Cell Biology - Division L

Research Output

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Article
2020

High school science fair: Positive and negative outcomes

Grinnell, F., Dalley, S. & Reisch, J., 2020, In : PloS one. 15, 2, e0229237.

Research output: Contribution to journalArticle

Open Access
2019

Abduction in the everyday practice of science: the logic of unintended experiments

Grinnell, F., Jun 1 2019, In : Transactions of the Charles S Peirce Society. 55, 3, p. 215-227 13 p.

Research output: Contribution to journalArticle

2018

High school science fair: Student opinions regarding whether participation should be required or optional and why

Grinnell, F., Dalley, S., Shepherd, K. & Reisch, J., Aug 1 2018, In : PLoS One. 13, 8, e0202320.

Research output: Contribution to journalArticle

4 Scopus citations
2017
2 Scopus citations

Effects of dynamic matrix remodelling on en masse migration of fibroblasts on collagen matrices

Ozcelikkale, A., Dutton, J. C., Grinnell, F. & Han, B., Oct 1 2017, In : Journal of the Royal Society Interface. 14, 135, 20170287.

Research output: Contribution to journalArticle

4 Scopus citations

High school science fair and research integrity

Grinnell, F., Dalley, S., Shepherd, K. & Reisch, J., Mar 1 2017, In : PLoS One. 12, 3, e0174252.

Research output: Contribution to journalArticle

4 Scopus citations
4 Scopus citations
2015

PDGF-stimulated dispersal of cell clusters and disruption of fibronectin matrix on three-dimensional collagen matrices requires matrix metalloproteinase-2

Da Rocha-Azevedo, B., Ho, C. H. & Grinnell, F., Mar 15 2015, In : Molecular biology of the cell. 26, 6, p. 1098-1105 8 p.

Research output: Contribution to journalArticle

3 Scopus citations

Preservation of tissue microstructure and functionality during freezing by modulation of cytoskeletal structure

Park, S., Seawright, A., Park, S., Dutton, J. C., Grinnell, F. & Han, B., May 1 2015, In : Journal of the Mechanical Behavior of Biomedical Materials. 45, p. 32-44 13 p.

Research output: Contribution to journalArticle

8 Scopus citations

Rethink our approach to assessing risk

Grinnell, F., Jun 17 2015, In : Nature. 522, 7556, p. 257 1 p.

Research output: Contribution to journalArticle

7 Scopus citations
2014

The different roles of myosin IIA and myosin IIB in contraction of 3D collagen matrices by human fibroblasts

Liu, Z., Ho, C. H. & Grinnell, F., Aug 15 2014, In : Experimental Cell Research. 326, 2, p. 295-306 12 p.

Research output: Contribution to journalArticle

11 Scopus citations
2013

Activation of MRTF-A-dependent gene expression with a small molecule promotes myofibroblast differentiation and wound healing

Velasquez, L. S., Sutherland, L. B., Liu, Z., Grinnell, F., Kamm, K. E., Schneider, J. W., Olson, E. N. & Small, E. M., Oct 15 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 42, p. 16850-16855 6 p.

Research output: Contribution to journalArticle

69 Scopus citations

Fibroblast cluster formation on 3D collagen matrices requires cell contraction dependent fibronectin matrix organization

da Rocha-Azevedo, B., Ho, C. H. & Grinnell, F., Feb 15 2013, In : Experimental Cell Research. 319, 4, p. 546-555 10 p.

Research output: Contribution to journalArticle

21 Scopus citations

Research Integrity and Everyday Practice of Science

Grinnell, F., Sep 1 2013, In : Science and Engineering Ethics. 19, 3, p. 685-701 17 p.

Research output: Contribution to journalArticle

9 Scopus citations

The effect of growth factor environment on fibroblast morphological response to substrate stiffness

Grinnell, F. & Ho, C. H., Jan 1 2013, In : Biomaterials. 34, 4, p. 965-974 10 p.

Research output: Contribution to journalArticle

21 Scopus citations

Thermomechanical analysis of freezing-induced cell-fluid-matrix interactions in engineered tissues

Han, B., Teo, K. Y., Ghosh, S., Dutton, J. C. & Grinnell, F., Feb 1 2013, In : Journal of the Mechanical Behavior of Biomedical Materials. 18, p. 67-80 14 p.

