Research Output 1999 2019

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2019

Drosophila Snazarus Regulates a Lipid Droplet Population at Plasma Membrane-Droplet Contacts in Adipocytes

Ugrankar, R., Bowerman, J., Hariri, H., Chandra, M., Chen, K., Bossanyi, M. F., Datta, S., Rogers, S., Eckert, K. M., Dias do Vale, G., Victoria, A., Fresquez, J., McDonald, J. G., Jean, S., Collins, B. M. & Henne, W. M., Sep 9 2019, In : Developmental Cell. 50, 5, p. 557-572.e5

Research output: Contribution to journalArticle

Cell membranes
Adipocytes
Contacts (fluid mechanics)
Drosophila
Cell Membrane
2 Citations (Scopus)

First international descriptive and interventional survey for cholesterol and non-cholesterol sterol determination by gas- and liquid-chromatography–Urgent need for harmonisation of analytical methods

Lütjohann, D., Björkhem, I., Friedrichs, S., Kerksiek, A., Lövgren-Sandblom, A., Geilenkeuser, W. J., Ahrends, R., Andrade, I., Ansorena, D., Astiasarán, I., Baila-Rueda, L., Barriuso, B., Becker, S., Bretillon, L., Browne, R. W., Caccia, C., Ceglarek, U., Cenarro, A., Crick, P. J., Fauler, G. & 30 others, Garcia-Llatas, G., Gray, R., Griffiths, W. J., Gylling, H., Harding, S., Helmschrodt, C., Iuliano, L., Janssen, H. G., Jones, P., Kaipiainen, L., Kannenberg, F., Lagarda, M. J., Leoni, V., Lottenberg, A. M., MacKay, D. S., Matysik, S., McDonald, J. G., Menendez-Carreño, M., Myrie, S. B., Sutti Nunes, V., Ostlund, R. E., Polisecki, E., Ramos, F., Rideout, T. C., Schaefer, E. J., Schmitz, G., Wang, Y., Zerbinati, C., Diczfalusy, U. & Schött, H. F., Jun 1 2019, In : Journal of Steroid Biochemistry and Molecular Biology. 190, p. 115-125 11 p.

Research output: Contribution to journalArticle

Open Access
Sterols
Gases
Cholesterol
Liquids
Gas chromatography
1 Citation (Scopus)

Functional Assessment of Lipoyltransferase-1 Deficiency in Cells, Mice, and Humans

Ni, M., Solmonson, A., Pan, C., Yang, C., Li, D., Notzon, A., Cai, L., Guevara, G., Zacharias, L. G., Faubert, B., Vu, H. S., Jiang, L., Ko, B., Morales, N. M., Pei, J., Dias do Vale, G., Rakheja, D., Grishin, N. V., McDonald, J. G., Gotway, G. K. & 3 others, McNutt, M. C., Pascual, J. M. & DeBerardinis, R. J., Apr 30 2019, In : Cell Reports. 27, 5, p. 1376-1386.e6

Research output: Contribution to journalArticle

Open Access
Functional assessment
Inborn Errors Metabolism
Metabolomics
Genomics
Metabolism

Liver-Derived Signals Sequentially Reprogram Myeloid Enhancers to Initiate and Maintain Kupffer Cell Identity

Sakai, M., Troutman, T. D., Seidman, J. S., Ouyang, Z., Spann, N. J., Abe, Y., Ego, K. M., Bruni, C. M., Deng, Z., Schlachetzki, J. C. M., Nott, A., Bennett, H., Chang, J., Vu, B. C. T., Pasillas, M. P., Link, V. M., Texari, L., Heinz, S., Thompson, B. M., McDonald, J. G. & 2 others, Geissmann, F. & Glass, C. K., Oct 15 2019, In : Immunity. 51, 4, p. 655-670.e8

Research output: Contribution to journalArticle

Open Access
Kupffer Cells
Desmosterol
Macrophages
Liver
Phenotype
Cholesterol
Endoplasmic Reticulum
Cell Membrane
cholesterol-binding protein
Membranes
3 Citations (Scopus)

Pyruvate-Carboxylase-Mediated Anaplerosis Promotes Antioxidant Capacity by Sustaining TCA Cycle and Redox Metabolism in Liver

