Cell Biology - Division C

Research Output 1996 2018

2018
3 Citations (Scopus)

Lysosomal cholesterol export reconstituted from fragments of Niemann-Pick C1

Trinh, M. N., Brown, M. S., Seemann, J., Goldstein, J. L. & Lu, F., Jul 26 2018, In : eLife. 7, e38564.

Research output: Contribution to journalArticle

Cholesterol
Glycocalyx
Lipid Bilayers
Lysosomes
Molecules
2017
18 Citations (Scopus)
Cholesterol
Mutation
Proteins
Lysosomal Storage Diseases
Endosomes
1 Citation (Scopus)

Cell Labeling with Magneto-Endosymbionts and the Dissection of the Subcellular Location, Fate, and Host Cell Interactions

Lee, K. R., Wakeel, A., Chakraborty, P., Foote, C. S., Kajiura, L., Barrozo, J. C., Chan, A. C., Bazarov, A. V., Spitler, R., Kutny, P. M., Denegre, J. M., Taft, R. A., Seemann, J., Rice, B. W., Contag, C. H., Rutt, B. K. & Bell, C. B., Jun 19 2017, (Accepted/In press) In : Molecular Imaging and Biology. p. 1-10 10 p.

Research output: Contribution to journalArticle

Cell Communication
Dissection
Cell Tracking
Magnetic Resonance Imaging
Autophagy
19 Citations (Scopus)

Golgi ribbon disassembly during mitosis, differentiation and disease progression

Wei, J. H. & Seemann, J., Aug 1 2017, In : Current Opinion in Cell Biology. 47, p. 43-51 9 p.

Research output: Contribution to journalReview article

Microtubule-Organizing Center
Golgi Apparatus
Protein Transport
Mitosis
Disease Progression
2016
11 Citations (Scopus)

Geranylgeranyl-regulated transport of the prenyltransferase UBIAD1 between membranes of the ER and Golgi

Schumacher, M. M., Jun, D. J., Jo, Y., Seemann, J. & DeBose-Boyd, R. A., Jul 1 2016, In : Journal of Lipid Research. 57, 7, p. 1286-1299 14 p.

Research output: Contribution to journalArticle

Dimethylallyltranstransferase
Endoplasmic Reticulum
Membranes
Oxidoreductases
Proteins
16 Citations (Scopus)
Spindle Apparatus
Mitosis
M Phase Cell Cycle Checkpoints
Centrosome
Metaphase
2015
42 Citations (Scopus)

GM130 Regulates Golgi-Derived Spindle Assembly by Activating TPX2 and Capturing Microtubules

Wei, J. H., Zhang, Z. C., Wynn, R. M. & Seemann, J., Jul 18 2015, In : Cell. 162, 2, p. 287-299 13 p., 8260.

Research output: Contribution to journalArticle

Karyopherins
Microtubules
Membranes
Organelles
Aurora Kinase A
5 Citations (Scopus)

Sec13 Regulates Expression of Specific Immune Factors Involved in Inflammation In Vivo

Moreira, T. G., Zhang, L., Shaulov, L., Harel, A., Kuss, S. K., Williams, J., Shelton, J., Somatilaka, B., Seemann, J., Yang, J., Sakthivel, R., Nussenzveig, D. R., Faria, A. M. C. & Fontoura, B. M. A., Dec 3 2015, In : Scientific Reports. 5, 17655.

Research output: Contribution to journalArticle

Immunologic Factors
Inflammation
COP-Coated Vesicles
T-Lymphocytes
Nuclear Pore
26 Citations (Scopus)

The prenyltransferase UBIAD1 is the target of geranylgeraniol in degradation of HMG CoA reductase

Schumacher, M. M., Elsabrouty, R., Seemann, J., Jo, Y. & DeBose-Boyd, R. A., Mar 5 2015, In : eLife. 2015, 4, e05560.

