Research Output

2020

A Medicinal Chemistry-Driven Approach Identified the Sterol Isomerase EBP as the Molecular Target of TASIN Colorectal Cancer Toxins

Theodoropoulos, P. C., Wang, W., Budhipramono, A., Thompson, B. M., Madhusudhan, N., Mitsche, M. A., McDonald, J. G., De Brabander, J. K. & Nijhawan, D., Apr 1 2020, In : Journal of the American Chemical Society. 142, 13, p. 6128-6138 11 p.

Research output: Contribution to journalArticle

Cholesterol 25-hydroxylase promotes efferocytosis and resolution of lung inflammation

Madenspacher, J. H., Morrell, E. D., Gowdy, K. M., McDonald, J. G., Thompson, B. M., Muse, G., Martinez, J., Thomas, S., Mikacenic, C., Nick, J. A., Abraham, E., Garantziotis, S., Stapleton, R. D., Meacham, J. M., Thomassen, M. J., Janssen, W. J., Cook, D. N., Wurfel, M. M. & Fessler, M. B., Jun 4 2020, In : JCI Insight. 5, 11

Research output: Contribution to journalArticle

Open Access

Cholesterol Stabilizes TAZ in Hepatocytes to Promote Experimental Non-alcoholic Steatohepatitis

Wang, X., Cai, B., Yang, X., Sonubi, O. O., Zheng, Z., Ramakrishnan, R., Shi, H., Valenti, L., Pajvani, U. B., Sandhu, J., Infante, R. E., Radhakrishnan, A., Covey, D. F., Guan, K. L., Buck, J., Levin, L. R., Tontonoz, P., Schwabe, R. F. & Tabas, I., May 5 2020, In : Cell Metabolism. 31, 5, p. 969-986.e7

Research output: Contribution to journalArticle

2 Scopus citations

Comparing primary prevention recommendations: A focused look at United States and European guidelines on dyslipidemia

Stone, N. J., Blumenthal, R. S., Lloyd-Jones, D. & Grundy, S. M., Jan 1 2020, (Accepted/In press) In : Circulation. p. 1117-1120 4 p.

Research output: Contribution to journalReview article

Mitochondrial substrate utilization regulates cardiomyocyte cell-cycle progression

Cardoso, A. C., Lam, N. T., Savla, J. J., Nakada, Y., Pereira, A. H. M., Elnwasany, A., Menendez-Montes, I., Ensley, E. L., Bezan Petric, U., Sharma, G., Sherry, A. D., Malloy, C. R., Khemtong, C., Kinter, M. T., Tan, W. L. W., Anene-Nzelu, C. G., Foo, R. S. Y., Nguyen, N. U. N., Li, S., Ahmed, M. S. & 14 others, Elhelaly, W. M., Abdisalaam, S., Asaithamby, A., Xing, C., Kanchwala, M., Vale, G., Eckert, K. M., Mitsche, M. A., McDonald, J. G., Hill, J. A., Huang, L., Shaul, P. W., Szweda, L. I. & Sadek, H. A., Feb 1 2020, In : Nature Metabolism. 2, 2, p. 167-178 12 p.

Research output: Contribution to journalArticle

2 Scopus citations

Niche-Specific Reprogramming of Epigenetic Landscapes Drives Myeloid Cell Diversity in Nonalcoholic Steatohepatitis

Seidman, J. S., Troutman, T. D., Sakai, M., Gola, A., Spann, N. J., Bennett, H., Bruni, C. M., Ouyang, Z., Li, R. Z., Sun, X., Vu, B. C. T., Pasillas, M. P., Ego, K. M., Gosselin, D., Link, V. M., Chong, L. W., Evans, R. M., Thompson, B. M., McDonald, J. G., Hosseini, M. & 3 others, Witztum, J. L., Germain, R. N. & Glass, C. K., Jun 16 2020, In : Immunity. 52, 6, p. 1057-1074.e7

Research output: Contribution to journalArticle

Oxysterols provide innate immunity to bacterial infection by mobilizing cell surface accessible cholesterol

Abrams, M. E., Johnson, K. A., Perelman, S. S., Zhang, L. S., Endapally, S., Mar, K. B., Thompson, B. M., McDonald, J. G., Schoggins, J. W., Radhakrishnan, A. & Alto, N. M., Jul 1 2020, In : Nature microbiology. 5, 7, p. 929-942 14 p.