Cappel, D. A., Deja, S., Duarte, J. A. G., Kucejova, B., Iñigo, M., Fletcher, J. A., Fu, X., Berglund, E. D., Liu, T., Elmquist, J. K., Hammer, S. T., Mishra, P., Browning, J. D. & Burgess, S. C., Jun 4 2019, In : Cell Metabolism. 29, 6, p. 1291-1305.e8

Research output: Contribution to journalArticle

Pyruvate Carboxylase
Oxidation-Reduction
Antioxidants
Liver
Gluconeogenesis
1 Citation (Scopus)

Schnyder corneal dystrophy-associated UBIAD1 inhibits ER-associated degradation of HMG CoA reductase in mice

Jo, Y., Hamilton, J. S., Hwang, S., Garland, K., Smith, G. A., Su, S., Fuentes, I., Neelam, S., Thompson, B. M., McDonald, J. G. & Debose-Boyd, R. A., Feb 20 2019, In : eLife. 8

Research output: Contribution to journalArticle

Open Access
Endoplasmic Reticulum-Associated Degradation
Hydroxymethylglutaryl CoA Reductases
Degradation
Cholesterol
Sterols

Targeted Determination of Tissue Energy Status by LC-MS/MS

Fu, X., Deja, S., Kucejova, B., Duarte, J. A. G., McDonald, J. G. & Burgess, S. C., Jan 1 2019, In : Analytical chemistry.

Research output: Contribution to journalArticle

Open Access
Liver
NAD
Assays
Nucleotides
Tissue
1 Citation (Scopus)

Target identification reveals lanosterol synthase as a vulnerability in glioma

Phillips, R. E., Yang, Y., Smith, R. C., Thompson, B. M., Yamasaki, T., Soto-Feliciano, Y. M., Funato, K., Liang, Y., Garcia-Bermudez, J., Wang, X., Garcia, B. A., Yamasaki, K., McDonald, J. G., Birsoy, K., Tabar, V. & Allis, C. D., Apr 16 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 16, p. 7957-7962 6 p.

Research output: Contribution to journalArticle

Glioma
Cholesterol
Homeostasis
Metabolomics
lanosterol synthase

Three-phase liquid extraction: A simple and fast method for lipidomic workflows

Dias do Vale, G., Martin, S. A., Mitsche, M. A., Thompson, B. M., Eckert, K. M. & McDonald, J. G., Jan 1 2019, In : Journal of lipid research. 60, 3, p. 694-706 13 p.

Research output: Contribution to journalArticle

Liquid-Liquid Extraction
Workflow
Lipids
Liquids
Liver
2018
1 Citation (Scopus)

27-Hydroxycholesterol, an Endogenous SERM, and Risk of Fracture in Postmenopausal Women: A Nested Case-Cohort Study in the Women's Health Initiative

Chang, P. Y., Feldman, D., Stefanick, M. L., McDonnell, D. P., Thompson, B. M., McDonald, J. G. & Lee, J. S., Jan 1 2018, (Accepted/In press) In : Journal of Bone and Mineral Research.

Research output: Contribution to journalArticle

Selective Estrogen Receptor Modulators
Women's Health
Cohort Studies
Hormones
Placebos
5 Citations (Scopus)

Cachexia-associated adipose loss induced by tumor-secreted leukemia inhibitory factor is counterbalanced by decreased leptin

Arora, G. K., Gupta, A., Narayanan, S., Guo, T., Iyengar, P. & Infante, R. E., Jul 26 2018, In : JCI insight. 3, 14

Research output: Contribution to journalArticle

Leukemia Inhibitory Factor
Cachexia
Leptin
Lipolysis
Adipocytes
14 Citations (Scopus)

Cell-specific discrimination of desmosterol and desmosterol mimetics confers selective regulation of LXR and SREBP in macrophages

Muse, E. D., Yu, S., Edillor, C. R., Tao, J., Spann, N. J., Troutman, T. D., Seidman, J. S., Henke, A., Roland, J. T., Ozeki, K. A., Thompson, B. M., McDonald, J. G., Bahadorani, J., Tsimikas, S., Grossman, T. R., Tremblay, M. S. & Glass, C. K., May 15 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 20, p. E4680-E4689

Research output: Contribution to journalArticle

Desmosterol
Sterol Regulatory Element Binding Proteins
Macrophages
Hypertriglyceridemia
Cholesterol
22 Citations (Scopus)

