Cell Biology - Division A

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2019

A nostalgic look back 40 years after the discovery of receptor-mediated endocytosis

Schmid, S. L., Jan 1 2019, In : Molecular Biology of the Cell. 30, 1, p. 1-3 3 p.

Research output: Contribution to journalArticle

Cell type and receptor identity regulate cholera toxin subunit B (CTB) internalization

Sethi, A., Wands, A. M., Mettlen, M., Krishnamurthy, S., Wu, H. & Kohler, J. J., Apr 6 2019, In : Interface Focus. 9, 2, 20180076.

Research output: Contribution to journalArticle

4 Scopus citations

Mutant p53 amplifies a dynamin-1/APPL1 endosome feedback loop that regulates recycling and migration

Lakoduk, A. M., Roudot, P., Mettlen, M., Grossman, H. M., Schmid, S. L. & Chen, P. H., Jun 3 2019, In : The Journal of cell biology. 218, 6, p. 1928-1942 15 p.

Research output: Contribution to journalArticle

Open Access

The plos biology xv collection: 15 years of exceptional science highlighted across 12 months

Richardson, L. A., Schmid, S. L., Bhandoola, A., Harly, C., Hedenström, A., Laub, M. T., Mace, G. M., Sengupta, P., Stock, A. M., Read, A. F., Malik, H. S., Estelle, M., Lowell, S. & Kimmelman, J., Feb 2019, In : PLoS biology. 17, 2, e3000180.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations
2018

A noncanonical role for dynamin-1 in regulating early stages of clathrin-mediated endocytosis in non-neuronal cells

Srinivasan, S., Burckhardt, C. J., Bhave, M., Chen, Z., Chen, P. H., Wang, X., Danuser, G. & Schmid, S. L., Apr 18 2018, In : PLoS Biology. 16, 4, e2005377.

Research output: Contribution to journalArticle

4 Scopus citations

Differential glucose requirement in skin homeostasis and injury identifies a therapeutic target for psoriasis

Zhang, Z., Zi, Z., Lee, E. E., Zhao, J., Contreras, D. C., South, A. P., Abel, E. D., Chong, B. F., Vandergriff, T., Hosler, G. A., Scherer, P. E., Mettlen, M., Rathmell, J. C., DeBerardinis, R. J. & Wang, R. C., Apr 16 2018, (Accepted/In press) In : Nature Medicine. p. 1-11 11 p.

Research output: Contribution to journalArticle

18 Scopus citations
2 Scopus citations
2017

A highly-sensitive high throughput assay for dynamin's basal GTPase activity

Mohanakrishnan, A., Tran, T. V. M., Kumar, M., Chen, H., Posner, B. A. & Schmid, S. L., Sep 2017, In : PloS one. 12, 9, e0185639.

Research output: Contribution to journalArticle

2 Scopus citations

Control of actin polymerization via the coincidence of phosphoinositides and high membrane curvature

Daste, F., Walrant, A., Holst, M. R., Gadsby, J. R., Mason, J., Lee, J. E., Brook, D., Mettlen, M., Larsson, E., Lee, S. F., Lundmark, R. & Gallop, J. L., Nov 1 2017, In : Journal of Cell Biology. 216, 11, p. 3745-3765 21 p.

Research output: Contribution to journalArticle

24 Scopus citations

Crosstalk between CLCb/Dyn1-Mediated Adaptive Clathrin-Mediated Endocytosis and Epidermal Growth Factor Receptor Signaling Increases Metastasis

Chen, P. H., Bendris, N., Hsiao, Y. J., Reis, C. R., Mettlen, M., Chen, H. Y., Yu, S. L. & Schmid, S. L., Feb 6 2017, In : Developmental Cell. 40, 3, p. 278-288.e5

Research output: Contribution to journalArticle

24 Scopus citations

Decoupling global biases and local interactions between cell biological variables

Zaritsky, A., Obolski, U., Gan, Z., Reis, C. R., Kadlecova, Z., Du, Y., Schmid, S. L. & Danuser, G., Mar 13 2017, In : eLife. 6, e22323.

Research output: Contribution to journalArticle

5 Scopus citations

Reciprocal regulation of signaling and endocytosis: Implications for the evolving cancer cell

Schmid, S. L., Sep 1 2017, In : Journal of Cell Biology. 216, 9, p. 2623-2632 10 p.

Research output: Contribution to journalArticle

38 Scopus citations

Regulation of clathrin-mediated endocytosis by hierarchical allosteric activation of AP2

Kadlecova, Z., Spielman, S. J., Loerke, D., Mohanakrishnan, A., Reed, D. K. & Schmid, S. L., 2017, In : Journal of Cell Biology. 216, 1, p. 167-179 13 p.

