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2012
9 Citations (Scopus)

Staging membrane fusion

Rizo-Rey, J., Sep 14 2012, In : Science. 337, 6100, p. 1300-1301 2 p.

Research output: Contribution to journalArticle

Optical Tweezers
SNARE Proteins
Membrane Fusion
Synaptic Vesicles
Neurotransmitter Agents
19 Citations (Scopus)

Structural, bioinformatic, and in vivo analyses of two treponema pallidum Lipoproteins reveal a unique TRAP transporter

Deka, R. K., Brautigam, C. A., Goldberg, M., Schuck, P., Tomchick, D. R. & Norgard, M. V., Mar 9 2012, In : Journal of Molecular Biology. 416, 5, p. 678-696 19 p.

Research output: Contribution to journalArticle

Treponema pallidum
Computational Biology
Lipoproteins
Ligands
Symporters
51 Citations (Scopus)

Structural analysis of human Cdc20 supports multisite degron recognition by APC/C

Tian, W., Li, B., Warrington, R., Tomchick, D. R., Yu, H. & Luo, X., Nov 6 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 45, p. 18419-18424 6 p.

Research output: Contribution to journalArticle

Securin
Anaphase-Promoting Complex-Cyclosome
Cell Cycle
Ubiquitination
Binding Sites
15 Citations (Scopus)

Structural and biochemical characterization of human mitochondrial branched-chain α-ketoacid dehydrogenase phosphatase

Wynn, R. M., Li, J., Brautigam, C. A., Chuang, J. L. & Chuang, D. T., Mar 16 2012, In : Journal of Biological Chemistry. 287, 12, p. 9178-9192 15 p.

Research output: Contribution to journalArticle

3-Methyl-2-Oxobutanoate Dehydrogenase (Lipoamide)
Phosphoric Monoester Hydrolases
Ions
Catalytic Domain
Metals
64 Citations (Scopus)
Nuclear Localization Signals
Amyotrophic Lateral Sclerosis
Proline
Sarcoma
Tyrosine
41 Citations (Scopus)

Structural and molecular characterization of iron-sensing hemerythrin-like domain within F-box and leucine-rich repeat protein 5 (FBXL5)

Thompson, J. W., Salahudeen, A. A., Chollangi, S., Ruiz, J. C., Brautigam, C. A., Makris, T. M., Lipscomb, J. D., Tomchick, D. R. & Bruick, R. K., Mar 2 2012, In : Journal of Biological Chemistry. 287, 10, p. 7357-7365 9 p.

Research output: Contribution to journalArticle

Hemerythrin
Iron
Iron Regulatory Protein 2
Ubiquitin-Protein Ligases
Regulator Genes
17 Citations (Scopus)
Treponema pallidum
Thermodynamics
Lipoproteins
Adenosine Triphosphate
Proteins
59 Citations (Scopus)

Structural basis for Marburg virus VP35-mediated immune evasion mechanisms.

Ramanan, P., Edwards, M. R., Shabman, R. S., Leung, D. W., Endlich-Frazier, A. C., Borek, D. M., Otwinowski, Z., Liu, G., Huh, J., Basler, C. F. & Amarasinghe, G. K., Dec 11 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 50, p. 20661-20666 6 p.

Research output: Contribution to journalArticle

Marburgvirus
Immune Evasion
Ebolavirus
Interferons
Phosphotransferases
16 Citations (Scopus)

Structural characterization of a unique interface between carbohydrate response element-binding protein (ChREBP) and 14-3-3β protein

Ge, Q., Huang, N., Wynn, R. M., Li, Y., Du, X., Miller, B., Zhang, H. & Uyeda, K., Dec 7 2012, In : Journal of Biological Chemistry. 287, 50, p. 41914-41921 8 p.

Research output: Contribution to journalArticle

14-3-3 Proteins
Response Elements
Carrier Proteins
Carbohydrates
Cell Nucleus Active Transport
37 Citations (Scopus)

Structural characterization of full-length NSF and 20S particles

Chang, L. F., Chen, S., Liu, C. C., Pan, X., Jiang, J., Bai, X. C., Xie, X., Wang, H. W. & Sui, S. F., Mar 1 2012, In : Nature Structural and Molecular Biology. 19, 3, p. 268-275 8 p.

