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2013

Activated RhoA is a positive feedback regulator of the Lbc family of Rho guanine nucleotide exchange factor proteins

Medina, F., Carter, A. M., Dada, O., Gutowski, S., Hadas, J., Chen, Z. & Sternweis, P. C., Apr 19 2013, In : Journal of Biological Chemistry. 288, 16, p. 11325-11333 9 p.

Research output: Contribution to journalArticle

27 Scopus citations

Allosteric inhibition of hypoxia inducible factor-2 with small molecules

Scheuermann, T. H., Li, Q., Ma, H. W., Key, J., Zhang, L., Chen, R., Garcia, J. A., Naidoo, J., Longgood, J., Frantz, D. E., Tambar, U. K., Gardner, K. H. & Bruick, R. K., Apr 1 2013, In : Nature chemical biology. 9, 4, p. 271-276 6 p.

Research output: Contribution to journalArticle

141 Scopus citations

Analysis of SNARE complex/synaptotagmin-1 interactions by one-dimensional NMR spectroscopy

Zhou, A., Brewer, K. D. & Rizo-Rey, J., May 21 2013, In : Biochemistry. 52, 20, p. 3446-3456 11 p.

Research output: Contribution to journalArticle

17 Scopus citations

Antileukemic activity of nuclear export inhibitors that spare normal hematopoietic cells

Etchin, J., Sun, Q., Kentsis, A., Farmer, A., Zhang, Z. C., Sanda, T., Mansour, M. R., Barcelo, C., McCauley, D., Kauffman, M., Shacham, S., Christie, A. L., Kung, A. L., Rodig, S. J., Chook, Y. M. & Look, A. T., Jan 1 2013, In : Leukemia. 27, 1, p. 66-74 9 p.

Research output: Contribution to journalArticle

107 Scopus citations

A small molecule modulates Jumonji histone demethylase activity and selectively inhibits cancer growth

Wang, L., Chang, J., Varghese, D., Dellinger, M., Kumar, S., Best, A. M., Ruiz, J., Bruick, R., Peña-Llopis, S., Xu, J., Babinski, D. J., Frantz, D. E., Brekken, R. A., Quinn, A. M., Simeonov, A., Easmon, J. & Martinez, E. D., Jun 24 2013, In : Nature communications. 4, 2035.

Research output: Contribution to journalArticle

Open Access
150 Scopus citations

Blue light-induced dimerization of a bacterial LOV-HTH DNA-binding protein

Zoltowski, B. D., Motta-Mena, L. B. & Gardner, K. H., Sep 24 2013, In : Biochemistry. 52, 38, p. 6653-6661 9 p.

Research output: Contribution to journalArticle

31 Scopus citations

Blue light regulated two-component systems: Enzymatic and functional analyses of light-oxygen-voltage (LOV)-histidine kinases and downstream response regulators

Correa, F., Ko, W. H., Ocasio, V., Bogomolni, R. A. & Gardner, K. H., Jul 9 2013, In : Biochemistry. 52, 27, p. 4656-4666 11 p.

Research output: Contribution to journalArticle

22 Scopus citations

Crystal structure of human Karyopherin β2 bound to the PY-NLS of Saccharomyces cerevisiae Nab2

Soniat, M., Sampathkumar, P., Collett, G., Gizzi, A. S., Banu, R. N., Bhosle, R. C., Chamala, S., Chowdhury, S., Fiser, A., Glenn, A. S., Hammonds, J., Hillerich, B., Khafizov, K., Love, J. D., Matikainen, B., Seidel, R. D., Toro, R., Rajesh Kumar, P., Bonanno, J. B., Chook, Y. M. & 1 others, Almo, S. C., Jun 1 2013, In : Journal of Structural and Functional Genomics. 14, 2, p. 31-35 5 p.

Research output: Contribution to journalArticle

10 Scopus citations

Development of inhibitors of the PAS-B domain of the HIF-2α transcription factor

Rogers, J. L., Bayeh, L., Scheuermann, T. H., Longgood, J., Key, J., Naidoo, J., Melito, L., Shokri, C., Frantz, D. E., Bruick, R. K., Gardner, K. H., MacMillan, J. B. & Tambar, U. K., Mar 11 2013, In : Journal of Medicinal Chemistry. 56, 4, p. 1739-1747 9 p.

Research output: Contribution to journalArticle

59 Scopus citations

Effectors of animal and plant pathogens use a common domain to bind host phosphoinositides

Salomon, D., Guo, Y., Kinch, L. N., Grishin, N. V., Gardner, K. H. & Orth, K., Dec 18 2013, In : Nature communications. 4, 2973.

