Cell Biology - Division T

Research Output 1965 2019

2019

Transient Internalization and Microtubule-Dependent Trafficking of a Ciliary Signaling Receptor from the Plasma Membrane to the Cilium

Ranjan, P., Awasthi, M. & Snell, W. J., Sep 9 2019, In : Current Biology. 29, 17, p. 2942-2947.e2

Research output: Contribution to journalArticle

Cilia
cilia
Cell membranes
Microtubules
microtubules
2018
2 Citations (Scopus)

Fusion surface structure, function, and dynamics of gamete fusogen HAP2

Feng, J., Dong, X., Pinello, J., Zhang, J., Lu, C., Iacob, R. E., Engen, J. R., Snell, W. J. & Springer, T. A., Oct 3 2018, In : eLife. 7

Research output: Contribution to journalArticle

Chlamydomonas
Germ Cells
Surface structure
Fusion reactions
Deuterium
2017
14 Citations (Scopus)

Targeting the Conserved Fusion Loop of HAP2 Inhibits the Transmission of Plasmodium berghei and falciparum

Angrisano, F., Sala, K. A., Da, D. F., Liu, Y., Pei, J., Grishin, N. V., Snell, W. J. & Blagborough, A. M., Dec 5 2017, In : Cell Reports. 21, 10, p. 2868-2878 11 p.

Research output: Contribution to journalArticle

Plasmodium berghei
Antimalarials
Plasmodium falciparum
Fusion reactions
Germ Cells
48 Citations (Scopus)

The Ancient Gamete Fusogen HAP2 Is a Eukaryotic Class II Fusion Protein

Fédry, J., Liu, Y., Péhau-Arnaudet, G., Pei, J., Li, W., Tortorici, M. A., Traincard, F., Meola, A., Bricogne, G., Grishin, N. V., Snell, W. J., Rey, F. A. & Krey, T., Feb 23 2017, In : Cell. 168, 5, p. 904-915.e10

Research output: Contribution to journalArticle

Germ Cells
Fusion reactions
Plasmodium
Proteins
Viral Matrix Proteins
2016
23 Citations (Scopus)

Endogenous B-ring oxysterols inhibit the hedgehog component smoothened in a manner distinct from cyclopamine or side-chain oxysterols

Sever, N., Mann, R. K., Xu, L., Snell, W. J., Hernandez-Lara, C. I., Porter, N. A. & Beachy, P. A., May 24 2016, In : Proceedings of the National Academy of Sciences of the United States of America. 113, 21, p. 5904-5909 6 p.

Research output: Contribution to journalArticle

Smith-Lemli-Opitz Syndrome
Lipids
Ergosterol
Chlamydomonas reinhardtii
Inborn Genetic Diseases
2015
10 Citations (Scopus)

Characterization, mutagenesis and mechanistic analysis of an ancient algal sterol C24-methyltransferase: Implications for understanding sterol evolution in the green lineage

Haubrich, B. A., Collins, E. K., Howard, A. L., Wang, Q., Snell, W. J., Miller, M. B., Thomas, C. D., Pleasant, S. K. & Nes, W. D., May 17 2015, In : Phytochemistry. 113, p. 64-72 9 p.

Research output: Contribution to journalArticle

Mutagenesis
methyltransferases
Methyltransferases
Sterols
mutagenesis
19 Citations (Scopus)
Membrane Fusion Proteins
Chlamydomonas
Germ Cells
Membranes
Proteins
44 Citations (Scopus)

Uni-directional ciliary membrane protein trafficking by a cytoplasmic retrograde IFT motor and ciliary ectosome shedding

Cao, M., Ning, J., Hernandez-Lara, C. I., Belzile, O., Wang, Q., Dutcher, S. K., Liu, Y. & Snell, W. J., Feb 17 2015, In : eLife. 2015, 4

Research output: Contribution to journalArticle

Cell-Derived Microparticles
Cilia
Protein Transport
Membrane Proteins
Membranes
2014
4 Citations (Scopus)

Fertilization: A sticky sperm protein in plants

Dresselhaus, T. & Snell, W. J., Feb 17 2014, In : Current Biology. 24, 4

Research output: Contribution to journalArticle

Plant Proteins
plant proteins
Fertilization
Germ Cells
Spermatozoa
5 Citations (Scopus)

Organelle size: A cilium length signal regulates IFT cargo loading

Pan, J. & Snell, W. J., Jan 20 2014, In : Current Biology. 24, 2

Research output: Contribution to journalArticle

Organelle Size
Cilia
cilia
Machinery
organelles
2013
32 Citations (Scopus)
Organelle Size
Protein Kinases
Phosphorylation
Flagella
Chlamydomonas
35 Citations (Scopus)

Comparative genomics in Chlamydomonas and Plasmodium identifies an ancient nuclear envelope protein family essential for sexual reproduction in protists, fungi, plants, and vertebrates

Ning, J., Otto, T. D., Pfander, C., Schwach, F., Brochet, M., Bushell, E., Goulding, D., Sanders, M., Lefebvre, P. A., Pei, J., Grishin, N. V., Vanderlaan, G., Billker, O. & Snell, W. J., May 15 2013, In : Genes and Development. 27, 10, p. 1198-1215 18 p.

