Center for Alzheimer's and Neurodegenerative Diseases

Research Output

2020

Site-Specific Hyperphosphorylation Inhibits, Rather than Promotes, Tau Fibrillization, Seeding Capacity, and Its Microtubule Binding

Haj-Yahya, M., Gopinath, P., Rajasekhar, K., Mirbaha, H., Diamond, M. I. & Lashuel, H. A., Mar 2 2020, In : Angewandte Chemie - International Edition. 59, 10, p. 4059-4067 9 p.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations
2019

Parkinson’s disease and multiple system atrophy have distinct -synuclein seed characteristics

Yamasaki, T. R., Holmes, B. B., Furman, J. L., Dhavale, D. D., Su, B. W., Song, E. S., Cairns, N. J., Kotzbauer, P. T. & Diamond, M. I., Jan 18 2019, In : Journal of Biological Chemistry. 294, 3, p. 1045-1058 14 p.

Research output: Contribution to journalArticle

21 Scopus citations

Propagation of protein aggregation in neurodegenerative diseases

Vaquer-Alicea, J. & Diamond, M. I., Jun 20 2019, In : Annual Review of Biochemistry. 88, p. 785-810 26 p.

Research output: Contribution to journalArticle

14 Scopus citations

Target engagement in an alzheimer trial: Crenezumab lowers amyloid β oligomers in cerebrospinal fluid

Yang, T., Dang, Y., Ostaszewski, B., Mengel, D., Steffen, V., Rabe, C., Bittner, T., Walsh, D. M. & Selkoe, D. J., Aug 2019, In : Annals of Neurology. 86, 2, p. 215-224 10 p.

Research output: Contribution to journalArticle

Open Access
7 Scopus citations

Tau local structure shields an amyloid-forming motif and controls aggregation propensity

Chen, D., Drombosky, K. W., Hou, Z., Sari, L., Kashmer, O. M., Ryder, B. D., Perez, V. A., Woodard, D. N. R., Lin, M. M., Diamond, M. I. & Joachimiak, L. A., Dec 1 2019, In : Nature communications. 10, 1, 2493.

Research output: Contribution to journalArticle

Open Access
6 Scopus citations

The ATP-powered gymnastics of TRiC/CCT: an asymmetric protein folding machine with a symmetric origin story

Gestaut, D., Limatola, A., Joachimiak, L. & Frydman, J., Apr 2019, In : Current Opinion in Structural Biology. 55, p. 50-58 9 p.

Research output: Contribution to journalReview article

5 Scopus citations

The Chaperonin TRiC/CCT Associates with Prefoldin through a Conserved Electrostatic Interface Essential for Cellular Proteostasis

Gestaut, D., Roh, S. H., Ma, B., Pintilie, G., Joachimiak, L. A., Leitner, A., Walzthoeni, T., Aebersold, R., Chiu, W. & Frydman, J., Apr 18 2019, In : Cell. 177, 3, p. 751-765.e15

Research output: Contribution to journalArticle

7 Scopus citations
2018

Amyloid fibrils embodying distinctive yeast prion phenotypes exhibit diverse morphologies

Ghosh, R., Dong, J., Wall, J. & Frederick, K. K., Sep 1 2018, In : FEMS Yeast Research. 18, 6

Research output: Contribution to journalArticle

8 Scopus citations

DNP-Assisted NMR Investigation of Proteins at Endogenous Levels in Cellular Milieu

Costello, W. N., Xiao, Y. & Frederick, K. K., Jan 1 2018, (Accepted/In press) In : Methods in Enzymology.

Research output: Contribution to journalArticle

2 Scopus citations

Inert and seed-competent tau monomers suggest structural origins of aggregation

Mirbaha, H., Chen, D., Morazova, O. A., Ruff, K. M., Sharma, A. M., Liu, X., Goodarzi, M., Pappu, R. V., Colby, D. W., Mirzaei, H., Joachimiak, L. A. & Diamond, M. I., Jul 10 2018, In : eLife. 7, e36584.

