Center for Alzheimer's and Neurodegenerative Diseases

Research output

Research output per year 1987 2009 2013 2014 2015 2017 2018 2020 2021 2022 2023 2024

• 121 Article
• 17 Review article
• 3 Comment/debate
• 2 Chapter
• 3 More
  • 1 Editorial
  • 1 Letter
  • 1 Short survey

Research output per year

Research output per year

Search results

• 2024

  Blood Markers in Relation to a History of Traumatic Brain Injury Across Stages of Cognitive Impairment in a Diverse Cohort

  Lobue, C., Stopschinski, B. E., Saez Calveras, N., Douglas, P. M., Huebinger, R., Cullum, C. M., Hart, J. & Gonzales, M. M., Jan 2 2024, In: Journal of Alzheimer's Disease. 97, 1, p. 345-358 14 p.

  Research output: Contribution to journal › Article › peer-review

  • cognitive impairment 100%
  • Traumatic Brain Injury 80%
  • brain 68%
  • Cognitive Dysfunction 66%
  • dementia 63%

• DNP-assisted solid-state NMR enables detection of proteins at nanomolar concentrations in fully protonated cellular milieu

  Costello, W. N., Xiao, Y., Mentink-Vigier, F., Kragelj, J. & Frederick, K. K., 2024, (Accepted/In press) In: Journal of biomolecular NMR.

  Research output: Contribution to journal › Article › peer-review

  • Solid-State NMR 100%
  • Dynamic Nuclear Polarization 46%
  • Protein 40%
  • Isotopes 39%
  • Proteins 36%

• Docking for Molecules That Bind in a Symmetric Stack with SymDOCK

  Smith, M. S., Knight, I. S., Kormos, R. C., Pepe, J. G., Kunach, P., Diamond, M. I., Shahmoradian, S. H., Irwin, J. J., DeGrado, W. F. & Shoichet, B. K., Jan 22 2024, In: Journal of Chemical Information and Modeling. 64, 2, p. 425-434 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Ligands 100%
  • Molecules 73%
  • Ligand 33%
  • energy 30%
  • Molecule 26%

• Tau seeding without tauopathy

  LaCroix, M. S., Artikis, E., Hitt, B. D., Beaver, J. D., Estill-Terpack, S. J., Gleason, K., Tamminga, C. A., Evers, B. M., White, C. L., Caughey, B. & Diamond, M. I., Jan 2024, In: Journal of Biological Chemistry. 300, 1, 105545.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Tauopathies 100%
  • Seeds 75%
  • Statistical Ensemble 73%
  • Alzheimer Disease 34%
  • Brain 28%

• Travels with tau prions

  Diamond, M. I., Jan 2024, In: Cytoskeleton. 81, 1, p. 83-88 6 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Tauopathies 100%
  • Prions 90%
  • Microtubule-Associated Proteins 43%
  • Valosin Containing Protein 30%
  • Heparan Sulfate Proteoglycans 23%
• 2023

  Anti-tau antibodies targeting a conformation-dependent epitope selectively bind seeds

  Hitt, B. D., Gupta, A., Singh, R., Yang, T., Beaver, J. D., Shang, P., White, C. L., Joachimiak, L. A. & Diamond, M. I., Nov 2023, In: Journal of Biological Chemistry. 299, 11, 105252.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Pick Disease of the Brain 100%
  • Epitope 89%
  • Seeds 89%
  • Progressive Supranuclear Palsy 88%
  • Epitopes 75%
  1 Scopus citations

• Conformational ensembles explain NMR spectra of frozen intrinsically disordered proteins

  Kragelj, J., Dumarieh, R., Xiao, Y. & Frederick, K. K., May 2023, In: Protein Science. 32, 5, e4628.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Intrinsically Disordered Proteins 100%
  • Statistical Ensemble 68%
  • NMR Spectrum 59%
  • Dynamic Nuclear Polarization 48%
  • Mugineic Acids 38%
  1 Scopus citations

• DnaJC7 specifically regulates tau seeding

  Perez, V. A., Sanders, D. W., Mendoza-Oliva, A., Stopschinski, B. E., Mullapudi, V., White, C. L., Joachimiak, L. A. & Diamond, M. I., Jun 2023, In: eLife. 12

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Protein Domains 100%
  • Mutation 41%
  • Protective 40%
  • Tauopathies 33%
  • tau Proteins 31%
  3 Scopus citations

