Cell Biology - Division S

Research Output

2020

MAP9 loss triggers chromosomal instability, initiates colorectal tumorigenesis, and is associated with poor survival of patients with colorectal cancer

Wang, S., Huang, J., Li, C., Zhao, L., Wong, C. C., Zhai, J., Zhou, Y., Deng, W., Zeng, Y., Gao, S., Zhang, Y., Wang, G., Guan, X. Y., Wei, H., Wong, S. H., He, H. H., Shay, J. W. & Yu, J., Feb 1 2020, In : Clinical Cancer Research. 26, 3, p. 746-757 12 p.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Proliferation of adult human bronchial epithelial cells without a telomere maintenance mechanism for over 200 population doublings

Peters-Hall, J. R., Min, J., Tedone, E., Sho, S., Siteni, S., Mender, I. & Shay, J. W., Jan 1 2020, In : FASEB Journal. 34, 1, p. 386-398 13 p.

Research output: Contribution to journalArticle

Open Access

TRA-1-60-positive/CD45low cells found in the peripheral blood of prostate cancer patients with metastatic disease – A proof-of-concept study

Schäfer, C., Ju, Y., Tak, Y., Vazquez, C., Han, S. J., Tan, E., Shay, J. W., Holmqvist, M., Danuser, G., Schopperle, W. M. & Bubley, G., Jan 2020, In : Heliyon. 6, 1, e03263.

Research output: Contribution to journalArticle

Open Access
2019

2D gel electrophoresis reveals dynamics of t-loop formation during the cell cycle and t-loop in maintenance regulated by heterochromatin state

Zhang, Z., Zhang, T., Ge, Y., Tang, M., Ma, W., Zhang, Q., Gong, S., Wright, W. E., Shay, J., Liu, H. & Zhao, Y., Apr 19 2019, In : Journal of Biological Chemistry. 294, 16, p. 6645-6656 12 p.

Research output: Contribution to journalArticle

Catalysis-dependent inactivation of human telomerase and its reactivation by intracellular telomerase-activating factors (iTAFs)

Sayed, M. E., Cheng, A., Yadav, G. P., Ludlow, A. T., Shay, J. W., Wright, W. E. & Jiang, Q. X., Jul 26 2019, In : Journal of Biological Chemistry. 294, 30, p. 11579-11596 18 p.

Research output: Contribution to journalArticle

Open Access

Clustered telomeres in phase-separated nuclear condensates engage mitotic DNA synthesis through BLM and RAD52

Min, J., Wright, W. E. & Shay, J. W., Jul 1 2019, In : Genes & development. 33, 13-14, p. 814-827 14 p.

Research output: Contribution to journalArticle

Open Access
9 Scopus citations

Decellularized mice colons as models to study the contribution of the extracellular matrix to cell behavior and colon cancer progression

Alabi, B. R., LaRanger, R. & Shay, J. W., Jan 1 2019, (Accepted/In press) In : Acta Biomaterialia.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Induction of LEF1 by MYC activates the WNT pathway and maintains cell proliferation

Hao, Y. H., Lafita-Navarro, M. C., Zacharias, L., Borenstein-Auerbach, N., Kim, M., Barnes, S., Kim, J., Shay, J., Deberardinis, R. J. & Conacci-Sorrell, M., Oct 17 2019, In : Cell Communication and Signaling. 17, 1, 129.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Infection with genotoxin-producing Salmonella enterica synergises with loss of the tumour suppressor APC in promoting genomic instability via the PI3K pathway in colonic epithelial cells

Martin, O. C. B., Bergonzini, A., D'Amico, F., Chen, P., Shay, J. W., Dupuy, J., Svensson, M., Masucci, M. G. & Frisan, T., Dec 1 2019, In : Cellular Microbiology. 21, 12, e13099.

Research output: Contribution to journalArticle

Open Access

In perspective: An update on telomere targeting in cancer

Sugarman, E. T., Zhang, G. & Shay, J. W., Jan 1 2019, In : Molecular Carcinogenesis. 58, 9, p. 1581-1588 8 p.