Research output: Contribution to journalArticle

41 Scopus citations

Profilin reduces aggregation and phase separation of huntingtin N-terminal fragments by preferentially binding to soluble monomers and oligomers

Posey, A. E., Ruff, K. M., Harmon, T. S., Crick, S. L., Li, A., Diamond, M. I. & Pappu, R. V., Mar 9 2018, In : Journal of Biological Chemistry. 293, 10, p. 3734-3746 13 p.

Research output: Contribution to journalArticle

25 Scopus citations

Rebuttal to Drs. Grinberg and Heinsen

Kaufman, S. K., Del Tredici, K., Braak, H. & Diamond, M. I., Nov 1 2018, In : Acta Neuropathologica. 136, 5, 1 p.

Research output: Contribution to journalLetter

Specific glycosaminoglycan chain length and sulfation patterns are required for cell uptake of tau versus -synuclein and -amyloid aggregates

Stopschinski, B. E., Holmes, B. B., Miller, G. M., Manon, V. A., Vaquer-Alicea, J., Prueitt, W. L., Hsieh-Wilson, L. C. & Diamond, M. I., Jul 6 2018, In : Journal of Biological Chemistry. 293, 27, p. 10826-10840 15 p.

Research output: Contribution to journalArticle

29 Scopus citations

Tau monomer encodes strains

Sharma, A. M., Thomas, T. L., Woodard, D. N. R., Kashmer, O. M. & Diamond, M. I., Dec 11 2018, In : eLife. 7

Research output: Contribution to journalArticle

14 Scopus citations

Tau seeding activity begins in the transentorhinal/entorhinal regions and anticipates phospho-tau pathology in Alzheimer’s disease and PART

Kaufman, S. K., Del Tredici, K., Thomas, T. L., Braak, H. & Diamond, M. I., May 11 2018, (Accepted/In press) In : Acta Neuropathologica. p. 1-11 11 p.

Research output: Contribution to journalArticle

37 Scopus citations
2017

Aggregation and Fibril Structure of AβM01-42 and Aβ1-42

Silvers, R., Colvin, M. T., Frederick, K. K., Jacavone, A. C., Lindquist, S., Linse, S. & Griffin, R. G., Sep 12 2017, In : Biochemistry. 56, 36, p. 4850-4859 10 p.

Research output: Contribution to journalArticle

9 Scopus citations

Cellular models for the study of prions

Holmes, B. B. & Diamond, M. I., Feb 1 2017, In : Cold Spring Harbor perspectives in medicine. 7, 2, a024026.

Research output: Contribution to journalArticle

9 Scopus citations

Characterization of tau prion seeding activity and strains from formaldehyde-fixed tissue

Kaufman, S. K., Thomas, T. L., Del Tredici, K., Braak, H. & Diamond, M. I., Jun 7 2017, In : Acta neuropathologica communications. 5, 1, 1 p.

Research output: Contribution to journalArticle

34 Scopus citations

Combining DNP NMR with segmental and specific labeling to study a yeast prion protein strain that is not parallel in-register

Frederick, K. K., Michaelis, V. K., Caporini, M. A., Andreas, L. B., Debelouchina, G. T., Griffin, R. G. & Lindquist, S., Apr 4 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 14, p. 3642-3647 6 p.

Research output: Contribution to journalArticle

24 Scopus citations

FRET and flow cytometry assays to measure proteopathic seeding activity in biological samples

Furman, J. L. & Diamond, M. I., 2017, Methods in Molecular Biology. Humana Press Inc., Vol. 1523. p. 349-359 11 p. (Methods in Molecular Biology; vol. 1523).

Research output: Chapter in Book/Report/Conference proceedingChapter

4 Scopus citations

Novel human neuronal tau model exhibiting neurofibrillary tangles and transcellular propagation

Reilly, P., Winston, C. N., Baron, K. R., Trejo, M., Rockenstein, E. M., Akers, J. C., Kfoury, N., Diamond, M., Masliah, E., Rissman, R. A. & Yuan, S. H., Oct 1 2017, In : Neurobiology of Disease. 106, p. 222-234 13 p.