Research output: Contribution to journalArticle

2 Scopus citations

Secondary prevention for atherosclerotic cardiovascular disease: Comparing recent US and European guidelines on dyslipidemia

Virani, S. S., Smith, S. C., Stone, N. J. & Grundy, S. M., 2020, (Accepted/In press) In : Circulation. p. 1121-1123 3 p.

Research output: Contribution to journalReview article

Open Access
1 Scopus citations
Open Access
2019

2018 AHA/ACC/AACVPR/AAPA/ABC/ACPM/ADA/AGS/APhA/ASPC/NLA/PCNA Guideline on the Management of Blood Cholesterol: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines

Grundy, S. M., Stone, N. J., Bailey, A. L., Beam, C., Birtcher, K. K., Blumenthal, R. S., Braun, L. T., De Ferranti, S., Faiella-Tommasino, J., Forman, D. E., Goldberg, R., Heidenreich, P. A., Hlatky, M. A., Jones, D. W., Lloyd-Jones, D., Lopez-Pajares, N., Ndumele, C. E., Orringer, C. E., Peralta, C. A., Saseen, J. J. & 4 others, Smith, S. C., Sperling, L., Virani, S. S. & Yeboah, J., Jun 18 2019, In : Circulation. 139, 25, p. E1082-E1143

Research output: Contribution to journalReview article

Open Access
305 Scopus citations

2018 AHA/ACC/AACVPR/AAPA/ABC/ACPM/ADA/AGS/APhA/ASPC/NLA/PCNA Guideline on the Management of Blood Cholesterol: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines

Grundy, S. M., Stone, N. J., Bailey, A. L., Beam, C., Birtcher, K. K., Blumenthal, R. S., Braun, L. T., de Ferranti, S., Faiella-Tommasino, J., Forman, D. E., Goldberg, R., Heidenreich, P. A., Hlatky, M. A., Jones, D. W., Lloyd-Jones, D., Lopez-Pajares, N., Ndumele, C. E., Orringer, C. E., Peralta, C. A., Saseen, J. J. & 4 others, Smith, S. C., Sperling, L., Virani, S. S. & Yeboah, J., Jun 25 2019, In : Journal of the American College of Cardiology. 73, 24, p. e285-e350

Research output: Contribution to journalArticle

339 Scopus citations

2018 AHA/ACC/AACVPR/AAPA/ABC/ACPM/ADA/AGS/APhA/ASPC/NLA/PCNA Guideline on the Management of Blood Cholesterol: Executive Summary: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines

Grundy, S. M., Stone, N. J., Bailey, A. L., Beam, C., Birtcher, K. K., Blumenthal, R. S., Braun, L. T., De Ferranti, S., Faiella-Tommasino, J., Forman, D. E., Goldberg, R., Heidenreich, P. A., Hlatky, M. A., Jones, D. W., Lloyd-Jones, D., Lopez-Pajares, N., Ndumele, C. E., Orringer, C. E., Peralta, C. A., Saseen, J. J. & 4 others, Smith, S. C., Sperling, L., Virani, S. S. & Yeboah, J., Jun 18 2019, In : Circulation. 139, 25, p. E1046-E1081

Research output: Contribution to journalReview article

Open Access
52 Scopus citations

2018 AHA/ACC/AACVPR/AAPA/ABC/ACPM/ADA/AGS/APhA/ASPC/NLA/PCNA Guideline on the Management of Blood Cholesterol: Executive Summary: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines

Grundy, S. M., Stone, N. J., Bailey, A. L., Beam, C., Birtcher, K. K., Blumenthal, R. S., Braun, L. T., de Ferranti, S., Faiella-Tommasino, J., Forman, D. E., Goldberg, R., Heidenreich, P. A., Hlatky, M. A., Jones, D. W., Lloyd-Jones, D., Lopez-Pajares, N., Ndumele, C. E., Orringer, C. E., Peralta, C. A., Saseen, J. J. & 4 others, Smith, S. C., Sperling, L., Virani, S. S. & Yeboah, J., Jun 25 2019, In : Journal of the American College of Cardiology. 73, 24, p. 3168-3209 42 p.

