Cell Biology - Division T

Research Output

2018

Fusion surface structure, function, and dynamics of gamete fusogen HAP2

Feng, J., Dong, X., Pinello, J., Zhang, J., Lu, C., Iacob, R. E., Engen, J. R., Snell, W. J. & Springer, T. A., Oct 3 2018, In : eLife. 7

Research output: Contribution to journalArticle

3 Scopus citations
2017

Targeting the Conserved Fusion Loop of HAP2 Inhibits the Transmission of Plasmodium berghei and falciparum

Angrisano, F., Sala, K. A., Da, D. F., Liu, Y., Pei, J., Grishin, N. V., Snell, W. J. & Blagborough, A. M., Dec 5 2017, In : Cell Reports. 21, 10, p. 2868-2878 11 p.

Research output: Contribution to journalArticle

23 Scopus citations

The Ancient Gamete Fusogen HAP2 Is a Eukaryotic Class II Fusion Protein

Fédry, J., Liu, Y., Péhau-Arnaudet, G., Pei, J., Li, W., Tortorici, M. A., Traincard, F., Meola, A., Bricogne, G., Grishin, N. V., Snell, W. J., Rey, F. A. & Krey, T., Feb 23 2017, In : Cell. 168, 5, p. 904-915.e10

Research output: Contribution to journalArticle

56 Scopus citations
2016

Endogenous B-ring oxysterols inhibit the hedgehog component smoothened in a manner distinct from cyclopamine or side-chain oxysterols

Sever, N., Mann, R. K., Xu, L., Snell, W. J., Hernandez-Lara, C. I., Porter, N. A. & Beachy, P. A., May 24 2016, In : Proceedings of the National Academy of Sciences of the United States of America. 113, 21, p. 5904-5909 6 p.

Research output: Contribution to journalArticle

26 Scopus citations
2015

Characterization, mutagenesis and mechanistic analysis of an ancient algal sterol C24-methyltransferase: Implications for understanding sterol evolution in the green lineage

Haubrich, B. A., Collins, E. K., Howard, A. L., Wang, Q., Snell, W. J., Miller, M. B., Thomas, C. D., Pleasant, S. K. & Nes, W. D., May 17 2015, In : Phytochemistry. 113, p. 64-72 9 p.

Research output: Contribution to journalArticle

15 Scopus citations
19 Scopus citations

Uni-directional ciliary membrane protein trafficking by a cytoplasmic retrograde IFT motor and ciliary ectosome shedding

Cao, M., Ning, J., Hernandez-Lara, C. I., Belzile, O., Wang, Q., Dutcher, S. K., Liu, Y. & Snell, W. J., Feb 17 2015, In : eLife. 2015, 4

Research output: Contribution to journalArticle

47 Scopus citations
2014

Fertilization: A sticky sperm protein in plants

Dresselhaus, T. & Snell, W. J., Feb 17 2014, In : Current Biology. 24, 4, p. R164-R166

Research output: Contribution to journalShort survey

4 Scopus citations

Organelle size: A cilium length signal regulates IFT cargo loading

Pan, J. & Snell, W. J., Jan 20 2014, In : Current Biology. 24, 2, p. R75-R78

Research output: Contribution to journalShort survey

6 Scopus citations
2013
36 Scopus citations

Comparative genomics in Chlamydomonas and Plasmodium identifies an ancient nuclear envelope protein family essential for sexual reproduction in protists, fungi, plants, and vertebrates

Ning, J., Otto, T. D., Pfander, C., Schwach, F., Brochet, M., Bushell, E., Goulding, D., Sanders, M., Lefebvre, P. A., Pei, J., Grishin, N. V., Vanderlaan, G., Billker, O. & Snell, W. J., May 15 2013, In : Genes and Development. 27, 10, p. 1198-1215 18 p.

Research output: Contribution to journalArticle

39 Scopus citations

Regulated membrane protein entry into flagella is facilitated by cytoplasmic microtubules and does not require IFT

Belzile, O., Hernandez-Lara, C. I., Wang, Q. & Snell, W. J., Aug 5 2013, In : Current Biology. 23, 15, p. 1460-1465 6 p.

Research output: Contribution to journalArticle

31 Scopus citations
2012

Evolutionarily conserved Δ25(27)-olefin ergosterol biosynthesis pathway in the alga Chlamydomonas reinhardtii

Miller, M. B., Haubrich, B. A., Wang, Q., Snell, W. J. & Nes, W. D., Aug 1 2012, In : Journal of lipid research. 53, 8, p. 1636-1645 10 p.