Research output: Contribution to journalArticle

37 Scopus citations

TRAIL-death receptor endocytosis and apoptosis are selectively regulated by dynamin-1 activation

Reis, C. R., Chen, P. H., Bendris, N. & Schmid, S. L., Jan 17 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 3, p. 504-509 6 p.

Research output: Contribution to journalArticle

19 Scopus citations
2016

Cell-Based Screen Identifies Human Interferon-Stimulated Regulators of Listeria monocytogenes Infection

Perelman, S. S., Abrams, M. E., Eitson, J. L., Chen, D., Jimenez, A., Mettlen, M., Schoggins, J. W. & Alto, N. M., Dec 21 2016, In : PLoS Pathogens. 12, 12, e1006102.

Research output: Contribution to journalArticle

8 Scopus citations

Diagonally Scanned Light-Sheet Microscopy for Fast Volumetric Imaging of Adherent Cells

Dean, K. M., Roudot, P., Reis, C. R., Welf, E. S., Mettlen, M. & Fiolka, R., Mar 29 2016, In : Biophysical Journal. 110, 6, p. 1456-1465 10 p.

Research output: Contribution to journalArticle

18 Scopus citations

Endocytic pathways and endosomal trafficking: a primer

Elkin, S. R., Lakoduk, A. M. & Schmid, S. L., Feb 9 2016, (Accepted/In press) In : Wiener Medizinische Wochenschrift. p. 1-9 9 p.

Research output: Contribution to journalArticle

54 Scopus citations

Identification and function of conformational dynamics in the multidomain GTPase dynamin

Srinivasan, S., Dharmarajan, V., Reed, D. K., Griffin, P. R. & Schmid, S. L., Feb 15 2016, In : EMBO Journal. 35, 4, p. 443-457 15 p.

Research output: Contribution to journalArticle

15 Scopus citations

Ikarugamycin: A Natural Product Inhibitor of Clathrin-Mediated Endocytosis

Elkin, S. R., Oswald, N. W., Reed, D. K., Mettlen, M., MacMillan, J. B. & Schmid, S. L., Oct 1 2016, In : Traffic. 17, 10, p. 1139-1149 11 p.

Research output: Contribution to journalArticle

17 Scopus citations

SNX9 promotes metastasis by enhancing cancer cell invasion via differential regulation of RhoGTPases

Bendris, N., Williams, K. C., Reis, C. R., Welf, E. S., Chen, P. H., Lemmers, B., Hahne, M., Leong, H. S. & Schmid, S. L., May 1 2016, In : Molecular Biology of the Cell. 27, 9, p. 1409-1419 11 p.

Research output: Contribution to journalArticle

14 Scopus citations

Sorting nexin 9 negatively regulates invadopodia formation and function in cancer cells

Bendris, N., Stearns, C. J. S., Reis, C. R., Rodriguez-Canales, J., Liu, H., Witkiewicz, A. W. & Schmid, S. L., Jul 15 2016, In : Journal of Cell Science. 129, 14, p. 2804-2816 13 p.

Research output: Contribution to journalArticle

9 Scopus citations
2015

A hemi-fission intermediate links two mechanistically distinct stages of membrane fission

Mattila, J. P., Shnyrova, A. V., Sundborger, A. C., Hortelano, E. R., Fuhrmans, M., Neumann, S., Müller, M., Hinshaw, J. E., Schmid, S. L. & Frolov, V. A., Aug 6 2015, In : Nature. 524, 7563, p. 109-113 5 p.

Research output: Contribution to journalArticle

49 Scopus citations

A systematic analysis reveals heterogeneous changes in the endocytic activities of cancer cells

Elkin, S. R., Bendris, N., Reis, C. R., Zhou, Y., Xie, Y., Huffman, K. E., Minna, J. D. & Schmid, S. L., Nov 1 2015, In : Cancer Research. 75, 21, p. 4640-4650 11 p.

Research output: Contribution to journalArticle

20 Scopus citations

Crosstalk between Akt/GSK3β signaling and dynamin-1 regulates clathrin-mediated endocytosis

Reis, C. R., Chen, P. H., Srinivasan, S., Aguet, F., Mettlen, M. & Schmid, S. L., Aug 13 2015, In : EMBO Journal. 34, 16, p. 2132-2146 15 p.

Research output: Contribution to journalArticle

46 Scopus citations

Fucosylation and protein glycosylation create functional receptors for cholera toxin

Wands, A. M., Fujita, A., McCombs, J. E., Cervin, J., Dedic, B., Rodriguez, A. C., Nischan, N., Bond, M. R., Mettlen, M., Trudgian, D. C., Lemoff, A., Quiding-Järbrink, M., Gustavsson, B., Steentoft, C., Clausen, H., Mirzaei, H., Teneberg, S., Yrlid, U. & Kohler, J. J., Oct 29 2015, In : eLife. 4, OCTOBER2015, e09545.