Research output: Contribution to journalArticle

213 Scopus citations
6 Scopus citations
Open Access
6 Scopus citations

27-Hydroxycholesterol, an Endogenous SERM, and Risk of Fracture in Postmenopausal Women: A Nested Case-Cohort Study in the Women's Health Initiative

Chang, P. Y., Feldman, D., Stefanick, M. L., McDonnell, D. P., Thompson, B. M., McDonald, J. G. & Lee, J. S., Jan 2019, In : Journal of Bone and Mineral Research. 34, 1, p. 59-66 8 p.

Research output: Contribution to journalArticle

1 Scopus citations

Biliopancreatic Diversion Induces Greater Metabolic Improvement Than Roux-en-Y Gastric Bypass

Harris, L. A., Kayser, B. D., Cefalo, C., Marini, L., Watrous, J. D., Ding, J., Jain, M., McDonald, J. G., Thompson, B. M., Fabbrini, E., Eagon, J. C., Patterson, B. W., Mittendorfer, B., Mingrone, G. & Klein, S., Nov 5 2019, In : Cell Metabolism. 30, 5, p. 855-864.e3

Research output: Contribution to journalArticle

3 Scopus citations

Cholesterol accessibility at the ciliary membrane controls hedgehog signaling

Kinnebrew, M., Iverson, E. J., Patel, B. B., Pusapati, G. V., Kong, J. H., Johnson, K. A., Luchetti, G., Eckert, K. M., McDonald, J. G., Covey, D. F., Siebold, C., Radhakrishnan, A. & Rohatgi, R., Oct 2019, In : eLife. 8, e50051.

Research output: Contribution to journalArticle

Open Access
7 Scopus citations

Cryo-EM structure of oxysterol-bound human Smoothened coupled to a heterotrimeric Gi

Qi, X., Liu, H., Thompson, B., McDonald, J., Zhang, C. & Li, X., Jul 11 2019, In : Nature. 571, 7764, p. 279-283 5 p.

Research output: Contribution to journalArticle

22 Scopus citations
Open Access
4 Scopus citations

Drosophila Snazarus Regulates a Lipid Droplet Population at Plasma Membrane-Droplet Contacts in Adipocytes

Ugrankar, R., Bowerman, J., Hariri, H., Chandra, M., Chen, K., Bossanyi, M. F., Datta, S., Rogers, S., Eckert, K. M., Vale, G., Victoria, A., Fresquez, J., McDonald, J. G., Jean, S., Collins, B. M. & Henne, W. M., Sep 9 2019, In : Developmental cell. 50, 5, p. 557-572.e5

Research output: Contribution to journalArticle

6 Scopus citations

Fatty Acid Desaturation Gets a NAD + Reputation

Lutkewitte, A. J., Burgess, S. C. & Finck, B. N., Apr 2 2019, In : Cell Metabolism. 29, 4, p. 790-792 3 p.

Research output: Contribution to journalShort survey

First international descriptive and interventional survey for cholesterol and non-cholesterol sterol determination by gas- and liquid-chromatography–Urgent need for harmonisation of analytical methods