• FTD-tau S320F mutation stabilizes local structure and allosterically promotes amyloid motif-dependent aggregation

  Chen, D., Bali, S., Singh, R., Wosztyl, A., Mullapudi, V., Vaquer-Alicea, J., Jayan, P., Melhem, S., Seelaar, H., van Swieten, J. C., Diamond, M. I. & Joachimiak, L. A., Dec 2023, In: Nature communications. 14, 1, 1625.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Frontotemporal Dementia 100%
  • mutations 93%
  • Amyloid 75%
  • Mutation 67%
  • Data Aggregation 43%
  4 Scopus citations

• Microglia as a cellular target of diclofenac therapy in Alzheimer’s disease

  Stopschinski, B. E., Weideman, R. A., McMahan, D., Jacob, D. A., Little, B. B., Chiang, H. S., Saez Calveras, N. & Stuve, O., Jan 1 2023, In: Therapeutic Advances in Neurological Disorders. 16

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  • Diclofenac 100%
  • Microglia 86%
  • Fenamates 79%
  • Alzheimer Disease 66%
  • Non-Steroidal Anti-Inflammatory Agents 46%
  3 Scopus citations

• Network of hotspot interactions cluster tau amyloid folds

  Mullapudi, V., Vaquer-Alicea, J., Bommareddy, V., Vega, A. R., Ryder, B. D., White, C. L., Diamond, M. I. & Joachimiak, L. A., Dec 2023, In: Nature communications. 14, 1, 895.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Amyloid 100%
  • proteins 83%
  • Amyloidogenic Proteins 70%
  • Molecular Cluster 68%
  • Microtubule-Associated Proteins 62%
  7 Scopus citations

• Saturation mutagenesis of α-synuclein reveals monomer fold that modulates aggregation

  Chlebowicz, J., Russ, W., Chen, D., Vega, A., Vernino, S., White, C. L., Rizo, J., Joachimiak, L. A. & Diamond, M. I., Oct 27 2023, In: Science Advances. 9, 43, eadh3457.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Synucleins 100%
  • Synucleinopathies 92%
  • Mutagenesis 65%
  • Protein Conformation 29%
  • Prions 27%

• The AAA+ chaperone VCP disaggregates Tau fibrils and generates aggregate seeds in a cellular system

  Saha, I., Yuste-Checa, P., Da Silva Padilha, M., Guo, Q., Körner, R., Holthusen, H., Trinkaus, V. A., Dudanova, I., Fernández-Busnadiego, R., Baumeister, W., Sanders, D. W., Gautam, S., Diamond, M. I., Hartl, F. U. & Hipp, M. S., Dec 2023, In: Nature communications. 14, 1, 560.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Valosin Containing Protein 100%
  • Seeds 62%
  • seeds 56%
  • proteins 48%
  • machinery 30%
  8 Scopus citations
• 2022

  Chaperoning shape-shifting tau in disease

  Ryder, B. D., Wydorski, P. M., Hou, Z. & Joachimiak, L. A., 2022, (Accepted/In press) In: Trends in biochemical sciences.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  • Tauopathies 100%
  • Amyloid 69%
  • Amyloid Fibril 43%
  • Protein 30%
  • Molecular Chaperones 30%
  10 Scopus citations

• Clinical Reasoning: A 59-Year-Old Man with Thymoma and Constitutional Symptoms, Seizures, and Multifocal CNS Lesions

  Stopschinski, B. E., Fredrich, S., Vernino, S., Phillips, L. & Blackburn, K. M., Dec 13 2022, In: Neurology. 99, 24, p. 1115-1121 7 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Thymoma 100%
  • Seizures 64%
  • Cholinergic Receptors 60%
  • Arm 48%
  • Antibodies 45%

• Cognitive Decline in Older People with Multiple Sclerosis—A Narrative Review of the Literature

  Chiang, H. S., Khera, A., Stopschinski, B. E., Stuve, O., Hart, J., Kelley, B. & Nguyen, T., Jun 2022, In: Geriatrics (Switzerland). 7, 3, 61.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  • multiple sclerosis 100%
  • Multiple Sclerosis 74%
  • Cognitive Dysfunction 69%
  • narrative 51%
  • dementia 47%
  2 Scopus citations

• Conformation-specific anti-tau antibodies distinguish human tauopathies

  Hitt, B. D., Yang, T., Beaver, J. D., Shang, P., Joachimiak, L. A., White, C. & Diamond, M., Dec 2022, In: Alzheimer's and Dementia. 18, S4, e066069.