Research output: Contribution to journalArticle

Open Access
33 Scopus citations

Evidence for an ABC-type riboflavin transporter system in pathogenic spirochetes

Deka, R. K., Brautigam, C. A., Biddy, B. A., Liu, W. Z. & Norgard, M. V., Mar 11 2013, In : mBio. 4, 1

Research output: Contribution to journalArticle

27 Scopus citations

Identification of patterns in diffraction intensities affected by radiation exposure

Borek, D., Dauter, Z. & Otwinowski, Z., Jan 1 2013, In : Journal of Synchrotron Radiation. 20, 1, p. 37-48 12 p.

Research output: Contribution to journalArticle

20 Scopus citations

Improving the thermal, radial, and temporal accuracy of the analytical ultracentrifuge through external references

Ghirlando, R., Balbo, A., Piszczek, G., Brown, P. H., Lewis, M. S., Brautigam, C. A., Schuck, P. & Zhao, H., Jan 1 2013, In : Analytical biochemistry. 440, 1, p. 81-95 15 p.

Research output: Contribution to journalArticle

45 Scopus citations

Molecular architecture of a eukaryotic translational initiation complex

Fernández, I. S., Bai, X. C., Hussain, T., Kelley, A. C., Lorsch, J. R., Ramakrishnan, V. & Scheres, S. H. W., Jan 1 2013, In : Science. 342, 6160, 1240585.

Research output: Contribution to journalArticle

88 Scopus citations

Multi-Signal Sedimentation Velocity Analysis with Mass Conservation for Determining the Stoichiometry of Protein Complexes

Brautigam, C. A., Padrick, S. B. & Schuck, P., May 16 2013, In : PloS one. 8, 5, e62694.

Research output: Contribution to journalArticle

10 Scopus citations

Novel pyridazinone inhibitors for vascular adhesion protein-1 (VAP-1): Old target-new inhibition mode

Bligt-Lindén, E., Pihlavisto, M., Szatmári, I., Otwinowski, Z., Smith, D. J., Lázár, L., Fülöp, F. & Salminen, T. A., Dec 27 2013, In : Journal of Medicinal Chemistry. 56, 24, p. 9837-9848 12 p.

Research output: Contribution to journalArticle

18 Scopus citations

Nuclear export inhibition through covalent conjugation and hydrolysis of Leptomycin B by CRM1

Sun, Q., Carrasco, Y. P., Hu, Y., Guo, X., Mirzaei, H., MacMillan, J. & Chook, Y. M., Jan 22 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 4, p. 1303-1308 6 p.

Research output: Contribution to journalArticle

89 Scopus citations

Nucleotide and partner-protein control of bacterial replicative helicase structure and function

Strycharska, M. S., Arias-Palomo, E., Lyubimov, A. Y., Erzberger, J. P., O'Shea, V. L., Bustamante, C. J. & Berger, J. M., Dec 26 2013, In : Molecular cell. 52, 6, p. 844-854 11 p.

Research output: Contribution to journalArticle

28 Scopus citations

Overview of current methods in sedimentation velocity and sedimentation equilibrium analytical ultracentrifugation

Zhao, H., Brautigam, C. A., Ghirlando, R. & Schuck, P., Feb 1 2013, In : Current Protocols in Protein Science. SUPPL.71, 20.12.

Research output: Contribution to journalArticle

99 Scopus citations

Phospho switch triggers brd4 chromatin binding and activator recruitment for gene-specific targeting

Wu, S. Y., Lee, A. Y., Lai, H. T., Zhang, H. & Chiang, C. M., Mar 7 2013, In : Molecular cell. 49, 5, p. 843-857 15 p.

Research output: Contribution to journalArticle

151 Scopus citations

Precisely ordered phosphorylation reactions in the p38 mitogen-activated protein (MAP) kinase cascade

Humphreys, J. M., Piala, A. T., Akella, R., He, H. & Goldsmith, E. J., Aug 9 2013, In : Journal of Biological Chemistry. 288, 32, p. 23322-23330 9 p.

Research output: Contribution to journalArticle

20 Scopus citations

Prevalent mechanism of membrane bridging by synaptotagmin-1

Seven, A. B., Brewer, K. D., Shi, L., Jiang, Q. X. & Rizo-Rey, J., Aug 28 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 34, p. E3243-E3252

Research output: Contribution to journalArticle

37 Scopus citations
4 Scopus citations

Reconstitution of the vital functions of Munc18 and Munc13 in neurotransmitter release

Ma, C., Su, L., Seven, A. B., Xu, Y. & Rizo-Rey, J., Jan 25 2013, In : Science. 339, 6118, p. 421-425 5 p.

