Research Output 1979 2019

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2013
16 Citations (Scopus)

Novel pyridazinone inhibitors for vascular adhesion protein-1 (VAP-1): Old target-new inhibition mode

Bligt-Lindén, E., Pihlavisto, M., Szatmári, I., Otwinowski, Z., Smith, D. J., Lázár, L., Fülöp, F. & Salminen, T. A., Dec 27 2013, In : Journal of Medicinal Chemistry. 56, 24, p. 9837-9848 12 p.

Research output: Contribution to journalArticle

Blood Vessels
Proteins
Amine Oxidase (Copper-Containing)
Monoamine Oxidase
Enzyme Inhibitors
81 Citations (Scopus)

Nuclear export inhibition through covalent conjugation and hydrolysis of Leptomycin B by CRM1

Sun, Q., Carrasco, Y. P., Hu, Y., Guo, X., Mirzaei, H., MacMillan, J. & Chook, Y. M., Jan 22 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 4, p. 1303-1308 6 p.

Research output: Contribution to journalArticle

Cell Nucleus Active Transport
Hydrolysis
Maintenance
Biological Products
Nuclear Export Signals
25 Citations (Scopus)

Nucleotide and partner-protein control of bacterial replicative helicase structure and function

Strycharska, M. S., Arias-Palomo, E., Lyubimov, A. Y., Erzberger, J. P., O'Shea, V. L., Bustamante, C. J. & Berger, J. M., Dec 26 2013, In : Molecular Cell. 52, 6, p. 844-854 11 p.

Research output: Contribution to journalArticle

Bacterial Proteins
Nucleotides
DnaB Helicases
DNA Primase
Peptide Elongation Factors
87 Citations (Scopus)

Overview of current methods in sedimentation velocity and sedimentation equilibrium analytical ultracentrifugation

Zhao, H., Brautigam, C. A., Ghirlando, R. & Schuck, P., Feb 2013, In : Current Protocols in Protein Science. SUPPL.71, 20.12.

Research output: Contribution to journalArticle

Ultracentrifugation
Sedimentation
Membrane Proteins
Multiprotein Complexes
Proteins
131 Citations (Scopus)

Phospho switch triggers brd4 chromatin binding and activator recruitment for gene-specific targeting

Wu, S. Y., Lee, A. Y., Lai, H. T., Zhang, H. & Chiang, C. M., Mar 7 2013, In : Molecular Cell. 49, 5, p. 843-857 15 p.

Research output: Contribution to journalArticle

Gene Targeting
Chromatin
Proteins
Epigenomics
Casein Kinase II
18 Citations (Scopus)

Precisely ordered phosphorylation reactions in the p38 mitogen-activated protein (MAP) kinase cascade

Humphreys, J. M., Piala, A. T., Akella, R., He, H. & Goldsmith, E. J., Aug 9 2013, In : Journal of Biological Chemistry. 288, 32, p. 23322-23330 9 p.

Research output: Contribution to journalArticle

Phosphorylation
p38 Mitogen-Activated Protein Kinases
Switches
Kinetics
In Vitro Techniques
35 Citations (Scopus)

Prevalent mechanism of membrane bridging by synaptotagmin-1

Seven, A. B., Brewer, K. D., Shi, L., Jiang, Q. X. & Rizo-Rey, J., 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 34

Research output: Contribution to journalArticle

Synaptotagmin I
Membranes
Neurotransmitter Agents
Membrane Fusion
Fluorescence Spectrometry
4 Citations (Scopus)
syphilis
lipoproteins
Treponema pallidum
Spirochaetales
X ray analysis
184 Citations (Scopus)

Reconstitution of the vital functions of Munc18 and Munc13 in neurotransmitter release

Ma, C., Su, L., Seven, A. B., Xu, Y. & Rizo-Rey, J., Jan 25 2013, In : Science. 339, 6118, p. 421-425 5 p.

