations

Antibacterial membrane attack by a pore-forming intestinal C-type lectin

Mukherjee, S., Zheng, H., Derebe, M. G., Callenberg, K. M., Partch, C. L., Rollins, D., Propheter, D. C., Rizo-Rey, J., Grabe, M., Jiang, Q. X. & Hooper, L. V., Jan 1 2014, In : Nature. 505, 7481, p. 103-107 5 p.

Research output: Contribution to journalArticle

138 Scopus citations

A plug release mechanism for membrane permeation by MLKL

Su, L., Quade, B., Wang, H., Sun, L., Wang, X. & Rizo-Rey, J., Sep 13 2014, In : Structure. 22, 10, p. 1489-1500 12 p.

Research output: Contribution to journalArticle

95 Scopus citations

Architecture of the large subunit of the mammalian mitochondrial ribosome

Greber, B. J., Boehringer, D., Leitner, A., Bieri, P., Voigts-Hoffmann, F., Erzberger, J. P., Leibundgut, M., Aebersold, R. & Ban, N., Jan 10 2014, In : Nature. 505, 7484, p. 515-519 5 p.

Research output: Contribution to journalArticle

136 Scopus citations

A tethered delivery mechanism explains the catalytic action of a microtubule polymerase

Ayaz, P., Munyoki, S., Geyer, E. A., Piedra, F. A., Vu, E. S., Bromberg, R., Otwinowski, Z., Grishin, N. V., Brautigam, C. A. & Rice, L. M., Aug 5 2014, In : eLife. 3, August2014, p. 1-19 19 p., e03069.

Research output: Contribution to journalArticle

53 Scopus citations

Bimodal-hybrid heterocyclic amine targeting oxidative pathways and copper mis-regulation in Alzheimer's disease

Gonzalez, P., Da Costa, V. C. P., Hyde, K., Wu, Q., Annunziata, O., Rizo-Rey, J., Akkaraju, G. & Green, K. N., Nov 1 2014, In : Metallomics. 6, 11, p. 2072-2082 11 p.

Research output: Contribution to journalArticle

20 Scopus citations

Chemically functionalized carbon films for single molecule imaging

Llaguno, M. C., Xu, H., Shi, L., Huang, N., Zhang, H., Liu, Q. & Jiang, Q. X., Mar 1 2014, In : Journal of Structural Biology. 185, 3, p. 405-417 13 p.

Research output: Contribution to journalArticle

12 Scopus citations

Chloride sensing by WNK1 involves inhibition of autophosphorylation

Piala, A. T., Moon, T. M., Akella, R., He, H., Cobb, M. H. & Goldsmith, E. J., May 6 2014, In : Science Signaling. 7, 324, ra41.

Research output: Contribution to journalArticle

148 Scopus citations
27 Scopus citations

Cryo-EM structure of the Plasmodium falciparum 80S ribosome bound to the anti-protozoan drug emetine

Wong, W., Bai, X. C., Brown, A., Fernandez, I. S., Hanssen, E., Condron, M., Tan, Y. H., Baum, J. & Scheres, S. H. W., Jun 9 2014, In : eLife. 2014, 3, e03080.

Research output: Contribution to journalArticle

138 Scopus citations

ECOD: An Evolutionary Classification of Protein Domains

Cheng, H., Schaeffer, R. D., Liao, Y., Kinch, L. N., Pei, J., Shi, S., Kim, B. H. & Grishin, N. V., Dec 1 2014, In : PLoS Computational Biology. 10, 12

Research output: Contribution to journalArticle

106 Scopus citations

Ena/VASP proteins cooperate with the WAVE complex to regulate the actin cytoskeleton

Chen, X. J., Squarr, A. J., Stephan, R., Chen, B., Higgins, T. E., Barry, D. J., Martin, M. C., Rosen, M. K., Bogdan, S. & Way, M., Sep 8 2014, In : Developmental Cell. 30, 5, p. 569-584 16 p.

Research output: Contribution to journalArticle

45 Scopus citations

Extracellular architecture of the SYG-1/SYG-2 adhesion complex instructs synaptogenesis

Özkan, E., Chia, P. H., Wang, R. R., Goriatcheva, N., Borek, D., Otwinowski, Z., Walz, T., Shen, K. & Garcia, K. C., Jan 30 2014, In : Cell. 156, 3, p. 482-494 13 p.

Research output: Contribution to journalArticle

36 Scopus citations

Full-length structure of a monomeric histidine kinase reveals basis for sensory regulation

Rivera-Cancel, G., Ko, W. H., Tomchick, D. R., Correa, F. & Gardner, K. H., Dec 16 2014, In : Proceedings of the National Academy of Sciences of the United States of America. 111, 50, p. 17839-17844 6 p.

Research output: Contribution to journalArticle

42 Scopus citations

Haemophilus ducreyi Hfq contributes to virulence gene regulation as cells enter stationary phase

Gangaiah, D., Labandeira, M., Zhang, X., Fortney, K. R., Ellinger, S., Zwickl, B., Baker, B., Liu, Y., Janowicz, D. M., Katz, B. P., Brautigam, C. A., Munson, R. S., Hansen, E. J. & Spinola, S. M., Feb 11 2014, In : mBio. 5, 1, e01081-13.