Research output: Contribution to journalArticle

8 Scopus citations
2011

Effects of freezing-induced cell-fluid-matrix interactions on the cells and extracellular matrix of engineered tissues

Teo, K. Y., DeHoyos, T. O., Dutton, J. C., Grinnell, F. & Han, B., Aug 1 2011, In : Biomaterials. 32, 23, p. 5380-5390 11 p.

Research output: Contribution to journalArticle

34 Scopus citations

The evolution of credibility

Grinnell, F., Feb 1 2011, In : Scientist. 25, 2, 1 p.

Research output: Contribution to journalArticle

2010

Promigratory and procontractile growth factor environments differentially regulate cell morphogenesis

Rhee, S., Ho, C. H. & Grinnell, F., Jan 15 2010, In : Experimental Cell Research. 316, 2, p. 232-244 13 p.

Research output: Contribution to journalArticle

21 Scopus citations

The differential regulation of cell motile activity through matrix stiffness and porosity in three dimensional collagen matrices

Miron-Mendoza, M., Seemann, J. & Grinnell, F., Sep 1 2010, In : Biomaterials. 31, 25, p. 6425-6435 11 p.

Research output: Contribution to journalArticle

148 Scopus citations
2008

Collagen fibril flow and tissue translocation coupled to fibroblast migration in 3D collagen matrices

Miron-Mendoza, M., Seemann, J. & Grinnell, F., May 1 2008, In : Molecular biology of the cell. 19, 5, p. 2051-2058 8 p.

Research output: Contribution to journalArticle

56 Scopus citations

Distinguishing fibroblast promigratory and procontractile growth factor environments in 3-D collagen matrices

Jiang, H., Rhee, S., Ho, C. H. & Grinnell, F., Jul 1 2008, In : FASEB Journal. 22, 7, p. 2151-2160 10 p.

Research output: Contribution to journalArticle

38 Scopus citations

Fibroblast mechanics in three-dimensional collagen matrices

Grinnell, F., Jul 1 2008, In : Journal of Bodywork and Movement Therapies. 12, 3, p. 191-193 3 p.

Research output: Contribution to journalArticle

35 Scopus citations

Oncogenic Ras-transformed human fibroblasts exhibit differential changes in contraction and migration in 3D collagen matrices

Menezes, G. C., Miron-Mendoza, M., Ho, C. H., Jiang, H. & Grinnell, F., Oct 1 2008, In : Experimental Cell Research. 314, 16, p. 3081-3091 11 p.

Research output: Contribution to journalArticle

20 Scopus citations
2007
106 Scopus citations
2006

Nested collagen matrices: A new model to study migration of human fibroblast populations in three dimensions

Grinnell, F., B. Rocha, L., Iucu, C., Rhee, S. & Jiang, H., Jan 1 2006, In : Experimental Cell Research. 312, 1, p. 86-94 9 p.

Research output: Contribution to journalArticle

83 Scopus citations

P21-activated kinase 1: Convergence point in PDGF- and LPA-stimulated collagen matrix contraction by human broblasts

Rhee, S. & Grinnell, F., Jan 30 2006, In : Journal of Cell Biology. 172, 3, p. 423-432 10 p.

Research output: Contribution to journalArticle

55 Scopus citations
2005

Cell-matrix entanglement and mechanical anchorage of fibroblasts in three-dimensional collagen matrices

Jiang, H. & Grinnell, F., Nov 1 2005, In : Molecular biology of the cell. 16, 11, p. 5070-5076 7 p.

Research output: Contribution to journalArticle

74 Scopus citations
2004

Human embryo research: From moral uncertainty to death

Grinnell, F., Dec 2004, In : American Journal of Bioethics. 4, 1, p. 12-11 2 p.

Research output: Contribution to journalArticle

3 Scopus citations
2003

Dendritic fibroblasts in three-dimensional collagen matrices

Grinnell, F., Ho, C. H., Tamariz, E., Lee, D. J. & Skuta, G., Feb 1 2003, In : Molecular biology of the cell. 14, 2, p. 384-395 12 p.

Research output: Contribution to journalArticle

160 Scopus citations
48 Scopus citations

Fibroblast quiescence in floating collagen matrices. Decrease in serum activation of MEK and Raf but not Ras

Fringer, J. & Grinnell, F., Jun 6 2003, In : Journal of Biological Chemistry. 278, 23, p. 20612-20617 6 p.