Research output: Contribution to journalArticle

197 Scopus citations

Recorded scan times can limit the accuracy of sedimentation coefficients in analytical ultracentrifugation

Zhao, H., Ghirlando, R., Piszczek, G., Curth, U., Brautigam, C. A. & Schuck, P., Jun 1 2013, In : Analytical biochemistry. 437, 1, p. 104-108 5 p.

Research output: Contribution to journalArticle

60 Scopus citations

Regulating the ARNT/TACC3 axis: Multiple approaches to manipulating protein/protein interactions with small molecules

Guo, Y., Partch, C. L., Key, J., Card, P. B., Pashkov, V., Patel, A., Bruick, R. K., Wurdak, H. & Gardner, K. H., Mar 15 2013, In : ACS chemical biology. 8, 3, p. 626-635 10 p.

Research output: Contribution to journalArticle

21 Scopus citations

Regulation of WASH-dependent actin polymerization and protein trafficking by ubiquitination

Hao, Y. H., Doyle, J. M., Ramanathan, S., Gomez, T. S., Jia, D., Xu, M., Chen, Z. J., Billadeau, D. D., Rosen, M. K. & Potts, P. R., Feb 28 2013, In : Cell. 152, 5, p. 1051-1064 14 p.

Research output: Contribution to journalArticle

104 Scopus citations

Ribosome structures to near-atomic resolution from thirty thousand cryo-EM particles

Bai, X. C., Fernandez, I. S., McMullan, G. & Scheres, S. H. W., Feb 19 2013, In : eLife. 2013, 2, e00461.

Research output: Contribution to journalArticle

279 Scopus citations

S. cerevisiae chromosomes biorient via gradual resolution of syntely between S phase and anaphase

Marco, E., Dorn, J. F., Hsu, P. H., Jaqaman, K., Sorger, P. K. & Danuser, G., Aug 29 2013, In : Cell. 154, 5, p. 1127-1139 13 p.

Research output: Contribution to journalArticle

16 Scopus citations

Signaling mechanisms of LOV domains: New insights from molecular dynamics studies

Freddolino, P. L., Gardner, K. H. & Schulten, K., Jun 18 2013, In : Photochemical and Photobiological Sciences. 12, 7, p. 1158-1170 13 p.

Research output: Contribution to journalArticle

52 Scopus citations

Solution structure of the WNK1 autoinhibitory domain, a WNK-specific PF2 domain

Moon, T. M., Correa, F., Kinch, L. N., Piala, A. T., Gardner, K. H. & Goldsmith, E. J., Apr 26 2013, In : Journal of Molecular Biology. 425, 8, p. 1245-1252 8 p.

Research output: Contribution to journalArticle

5 Scopus citations

Structural basis for activation and non-canonical catalysis of the Rap GTPase activating protein domain of plexin

Wang, Y., Pascoe, H. G., Brautigam, C. A., He, H. & Zhang, X., Oct 1 2013, In : eLife. 2013, 2, e01279.

Research output: Contribution to journalArticle

35 Scopus citations

Structural basis for autoactivation of human Mst2 kinase and its regulation by RASSF5

Ni, L., Li, S., Yu, J., Min, J., Brautigam, C. A., Tomchick, D. R., Pan, D. & Luo, X., Oct 8 2013, In : Structure. 21, 10, p. 1757-1768 12 p.

Research output: Contribution to journalArticle

52 Scopus citations

Structural characterization of V57D and V57P mutants of human cystatin C, an amyloidogenic protein

Orlikowska, M., Szymańska, A., Borek, D., Otwinowski, Z., Skowron, P. & Jankowska, E., Apr 1 2013, In : Acta Crystallographica Section D: Biological Crystallography. 69, 4, p. 577-586 10 p.

Research output: Contribution to journalArticle

5 Scopus citations

Structure of the human cohesin inhibitor Wapl

Ouyang, Z., Zheng, G., Song, J., Borek, D., Otwinowski, Z., Brautigam, C. A., Tomchick, D. R., Rankin, S. & Yu, H., Jul 9 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 28, p. 11355-11360 6 p.

Research output: Contribution to journalArticle

41 Scopus citations

Subtle interplay between synaptotagmin and complexin binding to the SNARE complex

Xu, J., Brewer, K. D., Perez-Castillejos, R. & Rizo-Rey, J., Sep 23 2013, In : Journal of Molecular Biology. 425, 18, p. 3461-3475 15 p.