Research output: Contribution to journalArticle

Syntaxin 1
Neurotransmitter Agents
Synaptotagmin I
Liposomes
R-SNARE Proteins
58 Citations (Scopus)

Recorded scan times can limit the accuracy of sedimentation coefficients in analytical ultracentrifugation

Zhao, H., Ghirlando, R., Piszczek, G., Curth, U., Brautigam, C. A. & Schuck, P., Jun 1 2013, In : Analytical Biochemistry. 437, 1, p. 104-108 5 p.

Research output: Contribution to journalArticle

Ultracentrifugation
Sedimentation
Information Storage and Retrieval
Molar mass
Data acquisition
21 Citations (Scopus)

Regulating the ARNT/TACC3 axis: Multiple approaches to manipulating protein/protein interactions with small molecules

Guo, Y., Partch, C. L., Key, J., Card, P. B., Pashkov, V., Patel, A., Bruick, R. K., Wurdak, H. & Gardner, K. H., Mar 15 2013, In : ACS Chemical Biology. 8, 3, p. 626-635 10 p.

Research output: Contribution to journalArticle

Molecules
Proteins
Screening
Transcription Factors
Hypoxia-Inducible Factor 1
91 Citations (Scopus)

Regulation of WASH-dependent actin polymerization and protein trafficking by ubiquitination

Hao, Y. H., Doyle, J. M., Ramanathan, S., Gomez, T. S., Jia, D., Xu, M., Chen, Z. J., Billadeau, D. D., Rosen, M. K. & Potts, P. R., Feb 28 2013, In : Cell. 152, 5, p. 1051-1064 14 p.

Research output: Contribution to journalArticle

Ubiquitination
Protein Transport
Ligases
Ubiquitin
Polymerization
268 Citations (Scopus)

Ribosome structures to near-atomic resolution from thirty thousand cryo-EM particles

Bai, X. C., Fernandez, I. S., McMullan, G. & Scheres, S. H. W., Feb 19 2013, In : eLife. 2013, 2, e00461.

Research output: Contribution to journalArticle

Ribosomes
Electrons
Detectors
Cryoelectron Microscopy
Electron irradiation
14 Citations (Scopus)

S. cerevisiae chromosomes biorient via gradual resolution of syntely between S phase and anaphase

Marco, E., Dorn, J. F., Hsu, P. H., Jaqaman, K., Sorger, P. K. & Danuser, G., Aug 29 2013, In : Cell. 154, 5, p. 1127-1139 13 p.

Research output: Contribution to journalArticle

Anaphase
Chromosomes
S Phase
Mitosis
Yeast
49 Citations (Scopus)
Molecular Dynamics Simulation
Phototropins
Molecular dynamics
Oxygen
molecular dynamics
5 Citations (Scopus)

Solution structure of the WNK1 autoinhibitory domain, a WNK-specific PF2 domain

Moon, T. M., Correa, F., Kinch, L. N., Piala, A. T., Gardner, K. H. & Goldsmith, E. J., Apr 26 2013, In : Journal of Molecular Biology. 425, 8, p. 1245-1252 8 p.

Research output: Contribution to journalArticle

Phosphotransferases
Peptides
Protein-Serine-Threonine Kinases
Threonine
Proline
33 Citations (Scopus)

Structural basis for activation and non-canonical catalysis of the Rap GTPase activating protein domain of plexin

Wang, Y., Pascoe, H. G., Brautigam, C. A., He, H. & Zhang, X., Oct 1 2013, In : eLife. 2013, 2, e01279.

Research output: Contribution to journalArticle

GTPase-Activating Proteins
Catalysis
Chemical activation
Semaphorins
Dimerization
48 Citations (Scopus)

Structural basis for autoactivation of human Mst2 kinase and its regulation by RASSF5

Ni, L., Li, S., Yu, J., Min, J., Brautigam, C. A., Tomchick, D. R., Pan, D. & Luo, X., Oct 8 2013, In : Structure. 21, 10, p. 1757-1768 12 p.

Research output: Contribution to journalArticle

Phosphotransferases
Homeostasis
Phosphorylation
Cell Proliferation
Apoptosis
5 Citations (Scopus)

Structural characterization of V57D and V57P mutants of human cystatin C, an amyloidogenic protein

Orlikowska, M., Szymańska, A., Borek, D., Otwinowski, Z., Skowron, P. & Jankowska, E., Apr 2013, In : Acta Crystallographica Section D: Biological Crystallography. 69, 4, p. 577-586 10 p.