Research output: Contribution to journalArticle

N-Ethylmaleimide-Sensitive Proteins
SNARE Proteins
Soluble N-Ethylmaleimide-Sensitive Factor Attachment Proteins
Adenosine Diphosphate
Cricetulus
526 Citations (Scopus)

Structure and dynamics of the M3 muscarinic acetylcholine receptor

Kruse, A. C., Hu, J., Pan, A. C., Arlow, D. H., Rosenbaum, D. M., Rosemond, E., Green, H. F., Liu, T., Chae, P. S., Dror, R. O., Shaw, D. E., Weis, W. I., Wess, J. & Kobilka, B. K., Feb 23 2012, In : Nature. 482, 7386, p. 552-556 5 p.

Research output: Contribution to journalArticle

Muscarinic Receptors
G-Protein-Coupled Receptors
Ligands
GTP-Binding Proteins
Allosteric Site
6 Citations (Scopus)

Structure of Escherichia coli RutC, a member of the YjgF family and putative aminoacrylate peracid reductase of the rut operon

Knapik, A. A., Petkowski, J. J., Otwinowski, Z., Cymborowski, M. T., Cooper, D. R., Chruszcz, M., Krajewska, W. M. & Minor, W., Nov 2012, In : Acta Crystallographica Section F: Structural Biology and Crystallization Communications. 68, 11, p. 1294-1299 6 p.

Research output: Contribution to journalArticle

Operon
Escherichia
Escherichia coli
Oxidoreductases
proteins
67 Citations (Scopus)
Kinetochores
Anaphase
Chromatids
Aneuploidy
Microtubules
10 Citations (Scopus)

Structure of the effector-binding domain of the arabinose repressor AraR from Bacillus subtilis

Procházková, K., Čermáková, K., Pachl, P., Sieglová, I., Fábry, M., Otwinowski, Z. & Řezáčová, P., Feb 2012, In : Acta Crystallographica Section D: Biological Crystallography. 68, 2, p. 176-185 10 p.

Research output: Contribution to journalArticle

Arabinose
Bacillus subtilis
Fluorometry
Differential Scanning Calorimetry
Metabolic Networks and Pathways
23 Citations (Scopus)

Structure of the Type III Secretion Effector Protein ExoU in Complex with Its Chaperone SpcU

Halavaty, A. S., Borek, D., Tyson, G. H., Veesenmeyer, J. L., Shuvalova, L., Minasov, G., Otwinowski, Z., Hauser, A. R. & Anderson, W. F., Nov 14 2012, In : PLoS One. 7, 11, e49388.

Research output: Contribution to journalArticle

type III secretion system
secretion
Bacteria
Proteins
proteins
229 Citations (Scopus)
Munc18 Proteins
SNARE Proteins
Membrane Fusion
Syntaxin 1
Synucleins

Translin. TRAX Complex (C3PO), a Novel Ribonuclease for the Degradation of Small RNAs.

Zhang, H. & Liu, Q., 2012, In : Enzymes. 32, p. 69-82 14 p.

Research output: Contribution to journalArticle

RNA Stability
Ribonucleases
RNA-Induced Silencing Complex
Ribonuclease P
RNA
204 Citations (Scopus)

Ubiquitin-Induced Oligomerization of the RNA Sensors RIG-I and MDA5 Activates Antiviral Innate Immune Response

Jiang, X., Kinch, L. N., Brautigam, C. A., Chen, X., Du, F., Grishin, N. V. & Chen, Z., Jun 29 2012, In : Immunity. 36, 6, p. 973-959 15 p.

Research output: Contribution to journalArticle

Polyubiquitin
Ubiquitin
Innate Immunity
Antiviral Agents
RNA
2011
271 Citations (Scopus)

A new generation of crystallographic validation tools for the Protein Data Bank

Read, R. J., Adams, P. D., Arendall, W. B., Brunger, A. T., Emsley, P., Joosten, R. P., Kleywegt, G. J., Krissinel, E. B., Lütteke, T., Otwinowski, Z., Perrakis, A., Richardson, J. S., Sheffler, W. H., Smith, J. L., Tickle, I. J., Vriend, G. & Zwart, P. H., Oct 12 2011, In : Structure. 19, 10, p. 1395-1412 18 p.