Research output: Contribution to journalArticle

Dimethylallyltranstransferase
Hydroxymethylglutaryl CoA Reductases
Oxidoreductases
Degradation
Cholesterol
2014
24 Citations (Scopus)
Endoplasmic Reticulum-Associated Degradation
Sterols
Proteasome Endopeptidase Complex
Adenosine Triphosphatases
Oxidoreductases
2013
13 Citations (Scopus)

Chemical principles for the design of a novel fluorescent probe with high cancer-targeting selectivity and sensitivity

Kang, C. C., Huang, W. C., Kouh, C. W., Wang, Z. F., Cho, C. C., Chang, C. C., Wang, C. L., Chang, T. C., Seemann, J. & Huang, L. J. S., Oct 2013, In : Integrative Biology (United Kingdom). 5, 10, p. 1217-1228 12 p.

Research output: Contribution to journalArticle

Fluorescent Dyes
Cells
Neoplasms
Mitochondria
Lysosomes
15 Citations (Scopus)

Point mutation in luminal Loop 7 of scap protein blocks interaction with Loop 1 and abolishes movement to Golgi

Zhang, Y., Motamed, M., Seemann, J., Brown, M. S. & Goldstein, J. L., May 17 2013, In : Journal of Biological Chemistry. 288, 20, p. 14059-14067 9 p.

Research output: Contribution to journalArticle

Point Mutation
Endoplasmic Reticulum
Cholesterol
Sterol Regulatory Element Binding Proteins
Immunoprecipitation
2012
34 Citations (Scopus)

Modular organization of the mammalian Golgi apparatus

Nakamura, N., Wei, J. H. & Seemann, J., Aug 2012, In : Current Opinion in Cell Biology. 24, 4, p. 467-474 8 p.

Research output: Contribution to journalArticle

Secretory Pathway
Golgi Apparatus
Post Translational Protein Processing
Cell Division
2011
39 Citations (Scopus)

Golgi biogenesis

Wang, Y. & Seemann, J., Oct 2011, In : Cold Spring Harbor perspectives in biology. 3, 10, p. 1-12 12 p.

Research output: Contribution to journalArticle

Cells
Organelles
Membranes
Eukaryotic Cells
Mitosis
51 Citations (Scopus)

Identification of luminal loop 1 of scap protein as the sterol sensor that maintains cholesterol homeostasis

Motamed, M., Zhang, Y., Wang, M. L., Seemann, J., Kwon, H. J., Goldstein, J. L. & Brown, M. S., May 20 2011, In : Journal of Biological Chemistry. 286, 20, p. 18002-18012 11 p.

Research output: Contribution to journalArticle

Sterols
Homeostasis
Cholesterol
Sensors
Sterol Regulatory Element Binding Proteins
31 Citations (Scopus)

The membrane-bound transcription factor CREB3L1 is activated in response to virus infection to inhibit proliferation of virus-infected cells

Denard, B., Seemann, J., Chen, Q., Gay, A., Huang, H., Chen, Y. & Ye, J., Jul 21 2011, In : Cell Host and Microbe. 10, 1, p. 65-74 10 p.

Research output: Contribution to journalArticle

Virus Diseases
Transcription Factors
Hepacivirus
Viruses
West Nile virus
2010
31 Citations (Scopus)

A regulating role of the JAK2 FERM domain in hyperactivation of JAK2(V617F)

Zhao, L., Ma, Y., Seemann, J. & Huang, L. J. S., Feb 15 2010, In : Biochemical Journal. 426, 1, p. 91-98 8 p.

Research output: Contribution to journalArticle

TYK2 Kinase
Janus Kinase 2
Phosphotransferases
Mutation
Substrates
88 Citations (Scopus)

CDK5RAP2 regulates centriole engagement and cohesion in mice

Barrera, J. A., Kao, L. R., Hammer, R. E., Seemann, J., Fuchs, J. L. & Megraw, T. L., Mar 16 2010, In : Developmental Cell. 18, 6, p. 913-926 14 p.

Research output: Contribution to journalArticle

Centrioles
Amplification
Cells
Centrosome
Proteins
13 Citations (Scopus)

Nakiterpiosin targets tubulin and triggers mitotic catastrophe in human cancer cells

Wei, J. H. & Seemann, J., Dec 2010, In : Molecular Cancer Therapeutics. 9, 12, p. 3375-3385 11 p.

Research output: Contribution to journalArticle

Tubulin
Microtubules
Neoplasms
Centrosome
M Phase Cell Cycle Checkpoints
138 Citations (Scopus)

The differential regulation of cell motile activity through matrix stiffness and porosity in three dimensional collagen matrices

Miron-Mendoza, M., Seemann, J. & Grinnell, F., Sep 2010, In : Biomaterials. 31, 25, p. 6425-6435 11 p.