Research output: Contribution to journalArticle

8 Scopus citations

Identification of a core sequence for the binding of BosR to the rpoS promoter region in Borrelia burgdorferi

Ouyang, Z., Zhou, J., Brautigam, C. A., Deka, R. & Norgard, M. V., May 2014, In : Microbiology (United Kingdom). 160, PART 5, p. 851-862 12 p.

Research output: Contribution to journalArticle

9 Scopus citations

Identification of an outer membrane lipoprotein involved in nasopharyngeal colonization by Moraxella catarrhalis in an animal model

Wang, W., Joslin, S. N., Pybus, C., Evans, A. S., Lichaa, F., Brautigam, C. A. & Hansen, E. J., 2014, In : Infection and immunity. 82, 6, p. 2287-2299 13 p.

Research output: Contribution to journalArticle

7 Scopus citations

Identification of lysine residues in the Borrelia burgdorferi DbpA adhesin required for murine infection

Fortune, D. E., Lin, Y. P., Deka, R. K., Groshong, A. M., Moore, B. P., Hagman, K. E., Leong, J. M., Tomchick, D. R. & Blevins, J. S., 2014, In : Infection and immunity. 82, 8, p. 3186-3198 13 p.

Research output: Contribution to journalArticle

18 Scopus citations

Initiation of translation by cricket paralysis virus IRES requires its translocation in the ribosome

Fernández, I. S., Bai, X. C., Murshudov, G., Scheres, S. H. W. & Ramakrishnan, V., May 8 2014, In : Cell. 157, 4, p. 823-831 9 p.

Research output: Contribution to journalArticle

126 Scopus citations

In silico derived small molecules bind the filovirus VP35 protein and inhibit its polymerase cofactor activity

Brown, C. S., Lee, M. S., Leung, D. W., Wang, T., Xu, W., Luthra, P., Anantpadma, M., Shabman, R. S., Melito, L. M., Macmillan, K. S., Borek, D. M., Otwinowski, Z., Ramanan, P., Stubbs, A. J., Peterson, D. S., Binning, J. M., Tonelli, M., Olson, M. A., Davey, R. A., Ready, J. M. & 2 others, Basler, C. F. & Amarasinghe, G. K., May 15 2014, In : Journal of Molecular Biology. 426, 10, p. 2045-2058 14 p.

Research output: Contribution to journalArticle

42 Scopus citations

In situ selectivity profiling and crystal structure of SML-8-73-1, an active site inhibitor of oncogenic K-Ras G12C

Hunter, J. C., Gurbani, D., Ficarro, S. B., Carrasco, M. A., Lim, S. M., Choi, H. G., Xie, T., Marto, J. A., Chen, Z., Gray, N. S. & Westover, K. D., Jan 1 2014, In : Proceedings of the National Academy of Sciences of the United States of America. 111, 24, p. 8895-8900 6 p.

Research output: Contribution to journalArticle

111 Scopus citations

Local F-actin network links synapse formation and axon branching

Chia, P. H., Chen, B., Li, P., Rosen, M. K. & Shen, K., Jan 27 2014, In : Cell. 156, 1-2, p. 208-220 13 p.

Research output: Contribution to journalArticle

64 Scopus citations

Measurement of the temperature of the resting rotor in analytical ultracentrifugation

Ghirlando, R., Zhao, H., Balbo, A., Piszczek, G., Curth, U., Brautigam, C. A. & Schuck, P., Aug 1 2014, In : Analytical biochemistry. 458, p. 37-39 3 p.

Research output: Contribution to journalArticle

7 Scopus citations

Mixed Lineage Kinase Domain-like Protein MLKL Causes Necrotic Membrane Disruption upon Phosphorylation by RIP3

Wang, H., Sun, L., Su, L., Rizo-Rey, J., Liu, L., Wang, L. F., Wang, F. S. & Wang, X., Apr 10 2014, In : Molecular cell. 54, 1, p. 133-146 14 p.

Research output: Contribution to journalArticle

598 Scopus citations

Molecular architecture of the 40S · eIF1 · eIF3 translation initiation complex

Erzberger, J. P., Stengel, F., Pellarin, R., Zhang, S., Schaefer, T., Aylett, C. H. S., Cimermančič, P., Boehringer, D., Sali, A., Aebersold, R. & Ban, N., Aug 28 2014, In : Cell. 158, 5, p. 1123-1135 13 p.

Research output: Contribution to journalArticle

129 Scopus citations

Mutation of mouse Samd4 causes leanness, myopathy, uncoupled mitochondrial respiration, and dysregulated mTORC1 signaling

Chen, Z., Holland, W., Shelton, J. M., Ali, A., Zhan, X., Won, S., Tomisato, W., Liu, C., Li, X., Moresco, E. M. Y. & Beutler, B., May 20 2014, In : Proceedings of the National Academy of Sciences of the United States of America. 111, 20, p. 7367-7372 6 p.