Research output: Contribution to journalArticle

Databases
Advisory Committees
Proteins
X-Rays
108 Citations (Scopus)

Arp2/3 complex is bound and activated by two WASP proteins

Padrick, S. B., Doolittle, L. K., Brautigam, C. A., King, D. S. & Rosen, M. K., Aug 16 2011, In : Proceedings of the National Academy of Sciences of the United States of America. 108, 33

Research output: Contribution to journalArticle

Actin-Related Protein 2
Actin-Related Protein 3
Wiskott-Aldrich Syndrome Protein
Proteins
Actins
9 Citations (Scopus)

A single active-site mutation of P450BM-3 dramatically enhances substrate binding and rate of product formation

Haines, D. C., Hegde, A., Chen, B., Zhao, W., Bondlela, M., Humphreys, J. M., Mullin, D. A., Tomchick, D. R., MacHius, M. & Peterson, J. A., Oct 4 2011, In : Biochemistry. 50, 39, p. 8333-8341 9 p.

Research output: Contribution to journalArticle

Catalytic Domain
Mutation
Substrates
Enzymes
Valine

A tribute to Lewis e Kay on his 50th birthday

Gardner, K. H., Mittermaier, A. & Mulder, F. A. A., Sep 2011, In : Journal of Biomolecular NMR. 51, 1-2, p. 3-4 2 p.

Research output: Contribution to journalArticle

20 Citations (Scopus)

Characterization of the structure and function of Escherichia coli DegQ as a representative of the DegQ-like proteases of bacterial HtrA family proteins

Bai, X. C., Pan, X. J., Wang, X. J., Ye, Y. Y., Chang, L. F., Leng, D., Lei, J. & Sui, S. F., Sep 7 2011, In : Structure. 19, 9, p. 1328-1337 10 p.

Research output: Contribution to journalArticle

Peptide Hydrolases
Escherichia coli
Cryoelectron Microscopy
Periplasm
Proteins
76 Citations (Scopus)

Chiral allene-containing phosphines in asymmetric catalysis

Cai, F., Pu, X., Qi, X., Lynch, V., Radha, A. & Ready, J. M., Nov 16 2011, In : Journal of the American Chemical Society. 133, 45, p. 18066-18069 4 p.

Research output: Contribution to journalArticle

Phosphines
Catalysis
Transition metals
Ligands
Enantioselectivity
40 Citations (Scopus)
Aryl Hydrocarbon Receptor Nuclear Translocator
Oxygen
Helix-Loop-Helix Motifs
Basic Helix-Loop-Helix Transcription Factors
Hypoxia
3 Citations (Scopus)

Crystallization and preliminary X-ray diffraction analysis of Val57 mutants of the amyloidogenic protein human cystatin C

Orlikowska, M., Jankowska, E., Borek, D., Otwinowski, Z., Skowron, P. & Szymaska, A., Dec 2011, In : Acta Crystallographica Section F: Structural Biology and Crystallization Communications. 67, 12, p. 1608-1611 4 p.

Research output: Contribution to journalArticle

Amyloidogenic Proteins
Cystatin C
Mutant Proteins
Crystallization
X-Ray Diffraction
4 Citations (Scopus)

Crystal structure of cardiac troponin C regulatory domain in complex with cadmium and deoxycholic acid reveals novel conformation

Li, A. Y., Lee, J., Borek, D., Otwinowski, Z., Tibbits, G. F. & Paetzel, M., Oct 28 2011, In : Journal of Molecular Biology. 413, 3, p. 699-711 13 p.

Research output: Contribution to journalArticle

Troponin C
Deoxycholic Acid
Cadmium
EF Hand Motifs
Calcium
152 Citations (Scopus)

Cytoskeletal control of CD36 diffusion promotes its receptor and signaling function

Jaqaman, K., Kuwata, H., Touret, N., Collins, R., Trimble, W. S., Danuser, G. & Grinstein, S., Aug 19 2011, In : Cell. 146, 4, p. 593-606 14 p.

Research output: Contribution to journalArticle

Cytoskeleton
Cluster Analysis
Ligands
Oxidized LDL Receptors
Membranes
39 Citations (Scopus)

Design, overexpression, and purification of polymerization-blocked yeast αβ-tubulin mutants

Johnson, V., Ayaz, P., Huddleston, P. & Rice, L. M., Oct 11 2011, In : Biochemistry. 50, 40, p. 8636-8644 9 p.

Research output: Contribution to journalArticle

Tubulin
Polymerization
Yeast
Purification
Yeasts
19 Citations (Scopus)

Evaluating the stoichiometry of macromolecular complexes using multisignal sedimentation velocity

Padrick, S. B. & Brautigam, C. A., May 2011, In : Methods. 54, 1, p. 39-55 17 p.