  Research output: Contribution to journal › Comment/debate › peer-review

  • Tauopathies 100%
  • Seeds 75%
  • dementia 74%
  • Anti-Idiotypic Antibodies 62%
  • brain 46%
  1 Scopus citations

• Development of a New DHFR-Based Destabilizing Domain with Enhanced Basal Turnover and Applicability in Mammalian Systems

  Nakahara, E., Mullapudi, V., Collier, G. E., Joachimiak, L. A. & Hulleman, J. D., Oct 21 2022, In: ACS chemical biology. 17, 10, p. 2877-2889 13 p.

  Research output: Contribution to journal › Article › peer-review

  • Tetrahydrofolate Dehydrogenase 100%
  • Dihydrofolates 94%
  • Escherichia coli 52%
  • Trimethoprim 50%
  • Mutation 31%
  1 Scopus citations

• Evidence-Based Evaluation and Management of Cognitive Impairment in Dementia With Lewy Bodies

  Khera, A., Stopschinski, B. E. & Chiang, H. S., Oct 1 2022, In: Psychiatric Annals. 52, 10, p. 404-409 6 p.

  Research output: Contribution to journal › Article › peer-review

  • Lewy Body Disease 100%
  • Cognitive Dysfunction 64%
  • Behavioral Symptoms 23%
  • Dementia 16%
  • Pharmacology 13%

• In-Cell NMR of Intact Mammalian Cells Preserved with the Cryoprotectants DMSO and Glycerol Have Similar DNP Performance

  Xiao, Y., Ghosh, R. & Frederick, K. K., Jan 25 2022, In: Frontiers in Molecular Biosciences. 8, 789478.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Cryoprotective Agent 100%
  • Dynamic Nuclear Polarization 99%
  • Dimethyl Sulfoxide 77%
  • Glycerol 73%
  • Mammalian Cell 72%
  6 Scopus citations

• RNA induces unique tau strains and stabilizes Alzheimer's disease seeds

  Zwierzchowski-Zarate, A. N., Mendoza-Oliva, A., Kashmer, O. M., Collazo-Lopez, J. E., White, C. L. & Diamond, M. I., Aug 2022, In: Journal of Biological Chemistry. 298, 8, 102132.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Seeds 100%
  • Alzheimer Disease 76%
  • Strain 68%
  • RNA 68%
  • Tauopathies 38%
  16 Scopus citations

• Seed-competent tau monomer initiates pathology in a tauopathy mouse model

  Mirbaha, H., Chen, D., Mullapudi, V., Terpack, S. J., White, C. L., Joachimiak, L. A. & Diamond, M. I., Aug 2022, In: Journal of Biological Chemistry. 298, 8, 102163.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Tauopathies 100%
  • Seeds 75%
  • Pathology 46%
  • Monomer 43%
  • Phosphorylation 20%
  15 Scopus citations

• Stability of the nitroxide biradical AMUPol in intact and lysed mammalian cells

  Ghosh, R., Dumarieh, R., Xiao, Y. & Frederick, K. K., Mar 2022, In: Journal of Magnetic Resonance. 336, 107150.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Dynamic Nuclear Polarization 100%
  • Mammalian Cell 72%
  • nitroxyl 50%
  • polarization 37%
  • cells 25%
  6 Scopus citations

• Tau seeding in cases of multiple sclerosis

  LaCroix, M. S., Mirbaha, H., Shang, P., Zandee, S., Foong, C., Prat, A., White, C. L., Stuve, O. & Diamond, M. I., Dec 2022, In: Acta Neuropathologica Communications. 10, 1, 146.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Multiple Sclerosis 100%
  • Tauopathies 76%
  • Brain 20%
  • tau Proteins 17%
  • Relapsing-Remitting Multiple Sclerosis 17%
  4 Scopus citations

• The dual fates of exogenous tau seeds: Lysosomal clearance versus cytoplasmic amplification

  Kolay, S., Vega, A. R., Dodd, D. A., Perez, V. A., Kashmer, O. M., White, C. L. & Diamond, M. I., Jun 2022, In: Journal of Biological Chemistry. 298, 6, 102014.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Clearance 100%
  • Seeds 94%
  • Autophagy Inhibitor 43%
  • Heparan Sulfate Proteoglycan 34%
  • Proteasome Inhibitor 34%
  8 Scopus citations