Lütjohann, D., Björkhem, I., Friedrichs, S., Kerksiek, A., Lövgren-Sandblom, A., Geilenkeuser, W. J., Ahrends, R., Andrade, I., Ansorena, D., Astiasarán, I., Baila-Rueda, L., Barriuso, B., Becker, S., Bretillon, L., Browne, R. W., Caccia, C., Ceglarek, U., Cenarro, A., Crick, P. J., Fauler, G. & 30 others, Garcia-Llatas, G., Gray, R., Griffiths, W. J., Gylling, H., Harding, S., Helmschrodt, C., Iuliano, L., Janssen, H. G., Jones, P., Kaipiainen, L., Kannenberg, F., Lagarda, M. J., Leoni, V., Lottenberg, A. M., MacKay, D. S., Matysik, S., McDonald, J., Menendez-Carreño, M., Myrie, S. B., Sutti Nunes, V., Ostlund, R. E., Polisecki, E., Ramos, F., Rideout, T. C., Schaefer, E. J., Schmitz, G., Wang, Y., Zerbinati, C., Diczfalusy, U. & Schött, H. F., Jun 2019, In : Journal of Steroid Biochemistry and Molecular Biology. 190, p. 115-125 11 p.

Research output: Contribution to journalArticle

Open Access
5 Scopus citations

Four Cases of Cholesterol Management Informed by the 2018 American Heart Association/American College of Cardiology Multisociety Guideline on the Management of Blood Cholesterol

Chuzi, S., Pfenniger, A., Lloyd-Jones, D. M., Blumenthal, R. S., Smith, S. C., Virani, S. S., Grundy, S. M. & Stone, N. J., May 2019, In : JAMA Cardiology. 4, 5, p. 473-477 5 p.

Research output: Contribution to journalArticle

Functional Assessment of Lipoyltransferase-1 Deficiency in Cells, Mice, and Humans

Ni, M., Solmonson, A., Pan, C., Yang, C., Li, D., Notzon, A., Cai, L., Guevara, G., Zacharias, L. G., Faubert, B., Vu, H. S., Jiang, L., Ko, B., Morales, N. M., Pei, J., Vale, G., Rakheja, D., Grishin, N. V., McDonald, J. G., Gotway, G. K. & 3 others, McNutt, M. C., Pascual, J. M. & DeBerardinis, R. J., Apr 30 2019, In : Cell Reports. 27, 5, p. 1376-1386.e6

Research output: Contribution to journalArticle

Open Access
4 Scopus citations
Open Access
9 Scopus citations

Insights into lipid accumulation in skeletal muscle in dysferlin-deficient mice

Agarwal, A. K., Tunison, K., Mitsche, M. A., McDonald, J. G. & Garg, A., 2019, In : Journal of lipid research. 60, 12, p. 2057-2073 17 p.

Research output: Contribution to journalArticle

1 Scopus citations

Liver-Derived Signals Sequentially Reprogram Myeloid Enhancers to Initiate and Maintain Kupffer Cell Identity

Sakai, M., Troutman, T. D., Seidman, J. S., Ouyang, Z., Spann, N. J., Abe, Y., Ego, K. M., Bruni, C. M., Deng, Z., Schlachetzki, J. C. M., Nott, A., Bennett, H., Chang, J., Vu, B. C. T., Pasillas, M. P., Link, V. M., Texari, L., Heinz, S., Thompson, B. M., McDonald, J. G. & 2 others, Geissmann, F. & Glass, C. K., Oct 15 2019, In : Immunity. 51, 4, p. 655-670.e8

Research output: Contribution to journalArticle

Open Access
20 Scopus citations
4 Scopus citations

Ostreolysin A and anthrolysin O use different mechanisms to control movement of cholesterol from the plasma membrane to the endoplasmic reticulum

Johnson, K. A., Endapally, S., Vazquez, D. C., Infante, R. E. & Radhakrishnan, A., Nov 15 2019, In : Journal of Biological Chemistry. 294, 46, p. 17289-17300 12 p.

Research output: Contribution to journalArticle

3 Scopus citations

Pyruvate-Carboxylase-Mediated Anaplerosis Promotes Antioxidant Capacity by Sustaining TCA Cycle and Redox Metabolism in Liver

Cappel, D. A., Deja, S., Duarte, J. A. G., Kucejova, B., Iñigo, M., Fletcher, J. A., Fu, X., Berglund, E. D., Liu, T., Elmquist, J. K., Hammer, S., Mishra, P., Browning, J. D. & Burgess, S. C., Jun 4 2019, In : Cell Metabolism. 29, 6, p. 1291-1305.e8

Research output: Contribution to journalArticle

12 Scopus citations

Schnyder corneal dystrophy-associated UBIAD1 inhibits ER-associated degradation of HMG CoA reductase in mice

Jo, Y., Hamilton, J. S., Hwang, S., Garland, K., Smith, G. A., Su, S., Fuentes, I., Neelam, S., Thompson, B. M., McDonald, J. G. & Debose-Boyd, R. A., Feb 2019, In : eLife. 8, e44396.