Research output: Contribution to journalArticle

Porosity
Stiffness matrix
Collagen
Cells
Cell Movement
57 Citations (Scopus)

Unraveling the Golgi ribbon

Wei, J. H. & Seemann, J., Nov 2010, In : Traffic. 11, 11, p. 1391-1400 10 p.

Research output: Contribution to journalArticle

Mitosis
Conformations
Animals
Cells
Golgi Apparatus
2009
10 Citations (Scopus)
Organelles
Cell Division
Microscopy
Microscopic examination
Cells
44 Citations (Scopus)

Mitotic division of the mammalian Golgi apparatus

Wei, J. H. & Seemann, J., Sep 2009, In : Seminars in Cell and Developmental Biology. 20, 7, p. 810-816 7 p.

Research output: Contribution to journalArticle

Golgi Apparatus
Organelles
Biological Phenomena
Secretory Pathway
Reproduction
6 Citations (Scopus)

Remodeling of the Golgi structure by ERK signaling

Wei, J. H. & Seemann, J., Jan 2009, In : Communicative and Integrative Biology. 2, 1, p. 35-36 2 p.

Research output: Contribution to journalArticle

phosphorylation
Phosphorylation
centrosomes
Centrosome
Mitogens
7 Citations (Scopus)

Spindle-dependent partitioning of the Golgi ribbon

Wei, J. H. & Seemann, J., 2009, In : Communicative and Integrative Biology. 2, 5, p. 406-407 2 p.

Research output: Contribution to journalArticle

mitotic spindle apparatus
Golgi apparatus
mitosis
Spindle Apparatus
Golgi Apparatus
70 Citations (Scopus)

Targeting sequences of UBXD8 and AAM-B reveal that the ER has a direct role in the emergence and regression of lipid droplets

Zehmer, J. K., Bartz, R., Bisel, B., Liu, P., Seemann, J. & Anderson, R. G. W., Oct 15 2009, In : Journal of Cell Science. 122, 20, p. 3694-3702 9 p.

Research output: Contribution to journalArticle

Endoplasmic Reticulum
Lipids
Proteins
Membranes
Secretory Pathway
38 Citations (Scopus)

The mitotic spindle mediates inheritance of the Golgi ribbon structure

Wei, J. H. & Seemann, J., Feb 9 2009, In : Journal of Cell Biology. 184, 3, p. 391-397 7 p.

Research output: Contribution to journalArticle

Spindle Apparatus
Spindle Poles
Microinjections
Tubulin
Mitosis
19 Citations (Scopus)

Vesicular stomatitis virus inhibits mitotic progression and triggers cell death

Chakraborty, P., Seemann, J., Mishra, R. K., Wei, J. H., Weil, L., Nussenzveig, D. R., Heiber, J., Barber, G. N., Dasso, M. & Fontoura, B. M. A., 2009, In : EMBO Reports. 10, 10, p. 1154-1160 7 p.

Research output: Contribution to journalArticle

Vesicular Stomatitis
Cell death
Viruses
Cell Death
Ribonucleoproteins
61 Citations (Scopus)

Viorio VopQ induces Pu-kmase-independent autophagy and antagonizes phagocytosis

Burdette, D. L., Seemann, J. & Orth, K., Aug 2009, In : Molecular Microbiology. 73, 4, p. 639-649 11 p.

Research output: Contribution to journalArticle

Autophagy
Phagocytosis
Vibrio parahaemolyticus
Cell Death
Chromosomes
2008
55 Citations (Scopus)

Collagen fibril flow and tissue translocation coupled to fibroblast migration in 3D collagen matrices

Miron-Mendoza, M., Seemann, J. & Grinnell, F., May 2008, In : Molecular Biology of the Cell. 19, 5, p. 2051-2058 8 p.

Research output: Contribution to journalArticle

Collagen
Fibroblasts
Cell Movement
Skin
Microscopy
114 Citations (Scopus)

ERK regulates Golgi and centrosome orientation towards the leading edge through GRASP65

Bisel, B., Wang, Y., Wei, J. H., Xiang, Y., Tang, D., Miron-Mendoza, M., Yoshimura, S. I., Nakamura, N. & Seemann, J., Sep 8 2008, In : Journal of Cell Biology. 182, 5, p. 837-843 7 p.

