Cell Biology - Division U

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Porcupines Medicine & Life Sciences
Catenins Medicine & Life Sciences
RNA Interference Medicine & Life Sciences
Hedgehogs Medicine & Life Sciences
Wnt Proteins Medicine & Life Sciences
Tankyrases Medicine & Life Sciences
Neoplasms Medicine & Life Sciences
Wnt Signaling Pathway Medicine & Life Sciences

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Profiles

No photo of Lawrence Lum

Lawrence Lum

Person: Academic

19942019

Research Output 1996 2019

1 Citation (Scopus)

CRISPR-Cas9-based mutagenesis frequently provokes on-target mRNA misregulation

Tuladhar, R., Yeu, Y., Tyler Piazza, J., Tan, Z., Rene Clemenceau, J., Wu, X., Barrett, Q., Herbert, J., Mathews, D. H., Kim, J., Hyun Hwang, T. & Lum, L., Dec 1 2019, In : Nature communications. 10, 1, 4056.

Research output: Contribution to journal › Article

Open Access
Clustered Regularly Interspaced Short Palindromic Repeats
mutagenesis
deletion
Mutagenesis
insertion

Stereoselective fatty acylation is essential for the release of lipidated WNT proteins from the acyltransferase Porcupine (PORCN)

Tuladhar, R., Yarravarapu, N., Ma, Y., Zhang, C., Herbert, J., Kim, J., Chen, C. & Lum, L., Jan 1 2019, In : Journal of Biological Chemistry. 294, 16, p. 6273-6282 10 p.

Research output: Contribution to journal › Article

Porcupines
Acylation
Animals
Acyltransferases
Proteins

A synthetic combinatorial approach to disabling deviant Hedgehog signaling

Fan, C. W., Yarravarapu, N., Shi, H., Kulak, O., Kim, J., Chen, C. & Lum, L., Dec 1 2018, In : Scientific Reports. 8, 1, 1133.

Research output: Contribution to journal › Article

Histone Deacetylases
Medulloblastoma
Critical Pathways
Basal Cell Carcinoma
DNA-Binding Proteins