Cilia-Associated Oxysterols Activate Smoothened

Raleigh, D. R., Sever, N., Choksi, P. K., Sigg, M. A., Hines, K. M., Thompson, B. M., Elnatan, D., Jaishankar, P., Bisignano, P., Garcia-Gonzalo, F. R., Krup, A. L., Eberl, M., Byrne, E. F. X., Siebold, C., Wong, S. Y., Renslo, A. R., Grabe, M., McDonald, J. G., Xu, L., Beachy, P. A. & 1 others, Reiter, J. F., Oct 18 2018, In : Molecular Cell. 72, 2, p. 316-327.e5

Research output: Contribution to journalArticle

Hedgehogs
Cilia
Medulloblastoma
Glycyrrhiza
Oxysterols
2 Citations (Scopus)

Cytosolic phosphoenolpyruvate carboxykinase as a cataplerotic pathway in the small intestine

Potts, A., Uchida, A., Deja, S., Berglund, E. D., Kucejova, B., Duarte, J. A., Fu, X., Browning, J. D., Magnuson, M. A. & Burgess, S. C., Aug 3 2018, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 315, 2, p. G249-G258

Research output: Contribution to journalArticle

Phosphoenolpyruvate
Small Intestine
Amino Acids
Gluconeogenesis
Enterocytes
8 Citations (Scopus)

Glucagon Receptor Antagonism Improves Glucose Metabolism and Cardiac Function by Promoting AMP-Mediated Protein Kinase in Diabetic Mice

Sharma, A. X., Quittner-Strom, E. B., Lee, Y. H., Johnson, J. A., Martin, S. A., Yu, X., Li, J., Lu, J., Cai, Z., Chen, S., Wang, M-Y., Zhang, Y., Pearson, M. J., Dorn, A. C., McDonald, J. G., Gordillo, R., Yan, H., Thai, D., Wang, Z., Unger, R. H. & 1 others, Holland, W. L., Feb 13 2018, In : Cell Reports. 22, 7, p. 1760-1773 14 p.

Research output: Contribution to journalArticle

Glucagon Receptors
Adenosine Monophosphate
Metabolism
Protein Kinases
Diabetic Cardiomyopathies
3 Citations (Scopus)

Impact of Socioeconomic Status on Pretreatment Weight Loss and Survival in Non-Small-Cell Lung Cancer

Lau, S. K. M., Gannavarapu, B. S., Carter, K., Gao, A., Ahn, C., Meyer, J. J., Sher, D. J., Jatoi, A., Infante, R. & Iyengar, P., Apr 1 2018, In : Journal of oncology practice. 14, 4, p. e211-e220

Research output: Contribution to journalArticle

Social Class
Non-Small Cell Lung Carcinoma
Weight Loss
Survival
Neoplasms
1 Citation (Scopus)

International descriptive and interventional survey for oxycholesterol determination by gas- and liquid-chromatographic methods

Lütjohann, D., Björkhem, I., Friedrichs, S., Kerksiek, A., Geilenkeuser, W. J., Lövgren-Sandblom, A., Ansorena, D., Astiasarán, I., Baila-Rueda, L., Barriuso, B., Bretillon, L., Browne, R. W., Caccia, C., Cenarro, A., Crick, P. J., Fauler, G., García-Llatas, G., Griffiths, W. J., Iuliano, L., Lagarda, M. J. & 11 others, Leoni, V., Lottenberg, A. M., Matysik, S., McDonald, J., Rideout, T. C., Schmitz, G., Nunes, V. S., Wang, Y., Zerbinati, C., Diczfalusy, U. & Schött, H. F., Oct 1 2018, In : Biochimie. 153, p. 26-32 7 p.

Research output: Contribution to journalArticle

Gases
Liquids
High performance liquid chromatography
Serum
High Pressure Liquid Chromatography
14 Citations (Scopus)
Essential Fatty Acids
Phospholipases
Phospholipids
Triglycerides
Lipids
2 Citations (Scopus)

Prevalence and Survival Impact of Pretreatment Cancer-Associated Weight Loss: A Tool for Guiding Early Palliative Care

Gannavarapu, B. S., Lau, S. K. M., Carter, K., Cannon, N. A., Gao, A., Ahn, C., Meyer, J. J., Sher, D. J., Jatoi, A., Infante, R. & Iyengar, P., Apr 1 2018, In : Journal of oncology practice. 14, 4, p. e238-e250