Research output: Contribution to journalArticle

Amyloidogenic Proteins
Cystatin C
Cysteine Proteases
Amino Acid Substitution
Crystallization
37 Citations (Scopus)

Structure of the human cohesin inhibitor Wapl

Ouyang, Z., Zheng, G., Song, J., Borek, D., Otwinowski, Z., Brautigam, C. A., Tomchick, D. R., Rankin, S. & Yu, H., Jul 9 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 28, p. 11355-11360 6 p.

Research output: Contribution to journalArticle

Chromatids
Protein C
Proteins
Protein Binding
Chromatin
25 Citations (Scopus)

Subtle interplay between synaptotagmin and complexin binding to the SNARE complex

Xu, J., Brewer, K. D., Perez-Castillejos, R. & Rizo-Rey, J., Sep 23 2013, In : Journal of Molecular Biology. 425, 18, p. 3461-3475 15 p.

Research output: Contribution to journalArticle

Synaptotagmins
SNARE Proteins
Synaptotagmin I
Membranes
complexin I
3 Citations (Scopus)

Synaptic vesicle fusion without SNARE transmembrane regions

Rizo-Rey, J. & Xu, J., Oct 28 2013, In : Developmental Cell. 27, 2, p. 124-126 3 p.

Research output: Contribution to journalArticle

SNARE Proteins
Synaptic Vesicles
Fusion reactions
Membranes
Membrane Fusion
24 Citations (Scopus)

The bacterial effector VopL organizes actin into filament-like structures

Zahm, J. A., Padrick, S. B., Chen, Z., Pak, C. W., Yunus, A. A., Henry, L., Tomchick, D. R., Chen, Z. & Rosen, M. K., Oct 10 2013, In : Cell. 155, 2, p. 423-434 12 p.

Research output: Contribution to journalArticle

Actin Cytoskeleton
Actins
Monomers
Actin-Related Protein 2-3 Complex
Vibrio parahaemolyticus
2 Citations (Scopus)

The haemophilus ducreyi fis protein is involved in controlling expression of the lspB-lspA2 operon and other virulence factors

Labandeira, M., Dodd, D. A., Brautigam, C. A., Fortney, K. R., Spinol, S. M. & Hansena, E. J., Nov 2013, In : Infection and Immunity. 81, 11, p. 4160-4170 11 p.

Research output: Contribution to journalArticle

Haemophilus ducreyi
Virulence Factors
Operon
Proteins
Virulence

The "super mutant" of yeast FMN adenylyltransferase enhances the enzyme turnover rate by attenuating product inhibition

Huerta, C., Grishin, N. V. & Zhang, H., May 28 2013, In : Biochemistry. 52, 21, p. 3615-3617 3 p.

Research output: Contribution to journalArticle

FMN adenylyltransferase
Yeast
Byproducts
Flavin-Adenine Dinucleotide
Riboflavin
15 Citations (Scopus)
FAD pyrophosphatase
Bimetals
Treponema pallidum
Lipoproteins
Homeostasis
51 Citations (Scopus)

Three-color single molecule imaging shows WASP detachment from Arp2/3 complex triggers actin filament branch formation

Smith, B. A., Padrick, S. B., Doolittle, L. K., Daugherty-Clarke, K., Corrêa, I. R., Xu, M. Q., Goode, B. L., Rosen, M. K. & Gelles, J., Sep 3 2013, In : eLife. 2013, 2, e01008.

Research output: Contribution to journalArticle

Actin-Related Protein 2-3 Complex
Actin Cytoskeleton
Wiskott-Aldrich Syndrome Protein
Actins
Color
13 Citations (Scopus)
Adenosylmethionine Decarboxylase
Trypanosoma brucei brucei
Chemical activation
Peptides
17 Citations (Scopus)

UAS domain of Ubxd8 and FAF1 polymerizes upon interaction with long-chain unsaturated fatty acids

Kim, H., Zhang, H., Meng, D., Russell, G., Lee, J. N. & Ye, J., Aug 2013, In : Journal of Lipid Research. 54, 8, p. 2144-2152 9 p.