Research output: Contribution to journalArticle

25 Scopus citations

The bacterial effector VopL organizes actin into filament-like structures

Zahm, J. A., Padrick, S. B., Chen, Z., Pak, C. W., Yunus, A. A., Henry, L., Tomchick, D. R., Chen, Z. & Rosen, M. K., Oct 10 2013, In : Cell. 155, 2, p. 423-434 12 p.

Research output: Contribution to journalArticle

26 Scopus citations

The haemophilus ducreyi fis protein is involved in controlling expression of the lspB-lspA2 operon and other virulence factors

Labandeira, M., Dodd, D. A., Brautigam, C. A., Fortney, K. R., Spinol, S. M. & Hansena, E. J., Nov 1 2013, In : Infection and immunity. 81, 11, p. 4160-4170 11 p.

Research output: Contribution to journalArticle

2 Scopus citations

The "super mutant" of yeast FMN adenylyltransferase enhances the enzyme turnover rate by attenuating product inhibition

Huerta, C., Grishin, N. V. & Zhang, H., May 28 2013, In : Biochemistry. 52, 21, p. 3615-3617 3 p.

Research output: Contribution to journalArticle

3 Scopus citations
15 Scopus citations

Three-color single molecule imaging shows WASP detachment from Arp2/3 complex triggers actin filament branch formation

Smith, B. A., Padrick, S. B., Doolittle, L. K., Daugherty-Clarke, K., Corrêa, I. R., Xu, M. Q., Goode, B. L., Rosen, M. K. & Gelles, J., Sep 3 2013, In : eLife. 2013, 2, e01008.

Research output: Contribution to journalArticle

57 Scopus citations
14 Scopus citations

UAS domain of Ubxd8 and FAF1 polymerizes upon interaction with long-chain unsaturated fatty acids

Kim, H., Zhang, H., Meng, D., Russell, G., Lee, J. N. & Ye, J., Aug 1 2013, In : Journal of lipid research. 54, 8, p. 2144-2152 9 p.

Research output: Contribution to journalArticle

17 Scopus citations
2012

Activation of p115-RhoGEF requires direct association of Gα13and the Dbl homology domain

Chen, Z., Guo, L., Hadas, J., Gutowski, S., Sprang, S. R. & Sternweis, P. C., Jul 20 2012, In : Journal of Biological Chemistry. 287, 30, p. 25490-25500 11 p.

Research output: Contribution to journalArticle

27 Scopus citations

A multi-faceted analysis of RutD reveals a novel family of α/β hydrolases

Knapik, A. A., Petkowski, J. J., Otwinowski, Z., Cymborowski, M. T., Cooper, D. R., Majorek, K. A., Chruszcz, M., Krajewska, W. M. & Minor, W., Oct 1 2012, In : Proteins: Structure, Function and Bioinformatics. 80, 10, p. 2359-2368 10 p.

Research output: Contribution to journalArticle

5 Scopus citations

A TOG:αβ-tubulin complex structure reveals conformation-based mechanisms for a microtubule polymerase

Ayaz, P., Ye, X., Huddleston, P., Brautigam, C. A. & Rice, L. M., Aug 17 2012, In : Science. 337, 6096, p. 857-860 4 p.

Research output: Contribution to journalArticle

126 Scopus citations

Autoinhibition of Mint1 adaptor protein regulates amyloid precursor protein binding and processing

Matos, M. F., Xu, Y., Dulubova, I., Otwinowski, Z., Richardson, J. M., Tomchick, D. R., Rizo-Rey, J. & Ho, A., Mar 6 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 10, p. 3802-3807 6 p.

Research output: Contribution to journalArticle

10 Scopus citations

Biophysical and bioinformatic analyses implicate the treponema pallidum tp34 lipoprotein (tp0971) in transition metal homeostasis

Brautigam, C. A., Deka, R. K., Ouyang, Z., Machius, M., Knutsen, G., Tomchick, D. R. & Norgard, M. V., Oct 1 2012, In : Journal of bacteriology. 194, 24, p. 6771-6781 11 p.

Research output: Contribution to journalArticle

11 Scopus citations

Cryo-EM structure of a 3D DNA-origami object

Bai, X. C., Martin, T. G., Scheres, S. H. W. & Dietz, H., Dec 4 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 49, p. 20012-20017 6 p.

Research output: Contribution to journalArticle

143 Scopus citations

Crystal structure of the heterodimeric CLOCK:BMAL1 transcriptional activator complex

Huang, N., Chelliah, Y., Shan, Y., Taylor, C. A., Yoo, S. H., Partch, C., Green, C. B., Zhang, H. & Takahashi, J. S., Jul 13 2012, In : Science. 337, 6091, p. 189-194 6 p.

Research output: Contribution to journalArticle

142 Scopus citations