Research output: Contribution to journalArticle

Palliative Care
Weight Loss
Survival
Neoplasms
Cachexia
2017
30 Citations (Scopus)
Premature Birth
Cohort Studies
Prospective Studies
Gestational Diabetes
17-alpha-hydroxy-progesterone caproate
7 Citations (Scopus)
Extramedullary Hematopoiesis
Hematopoietic Stem Cell Mobilization
Pregnancy
Hematopoietic Stem Cells
Estrogen Receptors
40 Citations (Scopus)

Acetyl CoA Carboxylase Inhibition Reduces Hepatic Steatosis but Elevates Plasma Triglycerides in Mice and Humans: A Bedside to Bench Investigation

Kim, C. W., Addy, C., Kusunoki, J., Anderson, N. N., Deja, S., Fu, X., Burgess, S. C., Li, C., Chakravarthy, M., Previs, S., Milstein, S., Fitzgerald, K., Kelley, D. E. & Horton, J. D., Aug 1 2017, In : Cell Metabolism. 26, 2, p. 394-406.e6

Research output: Contribution to journalArticle

Acetyl-CoA Carboxylase
Lipogenesis
Triglycerides
Liver
Unsaturated Fatty Acids
4 Citations (Scopus)

A comprehensive analysis of myocardial substrate preference emphasizes the need for a synchronized fluxomic/metabolomic research design

Ragavan, M., Kirpich, A., Fu, X., Burgess, S. C., McIntyre, L. M. & Merritt, M. E., 2017, In : American Journal of Physiology - Heart and Circulatory Physiology. 312, 6, p. H1215-H1223

Research output: Contribution to journalArticle

Metabolomics
Propionates
Research Design
Citric Acid Cycle
Pyruvic Acid
15 Citations (Scopus)

Addressing metabolic heterogeneity in clear cell renal cell carcinoma with quantitative Dixon MRI

Zhang, Y., Udayakumar, D., Cai, L., Hu, Z., Kapur, P., Kho, E. Y., Pavía-Jiménez, A., Fulkerson, M., de Leon, A. D., Yuan, Q., Dimitrov, I. E., Yokoo, T., Ye, J., Mitsche, M. A., Kim, H., McDonald, J. G., Xi, Y., Madhuranthakam, A. J., Dwivedi, D. K., Lenkinski, R. E. & 5 others, Cadeddu, J. A., Margulis, V., Brugarolas, J., DeBerardinis, R. J. & Pedrosa, I., Aug 3 2017, In : JCI insight. 2, 15

Research output: Contribution to journalArticle

Open Access
Renal Cell Carcinoma
Neoplasms
Fats
Lipids
Lipid Metabolism
7 Citations (Scopus)

Aerobic capacity mediates susceptibility for the transition from steatosis to steatohepatitis

Morris, E. M., McCoin, C. S., Allen, J. A., Gastecki, M. L., Koch, L. G., Britton, S. L., Fletcher, J. A., Fu, X., Ding, W. X., Burgess, S. C., Rector, R. S. & Thyfault, J. P., Jul 15 2017, In : Journal of Physiology. 595, 14, p. 4909-4926 18 p.

Research output: Contribution to journalArticle

Fatty Liver
Liver
High Fat Diet
Sucrose
Fatty Acids
2 Citations (Scopus)
Intestines
Cholesterol
Sterols
Intestinal Mucosa
Nutrition
27 Citations (Scopus)
Cell membranes
Endoplasmic Reticulum
Cholesterol
Cell Membrane
Anticholesteremic Agents
22 Citations (Scopus)

Distinct oxysterol requirements for positioning naïve and activated dendritic cells in the spleen

Lu, E., Dang, E. V., McDonald, J. G. & Cyster, J. G., Apr 7 2017, In : Science immunology. 2, 10

Research output: Contribution to journalArticle

Dendritic Cells
Spleen
Human Herpesvirus 4
Genes
Oxysterols
12 Citations (Scopus)

Effects of nanoparticles in species of aquaculture interest

Khosravi-Katuli, K., Prato, E., Lofrano, G., Guida, M., Vale, G. & Libralato, G., Jul 1 2017, In : Environmental Science and Pollution Research. 24, 21, p. 17326-17346 21 p.