Research output: Contribution to journalArticle

6 Scopus citations

Lung cancer progression using fast switching multiple ion beam radiation and countermeasure prevention

Luitel, K., Kim, S. B., Barron, S., Richardson, J. A. & Shay, J. W., Jan 1 2019, (Accepted/In press) In : Life Sciences in Space Research.

Research output: Contribution to journalArticle

MYC promotes tryptophan uptake and metabolism by the kynurenine pathway in colon cancer

Venkateswaran, N., Lafita-Navarro, M. C., Hao, Y. H., Kilgore, J. A., Perez-Castro, L., Braverman, J., Borenstein-Auerbach, N., Kim, M., Lesner, N. P., Mishra, P., Brabletz, T., Shay, J. W., DeBerardinis, R. J., Williams, N. S., Yilmaz, O. H. & Conacci-Sorrell, M., Sep 1 2019, In : Genes & development. 33, 17-18, p. 1236-1251 16 p.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Quantitative mitochondrial DNA copy number determination using droplet digital PCR with single-cell resolution

O'Hara, R., Tedone, E., Ludlow, A., Huang, E., Arosio, B., Mari, D. & Shay, J. W., Jan 1 2019, In : Genome Research. 29, 11, p. 1878-1888 11 p.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Telomere clustering drives ALT

Min, J. & Shay, J. W., Jan 1 2019, In : Aging. 11, 19, p. 8046-8047 2 p.

Research output: Contribution to journalEditorial

Telomere length and telomerase activity in T cells are biomarkers of high-performing centenarians

Tedone, E., Huang, E., O’Hara, R., Batten, K., Ludlow, A. T., Lai, T. P., Arosio, B., Mari, D., Wright, W. E. & Shay, J. W., Feb 1 2019, In : Aging Cell. 18, 1, e12859.

Research output: Contribution to journalArticle

Open Access
6 Scopus citations

Telomeres and telomerase: three decades of progress

Shay, J. W. & Wright, W. E., Jan 1 2019, In : Nature Reviews Genetics.

Research output: Contribution to journalArticle

42 Scopus citations

Transient introduction of human telomerase mRNA improves hallmarks of progeria cells

Li, Y., Zhou, G., Bruno, I. G., Zhang, N., Sho, S., Tedone, E., Lai, T. P., Cooke, J. P. & Shay, J. W., Aug 2019, In : Aging Cell. 18, 4, e12979.

Research output: Contribution to journalArticle

Open Access
4 Scopus citations
2018

Cholesterol depletion by tasin-1 induces apoptotic cell death through the er stress/ ros/jnk signaling in colon cancer cells

Zhang, L., Kim, S. B., Luitel, K. & Shay, J. W., May 1 2018, In : Molecular Cancer Therapeutics. 17, 5, p. 943-951 9 p.

Research output: Contribution to journalArticle

9 Scopus citations

Comparison of telomere length measurement methods

Lai, T. P., Wright, W. E. & Shay, J. W., Mar 5 2018, In : Philosophical Transactions of the Royal Society B: Biological Sciences. 373, 1741, 20160451.

Research output: Contribution to journalReview article

29 Scopus citations

DdTRAP: A method for sensitive and precise quantification of telomerase activity

Ludlow, A. T., Shelton, D., Wright, W. E. & Shay, J. W., Jan 1 2018, Methods in Molecular Biology. Humana Press Inc., p. 513-529 17 p. (Methods in Molecular Biology; vol. 1768).

Research output: Chapter in Book/Report/Conference proceedingChapter

3 Scopus citations

Exploiting TERT dependency as a therapeutic strategy for NRAS-mutant melanoma

Reyes-Uribe, P., Adrianzen-Ruesta, M. P., Deng, Z., Echevarria-Vargas, I., Mender, I., Saheb, S., Liu, Q., Altieri, D. C., Murphy, M. E., Shay, J. W., Lieberman, P. M. & Villanueva, J., Apr 26 2018, (Accepted/In press) In : Oncogene. p. 1-15 15 p.