Research output: Contribution to journalArticle

Centrosome
Extracellular Signal-Regulated MAP Kinases
Brefeldin A
Cell Polarity
Interphase
50 Citations (Scopus)

Golgi cisternal unstacking stimulates COPI vesicle budding and protein transport

Wang, Y., Wei, J. H., Bisel, B., Tang, D. & Seemann, J., Feb 20 2008, In : PLoS One. 3, 2, e1647.

Research output: Contribution to journalArticle

Coat Protein Complex I
protein transport
Protein Transport
Membranes
Proteins
10 Citations (Scopus)

Mitotic regulation of SREBP and ATF6 by separation of the Golgi and ER

Bartz, R. & Seemann, J., Jul 15 2008, In : Cell Cycle. 7, 14, p. 2100-2105 6 p.

Research output: Contribution to journalArticle

Mitosis
Chemical activation
Transcription Factors
Unfolded Protein Response
Interphase
58 Citations (Scopus)

Nucleoporin Levels Regulate Cell Cycle Progression and Phase-Specific Gene Expression

Chakraborty, P., Wang, Y., Wei, J. H., van Deursen, J., Yu, H., Malureanu, L., Dasso, M., Forbes, D. J., Levy, D. E., Seemann, J. & Fontoura, B. M. A., Nov 11 2008, In : Developmental Cell. 15, 5, p. 657-667 11 p.

Research output: Contribution to journalArticle

Nuclear Pore Complex Proteins
Gene expression
Cell Cycle
Cells
Gene Expression
31 Citations (Scopus)

Spatial separation of Golgi and ER during mitosis protects SREBP from unregulated activation

Bartz, R., Sun, L. P., Bisel, B., Wei, J. H. & Seemann, J., Apr 9 2008, In : EMBO Journal. 27, 7, p. 948-955 8 p.

Research output: Contribution to journalArticle

Sterol Regulatory Element Binding Proteins
Mitosis
Endoplasmic Reticulum
Chemical activation
Transcription Factors
2007
30 Citations (Scopus)

Active ADP-ribosylation factor-1 (ARF1) is required for mitotic Golgi fragmentation

Xiang, Y., Seemann, J., Bisel, B., Punthambaker, S. & Wang, Y., Jul 27 2007, In : Journal of Biological Chemistry. 282, 30, p. 21829-21837 9 p.

Research output: Contribution to journalArticle

ADP-Ribosylation Factor 1
Mitosis
Coat Protein Complex I
Membranes
Cytosol
23 Citations (Scopus)

Evidence that mono-ADP-ribosylation of CtBP1/BARS regulates lipid storage

Bartz, R., Seemann, J., Zehmer, J. K., Serrero, G., Chapman, K. D., Anderson, R. G. W. & Liu, P., Aug 2007, In : Molecular Biology of the Cell. 18, 8, p. 3015-3025 11 p.

Research output: Contribution to journalArticle

Brefeldin A
Adenosine Diphosphate
Lipids
Unfolded Protein Response
Co-Repressor Proteins
179 Citations (Scopus)
Sterol Regulatory Element Binding Proteins
Sterols
Endoplasmic Reticulum
Cholesterol
Proteins
2003
127 Citations (Scopus)

A direct role for GRASP65 as a mitotically regulated Golgi stacking factor

Wang, Y., Seemann, J., Pypaert, M., Shorter, J. & Warren, G., Jul 1 2003, In : EMBO Journal. 22, 13, p. 3279-3290 12 p.

Research output: Contribution to journalArticle

Phosphotransferases
Cyclin B
Membranes
Cyclin B1
Phosphorylation

Erratum: A direct role for GRASP65 as a mitotically regulated golgi stacking factor (EMBO Journal (22) (3279-3290))

Wang, Y., Seemann, J., Pypaert, M., Shorter, J. & Warren, G., Aug 1 2003, In : EMBO Journal. 22, 15, p. 4026 1 p.

Research output: Contribution to journalArticle

2002
107 Citations (Scopus)

Partitioning of the matrix fraction of the golgi apparatus during mitosis in animal cells

Seemann, J., Pypaert, M., Taguchi, T., Malsam, J. & Warren, G., Feb 1 2002, In : Science. 295, 5556, p. 848-851 4 p.