Research output: Contribution to journalArticle

16 Scopus citations

Tau reduction prevents neuronal loss and reverses pathological tau deposition and seeding in mice with tauopathy

DeVos, S. L., Miller, R. L., Schoch, K. M., Holmes, B. B., Kebodeaux, C. S., Wegener, A. J., Chen, G., Shen, T., Tran, H., Nichols, B., Zanardi, T. A., Kordasiewicz, H. B., Swayze, E. E., Bennett, C. F., Diamond, M. I. & Miller, T. M., Jan 25 2017, In : Science Translational Medicine. 9, 374, eaag0481.

Research output: Contribution to journalArticle

100 Scopus citations

The CNS in inbred transgenic models of 4-repeat Tauopathy develops consistent tau seeding capacity yet focal and diverse patterns of protein deposition

Eskandari-Sedighi, G., Daude, N., Gapeshina, H., Sanders, D. W., Kamali-Jamil, R., Yang, J., Shi, B., Wille, H., Ghetti, B., Diamond, M. I., Janus, C. & Westaway, D., Oct 4 2017, In : Molecular Neurodegeneration. 12, 1, 72.

Research output: Contribution to journalArticle

1 Scopus citations

The prion model for progression and diversity of neurodegenerative diseases

Stopschinski, B. E. & Diamond, M. I., Apr 1 2017, In : The Lancet Neurology. 16, 4, p. 323-332 10 p.

Research output: Contribution to journalReview article

59 Scopus citations

Ultrasensitive and selective detection of 3-repeat tau seeding activity in Pick disease brain and cerebrospinal fluid

Saijo, E., Ghetti, B., Zanusso, G., Oblak, A., Furman, J. L., Diamond, M. I., Kraus, A. & Caughey, B., May 1 2017, In : Acta Neuropathologica. 133, 5, p. 751-765 15 p.

Research output: Contribution to journalArticle

38 Scopus citations

Widespread tau seeding activity at early Braak stages

Furman, J. L., Vaquer-Alicea, J., White, C. L., Cairns, N. J., Nelson, P. T. & Diamond, M. I., Jan 1 2017, In : Acta Neuropathologica. 133, 1, p. 91-100 10 p.

Research output: Contribution to journalArticle

37 Scopus citations
2016

Active and passive immunotherapy against tau: Effects and potential mechanisms

Yanamandra, K., Diamond, M. I. & Holtzman, D. M., Jan 1 2016, Methods in Pharmacology and Toxicology. Humana Press Inc., p. 121-138 18 p. (Methods in Pharmacology and Toxicology; vol. PartF1).

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

Heparan sulfate proteoglycans mediate Aβ-induced oxidative stress and hypercontractility in cultured vascular smooth muscle cells

Reynolds, M. R., Singh, I., Azad, T. D., Holmes, B. B., Verghese, P. B., Dietrich, H. H., Diamond, M., Bu, G., Han, B. H. & Zipfel, G. J., Jan 22 2016, In : Molecular Neurodegeneration. 11, 1, 9.

Research output: Contribution to journalArticle

12 Scopus citations

Neuronal activity enhances tau propagation and tau pathology in vivo

Wu, J. W., Hussaini, S. A., Bastille, I. M., Rodriguez, G. A., Mrejeru, A., Rilett, K., Sanders, D. W., Cook, C., Fu, H., Boonen, R. A. C. M., Herman, M., Nahmani, E., Emrani, S., Figueroa, Y. H., Diamond, M. I., Clelland, C. L., Wray, S. & Duff, K. E., Aug 1 2016, In : Nature Neuroscience. 19, 8, p. 1085-1092 8 p.

Research output: Contribution to journalArticle

179 Scopus citations

Prions and Protein Assemblies that Convey Biological Information in Health and Disease

Sanders, D. W., Kaufman, S. K., Holmes, B. B. & Diamond, M. I., Feb 3 2016, In : Neuron. 89, 3, p. 433-448 16 p.

Research output: Contribution to journalArticle

37 Scopus citations

Tau Prion Strains Dictate Patterns of Cell Pathology, Progression Rate, and Regional Vulnerability In Vivo

Kaufman, S. K., Sanders, D. W., Thomas, T. L., Ruchinskas, A. J., Vaquer-Alicea, J., Sharma, A. M., Miller, T. M. & Diamond, M. I., Nov 23 2016, In : Neuron. 92, 4, p. 796-812 17 p.