Research output: Contribution to journalArticle

11 Scopus citations

Expression of contactin 4 is associated with malignant behavior in pheochromocytomas and paragangliomas

Evenepoel, L., Van Nederveen, F. H., Oudijk, L., Papathomas, T. G., Restuccia, D. F., Belt, E. J. T., De Herder, W. W., Feelders, R. A., Franssen, G. J. H., Hamoir, M., Maiter, D., Ghayee, H. K., Shay, J. W., Perren, A., Timmers, H. J. L. M., Van Eeden, S., Vroonen, L., Aydin, S., Robledo, M., Vikkula, M. & 4 others, De Krijger, R. R., Dinjens, W. N. M., Persu, A. & Korpershoek, E., Jan 1 2018, In : Journal of Clinical Endocrinology and Metabolism. 103, 1, p. 46-55 10 p.

Research output: Contribution to journalArticle

5 Scopus citations

Induced telomere damage to treat telomerase expressing therapy-resistant pediatric brain tumors

Sengupta, S., Sobo, M., Lee, K., Kumar, S. S., White, A. R., Mender, I., Fuller, C., Chow, L. M. L., Fouladi, M., Shay, J. W. & Drissi, R., Jul 1 2018, In : Molecular Cancer Therapeutics. 17, 7, p. 1504-1514 11 p.

Research output: Contribution to journalArticle

9 Scopus citations

Inducing rapid telomere irreparable damage in telomerase-expressing cancers

Zhang, G. & Shay, J. W., Nov 1 2018, In : Oncotarget. 9, 88, p. 35803-35804 2 p.

Research output: Contribution to journalEditorial

Induction of telomere dysfunction prolongs disease control of therapy-resistant melanoma

Zhang, G., Wu, L. W., Mender, I., Barzily-Rokni, M., Hammond, M. R., Ope, O., Cheng, C., Vasilopoulos, T., Randell, S., Sadek, N., Beroard, A., Xiao, M., Tian, T., Tan, J., Saeed, U., Sugarman, E., Krepler, C., Brafford, P., Sproesser, K., Murugan, S. & 24 others, Somasundaram, R., Garman, B., Wubbenhorst, B., Woo, J., Yin, X., Liu, Q., Frederick, D. T., Miao, B., Xu, W., Karakousis, G. C., Xu, X., Schuchter, L. M., Mitchell, T. C., Kwong, L. N., Amaravadi, R. K., Lu, Y., Boland, G. M., Wei, Z., Nathanson, K., Herbig, U., Mills, G. B., Flaherty, K. T., Herlyn, M. & Shay, J. W., Oct 1 2018, In : Clinical Cancer Research. 24, 19, p. 4771-4784 14 p.

Research output: Contribution to journalArticle

10 Scopus citations
15 Scopus citations

Long-term culture and cloning of primary human bronchial basal cells that maintain multipotent differentiation capacity and CFTR channel function

Peters-Hall, J. R., Coquelin, M. L., Torres, M. J., Laranger, R., Alabi, B. R., Sho, S., Calva-Moreno, J. F., Thomas, P. J. & Shay, J. W., Aug 2018, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 315, 2, p. L313-L327

Research output: Contribution to journalArticle

8 Scopus citations

NOVA1 regulates hTERT splicing and cell growth in non-small cell lung cancer

Ludlow, A. T., Wong, M. S., Robin, J. D., Batten, K., Yuan, L., Lai, T. P., Dahlson, N., Zhang, L., Mender, I., Tedone, E., Sayed, M. E., Wright, W. E. & Shay, J. W., Dec 1 2018, In : Nature communications. 9, 1, 3112.

Research output: Contribution to journalArticle

11 Scopus citations

Proton radiation-induced cancer progression

Luitel, K., Bozeman, R., Kaisani, A., Kim, S. B., Barron, S., Richardson, J. A. & Shay, J. W., Jan 1 2018, (Accepted/In press) In : Life Sciences in Space Research.