Research output: Contribution to journalArticle

33 Scopus citations
2014

A Protein Kinase C Phosphorylation Motif in GLUT1 Affects Glucose Transport and is Mutated in GLUT1 Deficiency Syndrome

Lee, E. E., Ma, J., Sacharidou, A., Mi, W., Salato, V. K., Nguyen, N., Jiang, Y., Pascual, J. M., North, P. E., Shaul, P. W., Mettlen, M. & Wang, R. C., Nov 24 2014, (Accepted/In press) In : Molecular Cell.

Research output: Contribution to journalArticle

37 Scopus citations

Endocytosis: Past, Present, And future

Schmid, S. L., Sorkin, A. & Zerial, M., Dec 1 2014, In : Cold Spring Harbor Perspectives in Biology. 6, 12, a022509.

Research output: Contribution to journalArticle

21 Scopus citations

Imaging and modeling the dynamics of clathrin-mediated endocytosis

Mettlen, M. & Danuser, G., Dec 1 2014, In : Cold Spring Harbor Perspectives in Biology. 6, 12, a017038.

Research output: Contribution to journalArticle

15 Scopus citations

Intrapolypeptide Interactions between the GTPase Effector Domain (GED) and the GTPase Domain Form the Bundle Signaling Element in Dynamin Dimers

Srinivasan, S., Mattila, J. P. & Schmid, S. L., Sep 16 2014, In : Biochemistry. 53, 36, p. 5724-5726 3 p.

Research output: Contribution to journalArticle

3 Scopus citations
2013

Advances in analysis of low signal-to-noise images link dynamin and AP2 to the functions of an endocytic checkpoint

Aguet, F., Antonescu, C., Mettlen, M., Schmid, S. & Danuser, G., Aug 12 2013, In : Developmental cell. 26, 3, p. 279-291 13 p.

Research output: Contribution to journalArticle

153 Scopus citations

Analyzing membrane remodeling and fission using supported bilayers with excess membrane reservoir

Neumann, S., Pucadyil, T. J. & Schmid, S. L., Jan 1 2013, In : Nature Protocols. 8, 1, p. 213-222 10 p.

Research output: Contribution to journalArticle

20 Scopus citations

An siRNA screen for NFAT activation identifies septins as coordinators of store-operated Ca2+ entry

Sharma, S., Quintana, A., Findlay, G. M., Mettlen, M., Baust, B., Jain, M., Nilsson, R., Rao, A. & Hogan, P. G., Jun 24 2013, In : Nature. 499, 7457, p. 238-242 5 p.

Research output: Contribution to journalArticle

143 Scopus citations

Dual role of BAR domain-containing proteins in regulating vesicle release catalyzed by the GTPase, dynamin-2

Neumann, S. & Schmid, S. L., Aug 30 2013, In : Journal of Biological Chemistry. 288, 35, p. 25119-25128 10 p.

Research output: Contribution to journalArticle

37 Scopus citations

Dynamin-Catalyzed Membrane Fission Requires Coordinated GTP Hydrolysis

Liu, Y. W., Mattila, J. P. & Schmid, S. L., Jan 31 2013, In : PloS one. 8, 1, e55691.

Research output: Contribution to journalArticle

13 Scopus citations

Geometric catalysis of membrane fission driven by flexible dynamin rings

Shnyrova, A. V., Bashkirov, P. V., Akimov, S. A., Pucadyil, T. J., Zimmerberg, J., Schmid, S. L. & Frolov, V. A., Mar 22 2013, In : Science. 339, 6126, p. 1433-1436 4 p.

Research output: Contribution to journalArticle

81 Scopus citations

Integrated Electron Microscopy: Super-Duper Resolution

Krijnse Locker, J. & Schmid, S. L., Aug 1 2013, In : PLoS biology. 11, 8, e1001639.

Research output: Contribution to journalArticle

6 Scopus citations
2012

Context-Dependent Proangiogenic Function of Bone Morphogenetic Protein Signaling Is Mediated by Disabled Homolog 2

Kim, J. D., Kang, H., Larrivée, B., Lee, M. Y., Mettlen, M., Schmid, S. L., Roman, B. L., Qyang, Y., Eichmann, A. & Jin, S. W., Aug 14 2012, In : Developmental Cell. 23, 2, p. 441-448 8 p.