Research output: Contribution to journalArticle

Golgi Apparatus
Mitosis
Brefeldin A
Mutant Proteins
Enzymes
154 Citations (Scopus)

Sequential tethering of Golgins and catalysis of SNAREpin assembly by the vesicle-tethering protein p115

Shorter, J., Beard, M. B., Seemann, J., Barbara Dirac-Svejstrup, A. & Warren, G., Apr 1 2002, In : Journal of Cell Biology. 157, 1, p. 45-62 18 p.

Research output: Contribution to journalArticle

SNARE Proteins
Catalysis
Coat Protein Complex I
Qa-SNARE Proteins
Proteins
2000
358 Citations (Scopus)

A complex of mammalian Ufd1 and Npl4 links the AAA-ATPase, p97, to ubiquitin and nuclear transport pathways

Meyer, H. H., Shorter, J. G., Seemann, J., Pappin, D. & Warren, G., May 15 2000, In : EMBO Journal. 19, 10, p. 2181-2192 12 p.

Research output: Contribution to journalArticle

Membrane Fusion
Cell Nucleus Active Transport
Ubiquitin
Fusion reactions
Membranes
207 Citations (Scopus)

Matrix proteins can generate the higher order architecture of the Golgi apparatus

Seemann, J., Jokitalo, E., Pypaert, M. & Warren, G., Oct 26 2000, In : Nature. 407, 6807, p. 1022-1026 5 p.

Research output: Contribution to journalArticle

Golgi Apparatus
Reticulum
Organelles
Proteins
Enzymes
140 Citations (Scopus)

Structural basis of the Ca2+-dependent association between S100C (S100A11) and its target, the N-terminal part of annexin I

Réty, S., Osterloh, D., Arié, J. P., Tabaries, S., Seeman, J., Russo-Marie, F., Gerke, V. & Lewit-Bentley, A., Feb 1 2000, In : Structure. 8, 2, p. 175-184 10 p.

Research output: Contribution to journalArticle

Annexin A1
S100 Proteins
Annexins
Peptides
Calcium-Binding Proteins
51 Citations (Scopus)

The amino-terminal domain of the golgi protein Giantin interacts directly with the vesicle-tethering protein p115

Lesa, G. M., Seemann, J., Shortert, J., Vandekerckhove, J. & Warren, G., Jan 28 2000, In : Journal of Biological Chemistry. 275, 4, p. 2831-2836 6 p.

Research output: Contribution to journalArticle

Membranes
Proteins
Protein Subunits
Reforming reactions
Mitosis
145 Citations (Scopus)

The role of the tethering proteins p115 and GM130 in transport through the Golgi apparatus in vivo

Seemann, J., Jokitalo, E. J. & Warren, G., Feb 2000, In : Molecular Biology of the Cell. 11, 2, p. 635-645 11 p.

Research output: Contribution to journalArticle

Golgi Apparatus
Transport Vesicles
Membranes
COP-Coated Vesicles
Proteins
1997
54 Citations (Scopus)

Annexin i targets S100C to early endosomes

Seemann, J., Weber, K. & Gerke, V., Aug 11 1997, In : FEBS Letters. 413, 1, p. 185-190 6 p.

Research output: Contribution to journalArticle

Annexin A1
Annexins
Endosomes
Membranes
Transferrin Receptors
93 Citations (Scopus)

Identification and characterization of a novel type of annexin-membrane interaction: Ca2+ is not required for the association of annexin II with early endosomes

Jost, M., Zeuschner, D., Seemann, J., Weber, K. & Gerke, V., Jan 1997, In : Journal of Cell Science. 110, 2, p. 221-228 8 p.

Research output: Contribution to journalArticle

Annexin A2
Annexins
Endosomes
Membranes
Subcellular Fractions
1996
69 Citations (Scopus)

Structural requirements for annexin I-S100C complex-formation

Seemann, J., Weber, K. & Gerke, V., 1996, In : Biochemical Journal. 319, 1, p. 123-129 7 p.

Research output: Contribution to journalArticle

Annexin A1
Tryptophan
Carrier Proteins
Annexin A2
Ligands