Research output: Contribution to journalArticle

Open Access
8 Scopus citations

Structural basis for human sterol isomerase in cholesterol biosynthesis and multidrug recognition

Long, T., Hassan, A., Thompson, B. M., McDonald, J. G., Wang, J. & Li, X., Dec 1 2019, In : Nature communications. 10, 1, 2452.

Research output: Contribution to journalArticle

Open Access
7 Scopus citations

Targeted Determination of Tissue Energy Status by LC-MS/MS

Fu, X., Deja, S., Kucejova, B., Duarte, J. A. G., McDonald, J. G. & Burgess, S. C., Jan 1 2019, In : Analytical chemistry.

Research output: Contribution to journalArticle

Open Access
5 Scopus citations

Target identification reveals lanosterol synthase as a vulnerability in glioma

Phillips, R. E., Yang, Y., Smith, R. C., Thompson, B. M., Yamasaki, T., Soto-Feliciano, Y. M., Funato, K., Liang, Y., Garcia-Bermudez, J., Wang, X., Garcia, B. A., Yamasaki, K., McDonald, J. G., Birsoy, K., Tabar, V. & Allis, C. D., Apr 16 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 16, p. 7957-7962 6 p.

Research output: Contribution to journalArticle

9 Scopus citations

The 2018 AHA/ACC/Multi-Society Cholesterol guidelines: Looking at past, present and future

Stone, N. J. & Grundy, S. M., Sep 1 2019, In : Progress in Cardiovascular Diseases. 62, 5, p. 375-383 9 p.

Research output: Contribution to journalReview article

6 Scopus citations

Three-phase liquid extraction: A simple and fast method for lipidomic workflows

Vale, G., Martin, S. A., Mitsche, M. A., Thompson, B. M., Eckert, K. M. & McDonald, J. G., Jan 1 2019, In : Journal of lipid research. 60, 3, p. 694-706 13 p.

Research output: Contribution to journalArticle

5 Scopus citations
2 Scopus citations

Very High-Risk ASCVD and Eligibility for Nonstatin Therapies Based on the 2018 AHA/ACC Cholesterol Guidelines

Virani, S. S., Akeroyd, J. M., Smith, S. C., Al-Mallah, M., Maddox, T. M., Morris, P. B., Petersen, L. A., Ballantyne, C. M., Grundy, S. M. & Stone, N. J., Aug 6 2019, In : Journal of the American College of Cardiology. 74, 5, p. 712-714 3 p.

Research output: Contribution to journalLetter

6 Scopus citations
2018

Cachexia-associated adipose loss induced by tumor-secreted leukemia inhibitory factor is counterbalanced by decreased leptin

Arora, G. K., Gupta, A., Narayanan, S., Guo, T., Iyengar, P. & Infante, R. E., Jul 26 2018, In : JCI Insight. 3, 14

Research output: Contribution to journalArticle

8 Scopus citations

Cell-specific discrimination of desmosterol and desmosterol mimetics confers selective regulation of LXR and SREBP in macrophages

Muse, E. D., Yu, S., Edillor, C. R., Tao, J., Spann, N. J., Troutman, T. D., Seidman, J. S., Henke, A., Roland, J. T., Ozeki, K. A., Thompson, B. M., McDonald, J. G., Bahadorani, J., Tsimikas, S., Grossman, T. R., Tremblay, M. S. & Glass, C. K., May 15 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 20, p. E4680-E4689