Research output: Contribution to journalArticle

Unsaturated Fatty Acids
Polymerization
Fatty Acids
Glutamates
Oligomerization
2012
25 Citations (Scopus)

Activation of p115-RhoGEF requires direct association of Gα13and the Dbl homology domain

Chen, Z., Guo, L., Hadas, J., Gutowski, S., Sprang, S. R. & Sternweis, P. C., Jul 20 2012, In : Journal of Biological Chemistry. 287, 30, p. 25490-25500 11 p.

Research output: Contribution to journalArticle

Rho Guanine Nucleotide Exchange Factors
Chemical activation
Association reactions
Guanine Nucleotide Exchange Factors
Binding Sites
4 Citations (Scopus)

A multi-faceted analysis of RutD reveals a novel family of α/β hydrolases

Knapik, A. A., Petkowski, J. J., Otwinowski, Z., Cymborowski, M. T., Cooper, D. R., Majorek, K. A., Chruszcz, M., Krajewska, W. M. & Minor, W., Oct 2012, In : Proteins: Structure, Function and Bioinformatics. 80, 10, p. 2359-2368 10 p.

Research output: Contribution to journalArticle

Uracil
Hydrolases
Catalytic Domain
3-oxoadipate enol-lactonase
Operon
114 Citations (Scopus)

A TOG: αβ-tubulin complex structure reveals conformation-based mechanisms for a microtubule polymerase

Ayaz, P., Ye, X., Huddleston, P., Brautigam, C. A. & Rice, L. M., Aug 17 2012, In : Science. 337, 6096, p. 857-860 4 p.

Research output: Contribution to journalArticle

Tubulin
Microtubules
Genes
Neoplasms
Catalysis
10 Citations (Scopus)

Autoinhibition of Mint1 adaptor protein regulates amyloid precursor protein binding and processing

Matos, M. F., Xu, Y., Dulubova, I., Otwinowski, Z., Richardson, J. M., Tomchick, D. R., Rizo-Rey, J. & Ho, A., Mar 6 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 10, p. 3802-3807 6 p.

Research output: Contribution to journalArticle

Amyloid beta-Protein Precursor
Amyloid
Protein Binding
Phosphotyrosine
Mentha
11 Citations (Scopus)

Biophysical and bioinformatic analyses implicate the treponema pallidum tp34 lipoprotein (tp0971) in transition metal homeostasis

Brautigam, C. A., Deka, R. K., Ouyang, Z., Machius, M., Knutsen, G., Tomchick, D. R. & Norgard, M. V., Oct 2012, In : Journal of Bacteriology. 194, 24, p. 6771-6781 11 p.

Research output: Contribution to journalArticle

Treponema pallidum
Computational Biology
Lipoproteins
Homeostasis
Metals
130 Citations (Scopus)

Cryo-EM structure of a 3D DNA-origami object

Bai, X. C., Martin, T. G., Scheres, S. H. W. & Dietz, H., Dec 4 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 49, p. 20012-20017 6 p.

Research output: Contribution to journalArticle

DNA
Nanotechnology
Macromolecular Substances
Ribosomes
Equipment and Supplies
123 Citations (Scopus)

Crystal structure of the heterodimeric CLOCK: BMAL1 transcriptional activator complex

Huang, N., Chelliah, Y., Shan, Y., Taylor, C. A., Yoo, S. H., Partch, C., Green, C. B., Zhang, H. & Takahashi, J. S., Jul 13 2012, In : Science. 337, 6091, p. 189-194 6 p.

Research output: Contribution to journalArticle

Circadian Clocks
Protein Subunits
Dimerization
Periodicity
Mammals
15 Citations (Scopus)

Enlightening molecular mechanisms through study of protein interactions

Rizo-Rey, J., Rosen, M. K. & Gardner, K. H., Oct 2012, In : Journal of Molecular Cell Biology. 4, 5, p. 270-283 14 p.