Research output: Contribution to journalArticle

Aquaculture
Nanoparticles
aquaculture
Toxicity
toxicity
6 Citations (Scopus)

Epstein-Barr virus-induced gene 2 mediates allergen-induced leukocyte migration into airways

Shen, Z. J., Hu, J., Kashi, V. P., Kelly, E. A., Denlinger, L. C., Lutchman, K., McDonald, J. G., Jarjour, N. N. & Malter, J. S., Jun 15 2017, In : American Journal of Respiratory and Critical Care Medicine. 195, 12, p. 1576-1585 10 p.

Research output: Contribution to journalArticle

Human Herpesvirus 4
Allergens
Leukocytes
Eosinophils
Genes
30 Citations (Scopus)

Expression of SREBP-1c requires SREBP-2-mediated generation of a sterol ligand for LXR in livers of mice

Rong, S., Cortés, V. A., Rashid, S., Anderson, N. N., McDonald, J. G., Liang, G., Moon, Y. A., Hammer, R. E. & Horton, J. D., Feb 28 2017, In : eLife. 6, e25015.

Research output: Contribution to journalArticle

Sterol Regulatory Element Binding Protein 1
Sterols
Liver
Hepatocytes
Ligands
44 Citations (Scopus)

FGF19, FGF21, and an FGFR1/β-Klotho-Activating Antibody Act on the Nervous System to Regulate Body Weight and Glycemia

Lan, T., Morgan, D. A., Rahmouni, K., Sonoda, J., Fu, X., Burgess, S. C., Holland, W. L., Kliewer, S. A. & Mangelsdorf, D. J., 2017, (Accepted/In press) In : Cell Metabolism.

Research output: Contribution to journalArticle

Nervous System
Body Weight
Antibodies
Weight Loss
Neurons
26 Citations (Scopus)

Lipidomic and Transcriptomic Basis of Lysosomal Dysfunction in Progranulin Deficiency

Evers, B. M., Rodriguez-Navas, C., Tesla, R. J., Prange-Kiel, J., Wasser, C. R., Yoo, K. S., McDonald, J., Cenik, B., Ravenscroft, T. A., Plattner, F., Rademakers, R., Yu, G., White, C. L. & Herz, J., Sep 12 2017, In : Cell Reports. 20, 11, p. 2565-2574 10 p.

Research output: Contribution to journalArticle

Frontotemporal Dementia
Brain
Ceroid
Neurodegenerative diseases
Lysosomes
13 Citations (Scopus)

Low-density lipoprotein docosahexaenoic acid nanoparticles induce ferroptotic cell death in hepatocellular carcinoma

Ou, W., Mulik, R. S., Anwar, A., McDonald, J. G., He, X. & Corbin, I. R., Nov 1 2017, In : Free Radical Biology and Medicine. 112, p. 597-607 11 p.

Research output: Contribution to journalArticle

Docosahexaenoic Acids
Cell death
LDL Lipoproteins
Nanoparticles
Hepatocellular Carcinoma
38 Citations (Scopus)

Oxysterol Restraint of Cholesterol Synthesis Prevents AIM2 Inflammasome Activation

Dang, E. V., McDonald, J. G., Russell, D. W. & Cyster, J. G., 2017, (Accepted/In press) In : Cell.

Research output: Contribution to journalArticle

Inflammasomes
Macrophages
Melanoma
Chemical activation
Cholesterol
10 Citations (Scopus)

The mitochondrial pyruvate carrier mediates high fat diet-induced increases in hepatic TCA cycle capacity

Rauckhorst, A. J., Gray, L. R., Sheldon, R. D., Fu, X., Pewa, A. D., Feddersen, C. R., Dupuy, A. J., Gibson-Corley, K. N., Cox, J. E., Burgess, S. C. & Taylor, E. B., Nov 1 2017, In : Molecular Metabolism. 6, 11, p. 1468-1479 12 p.