Research output: Contribution to journalArticle

Chlamydomonas
Plasmodium
Nuclear Envelope
Nuclear Proteins
Genomics
30 Citations (Scopus)

Regulated membrane protein entry into flagella is facilitated by cytoplasmic microtubules and does not require IFT

Belzile, O., Hernandez-Lara, C. I., Wang, Q. & Snell, W. J., Aug 5 2013, In : Current Biology. 23, 15, p. 1460-1465 6 p.

Research output: Contribution to journalArticle

Flagella
flagellum
Microtubules
membrane proteins
microtubules
2012
27 Citations (Scopus)

Evolutionarily conserved Δ25(27)-olefin ergosterol biosynthesis pathway in the alga Chlamydomonas reinhardtii

Miller, M. B., Haubrich, B. A., Wang, Q., Snell, W. J. & Nes, W. D., Aug 2012, In : Journal of Lipid Research. 53, 8, p. 1636-1645 10 p.

Research output: Contribution to journalArticle

Ergosterol
Chlamydomonas reinhardtii
Biosynthesis
Alkenes
Sterols
1 Citation (Scopus)

Plant gametes do fertilization with a twist

Snell, W. J., Nov 23 2012, In : Science. 338, 6110, p. 1038-1039 2 p.

Research output: Contribution to journalArticle

Plant Germ Cells
Fertilization
2011
32 Citations (Scopus)

The phosphorylation state of an aurora-like kinase marks the length of growing flagella in Chlamydomonas

Luo, M., Cao, M., Kan, Y., Li, G., Snell, W. & Pan, J., Apr 12 2011, In : Current Biology. 21, 7, p. 586-591 6 p.

Research output: Contribution to journalArticle

Aurora Kinases
Chlamydomonas
Phosphorylation
Flagella
flagellum
2010
31 Citations (Scopus)

Membrane fusion triggers rapid degradation of two gamete-specific, fusion-essential proteins in a membrane block to polygamy in Chlamydomonas

Liu, Y., Misamore, M. J. & Snell, W. J., May 1 2010, In : Development. 137, 9, p. 1473-1481 9 p.

Research output: Contribution to journalArticle

Chlamydomonas
Membrane Fusion
Marriage
Germ Cells
Zygote
104 Citations (Scopus)

The ciliary membrane

Rohatgi, R. & Snell, W. J., Aug 2010, In : Current Opinion in Cell Biology. 22, 4, p. 541-546 6 p.

Research output: Contribution to journalArticle

Membranes
Flagella
Cilia
Membrane Lipids
Organelles
2009
84 Citations (Scopus)

A microtubule depolymerizing kinesin functions during both flagellar disassembly and flagellar assembly in Chlamydomonas

Piao, T., Luo, M., Wang, L., Guo, Y., Li, D., Li, P., Snell, W. J. & Pan, J., Mar 24 2009, In : Proceedings of the National Academy of Sciences of the United States of America. 106, 12, p. 4713-4718 6 p.

Research output: Contribution to journalArticle

Chlamydomonas
Kinesin
Flagella
Microtubules
Organelles
15 Citations (Scopus)

Flagellar Adhesion, Flagellar-Generated Signaling, and Gamete Fusion during Mating

Snell, W. J. & Goodenough, U. W., 2009, The Chlamydomonas Sourcebook 3-Vol set. Elsevier Inc., Vol. 3. p. 369-394 26 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Flagella
Agglutinins
agglutinins
flagellum
Germ Cells
66 Citations (Scopus)

Izumo is part of a multiprotein family whose members form large complexes on mammalian sperm

Ellerman, D. A., Pei, J., Gupta, S., Snell, W. J., Myles, D. & Primakoff, P., Dec 2009, In : Molecular Reproduction and Development. 76, 12, p. 1188-1199 12 p.