Research output: Contribution to journalArticle

1 Scopus citations

Reconstituting Mouse Lungs with Conditionally Reprogrammed Human Bronchial Epithelial Cells

Laranger, R., Peters-Hall, J. R., Coquelin, M., Alabi, B. R., Chen, C. T., Wright, W. E. & Shay, J. W., Apr 1 2018, In : Tissue Engineering - Part A. 24, 7-8, p. 559-568 10 p.

Research output: Contribution to journalArticle

8 Scopus citations

Reflections on telomere dynamics and ageing-related diseases in humans

Aviv, A. & Shay, J. W., Mar 5 2018, In : Philosophical Transactions of the Royal Society B: Biological Sciences. 373, 1741, 20160436.

Research output: Contribution to journalArticle

37 Scopus citations

Silencing the snail-dependent RNA splice regulator ESRP1 drives malignant transformation of human pulmonary epithelial cells

Walser, T. C., Jing, Z., Tran, L. M., Lin, Y. Q., Yakobian, N., Wang, G., Krysan, K., Zhu, L. X., Sharma, S., Lee, M. H., Belperio, J. A., Ooi, A. T., Gomperts, B. N., Shay, J. W., Larsen, J. E., Minna, J. D., Hong, L. S., Fishbein, M. C. & Dubinett, S. M., Apr 15 2018, In : Cancer Research. 78, 8, p. 1986-1999 14 p.

Research output: Contribution to journalArticle

3 Scopus citations

Telomerase-Mediated Strategy for Overcoming Non–Small Cell Lung Cancer Targeted Therapy and Chemotherapy Resistance

Mender, I., LaRanger, R., Luitel, K., Peyton, M., Girard, L., Lai, T. P., Batten, K., Cornelius, C., Dalvi, M. P., Ramirez, M., Du, W., Wu, L. F., Altschuler, S. J., Brekken, R., Martinez, E. D., Minna, J. D., Wright, W. E. & Shay, J. W., Aug 1 2018, In : Neoplasia (United States). 20, 8, p. 826-837 12 p.

Research output: Contribution to journalArticle

7 Scopus citations

Telomere length-dependent transcription and epigenetic modifications in promoters remote from telomere ends

Mukherjee, A. K., Sharma, S., Sengupta, S., Saha, D., Kumar, P., Hussain, T., Srivastava, V., Roy, S. D., Shay, J. W. & Chowdhury, S., Nov 1 2018, In : PLoS Genetics. 14, 11, e1007782.

Research output: Contribution to journalArticle

7 Scopus citations

Telomeres and aging

Shay, J. W., Jun 1 2018, In : Current Opinion in Cell Biology. 52, p. 1-7 7 p.

Research output: Contribution to journalReview article

24 Scopus citations

The aryl hydrocarbon receptor regulates nucleolar activity and protein synthesis in MYC-expressing cells

Lafita-Navarro, M. C., Kim, M., Borenstein-Auerbach, N., Venkateswaran, N., Hao, Y. H., Ray, R., Brabletz, T., Scaglioni, P. P., Shay, J. W. & Conacci-Sorrell, M., Oct 1 2018, In : Genes & development. 32, 19-20, p. 1303-1308 6 p.

Research output: Contribution to journalArticle

3 Scopus citations

Truncated adenomatous polyposis coli mutation induces Asef-activated Golgi fragmentation

Kim, S. B., Zhang, L., Yoon, J., Lee, J., Min, J., Li, W., Grishin, N. V., Moon, Y. A., Wright, W. E. & Shay, J. W., Sep 1 2018, In : Molecular and cellular biology. 38, 17, e00135-18.

Research output: Contribution to journalArticle

1 Scopus citations
2017

Alternative lengthening of telomeres can be maintained by preferential elongation of lagging strands

Min, J., Wright, W. E. & Shay, J. W., Mar 17 2017, In : Nucleic acids research. 45, 5, p. 2615-2628 14 p.

Research output: Contribution to journalArticle

23 Scopus citations

Alternative lengthening of telomeres mediated by mitotic DNA synthesis engages breakinduced replication processes

Min, J., Wright, W. E. & Shay, J. W., Oct 1 2017, In : Molecular and Cellular Biology. 37, 20, e00226-17.