Research output: Contribution to journalArticle

Interferometry
Macromolecular Substances
Spectrophotometry
Hydrodynamics
Sedimentation
16 Citations (Scopus)

Evolutionary development of redundant nuclear localization signals in the mRNA export factor NXF1

Zhang, Z. C., Satterly, N., Fontoura, B. M. A. & Chook, Y. M., Dec 1 2011, In : Molecular Biology of the Cell. 22, 23, p. 4657-4668 12 p.

Research output: Contribution to journalArticle

Karyopherins
Nuclear Localization Signals
Messenger RNA
Cell Nucleus Active Transport
Eukaryota
24 Citations (Scopus)

Generation of a consensus protein domain dictionary

Schaeffer, R. D., Jonsson, A. L., Simms, A. M. & Daggett, V., Jan 1 2011, In : Bioinformatics. 27, 1, p. 46-54 9 p., btq625.

Research output: Contribution to journalArticle

Glossaries
Proteins
Protein
Fold
Folding
28 Citations (Scopus)

Identification of gene products involved in the oxidative stress response of Moraxella catarrhalis

Hoopman, T. C., Liu, W., Joslin, S. N., Pybus, C., Brautigam, C. A. & Hansen, E. J., Feb 2011, In : Infection and Immunity. 79, 2, p. 745-755 11 p.

Research output: Contribution to journalArticle

Moraxella (Branhamella) catarrhalis
Oxidative Stress
Genes
Catalase
Biofilms
21 Citations (Scopus)

Importin-α protein binding to a nuclear localization signal of carbohydrate response element-binding protein (ChREBP)

Ge, Q., Nakagawa, T., Max Wynn, R., Chook, Y. M., Miller, B. C. & Uyeda, K., Aug 12 2011, In : Journal of Biological Chemistry. 286, 32, p. 28119-28127 9 p.

Research output: Contribution to journalArticle

Karyopherins
Nuclear Localization Signals
Response Elements
Protein Binding
Carrier Proteins
16 Citations (Scopus)

Malleability of folding intermediates in the homeodomain superfamily

Banachewicz, W., Religa, T. L., Schaeffer, R. D., Daggett, V. & Fersht, A. R., Apr 5 2011, In : Proceedings of the National Academy of Sciences of the United States of America. 108, 14, p. 5596-5601 6 p.

Research output: Contribution to journalArticle

Helix-Turn-Helix Motifs
Molecular Dynamics Simulation
Peptides
12 Citations (Scopus)

Manifestations of native topology in the denatured state ensemble of rhodopseudomonas palustris cytochrome c′

Dar, T. A., Schaeffer, R. D., Daggett, V. & Bowler, B. E., Feb 15 2011, In : Biochemistry. 50, 6, p. 1029-1041 13 p.

Research output: Contribution to journalArticle

Rhodopseudomonas
Cytochromes c
Heme
Histidine
Guanidine
39 Citations (Scopus)

Mechanism of actin filament nucleation by the bacterial effector VopL

Yu, B., Cheng, H. C., Brautigam, C. A., Tomchick, D. R. & Rosen, M. K., Sep 2011, In : Nature Structural and Molecular Biology. 18, 9, p. 1068-1074 7 p.

Research output: Contribution to journalArticle

Vibrio parahaemolyticus
Actin Cytoskeleton
Actins
Proteins
Stress Fibers
14 Citations (Scopus)

Membrane bridging and hemifusion by denaturated Munc18

Xu, Y., Seven, A., Su, L., Jiang, Q. X. & Rizo-Rey, J., 2011, In : PLoS One. 6, 7, e22012.

Research output: Contribution to journalArticle

Liposomes
Munc18 Proteins
Fluorescence
Denaturation
fluorescence
43 Citations (Scopus)

Mitotic centromeric targeting of HP1 and its binding to Sgo1 are dispensable for sister-chromatid cohesion in human cells

Kang, J., Chaudhary, J., Dong, H., Kim, S., Brautigam, C. A. & Yua, H., Apr 15 2011, In : Molecular Biology of the Cell. 22, 8, p. 1181-1190 10 p.

Research output: Contribution to journalArticle

Chromatids
Centromere
Mitosis
Protein Binding
Interphase
25 Citations (Scopus)

Modulating LOV domain photodynamics with a residue alteration outside the chromophore binding site

Song, S. H., Freddolino, P. L., Nash, A. I., Carroll, E. C., Schulten, K., Gardner, K. H. & Larsen, D. S., Apr 5 2011, In : Biochemistry. 50, 13, p. 2411-2423 13 p.