• VCP suppresses proteopathic seeding in neurons

  Zhu, J., Pittman, S., Dhavale, D., French, R., Patterson, J. N., Kaleelurrrahuman, M. S., Sun, Y., Vaquer-Alicea, J., Maggiore, G., Clemen, C. S., Buscher, W. J., Bieschke, J., Kotzbauer, P., Ayala, Y., Diamond, M. I., Davis, A. A. & Weihl, C., Dec 2022, In: Molecular neurodegeneration. 17, 1, 30.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Valosin Containing Protein 100%
  • Neurons 37%
  • Biosensing Techniques 26%
  • Seeds 16%
  • Mutation 12%
  11 Scopus citations
• 2021

  Anatomic survey of seeding in Alzheimer’s disease brains reveals unexpected patterns

  Stopschinski, B. E., Del Tredici, K., Estill-Terpack, S. J., Ghebremdehin, E., Yu, F. F., Braak, H. & Diamond, M. I., Dec 2021, In: Acta Neuropathologica Communications. 9, 1, 164.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Alzheimer Disease 100%
  • Pathology 81%
  • Brain 63%
  • Tauopathies 49%
  • Basal Nucleus of Meynert 26%
  14 Scopus citations

• Deep learning reveals disease-specific signatures of white matter pathology in tauopathies

  Vega, A. R., Chkheidze, R., Jarmale, V., Shang, P., Foong, C., Diamond, M. I., White, C. L. & Rajaram, S., Dec 2021, In: Acta Neuropathologica Communications. 9, 1, 170.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Deep Learning 100%
  • Tauopathies 98%
  • White Matter 66%
  • Pathology 46%
  • Gray Matter 36%
  11 Scopus citations

• DnaJC7 binds natively folded structural elements in tau to inhibit amyloid formation

  Hou, Z., Wydorski, P. M., Perez, V. A., Mendoza-Oliva, A., Ryder, B. D., Mirbaha, H., Kashmer, O. & Joachimiak, L. A., Dec 1 2021, In: Nature communications. 12, 1, 5338.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Protein Domains 100%
  • Amyloid 93%
  • Tetratricopeptide Repeat 74%
  • tau Proteins 62%
  • Molecular Chaperones 60%
  10 Scopus citations

• In-Cell Sensitivity-Enhanced NMR of Intact Viable Mammalian Cells

  Ghosh, R., Xiao, Y., Kragelj, J. & Frederick, K. K., Nov 10 2021, In: Journal of the American Chemical Society. 143, 44, p. 18454-18466 13 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Dynamic Nuclear Polarization 100%
  • Nuclear magnetic resonance 83%
  • Mammalian Cell 72%
  • Cells 68%
  • Proteins 64%
  26 Scopus citations

• Risk of transmissibility from neurodegenerative disease-associated proteins: Experimental knowns and unknowns

  Asher, D. M., Belay, E., Bigio, E., Brandner, S., Brubaker, S. A., Caughey, B., Clark, B., Damon, I., Diamond, M., Freund, M., Hyman, B. T., Jucker, M., Keene, C. D., Lieberman, A. P., MacKiewicz, M., Montine, T. J., Morgello, S., Phelps, C., Safar, J., Schneider, J. A., & 5 othersSchonberger, L. B., Sigurdson, C., Silverberg, N., Trojanowski, J. Q. & Frosch, M. P., 2021, In: Journal of neuropathology and experimental neurology. 79, 11, p. 1141-1146 6 p.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  • Neurodegenerative Diseases 100%
  • Proteins 42%
  • Creutzfeldt-Jakob Syndrome 37%
  • Prion Diseases 35%
  • Animal Models 20%
  24 Scopus citations

• Tau seeding in chronic traumatic encephalopathy parallels disease severity

  Kaufman, S. K., Svirsky, S., Cherry, J. D., McKee, A. C. & Diamond, M. I., Dec 2021, In: Acta Neuropathologica. 142, 6, p. 951-960 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Chronic Traumatic Encephalopathy 100%
  • Tauopathies 66%
  • Biosensing Techniques 44%
  • Seeds 25%
  • Brain 24%
  6 Scopus citations

• Tau strains shape disease

  Vaquer-Alicea, J., Diamond, M. I. & Joachimiak, L. A., Jul 2021, In: Acta Neuropathologica. 142, 1, p. 57-71 15 p.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  • Tauopathies 100%
  • Prions 72%
  • Neurodegenerative Diseases 25%
  • Pick Disease of the Brain 22%
  • Brain 21%
  66 Scopus citations