Research output: Contribution to journalArticle

21 Scopus citations

Cilia-Associated Oxysterols Activate Smoothened

Raleigh, D. R., Sever, N., Choksi, P. K., Sigg, M. A., Hines, K. M., Thompson, B. M., Elnatan, D., Jaishankar, P., Bisignano, P., Garcia-Gonzalo, F. R., Krup, A. L., Eberl, M., Byrne, E. F. X., Siebold, C., Wong, S. Y., Renslo, A. R., Grabe, M., McDonald, J. G., Xu, L., Beachy, P. A. & 1 others, Reiter, J. F., Oct 18 2018, In : Molecular cell. 72, 2, p. 316-327.e5

Research output: Contribution to journalArticle

32 Scopus citations

Cytosolic phosphoenolpyruvate carboxykinase as a cataplerotic pathway in the small intestine

Potts, A., Uchida, A., Deja, S., Berglund, E. D., Kucejova, B., Duarte, J. A., Fu, X., Browning, J. D., Magnuson, M. A. & Burgess, S. C., Aug 3 2018, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 315, 2, p. G249-G258

Research output: Contribution to journalArticle

4 Scopus citations

Glucagon Receptor Antagonism Improves Glucose Metabolism and Cardiac Function by Promoting AMP-Mediated Protein Kinase in Diabetic Mice

Sharma, A. X., Quittner-Strom, E. B., Lee, Y. H., Johnson, J. A., Martin, S. A., Yu, X., Li, J., Lu, J., Cai, Z., Chen, S., Wang, M-Y., Zhang, Y., Pearson, M. J., Dorn, A. C., McDonald, J. G., Gordillo, R., Yan, H., Thai, D., Wang, Z., Unger, R. H. & 1 others, Holland, W. L., Feb 13 2018, In : Cell Reports. 22, 7, p. 1760-1773 14 p.

Research output: Contribution to journalArticle

13 Scopus citations

Impact of Socioeconomic Status on Pretreatment Weight Loss and Survival in Non-Small-Cell Lung Cancer

Lau, S. K. M., Gannavarapu, B. S., Carter, K., Gao, A., Ahn, C., Meyer, J. J., Sher, D. J., Jatoi, A., Infante, R. & Iyengar, P., Apr 1 2018, In : Journal of oncology practice. 14, 4, p. e211-e220

Research output: Contribution to journalArticle

5 Scopus citations

International descriptive and interventional survey for oxycholesterol determination by gas- and liquid-chromatographic methods

Lütjohann, D., Björkhem, I., Friedrichs, S., Kerksiek, A., Geilenkeuser, W. J., Lövgren-Sandblom, A., Ansorena, D., Astiasarán, I., Baila-Rueda, L., Barriuso, B., Bretillon, L., Browne, R. W., Caccia, C., Cenarro, A., Crick, P. J., Fauler, G., García-Llatas, G., Griffiths, W. J., Iuliano, L., Lagarda, M. J. & 11 others, Leoni, V., Lottenberg, A. M., Matysik, S., McDonald, J., Rideout, T. C., Schmitz, G., Nunes, V. S., Wang, Y., Zerbinati, C., Diczfalusy, U. & Schött, H. F., Oct 2018, In : Biochimie. 153, p. 26-32 7 p.

Research output: Contribution to journalArticle

4 Scopus citations
30 Scopus citations

Prevalence and Survival Impact of Pretreatment Cancer-Associated Weight Loss: A Tool for Guiding Early Palliative Care

Gannavarapu, B. S., Lau, S. K. M., Carter, K., Cannon, N. A., Gao, A., Ahn, C., Meyer, J. J., Sher, D. J., Jatoi, A., Infante, R. & Iyengar, P., Apr 1 2018, In : Journal of oncology practice. 14, 4, p. e238-e250

Research output: Contribution to journalArticle

4 Scopus citations
2017

17-alpha Hydroxyprogesterone caproate did not reduce the rate of recurrent preterm birth in a prospective cohort study

Nelson, D. B., McIntire, D. D., McDonald, J., Gard, J., Turrichi, P. & Leveno, K. J., Jan 10 2017, (Accepted/In press) In : American Journal of Obstetrics and Gynecology.

Research output: Contribution to journalArticle

39 Scopus citations