Research output: Contribution to journalArticle

49 Scopus citations

A method for measuring the distribution of the shortest telomeres in cells and tissues

Lai, T. P., Zhang, N., Noh, J., Mender, I., Tedone, E., Huang, E., Wright, W. E., Danuser, G. & Shay, J. W., Dec 1 2017, In : Nature Communications. 8, 1, 1356.

Research output: Contribution to journalArticle

25 Scopus citations

Amplification of F-Actin Disassembly and Cellular Repulsion by Growth Factor Signaling

Yoon, J., Kim, S. B., Ahmed, G., Shay, J. W. & Terman, J. R., 2017, (Accepted/In press) In : Developmental Cell.

Research output: Contribution to journalArticle

11 Scopus citations

c9orf72 Disease-Related Foci Are Each Composed of One Mutant Expanded Repeat RNA

Liu, J., Hu, J., Ludlow, A. T., Pham, J. T., Shay, J. W., Rothstein, J. D. & Corey, D. R., Feb 16 2017, In : Cell Chemical Biology. 24, 2, p. 141-148 8 p.

Research output: Contribution to journalArticle

16 Scopus citations

Multiple Roles of APC and its Therapeutic Implications in Colorectal Cancer

Zhang, L. & Shay, J. W., Aug 1 2017, In : Journal of the National Cancer Institute. 109, 8, djw332.

Research output: Contribution to journalReview article

46 Scopus citations

Mutations, Cancer and the Telomere Length Paradox

Aviv, A., Anderson, J. J. & Shay, J. W., Apr 1 2017, In : Trends in Cancer. 3, 4, p. 253-258 6 p.

Research output: Contribution to journalReview article

29 Scopus citations

New insights into melanoma development

Shay, J. W., Sep 29 2017, In : Science. 357, 6358, p. 1358-1359 2 p.

Research output: Contribution to journalShort survey

7 Scopus citations

Non-malignant respiratory epithelial cells preferentially proliferate from resected non-small cell lung cancer specimens cultured under conditionally reprogrammed conditions

Gao, B., Huang, C., Kernstine, K., Pelekanou, V., Kluger, Y., Jiang, T., Peters-Hall, J. R., Coquelin, M., Girard, L., Zhang, W., Huffman, K., Oliver, D., Kinose, F., Haura, E., Teer, J. K., Rix, U., Le, A. T., Aisner, D. L., Varella-Garcia, M., Doebele, R. C. & 10 others, Covington, K. R., Hampton, O. A., Doddapaneni, H. V., Jayaseelan, J. C., Hu, J., Wheeler, D. A., Shay, J. W., Rimm, D. L., Gazdar, A. & Minna, J. D., Jan 1 2017, In : Oncotarget. 8, 7, p. 11114-11126 13 p.

Research output: Contribution to journalArticle

6 Scopus citations

Resveratrol reverses the Warburg effect by targeting the pyruvate dehydrogenase complex in colon cancer cells

Saunier, E., Antonio, S., Regazzetti, A., Auzeil, N., Laprévote, O., Shay, J. W., Coumoul, X., Barouki, R., Benelli, C., Huc, L. & Bortoli, S., Dec 1 2017, In : Scientific reports. 7, 1, 7006.

Research output: Contribution to journalArticle

24 Scopus citations

Telomere G-rich overhang length measurement: DSN method

Zhao, Y., Shay, J. W. & Wright, W. E., 2017, Methods in Molecular Biology. Humana Press Inc., Vol. 1587. p. 55-62 8 p. (Methods in Molecular Biology; vol. 1587).

Research output: Chapter in Book/Report/Conference proceedingChapter

Telomere terminal G/C strand synthesis: Measuring telomerase action and C-rich fill-in

Zhao, Y., Shay, J. W. & Wright, W. E., 2017, Methods in Molecular Biology. Humana Press Inc., Vol. 1587. p. 71-82 12 p. (Methods in Molecular Biology; vol. 1587).

Research output: Chapter in Book/Report/Conference proceedingChapter