Research output: Contribution to journalArticle

SNARE Proteins
Syntaxin 1
Proteins
Neurotransmitter Agents
Synaptotagmin I
27 Citations (Scopus)

Hemerythrin-like domain within F-box and leucine-rich repeat protein 5 (FBXL5) communicates cellular iron and oxygen availability by distinct mechanisms

Chollangi, S., Thompson, J. W., Ruiz, J. C., Gardner, K. H. & Bruick, R. K., Jul 6 2012, In : Journal of Biological Chemistry. 287, 28, p. 23710-23717 8 p.

Research output: Contribution to journalArticle

Hemerythrin
Iron
Availability
Oxygen
Iron-Regulatory Proteins
226 Citations (Scopus)

High-precision isothermal titration calorimetry with automated peak-shape analysis

Keller, S., Vargas, C., Zhao, H., Piszczek, G., Brautigam, C. A. & Schuck, P., Jun 5 2012, In : Analytical Chemistry. 84, 11, p. 5066-5073 8 p.

Research output: Contribution to journalArticle

Calorimetry
Titration
Isotherms
Thermodynamics
Enthalpy
6 Citations (Scopus)

How plants see the invisible

Gardner, K. H. & Correa, F., Mar 23 2012, In : Science. 335, 6075, p. 1451-1452 2 p.

Research output: Contribution to journalArticle

Ultraviolet Rays
Amino Acids
25 Citations (Scopus)

Identification of natural and artificial DNA substrates for light-activated LOV-HTH transcription factor EL222

Rivera-Cancel, G., Motta-Mena, L. B. & Gardner, K. H., Dec 18 2012, In : Biochemistry. 51, 50, p. 10024-10034 11 p.

Research output: Contribution to journalArticle

Transcription Factors
Oxygen
Light
DNA
Electric potential
5 Citations (Scopus)

In support of the BMRB.

Markley, J. L., Akutsu, H., Asakura, T., Baldus, M., Boelens, R., Bonvin, A., Kaptein, R., Bax, A., Bezsonova, I., Gryk, M. R., Hoch, J. C., Korzhnev, D. M., Maciejewski, M. W., Case, D., Chazin, W. J., Cross, T. A., Dames, S., Kessler, H., Lange, O., Madl, T. & 71 others, Reif, B., Sattler, M., Eliezer, D., Fersht, A., Forman-Kay, J., Kay, L. E., Fraser, J., Gross, J., Kortemme, T., Sali, A., Fujiwara, T., Gardner, K. H., Luo, X., Rizo-Rey, J., Rosen, M. K., Gil, R. R., Ho, C., Rule, G., Gronenborn, A. M., Ishima, R., Klein-Seetharaman, J., Tang, P., van der Wel, P., Xu, Y., Grzesiek, S., Hiller, S., Seelig, J., Laue, E. D., Mott, H., Nietlispach, D., Barsukov, I., Lian, L. Y., Middleton, D., Blumenschein, T., Moore, G., Campbell, I., Schnell, J., Vakonakis, I. J., Watts, A., Conte, M. R., Mason, J., Pfuhl, M., Sanderson, M. R., Craven, J., Williamson, M., Dominguez, C., Roberts, G., Günther, U., Overduin, M., Werner, J., Williamson, P., Blindauer, C., Crump, M., Driscoll, P., Frenkiel, T., Golovanov, A., Matthews, S., Parkinson, J., Uhrin, D., Williams, M., Neuhaus, D., Oschkinat, H., Ramos, A., Shaw, D. E., Steinbeck, C., Vendruscolo, M., Vuister, G. W., Walters, K. J., Weinstein, H., Wüthrich, K. & Yokoyama, S., Sep 2012, In : Nature structural & molecular biology. 19, 9, p. 854-860 7 p.

Research output: Contribution to journalArticle

81 Citations (Scopus)

Multiple repeat elements within the FAM21 tail link the WASH actin regulatory complex to the retromer

Jia, D., Gomez, T. S., Billadeau, D. D. & Rosen, M. K., Jun 15 2012, In : Molecular Biology of the Cell. 23, 12, p. 2352-2361 10 p.