• Ultrasensitive tau biosensor cells detect no seeding in Alzheimer’s disease CSF

  Hitt, B. D., Vaquer-Alicea, J., Manon, V. A., Beaver, J. D., Kashmer, O. M., Garcia, J. N. & Diamond, M. I., Dec 2021, In: Acta Neuropathologica Communications. 9, 1, 99.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Biosensing Techniques 100%
  • Cerebrospinal Fluid 71%
  • Alzheimer Disease 63%
  • Seeds 62%
  • Fluorescence Resonance Energy Transfer 54%
  24 Scopus citations
• 2020

  Alzheimer's disease risk modifier genes do not affect tau aggregate uptake, seeding or maintenance in cell models

  Kolay, S. & Diamond, M. I., Sep 1 2020, In: FEBS Open Bio. 10, 9, p. 1912-1920 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Modifier Genes 100%
  • Beta-Amyloid 78%
  • Alzheimer Disease 54%
  • Maintenance 48%
  • Gene Knockout Techniques 36%
  4 Scopus citations

• An evolution-based model for designing chorismate mutase enzymes

  Russ, W. P., Figliuzzi, M., Stocker, C., Barrat-Charlaix, P., Socolich, M., Kast, P., Hilvert, D., Monasson, R., Cocco, S., Weigt, M. & Ranganathan, R., Jul 24 2020, In: Science. 369, 6502, p. 440-445 6 p.

  Research output: Contribution to journal › Article › peer-review

  • Chorismate Mutase 100%
  • Enzymes 28%
  • Aromatic Amino Acids 25%
  • Synthetic Genes 24%
  • Statistical Models 19%
  134 Scopus citations

• A synthetic heparinoid blocks Tau aggregate cell uptake and amplification

  Stopschinski, B. E., Thomas, T. L., Nadji, S., Darvish, E., Fan, L., Holmes, B. B., Modi, A. R., Finnell, J. G., Kashmer, O. M., Estill-Terpack, S., Mirbaha, H., Luu, H. S. & Diamond, M. I., Mar 6 2020, In: Journal of Biological Chemistry. 295, 10, p. 2974-2983 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Heparinoid 100%
  • Heparinoids 92%
  • Heparin 59%
  • Prions 53%
  • Tauopathies 39%
  23 Scopus citations

• Cryogenic sample loading into a magic angle spinning nuclear magnetic resonance spectrometer that preserves cellular viability

  Ghosh, R., Kragelj, J., Xiao, Y. & Frederick, K. K., 2020, In: Journal of Visualized Experiments. 2020, 163, p. 1-12 12 p., e61733.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Magnetic resonance spectrometers 100%
  • Magic angle spinning 96%
  • Nuclear magnetic resonance 63%
  • Mugineic Acids 60%
  • Cryogenics 58%
  11 Scopus citations

• Michler's hydrol blue elucidates structural differences in prion strains

  Xiao, Y., Rocha, S., Kitts, C. C., Reymer, A., Beke-Somfai, T., Frederick, K. K. & Nordén, B., Nov 24 2020, In: Proceedings of the National Academy of Sciences of the United States of America. 117, 47, p. 29677-29683 7 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Prions 100%
  • Amyloid 76%
  • Density Functional Theory 28%
  • Coloring Agents 26%
  • Fluorescence 26%
  2 Scopus citations

• RNA sectors and allosteric function within the ribosome

  Walker, A. S., Russ, W. P., Ranganathan, R. & Schepartz, A., Aug 2020, In: Proceedings of the National Academy of Sciences of the United States of America. 117, 33, p. 19879-19887 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Ribosomes 100%
  • Large Ribosome Subunits 21%
  • Genetic Code 19%
  • Proteins 15%
  • High-Throughput Nucleotide Sequencing 13%
  9 Scopus citations

• Segmental labeling: Applications to protein NMR and DNP

  Ghosh, R., Madrid, C. L. & Frederick, K. K., 2020, In: eMagRes. 9, 1, p. 71-80 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Inteins 100%
  • Dynamic Nuclear Polarization 93%
  • Magic angle spinning 89%
  • Nuclear magnetic resonance 78%
  • Labeling 63%
  2 Scopus citations

• Site-Specific Hyperphosphorylation Inhibits, Rather than Promotes, Tau Fibrillization, Seeding Capacity, and Its Microtubule Binding