Research output: Contribution to journalArticle

Spermatozoa
Proteins
Testis
Membrane Proteins
Multiprotein Complexes
39 Citations (Scopus)

SnapShot: Intraflagellar Transport

Cole, D. G. & Snell, W. J., May 15 2009, In : Cell. 137, 4

Research output: Contribution to journalArticle

2008
154 Citations (Scopus)

The conserved plant sterility gene HAP2 functions after attachment of fusogenic membranes in Chlamydomonas and Plasmodium gametes

Liu, Y., Tewari, R., Ning, J., Blagborough, A. M., Garbom, S., Pei, J., Grishin, N. V., Steele, R. E., Sinden, R. E., Snell, W. J. & Billker, O., Apr 15 2008, In : Genes and Development. 22, 8, p. 1051-1068 18 p.

Research output: Contribution to journalArticle

Chlamydomonas
Plant Genes
Plasmodium
Germ Cells
Infertility
2007
2 Citations (Scopus)

A ciliary timer for S-phase entry

Snell, W. J. & Golemis, E. A., Oct 2007, In : Nature Reviews Molecular Cell Biology. 8, 10

Research output: Contribution to journalArticle

Basal Bodies
Centrioles
Cyclin E
Cell Cycle Proteins
Cilia
111 Citations (Scopus)

The Primary Cilium: Keeper of the Key to Cell Division

Pan, J. & Snell, W., Jun 29 2007, In : Cell. 129, 7, p. 1255-1257 3 p.

Research output: Contribution to journalArticle

Centrioles
Centrosome
Cilia
Cell Division
Cells
2006
109 Citations (Scopus)

Intraflagellar Transport Particles Participate Directly in Cilium-Generated Signaling in Chlamydomonas

Wang, Q., Pan, J. & Snell, W. J., May 5 2006, In : Cell. 125, 3, p. 549-562 14 p.

Research output: Contribution to journalArticle

Chlamydomonas
Flagella
Cilia
Machinery
Adhesion
2005
66 Citations (Scopus)
Chlamydomonas
Flagella
Algae
Machinery
Binding Sites
182 Citations (Scopus)

Cilium-generated signaling and cilia-related disorders

Pan, J., Wang, Q. & Snell, W. J., Apr 2005, In : Laboratory Investigation. 85, 4, p. 452-463 12 p.

Research output: Contribution to journalArticle

Cilia
Polycystic Kidney Diseases
Flagella
Bardet-Biedl Syndrome
Organelles
2004
108 Citations (Scopus)

An aurora kinase is essential for flagellar disassembly in Chlamydomonas

Pan, J., Wang, Q. & Snell, W. J., Mar 2004, In : Developmental Cell. 6, 3, p. 445-451 7 p.

Research output: Contribution to journalArticle

Aurora Kinases
Chlamydomonas
Flagella
Phosphorylation
Cilia
110 Citations (Scopus)

Cilia and flagella revealed: From flagellar assembly in Chlamydomonas to human obesity disorders

Snell, W. J., Pan, J. & Wang, Q., Jun 11 2004, In : Cell. 117, 6, p. 693-697 5 p.

Research output: Contribution to journalArticle

Chlamydomonas
Flagella
Cilia
Machinery
Obesity
2003
31 Citations (Scopus)
Chlamydomonas
Fertilization
Germ Cells
Protein-Tyrosine Kinases
Adhesion
22 Citations (Scopus)

Kinesin II and regulated intraflagellar transport of Chlamydomonas aurora protein kinase

Pan, J. & Snell, W. J., Jun 1 2003, In : Journal of Cell Science. 116, 11, p. 2179-2186 8 p.

Research output: Contribution to journalArticle

Aurora Kinases
Chlamydomonas
Flagella
Protein Kinases
Cilia
15 Citations (Scopus)

Protein transport and signal transduction during fertilization in Chlamydomonas

Pan, J., Misamore, M. J., Wang, Q. & Snell, W. J., Jul 1 2003, In : Traffic. 4, 7, p. 452-459 8 p.

Research output: Contribution to journalArticle

Chlamydomonas
Signal transduction
Protein Transport
Zygote
Fertilization
55 Citations (Scopus)
Chlamydomonas
Germ Cells
Organelles
Membranes
Proteins
2002
45 Citations (Scopus)

An algal nucleus-encoded subunit of mitochondrial ATP synthase rescues a defect in the analogous human mitochondrial-encoded subunit

Ojaimi, J., Pan, J., Santra, S., Snell, W. J. & Schon, E. A., Nov 1 2002, In : Molecular Biology of the Cell. 13, 11, p. 3836-3844 9 p.

Research output: Contribution to journalArticle

Mitochondrial Proton-Translocating ATPases
Chlamydomonas reinhardtii
Mitochondrial DNA
Peptides
Adenosine Triphosphatases
56 Citations (Scopus)

Kinesin-II is required for flagellar sensory transduction during fertilization in Chlamydomonas

Pan, J. & Snell, W. J., 2002, In : Molecular Biology of the Cell. 13, 4, p. 1417-1426 10 p.