Research output: Contribution to journalArticle

High Fat Diet
Liver
Hyperglycemia
Hepatocytes
Pyruvic Acid
2016
13 Citations (Scopus)

Aerobic capacity and hepatic mitochondrial lipid oxidation alters susceptibility for chronic high-fat diet-induced hepatic steatosis

Morris, E. M., Meers, G. M. E., Koch, L. G., Britton, S. L., Fletcher, J. A., Fu, X., Shankar, K., Burgess, S. C., Ibdah, J. A., Rector, R. S. & Thyfault, J. P., 2016, In : American Journal of Physiology - Endocrinology and Metabolism. 311, 4, p. E749-E760

Research output: Contribution to journalArticle

High Fat Diet
Running
Lipids
Liver
Citric Acid Cycle
37 Citations (Scopus)

CCC- and WASH-mediated endosomal sorting of LDLR is required for normal clearance of circulating LDL

Bartuzi, P., Billadeau, D. D., Favier, R., Rong, S., Dekker, D., Fedoseienko, A., Fieten, H., Wijers, M., Levels, J. H., Huijkman, N., Kloosterhuis, N., Van Der Molen, H., Brufau, G., Groen, A. K., Elliott, A. M., Kuivenhoven, J. A., Plecko, B., Grangl, G., McGaughran, J., Horton, J. D. & 3 others, Burstein, E., Hofker, M. H. & Van De Sluis, B., Mar 11 2016, In : Nature Communications. 7, 10961.

Research output: Contribution to journalArticle

Wiskott-Aldrich Syndrome Protein
lipoproteins
LDL Receptors
clearances
classifying
16 Citations (Scopus)

Contribution of accelerated degradation to feedback regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase and cholesterol metabolism in the liver

Hwang, S., Hartman, I. Z., Calhoun, L. N., Garland, K., Young, G. A., Mitsche, M. A., McDonald, J., Xu, F., Engelking, L. & DeBose-Boyd, R. A., Jun 24 2016, In : Journal of Biological Chemistry. 291, 26, p. 13479-13494 16 p.

Research output: Contribution to journalArticle

Metabolism
Coenzyme A
Liver
Oxidoreductases
Feedback
15 Citations (Scopus)

Erratum: Mitochondrial metabolism mediates oxidative stress and inflammation in fatty liver (American Society for Clinical Investigation (2015) 125:12 (4447-4462) DOI: 10.1172/JCI82204)

Satapati, S., Kucejova, B., Duarte, J. A. G., Fletcher, J. A., Reynolds, L., Sunny, N. E., He, T., Nair, L. A., Livingston, K. A., Fu, X., Merritt, M. E., Sherry, A. D., Malloy, C. R., Shelton, J. M., Lambert, J., Parks, E. J., Corbin, I., Magnuson, M. A., Browning, J. D. & Burgess, S. C., Apr 1 2016, In : Journal of Clinical Investigation. 126, 4, p. 1605 1 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

Hepatic mTORC1 Opposes Impaired Insulin Action to Control Mitochondrial Metabolism in Obesity

Kucejova, B., Duarte, J., Satapati, S., Fu, X., Ilkayeva, O., Newgard, C. B., Brugarolas, J. & Burgess, S. C., Jul 12 2016, In : Cell Reports. 16, 2, p. 508-519 12 p.

Research output: Contribution to journalArticle

Metabolism
Obesity
Insulin
Insulin Receptor
Liver
7 Citations (Scopus)

Transcription factor hepatocyte nuclear factor-1β regulates renal cholesterol metabolism

Aboudehen, K., Kim, M. S., Mitsche, M., Garland, K., Anderson, N., Noureddine, L., Pontoglio, M., Patel, V., Xie, Y., Debose-Boyd, R. & Igarashi, P., Aug 1 2016, In : Journal of the American Society of Nephrology. 27, 8, p. 2408-2421 14 p.

Research output: Contribution to journalArticle

Hepatocyte Nuclear Factor 1
Cholesterol
Kidney
Sterols
Hydroxymethylglutaryl CoA Reductases
2015
75 Citations (Scopus)

6-Phosphogluconate dehydrogenase links oxidative PPP, lipogenesis and tumour growth by inhibiting LKB1-AMPK signalling

Lin, R., Elf, S., Shan, C., Kang, H. B., Ji, Q., Zhou, L., Hitosugi, T., Zhang, L., Zhang, S., Seo, J. H., Xie, J., Tucker, M., Gu, T. L., Sudderth, J., Jiang, L., Mitsche, M., DeBerardinis, R. J., Wu, S., Li, Y., Mao, H. & 17 others, Chen, P. R., Wang, D., Chen, G. Z., Hurwitz, S. J., Lonial, S., Arellano, M. L., Khoury, H. J., Khuri, F. R., Lee, B. H., Lei, Q., Brat, D. J., Ye, K., Boggon, T. J., He, C., Kang, S., Fan, J. & Chen, J., Nov 1 2015, In : Nature Cell Biology. 17, 11, p. 1484-1496 13 p.