  Haj-Yahya, M., Gopinath, P., Rajasekhar, K., Mirbaha, H., Diamond, M. I. & Lashuel, H. A., Mar 2 2020, In: Angewandte Chemie - International Edition. 59, 10, p. 4059-4067 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Agglomeration 100%
  • Phosphorylation 92%
  • Polymerization Reaction 69%
  • Pathology 65%
  • Polymerization 64%
  55 Scopus citations
• 2019

  Parkinson’s disease and multiple system atrophy have distinct -synuclein seed characteristics

  Yamasaki, T. R., Holmes, B. B., Furman, J. L., Dhavale, D. D., Su, B. W., Song, E. S., Cairns, N. J., Kotzbauer, P. T. & Diamond, M. I., Jan 18 2019, In: Journal of Biological Chemistry. 294, 3, p. 1045-1058 14 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Synucleins 100%
  • Multiple System Atrophy 87%
  • Seeds 67%
  • Parkinson Disease 55%
  • Prions 46%
  124 Scopus citations

• Propagation of protein aggregation in neurodegenerative diseases

  Vaquer-Alicea, J. & Diamond, M. I., Jun 20 2019, In: Annual review of biochemistry. 88, p. 785-810 26 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Amyloidogenic Proteins 100%
  • Neurodegenerative Diseases 97%
  • Neuropathology 83%
  • Amyloid 70%
  • Synucleins 56%
  184 Scopus citations

• Target engagement in an alzheimer trial: Crenezumab lowers amyloid β oligomers in cerebrospinal fluid

  Yang, T., Dang, Y., Ostaszewski, B., Mengel, D., Steffen, V., Rabe, C., Bittner, T., Walsh, D. M. & Selkoe, D. J., Aug 2019, In: Annals of Neurology. 86, 2, p. 215-224 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • crenezumab 100%
  • Amyloid 44%
  • Cerebrospinal Fluid 40%
  • Placebos 26%
  • Alzheimer Disease 18%
  65 Scopus citations

• Tau local structure shields an amyloid-forming motif and controls aggregation propensity

  Chen, D., Drombosky, K. W., Hou, Z., Sari, L., Kashmer, O. M., Ryder, B. D., Perez, V. A., Woodard, D. N. R., Lin, M. M., Diamond, M. I. & Joachimiak, L. A., Dec 1 2019, In: Nature communications. 10, 1, 2493.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Tauopathies 100%
  • mutations 85%
  • Mutation 62%
  • tau Proteins 46%
  • Amyloid Plaques 40%
  95 Scopus citations
• 2018

  Amyloid fibrils embodying distinctive yeast prion phenotypes exhibit diverse morphologies

  Ghosh, R., Dong, J., Wall, J. & Frederick, K. K., Sep 1 2018, In: FEMS Yeast Research. 18, 6, foy059.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Prions 100%
  • Amyloid 76%
  • Yeasts 65%
  • Phenotype 48%
  • Molecular Structure 16%
  16 Scopus citations

• A set of experimentally validated, mutually orthogonal primers for combinatorially specifying genetic components

  Subramanian, S. K., Russ, W. P. & Ranganathan, R., Jun 6 2018, In: Synthetic Biology. 3, 1, ysx008.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Deoxyribonucleic Acid 100%
  • Genes 81%
  • Oligonucleotide 75%
  • Oligonucleotides 50%
  • Synthetic biology 50%
  3 Scopus citations

• DNP-Assisted NMR Investigation of Proteins at Endogenous Levels in Cellular Milieu

  Costello, W. N., Xiao, Y. & Frederick, K. K., Jan 1 2018, (Accepted/In press) In: Methods in Enzymology.

  Research output: Contribution to journal › Article › peer-review

  • Magnetic Resonance Spectroscopy 100%
  • Dynamic Nuclear Polarization 84%
  • NMR Spectroscopy 79%
  • Environment 67%
  • Protein Structure 58%
  12 Scopus citations

• Inert and seed-competent tau monomers suggest structural origins of aggregation

  Mirbaha, H., Chen, D., Morazova, O. A., Ruff, K. M., Sharma, A. M., Liu, X., Goodarzi, M., Pappu, R. V., Colby, D. W., Mirzaei, H., Joachimiak, L. A. & Diamond, M. I., Jul 10 2018, In: eLife. 7, e36584.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Seeds 100%
  • Limited Proteolysis 63%
  • Monomer 57%
  • Tauopathies 33%
  • Probe 29%
  144 Scopus citations