Research output: Contribution to journalArticle

42 Scopus citations

Structural Analysis of Dynamin Reveals a Mechanism of Membrane Fission

Hinshaw, J., Chappie, J. S., Mears, J. A., Fang, S., Leonard, M., Schmid, S. L., Milligan, R. A., Dyda, F. & Hinshaw, J. E., 2012, In : Microscopy and Microanalysis. 18, p. 58-59 2 p.

Research output: Contribution to journalArticle

Structural tuning of the fluorescent protein iLOV for improved photostability

Christie, J. M., Hitomi, K., Arvai, A. S., Hartfield, K. A., Mettlen, M., Pratt, A. J., Tainer, J. A. & Getzoff, E. D., Jun 22 2012, In : Journal of Biological Chemistry. 287, 26, p. 22295-22304 10 p.

Research output: Contribution to journalArticle

87 Scopus citations
13 Scopus citations
2011

A new role for the dynamin GTPase in the regulation of fusion pore expansion

Anantharam, A., Bittner, M. A., Aikman, R. L., Stuenkel, E. L., Schmid, S. L., Axelrod, D. & Holz, R. W., Jun 1 2011, In : Molecular biology of the cell. 22, 11, p. 1907-1918 12 p.

Research output: Contribution to journalArticle

84 Scopus citations

A pseudoatomic model of the dynamin polymer identifies a hydrolysis-dependent powerstroke

Chappie, J. S., Mears, J. A., Fang, S., Leonard, M., Schmid, S. L., Milligan, R. A., Hinshaw, J. E. & Dyda, F., Sep 30 2011, In : Cell. 147, 1, p. 209-222 14 p.

Research output: Contribution to journalArticle

135 Scopus citations

Clusters of bioactive compounds target dynamic endomembrane networks in vivo

Drakakaki, G., Robert, S., Szatmari, A. M., Brown, M. Q., Nagawa, S., Van Damme, D., Leonard, M., Yang, Z., Girke, T., Schmid, S. L., Russinova, E., Friml, J., Raikhel, N. V. & Hicks, G. R., Oct 25 2011, In : Proceedings of the National Academy of Sciences of the United States of America. 108, 43, p. 17850-17855 6 p.

Research output: Contribution to journalArticle

79 Scopus citations

Common membrane trafficking defects of disease-associated dynamin 2 mutations

Liu, Y. W., Lukiyanchuk, V. & Schmid, S. L., Nov 1 2011, In : Traffic. 12, 11, p. 1620-1633 14 p.

Research output: Contribution to journalArticle

33 Scopus citations

Differential curvature sensing and generating activities of dynamin isoforms provide opportunities for tissue-specific regulation

Liu, Y. W., Neumann, S., Ramachandran, R., Ferguson, S. M., Pucadyil, T. J. & Schmid, S. L., Jun 28 2011, In : Proceedings of the National Academy of Sciences of the United States of America. 108, 26, p. E234-E242

Research output: Contribution to journalArticle

50 Scopus citations

Dynamin: Functional design of a membrane fission catalyst

Schmid, S. L. & Frolov, V. A., Oct 18 2011, In : Annual Review of Cell and Developmental Biology. 27, p. 79-105 27 p.

Research output: Contribution to journalArticle

188 Scopus citations

Hotspots Organize Clathrin-Mediated Endocytosis by Efficient Recruitment and Retention of Nucleating Resources

Nunez, D., Antonescu, C., Mettlen, M., Liu, A., Schmid, S. L., Loerke, D. & Danuser, G., Dec 1 2011, In : Traffic. 12, 12, p. 1868-1878 11 p.

Research output: Contribution to journalArticle

37 Scopus citations

Measuring the hierarchy of molecular events during clathrin-mediated endocytosis

Loerke, D., Mettlen, M., Schmid, S. L. & Danuser, G., Jul 1 2011, In : Traffic. 12, 7, p. 815-825 11 p.

Research output: Contribution to journalArticle

38 Scopus citations

Phosphatidylinositol-(4,5)-bisphosphate regulates clathrin-coated pit initiation, stabilization, and size

Antonescu, C. N., Aguet, F., Danuser, G. & Schmid, S. L., Jul 15 2011, In : Molecular biology of the cell. 22, 14, p. 2588-2600 13 p.

Research output: Contribution to journalArticle

76 Scopus citations
2010

A richer and more diverse future for cell biology.

Schmid, S. L., Carnes, M., Goodenough, U., Hopkins, N., Leboy, P., Masur, S., Valian, V. & ASCB Women in Cell Biology Committee, W. I. C. B. C., Nov 2010, In : Molecular biology of the cell. 21, 22, p. 3821-3822 2 p.

Research output: Contribution to journalArticle