Research output: Contribution to journalArticle

Phosphogluconate Dehydrogenase
Pentose Phosphate Pathway
Lipogenesis
AMP-Activated Protein Kinases
Growth
6 Citations (Scopus)

Adsorption of Cadmium on Titanium Dioxide Nanoparticles in Freshwater Conditions - A Chemodynamic Study

Vale, G., Franco, C., Brunnert, A. M. & dos Santos, M. M. C., Jan 1 2015, In : Electroanalysis. 27, 10, p. 2439-2447 9 p.

Research output: Contribution to journalArticle

Cadmium
Titanium dioxide
Nanoparticles
Adsorption
Crystalline materials
88 Citations (Scopus)

Biomarkers of NAFLD progression: A lipidomics approach to an epidemic 1

Gorden, D. L., Myers, D. S., Ivanova, P. T., Fahy, E., Maurya, M. R., Gupta, S., Min, J., Spann, N. J., McDonald, J. G., Kelly, S. L., Duan, J., Sullards, M. C., Leiker, T. J., Barkley, R. M., Quehenberger, O., Armando, A. M., Milne, S. B., Mathews, T. P., Armstrong, M. D., Li, C. & 13 others, Melvin, W. V., Clements, R. H., Washington, M. K., Mendonsa, A. M., Witztum, J. L., Guan, Z., Glass, C. K., Murphy, R. C., Dennis, E. A., Merrill, A. H., Russell, D. W., Subramaniam, S. & Brown, H. A., Mar 1 2015, In : Journal of Lipid Research. 56, 3, p. 722-736 15 p.

Research output: Contribution to journalArticle

Biomarkers
Liver
Disease Progression
Metabolites
Biopsy
30 Citations (Scopus)

Deletion of ELOVL6 blocks the synthesis of oleic acid but does not prevent the development of fatty liver or insulin resistance

Moon, Y. A., Ochoa, C. R., Mitsche, M. A., Hammer, R. E. & Horton, J. D., Jan 1 2015, In : Journal of Lipid Research. 55, 12, p. 2597-2605 9 p., A16.

Research output: Contribution to journalArticle

Fatty Liver
Oleic Acid
Liver
Insulin Resistance
Fatty Acids
35 Citations (Scopus)

Fatty Acid Oxidation Mediated by Acyl-CoA Synthetase Long Chain 3 Is Required for Mutant KRAS Lung Tumorigenesis

Padanad, M. S., Konstantinidou, G., Venkateswaran, N., Melegari, M., Rindhe, S., Mitsche, M., Yang, C., Batten, K., Huffman, K. E., Liu, J., Tang, X., Rodriguez-Canales, J., Kalhor, N., Shay, J. W., Minna, J. D., McDonald, J., Wistuba, I. I., DeBerardinis, R. J. & Scaglioni, P. P., Dec 29 2015, (Accepted/In press) In : Cell Reports.

Research output: Contribution to journalArticle

Coenzyme A Ligases
Lung Neoplasms
Carcinogenesis
Fatty Acids
Cells
40 Citations (Scopus)

Flux analysis of cholesterol biosynthesis in vivo reveals multiple tissue and cell-type specific pathways

Mitsche, M. A., McDonald, J. G., Hobbs, H. H. & Cohen, J. C., Jun 26 2015, In : eLife. 4, JUNE 2015, p. 1-21 21 p., e07999.

Research output: Contribution to journalArticle

Biosynthesis
Sterols
Cholesterol
Tissue
Fluxes
66 Citations (Scopus)

Hepatic mitochondrial pyruvate carrier 1 is required for efficient regulation of gluconeogenesis and whole-body glucose homeostasis

Gray, L. R., Sultana, M. R., Rauckhorst, A. J., Oonthonpan, L., Tompkins, S. C., Sharma, A., Fu, X., Miao, R., Pewa, A. D., Brown, K. S., Lane, E. E., Dohlman, A., Zepeda-Orozco, D., Xie, J., Rutter, J., Norris, A. W., Cox, J. E., Burgess, S. C., Potthoff, M. J. & Taylor, E. B., Oct 6 2015, In : Cell Metabolism. 22, 4, p. 669-681 13 p.

Research output: Contribution to journalArticle

Gluconeogenesis
Homeostasis
Glucose
Liver
Hyperglycemia