Research output: Contribution to journalArticle

128 Scopus citations
2015

A highly sensitive novel immunoassay specifically detects low levels of soluble Aβ oligomers in human cerebrospinal fluid

Yang, T., O'Malley, T. T., Kanmert, D., Jerecic, J., Zieske, L. R., Zetterberg, H., Hyman, B. T., Walsh, D. M. & Selkoe, D. J., 2015, In : Alzheimer's Research and Therapy. 7, 1, 7.

Research output: Contribution to journalArticle

Open Access
45 Scopus citations

Distinct therapeutic mechanisms of Tau antibodies: Promoting microglial clearance versus blocking neuronal uptake

Funk, K. E., Mirbaha, H., Jiang, H., Holtzman, D. M. & Diamond, M. I., Aug 28 2015, In : Journal of Biological Chemistry. 290, 35, p. 21652-21662 11 p.

Research output: Contribution to journalArticle

53 Scopus citations

N17 Modifies Mutant Huntingtin Nuclear Pathogenesis and Severity of Disease in HD BAC Transgenic Mice

Gu, X., Cantle, J. P., Greiner, E. R., Lee, C. Y. D., Barth, A. M., Gao, F., Park, C. S., Zhang, Z., Sandoval-Miller, S., Zhang, R. L., Diamond, M., Mody, I., Coppola, G. & Yang, X. W., Feb 18 2015, In : Neuron. 85, 4, p. 726-741 16 p.

Research output: Contribution to journalArticle

34 Scopus citations

Photo-activatable Cre recombinase regulates gene expression in vivo

Schindler, S. E., McCall, J. G., Yan, P., Hyrc, K. L., Li, M., Tucker, C. L., Lee, J. M., Bruchas, M. R. & Diamond, M. I., Sep 9 2015, In : Scientific Reports. 5, 13627.

Research output: Contribution to journalArticle

41 Scopus citations

Propagation of prions causing synucleinopathies in cultured cells

Woerman, A. L., Stöhr, J., Aoyagi, A., Rampersaud, R., Krejciova, Z., Watts, J. C., Ohyama, T., Patel, S., Widjaja, K., Oehler, A., Sanders, D. W., Diamond, M. I., Seeley, W. W., Middleton, L. T., Gentleman, S. M., Mordes, D. A., Südhof, T. C., Giles, K. & Prusiner, S. B., Sep 1 2015, In : Proceedings of the National Academy of Sciences of the United States of America. 112, 35, p. E4949-E4958

Research output: Contribution to journalArticle

98 Scopus citations

Sensitive detection of proteopathic seeding activity with FRET flow cytometry

Furman, J. L., Holmes, B. B. & Diamond, M. I., Dec 8 2015, In : Journal of Visualized Experiments. 2015, 106, e53205.

Research output: Contribution to journalArticle

20 Scopus citations

Sensitivity-Enhanced NMR Reveals Alterations in Protein Structure by Cellular Milieus

Frederick, K. K., Michaelis, V. K., Corzilius, B., Ong, T. C., Jacavone, A. C., Griffin, R. G. & Lindquist, S., Oct 22 2015, In : Cell. 163, 3, p. 620-628 9 p.

Research output: Contribution to journalArticle

70 Scopus citations

Subcellular localization and Ser-137 phosphorylation regulate tumor-suppressive activity of Profilin-1

Diamond, M. I., Cai, S., Boudreau, A., Carey, C. J., Lyle, N., Pappu, R. V., Swamidass, S. J., Bissell, M., Piwnica-Worms, H. & Shao, J., Apr 3 2015, In : Journal of Biological Chemistry. 290, 14, p. 9075-9086 12 p.

Research output: Contribution to journalArticle

7 Scopus citations

Tau trimers are the minimal propagation unit spontaneously internalized to seed intracellular aggregation

Mirbaha, H., Holmes, B. B., Sanders, D. W., Bieschke, J. & Diamond, M. I., Jun 12 2015, In : Journal of Biological Chemistry. 290, 24, p. 14893-14903 11 p.

Research output: Contribution to journalArticle

90 Scopus citations

The green tea polyphenol (-)-epigallocatechin gallate prevents the aggregation of tau protein into toxic oligomers at substoichiometric ratios

Wobst, H. J., Sharma, A., Diamond, M. I., Wanker, E. E. & Bieschke, J., Feb 2 2015, In : FEBS Letters. 589, 1, p. 77-83 7 p.