Research output: Contribution to journalArticle

30 Scopus citations

Plant gametes do fertilization with a twist

Snell, W. J., Nov 23 2012, In : Science. 338, 6110, p. 1038-1039 2 p.

Research output: Contribution to journalShort survey

1 Scopus citations
2011

The phosphorylation state of an aurora-like kinase marks the length of growing flagella in Chlamydomonas

Luo, M., Cao, M., Kan, Y., Li, G., Snell, W. & Pan, J., Apr 12 2011, In : Current Biology. 21, 7, p. 586-591 6 p.

Research output: Contribution to journalArticle

35 Scopus citations
2010

Membrane fusion triggers rapid degradation of two gamete-specific, fusion-essential proteins in a membrane block to polygamy in Chlamydomonas

Liu, Y., Misamore, M. J. & Snell, W. J., May 1 2010, In : Development. 137, 9, p. 1473-1481 9 p.

Research output: Contribution to journalArticle

33 Scopus citations

The ciliary membrane

Rohatgi, R. & Snell, W. J., Aug 1 2010, In : Current Opinion in Cell Biology. 22, 4, p. 541-546 6 p.

Research output: Contribution to journalReview article

104 Scopus citations
2009

A microtubule depolymerizing kinesin functions during both flagellar disassembly and flagellar assembly in Chlamydomonas

Piao, T., Luo, M., Wang, L., Guo, Y., Li, D., Li, P., Snell, W. J. & Pan, J., Mar 24 2009, In : Proceedings of the National Academy of Sciences of the United States of America. 106, 12, p. 4713-4718 6 p.

Research output: Contribution to journalArticle

88 Scopus citations

Flagellar Adhesion, Flagellar-Generated Signaling, and Gamete Fusion during Mating

Snell, W. J. & Goodenough, U. W., Dec 1 2009, The Chlamydomonas Sourcebook 3-Vol set. Elsevier Inc., Vol. 3. p. 369-394 26 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

15 Scopus citations

Izumo is part of a multiprotein family whose members form large complexes on mammalian sperm

Ellerman, D. A., Pei, J., Gupta, S., Snell, W. J., Myles, D. & Primakoff, P., Dec 1 2009, In : Molecular Reproduction and Development. 76, 12, p. 1188-1199 12 p.

Research output: Contribution to journalArticle

71 Scopus citations

SnapShot: Intraflagellar Transport

Cole, D. G. & Snell, W. J., May 15 2009, In : Cell. 137, 4, p. 784-784.e1

Research output: Contribution to journalShort survey

40 Scopus citations
2008

The conserved plant sterility gene HAP2 functions after attachment of fusogenic membranes in Chlamydomonas and Plasmodium gametes

Liu, Y., Tewari, R., Ning, J., Blagborough, A. M., Garbom, S., Pei, J., Grishin, N. V., Steele, R. E., Sinden, R. E., Snell, W. J. & Billker, O., Apr 15 2008, In : Genes and Development. 22, 8, p. 1051-1068 18 p.

Research output: Contribution to journalArticle

165 Scopus citations
2007

A ciliary timer for S-phase entry

Snell, W. J. & Golemis, E. A., Oct 1 2007, In : Nature Reviews Molecular Cell Biology. 8, 10, p. 1P

Research output: Contribution to journalLetter

2 Scopus citations

The Primary Cilium: Keeper of the Key to Cell Division

Pan, J. & Snell, W., Jun 29 2007, In : Cell. 129, 7, p. 1255-1257 3 p.

Research output: Contribution to journalShort survey

112 Scopus citations
2006

Intraflagellar Transport Particles Participate Directly in Cilium-Generated Signaling in Chlamydomonas

Wang, Q., Pan, J. & Snell, W. J., May 5 2006, In : Cell. 125, 3, p. 549-562 14 p.

Research output: Contribution to journalArticle

110 Scopus citations
2005
69 Scopus citations

Cilium-generated signaling and cilia-related disorders

Pan, J., Wang, Q. & Snell, W. J., Apr 1 2005, In : Laboratory Investigation. 85, 4, p. 452-463 12 p.

Research output: Contribution to journalShort survey

188 Scopus citations
2004

An aurora kinase is essential for flagellar disassembly in Chlamydomonas

Pan, J., Wang, Q. & Snell, W. J., Mar 1 2004, In : Developmental Cell. 6, 3, p. 445-451 7 p.

Research output: Contribution to journalArticle

109 Scopus citations

Cilia and flagella revealed: From flagellar assembly in Chlamydomonas to human obesity disorders

Snell, W. J., Pan, J. & Wang, Q., Jun 11 2004, In : Cell. 117, 6, p. 693-697 5 p.