Research output: Contribution to journalArticle

Actins
Wiskott-Aldrich Syndrome Protein Family
Wiskott-Aldrich Syndrome Protein
Coated Vesicles
Calorimetry
24 Citations (Scopus)

Multivalent di-nucleosome recognition enables the Rpd3S histone deacetylase complex to tolerate decreased H3K36 methylation levels

Huh, J. W., Wu, J., Lee, C. H., Yun, M., Gilada, D., Brautigam, C. A. & Li, B., Aug 29 2012, In : EMBO Journal. 31, 17, p. 3564-3574 11 p.

Research output: Contribution to journalArticle

Methylation
Histone Deacetylases
Nucleosomes
Chromatin
Histones
83 Citations (Scopus)

NESdb: A database of NES-containing CRM1 cargoes

Xu, D., Grishin, N. V. & Chook, Y. M., Sep 15 2012, In : Molecular Biology of the Cell. 23, 18, p. 3673-3676 4 p.

Research output: Contribution to journalArticle

Nuclear Export Signals
Databases
Nonprofit Organizations
Karyopherins
Cell Nucleus Active Transport
555 Citations (Scopus)

Phase transitions in the assembly of multivalent signalling proteins

Li, P., Banjade, S., Cheng, H. C., Kim, S., Chen, B., Guo, L., Llaguno, M., Hollingsworth, J. V., King, D. S., Banani, S. F., Russo, P. S., Jiang, Q. X., Nixon, B. T. & Rosen, M. K., Mar 15 2012, In : Nature. 483, 7389, p. 336-340 5 p.

Research output: Contribution to journalArticle

Phase Transition
Actins
Wiskott-Aldrich Syndrome Protein
Actin-Related Protein 2-3 Complex
Proteins
52 Citations (Scopus)

Regulation from within: The cytoskeleton in transmembrane signaling

Jaqaman, K. & Grinstein, S., Oct 2012, In : Trends in Cell Biology. 22, 10, p. 515-526 12 p.

Research output: Contribution to journalArticle

Cytoskeleton
Cluster Analysis
Membrane Lipids
Cell Membrane
Membranes
153 Citations (Scopus)

Requirements for efficient correction of Δf508 CFTR revealed by analyses of evolved sequences

Mendoza, J. L., Schmidt, A., Li, Q., Nuvaga, E., Barrett, T., Bridges, R. J., Feranchak, A. P., Brautigam, C. A. & Thomas, P. J., Jan 20 2012, In : Cell. 148, 1-2, p. 164-174 11 p.

Research output: Contribution to journalArticle

Sequence Analysis
Cystic Fibrosis Transmembrane Conductance Regulator
Defects
Mutation
Ceilings
159 Citations (Scopus)

Selective inhibitors of nuclear export show that CRM1/XPO1 is a target in chronic lymphocytic leukemia

Lapalombella, R., Sun, Q., Williams, K., Tangeman, L., Jha, S., Zhong, Y., Goettl, V., Mahoney, E., Berglund, C., Gupta, S., Farmer, A., Mani, R., Johnson, A. J., Lucas, D., Mo, X., Daelemans, D., Sandanayaka, V., Shechter, S., McCauley, D., Shacham, S. & 3 others, Kauffman, M., Chook, Y. M. & Byrd, J. C., Nov 29 2012, In : Blood. 120, 23, p. 4621-4634 14 p.

Research output: Contribution to journalArticle

Cell Nucleus Active Transport
B-Cell Chronic Lymphocytic Leukemia
Toxicity
Tumor Suppressor Proteins
Cysteine
60 Citations (Scopus)

Sequence and structural analyses of nuclear export signals in the NESdb database

Xu, D., Farmer, A., Collett, G., Grishin, N. V. & Chook, Y. M., Sep 15 2012, In : Molecular Biology of the Cell. 23, 18, p. 3677-3693 17 p.

Research output: Contribution to journalArticle

Nuclear Export Signals
Sequence Analysis
Databases
Amino Acids
Position-Specific Scoring Matrices