Research output: Contribution to journalArticle

Chromophores
Binding Sites
Oxygen
Light
Electric potential
22 Citations (Scopus)

Modulation of a GEF switch: Autoinhibition of the intrinsic guanine nucleotide exchange activity of p115-RhoGEF

Chen, Z., Guo, L., Sprang, S. R. & Sternweis, P. C., Jan 2011, In : Protein Science. 20, 1, p. 107-117 11 p.

Research output: Contribution to journalArticle

Rho Guanine Nucleotide Exchange Factors
Guanine Nucleotides
Crystal structure
Switches
Modulation
161 Citations (Scopus)

Munc13 mediates the transition from the closed syntaxin-Munc18 complex to the SNARE complex

Ma, C., Li, W., Xu, Y. & Rizo-Rey, J., 2011, In : Nature Structural and Molecular Biology. 18, 5, p. 542-549 8 p.

Research output: Contribution to journalArticle

Syntaxin 1
Qa-SNARE Proteins
SNARE Proteins
Synaptic Vesicles
Neurotransmitter Agents
23 Citations (Scopus)

Mutational and structural studies of the PixD BLUF output signal that affects light-regulated interactions with PixE

Yuan, H., Dragnea, V., Wu, Q., Gardner, K. H. & Bauer, C. E., Jul 26 2011, In : Biochemistry. 50, 29, p. 6365-6375 11 p.

Research output: Contribution to journalArticle

Flavin-Adenine Dinucleotide
Light
Mutation
Excited states
Acrylamide
12 Citations (Scopus)

NMR structure and calcium-binding properties of the tellurite resistance protein TerD from klebsiella pneumoniae

Pan, Y. R., Lou, Y. C., Seven, A. B., Rizo-Rey, J. & Chen, C., Feb 4 2011, In : Journal of Molecular Biology. 405, 5, p. 1188-1201 14 p.

Research output: Contribution to journalArticle

Klebsiella pneumoniae
Calcium
Proteins
Binding Sites
Tellurium
211 Citations (Scopus)

Nuclear import by karyopherin-βs: Recognition and inhibition

Chook, Y. M. & Süel, K. E., Sep 2011, In : Biochimica et Biophysica Acta - Molecular Cell Research. 1813, 9, p. 1593-1606 14 p.

Research output: Contribution to journalArticle

Karyopherins
Cell Nucleus Active Transport
Cytoplasm
Nuclear Localization Signals
Nuclear Proteins
120 Citations (Scopus)

PlusTipTracker: Quantitative image analysis software for the measurement of microtubule dynamics

Applegate, K. T., Besson, S., Matov, A., Bagonis, M. H., Jaqaman, K. & Danuser, G., Nov 2011, In : Journal of Structural Biology. 176, 2, p. 168-184 17 p.

Research output: Contribution to journalArticle

Microtubules
Software
Motion Pictures
Growth
Computational Biology
26 Citations (Scopus)

Reluctance to membrane binding enables accessibility of the synaptobrevin SNARE motif for SNARE complex formation

Brewer, K. D., Li, W., Horne, B. E. & Rizo-Rey, J., Aug 2 2011, In : Proceedings of the National Academy of Sciences of the United States of America. 108, 31, p. 12723-12728 6 p.

Research output: Contribution to journalArticle

R-SNARE Proteins
SNARE Proteins
Membranes
Micelles
Liposomes
282 Citations (Scopus)

RIM proteins tether Ca2+ channels to presynaptic active zones via a direct PDZ-domain interaction

Kaeser, P. S., Deng, L., Wang, Y., Dulubova, I., Liu, X., Rizo-Rey, J. & Südhof, T. C., Jan 21 2011, In : Cell. 144, 2, p. 282-295 14 p.

Research output: Contribution to journalArticle

PDZ Domains
Reaction injection molding
Neurotransmitter Agents
Synapses
Proteins

Special issue as a tribute to Lewis E Kay on his 50th birthday.

Gardner, K. H., Mittermaier, A. & Mulder, F. A. A., Sep 2011, In : Journal of Biomolecular NMR. 51, 1-2, p. 3-207 205 p.

Research output: Contribution to journalArticle

21st Century History
20th Century History
Magnetic resonance spectroscopy
Canada
Magnetic Resonance Spectroscopy