Research output: Contribution to journalReview article

113 Scopus citations
2003
31 Scopus citations

Kinesin II and regulated intraflagellar transport of Chlamydomonas aurora protein kinase

Pan, J. & Snell, W. J., Jun 1 2003, In : Journal of cell science. 116, 11, p. 2179-2186 8 p.

Research output: Contribution to journalReview article

22 Scopus citations

Protein transport and signal transduction during fertilization in Chlamydomonas

Pan, J., Misamore, M. J., Wang, Q. & Snell, W. J., Jul 1 2003, In : Traffic. 4, 7, p. 452-459 8 p.

Research output: Contribution to journalReview article

15 Scopus citations
57 Scopus citations
2002

An algal nucleus-encoded subunit of mitochondrial ATP synthase rescues a defect in the analogous human mitochondrial-encoded subunit

Ojaimi, J., Pan, J., Santra, S., Snell, W. J. & Schon, E. A., Nov 1 2002, In : Molecular biology of the cell. 13, 11, p. 3836-3844 9 p.

Research output: Contribution to journalArticle

47 Scopus citations

Kinesin-II is required for flagellar sensory transduction during fertilization in Chlamydomonas

Pan, J. & Snell, W. J., Apr 25 2002, In : Molecular biology of the cell. 13, 4, p. 1417-1426 10 p.

Research output: Contribution to journalArticle

56 Scopus citations
2001

Ectopic expression of a Chlamydomonas mt+-specific homeodomain protein in mt- gametes initiates zygote development without gamete fusion

Zhao, H., Lu, M., Singh, R. & Snell, W. J., Oct 15 2001, In : Genes and Development. 15, 20, p. 2767-2777 11 p.

Research output: Contribution to journalArticle

32 Scopus citations
2000
38 Scopus citations

Signal transduction during fertilization in the unicellular green alga, Chlamydomonas

Pan, J. & Snell, W. J., Jan 1 2000, In : Current Opinion in Microbiology. 3, 6, p. 596-602 7 p.

Research output: Contribution to journalReview article

60 Scopus citations
1999

Flagellar adhesion between mt+ and mt- Chlamydomonas gametes regulates phosphorylation of the mt+-specific homeodomain protein GSP1

Wilson, N. F., O'Connell, J. S., Lu, M. & Snell, W. J., Nov 26 1999, In : Journal of Biological Chemistry. 274, 48, p. 34383-34388 6 p.

Research output: Contribution to journalArticle

17 Scopus citations
1998

A gamete-specific, sex-limited homeodomain protein in Chlamydomonas

Kurvari, V., Grishin, N. V. & Snell, W. J., Dec 28 1998, In : Journal of Cell Biology. 143, 7, p. 1971-1980 10 p.

Research output: Contribution to journalArticle

43 Scopus citations

Microvilli and cell-cell fusion during fertilization

Wilson, N. F. & Snell, W. J., Mar 1998, In : Trends in Cell Biology. 8, 3, p. 93-96 4 p.

Research output: Contribution to journalArticle

44 Scopus citations
1997
28 Scopus citations
1996

Cell adhesion-dependent inactivation of a soluble protein kinase during fertilization in Chlamydomonas

Zhang, Y., Luo, Y., Emmett, K. & Snell, W. J., Apr 1996, In : Molecular biology of the cell. 7, 4, p. 515-527 13 p.

Research output: Contribution to journalArticle

6 Scopus citations
11 Scopus citations
3 Scopus citations

The molecules of mammalian fertilization

Snell, W. J. & White, J. M., May 31 1996, In : Cell. 85, 5, p. 629-637 9 p.

Research output: Contribution to journalReview article

207 Scopus citations
1995

Chapter 64 Flagellar Adenylyl Cyclases in Chlamydomonas

Zhang, Y. & Snell, W. J., Jan 1 1995, In : Methods in Cell Biology. 47, C, p. 459-465 7 p.

Research output: Contribution to journalArticle

4 Scopus citations

Increased transcript levels of a methionine synthase during adhesion-induced activation of Chlamydomonas reinhardtii gametes

Kurvari, V., Qian, F. & Snell, W. J., Dec 1 1995, In : Plant Molecular Biology. 29, 6, p. 1235-1252 18 p.

Research output: Contribution to journalArticle

23 Scopus citations
1994
Open Access
31 Scopus citations
1993

Differential regulation of adenylylcyclases in vegetative and gametic flagella of chlamydomonas

Zhang, Y. & Snell, W. J., Jan 1 1993, In : Journal of Biological Chemistry. 268, 3, p. 1786-1791 6 p.

Research output: Contribution to journalArticle

22 Scopus citations