Research output: Contribution to journalArticle

69 Scopus citations
2014

Chemical cross-linking/mass spectrometry targeting acidic residues in proteins and protein complexes

Leitner, A., Joachimiak, L. A., Unverdorben, P., Walzthoeni, T., Frydman, J., Förster, F. & Aebersold, R., Jul 1 2014, In : Proceedings of the National Academy of Sciences of the United States of America. 111, 26, p. 9455-9460 6 p.

Research output: Contribution to journalArticle

Open Access
105 Scopus citations

Distinct prion strains are defined by amyloid core structure and chaperone binding site dynamics

Frederick, K. K., Debelouchina, G. T., Kayatekin, C., Dorminy, T., Jacavone, A. C., Griffin, R. G. & Lindquist, S., Feb 20 2014, In : Chemistry and Biology. 21, 2, p. 295-305 11 p.

Research output: Contribution to journalArticle

47 Scopus citations

Distinct tau prion strains propagate in cells and mice and define different tauopathies

Sanders, D. W., Kaufman, S. K., DeVos, S. L., Sharma, A. M., Mirbaha, H., Li, A., Barker, S. J., Foley, A. C., Thorpe, J. R., Serpell, L. C., Miller, T. M., Grinberg, L. T., Seeley, W. W. & Diamond, M. I., Jun 18 2014, In : Neuron. 82, 6, p. 1271-1288 18 p.

Research output: Contribution to journalArticle

413 Scopus citations

Inhibition of the androgen receptor by mineralocorticoids at levels physiologically achieved in serum in patients treated with abiraterone acetate

Kim, W., Jones, J. O., Diamond, M., Haqq, C., Molina, A., Small, E. J. & Ryan, C. J., Jul 2014, In : Prostate Cancer and Prostatic Diseases. 17, 3, p. 292-299 8 p.

Research output: Contribution to journalArticle

6 Scopus citations

Orientation of aromatic residues in amyloid cores: Structural insights into prion fiber diversity

Reymer, A., Frederick, K. K., Rocha, S., Beke-Somfai, T., Kitts, C. C., Lindquist, S. & Nordén, B., Dec 2 2014, In : Proceedings of the National Academy of Sciences of the United States of America. 111, 48, p. 17158-17163 6 p.

Research output: Contribution to journalArticle

8 Scopus citations

Prion-like nuclear aggregation of TDP-43 during heat shock is regulated by HSP40/70 chaperones

Udan-Johns, M., Bengoechea, R., Bell, S., Shao, J., Diamond, M. I., True, H. L., Weihl, C. C. & Baloh, R. H., Jan 1 2014, In : Human molecular genetics. 23, 1, p. 157-170 14 p., ddt408.

Research output: Contribution to journalArticle

52 Scopus citations

Prion-like properties of Tau protein: The importance of extracellular Tau as a therapeutic target

Holmes, B. B. & Diamond, M. I., Jan 1 2014, In : Journal of Biological Chemistry. 289, 29, p. 19855-19861 7 p.

Research output: Contribution to journalShort survey

100 Scopus citations

Proteopathic tau seeding predicts tauopathy in vivo

Holmes, B. B., Furman, J. L., Mahan, T. E., Yamasaki, T. R., Mirbaha, H., Eades, W. C., Belaygorod, L., Cairns, N. J., Holtzman, D. M. & Diamond, M. I., Oct 14 2014, In : Proceedings of the National Academy of Sciences of the United States of America. 111, 41, p. E4376-E4385

Research output: Contribution to journalArticle

165 Scopus citations

Soluble Aβ oligomers are rapidly sequestered from brain ISF in vivo and bind GM1 ganglioside on cellular membranes

Hong, S., Ostaszewski, B. L., Yang, T., O'Malley, T. T., Jin, M., Yanagisawa, K., Li, S., Bartels, T. & Selkoe, D. J., Apr 16 2014, In : Neuron. 82, 2, p. 308-319 12 p.

Research output: Contribution to journalArticle

Open Access
98 Scopus citations