Research output: Contribution to journalArticle

17 Scopus citations

Phase transitions of multivalent proteins can promote clustering of membrane receptors

Banjade, S. & Rosen, M. K., 2014, In : eLife. 3, e04123.

Research output: Contribution to journalArticle

144 Scopus citations

Re-examining how complexin inhibits neurotransmitter release: SNARE complex insertion or electrostatic hindrance?

Trimbuch, T., Xu, J., Flaherty, D., Tomchick, D. R., Rizo-Rey, J. & Rosenmund, C., May 8 2014, In : eLife. 2014, 3, e02391.

Research output: Contribution to journalArticle

41 Scopus citations

Regulation of microtubule motors by tubulin isotypes and post-translational modifications

Sirajuddin, M., Rice, L. M. & Vale, R. D., Apr 2014, In : Nature cell biology. 16, 4, p. 335-344 10 p.

Research output: Contribution to journalArticle

231 Scopus citations

Retromer binding to FAM21 and the WASH complex is perturbed by the Parkinson disease-linked VPS35(D620N) mutation

McGough, I. J., Steinberg, F., Jia, D., Barbuti, P. A., McMillan, K. J., Heesom, K. J., Whone, A. L., Caldwell, M. A., Billadeau, D. D., Rosen, M. K. & Cullen, P. J., Jul 21 2014, In : Current Biology. 24, 14, p. 1670-1676 7 p.

Research output: Contribution to journalArticle

87 Scopus citations
9 Scopus citations

Structure and Ca2+-binding properties of the tandem C 2 Domains of E-Syt2

Xu, J., Bacaj, T., Zhou, A., Tomchick, D. R., Südhof, T. C. & Rizo-Rey, J., Feb 4 2014, In : Structure. 22, 2, p. 269-280 12 p.

Research output: Contribution to journalArticle

24 Scopus citations

Structure of cohesin subcomplex pinpoints direct shugoshin-Wapl antagonism in centromeric cohesion

Hara, K., Zheng, G., Qu, Q., Liu, H., Ouyang, Z., Chen, Z., Tomchick, D. R. & Yu, H., Jan 1 2014, In : Nature Structural and Molecular Biology. 21, 10, p. 864-870 7 p.

Research output: Contribution to journalArticle

72 Scopus citations

Structure of the effector-binding domain of deoxyribonucleoside regulator DeoR from Bacillus subtilis

Škerlová, J., Fábry, M., Hubálek, M., Otwinowski, Z. & Řezáčová, P., Sep 1 2014, In : FEBS Journal. 281, 18, p. 4280-4292 13 p.

Research output: Contribution to journalArticle

3 Scopus citations

Structure of the large ribosomal subunit from human mitochondria

Brown, A., Amunts, A., Bai, X. C., Sugimoto, Y., Edwards, P. C., Murshudov, G., Scheres, S. H. W. & Ramakrishnan, V., Nov 7 2014, In : Science. 346, 6210, p. 718-722 5 p.

Research output: Contribution to journalArticle

142 Scopus citations

Structure of the yeast mitochondrial

Amunts, A., Brown, A., Bai, X. C., Llácer, J. L., Hussain, T., Emsley, P., Long, F., Murshudov, G., Scheres, S. H. W. & Ramakrishnan, V., Jan 1 2014, In : Science. 343, 6178, p. 1485-1489 5 p.

Research output: Contribution to journalArticle

306 Scopus citations

Substrate-Specific Activation of the Mitotic Kinase Bub1 through Intramolecular Autophosphorylation and Kinetochore Targeting

Lin, Z., Jia, L., Tomchick, D. R., Luo, X. & Yu, H., Nov 4 2014, In : Structure. 22, 11, p. 1616-1627 12 p.

Research output: Contribution to journalArticle

17 Scopus citations

The contribution of αβ-tubulin curvature to microtubule dynamics

Brouhard, G. J. & Rice, L. M., Jan 1 2014, In : Journal of Cell Biology. 207, 3, p. 323-334 12 p.

Research output: Contribution to journalArticle

107 Scopus citations

The cytosolic DNA sensor cGAS forms an oligomeric complex with DNA and undergoes switch-like conformational changes in the activation loop

Zhang, X., Wu, J., Du, F., Xu, H., Sun, L., Chen, Z., Brautigam, C. A., Zhang, X. & Chen, Z., Feb 13 2014, In : Cell Reports. 6, 3, p. 421-430 10 p.

Research output: Contribution to journalArticle

130 Scopus citations

The haemophilus ducreyi lspa1 protein inhibits phagocytosis by using a new mechanism involving Activation of C-terminal src kinase

Dodd, D. A., Worth, R. G., Rosen, M. K., Grinstein, S., van Oers, N. S. C. & Hansen, E. J., May 20 2014, In : mBio. 5, 3, e01178-14.

Research output: Contribution to journalArticle

7 Scopus citations