Research output: Contribution to journalArticle

Chlamydomonas
Fertilization
Germ Cells
Flagella
Agglutinins
2001
32 Citations (Scopus)

Ectopic expression of a Chlamydomonas mt+-specific homeodomain protein in mt- gametes initiates zygote development without gamete fusion

Zhao, H., Lu, M., Singh, R. & Snell, W. J., Oct 15 2001, In : Genes and Development. 15, 20, p. 2767-2777 11 p.

Research output: Contribution to journalArticle

Chlamydomonas
Homeodomain Proteins
Zygote
Germ Cells
Genes
2000
37 Citations (Scopus)
Chlamydomonas
Flagella
Germ Cells
Protein Kinases
Chemical activation
59 Citations (Scopus)

Signal transduction during fertilization in the unicellular green alga, Chlamydomonas

Pan, J. & Snell, W. J., 2000, In : Current Opinion in Microbiology. 3, 6, p. 596-602 7 p.

Research output: Contribution to journalArticle

Chlamydomonas
Chlorophyta
Fertilization
Germ Cells
Signal Transduction
1999
17 Citations (Scopus)

Flagellar adhesion between mt+ and mt- Chlamydomonas gametes regulates phosphorylation of the mt+-specific homeodomain protein GSP1

Wilson, N. F., O'Connell, J. S., Lu, M. & Snell, W. J., Nov 26 1999, In : Journal of Biological Chemistry. 274, 48, p. 34383-34388 6 p.

Research output: Contribution to journalArticle

Chlamydomonas
Homeodomain Proteins
Phosphorylation
Germ Cells
Adhesion
1998
43 Citations (Scopus)

A gamete-specific, sex-limited homeodomain protein in Chlamydomonas

Kurvari, V., Grishin, N. V. & Snell, W. J., Dec 28 1998, In : Journal of Cell Biology. 143, 7, p. 1971-1980 10 p.

Research output: Contribution to journalArticle

Chlamydomonas
Homeodomain Proteins
Germ Cells
Gametogenesis
Plant Proteins
43 Citations (Scopus)

Microvilli and cell-cell fusion during fertilization

Wilson, N. F. & Snell, W. J., Mar 1998, In : Trends in Cell Biology. 8, 3, p. 93-96 4 p.

Research output: Contribution to journalArticle

Cell Fusion
Microvilli
Fertilization
Cell Surface Extensions
Biological Phenomena
1997
26 Citations (Scopus)
Chlamydomonas
Cell Fusion
Fertilization
Germ Cells
Organelles
1996
6 Citations (Scopus)

Cell adhesion-dependent inactivation of a soluble protein kinase during fertilization in Chlamydomonas

Zhang, Y., Luo, Y., Emmett, K. & Snell, W. J., Apr 1996, In : Molecular Biology of the Cell. 7, 4, p. 515-527 13 p.

Research output: Contribution to journalArticle

Chlamydomonas
Fertilization
Cell Adhesion
Germ Cells
Protein Kinases
11 Citations (Scopus)
Chlamydomonas
Molecular Cloning
Fertilization
Protein Kinases
Phosphorylation
3 Citations (Scopus)
Gametogenesis
Chlamydomonas
Flagella
Fertilization
Protein Kinases
206 Citations (Scopus)

The molecules of mammalian fertilization

Snell, W. J. & White, J. M., May 31 1996, In : Cell. 85, 5, p. 629-637 9 p.

Research output: Contribution to journalArticle

Molecules
1995
4 Citations (Scopus)

Chapter 64 Flagellar Adenylyl Cyclases in Chlamydomonas

Zhang, Y. & Snell, W. J., 1995, In : Methods in Cell Biology. 47, C, p. 459-465 7 p.

Research output: Contribution to journalArticle

Protozoan Proteins
Chlamydomonas
Plant Proteins
Enzyme Activation
Flagella
23 Citations (Scopus)

Increased transcript levels of a methionine synthase during adhesion-induced activation of Chlamydomonas reinhardtii gametes

Kurvari, V., Qian, F. & Snell, W. J., Dec 1995, In : Plant Molecular Biology. 29, 6, p. 1235-1252 18 p.

Research output: Contribution to journalArticle

5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase
methionine synthase
Chlamydomonas reinhardtii
Germ Cells
adhesion
1994
31 Citations (Scopus)
Chlamydomonas
Flagella
Adenylyl Cyclases
Protein Kinases
Agglutinins