Research output: Contribution to journalArticle

40 Scopus citations
25 Scopus citations
2002

Modulation of fibroblast morphology and adhesion during collagen matrix remodeling

Tamariz, E. & Grinnell, F., Nov 1 2002, In : Molecular biology of the cell. 13, 11, p. 3915-3929 15 p.

Research output: Contribution to journalArticle

187 Scopus citations
96 Scopus citations
2001
77 Scopus citations
2000

Activation of ERK and p38 MAP kinases in human fibroblasts during collagen matrix contraction

Lee, D. J., Rosenfeldt, H. & Grinnell, F., May 25 2000, In : Experimental Cell Research. 257, 1, p. 190-197 8 p.

Research output: Contribution to journalArticle

44 Scopus citations

Fibroblast-collagen-matrix contraction: growth-factor signalling and mechanical loading

Grinnell, F., Sep 1 2000, In : Trends in Cell Biology. 10, 9, p. 362-365 4 p.

Research output: Contribution to journalArticle

311 Scopus citations

Fibroblast quiescence and the disruption of ERK signaling in mechanically unloaded collagen matrices

Rosenfeldt, H. & Grinnell, F., Feb 4 2000, In : Journal of Biological Chemistry. 275, 5, p. 3088-3092 5 p.

Research output: Contribution to journalArticle

75 Scopus citations
1999

Ambiguity, Trust, and the Responsible Conduct of Research

Grinnell, F., Jan 1 1999, In : Science and Engineering Ethics. 5, 2, p. 205-214 10 p.

Research output: Contribution to journalArticle

9 Scopus citations

Differences in the regulation of fibroblast contraction of floating versus stressed collagen matrices

Grinnell, F., Ho, C. H., Lin, Y. C. & Skuta, G., Jan 8 1999, In : Journal of Biological Chemistry. 274, 2, p. 918-923 6 p.

Research output: Contribution to journalArticle

148 Scopus citations

Increased myosin light chain phosphorylation is not required for growth factor stimulation of collagen matrix contraction

Skuta, G., Ho, C. H. & Grinnell, F., Oct 15 1999, In : Journal of Biological Chemistry. 274, 42, p. 30163-30168 6 p.

Research output: Contribution to journalArticle

25 Scopus citations

Release of mechanical tension triggers apoptosis of human fibroblasts in a model of regressing granulation tissue

Grinnell, F., Zhu, M., Carlson, M. A. & Abrams, J. M., May 1 1999, In : Experimental Cell Research. 248, 2, p. 608-619 12 p.

Research output: Contribution to journalArticle

218 Scopus citations
1998

Collagenase-1 complexes with α2-macroglobulin in the acute and chronic wound environments

Grinnell, F., Zhu, M. & Parks, W. C., 1998, In : Journal of Investigative Dermatology. 110, 5, p. 771-776 6 p.

Research output: Contribution to journalArticle

33 Scopus citations

Decreased PDGF receptor kinase activity in fibroblasts contracting stressed collagen matrices

Lin, Y. C., Ho, C. H. & Grinnell, F., May 1 1998, In : Experimental Cell Research. 240, 2, p. 377-387 11 p.

Research output: Contribution to journalArticle

15 Scopus citations

Identification of proteinase 3 as the major caseinolytic activity in acute human wound fluid

He, Y., Young, P. K. & Grinnell, F., 1998, In : Journal of Investigative Dermatology. 110, 1, p. 67-71 5 p.

Research output: Contribution to journalArticle

16 Scopus citations

Increased c-fos mRNA expression by human fibroblasts contracting stressed collagen matrices

Rosenfeldt, H., Lee, D. J. & Grinnell, F., May 1998, In : Molecular and cellular biology. 18, 5, p. 2659-2667 9 p.

Research output: Contribution to journalArticle

Open Access
34 Scopus citations
1997
31 Scopus citations

Truth, fairness, and the definition of scientific misconduct

Grinnell, F., Feb 1997, In : Journal of Laboratory and Clinical Medicine. 129, 2, p. 189-192 4 p.

Research output: Contribution to journalArticle

3 Scopus citations
1996
Open Access
153 Scopus citations