Center for the Genetics of Host Defense

Research Output 1999 2019

2019
2 Citations (Scopus)
Hedgehogs
Zinc Fingers
Transcription
Proteomics
Modulators

Enhanced susceptibility to chemically induced colitis caused by excessive endosomal TLR signaling in LRBA-deficient mice

Wang, K. W., Zhan, X., McAlpine, W., Zhang, Z., Choi, J. H., Shi, H., Misawa, T., Yue, T., Zhang Ph.D., D-W., Wang, Y., Ludwig, S., Russell, J., Tang, M., Li, X., Murray, A. R., Moresco, E. M. Y., Turer, E. E. & Beutler, B., Jan 1 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 166, 23, p. 11380-11389 10 p.

Research output: Contribution to journalArticle

Dextran Sulfate
Toll-Like Receptors
Regulatory T-Lymphocytes
Colitis
Dendritic Cells

LMBR1L regulates lymphopoiesis through Wnt/β-catenin signaling

Choi, J. H., Zhong, X., McAlpine, W., Liao, T. C., Zhang Ph.D., D-W., Fang, B., Russell, J., Ludwig, S., Nair-Gill, E., Zhang, Z., Wang, K. W., Misawa, T., Zhan, X., Choi, M., Wang, T., Li, X., Tang, M., Sun, Q., Yu, L., Murray, A. R. & 2 others, Moresco, E. Y. & Beutler, B., Jan 1 2019, In : Science. 364, 6440, eaau0812.

Research output: Contribution to journalArticle

Lymphopoiesis
Catenins
Wnt2 Protein
Ethylnitrosourea
Wnt Signaling Pathway
1 Citation (Scopus)

Research Techniques Made Simple: Forward Genetic Screening to Uncover Genes Involved in Skin Biology

McAlpine, W., Russell, J. L., Murray, A. R., Beutler, B. A. & Turer, E. E., Sep 1 2019, In : Journal of Investigative Dermatology. 139, 9, p. 1848-1853.e1

Research output: Contribution to journalShort survey

Genetic Testing
Skin
Screening
Research Design
Genes

Structural Basis of TLR2/TLR1 Activation by the Synthetic Agonist Diprovocim

Su, L., Wang, Y., Wang, J., Mifune, Y., Morin, M. D., Jones, B. T., Moresco, E. M. Y., Boger, D. L., Beutler, B. A. & Zhang, H., Mar 28 2019, In : Journal of Medicinal Chemistry. 62, 6, p. 2938-2949 12 p.

Research output: Contribution to journalArticle

Ligands
Lipopeptides
Hydrogen Bonding
Hydrophobic and Hydrophilic Interactions
Melanoma

Syndromic immune disorder caused by a viable hypomorphic allele of spliceosome component Snrnp40

Zhang, D., Yue, T., Choi, J. H., Nair-Gill, E., Zhong, X., Wang, K. W., Zhan, X., Li, X., Choi, M., Tang, M., Quan, J., Hildebrand, S., Moresco, E. M. Y. & Beutler, B., Jan 1 2019, (Accepted/In press) In : Nature Immunology.

Research output: Contribution to journalArticle

Spliceosomes
Immune System Diseases
Alleles
Hematopoietic Stem Cells
U5 Small Nuclear Ribonucleoproteins
2018
9 Citations (Scopus)

Adjuvant effect of the novel TLR1/TLR2 agonist Diprovocim synergizes with anti–PD-L1 to eliminate melanoma in mice

Wang, Y., Su, L., Morin, M. D., Jones, B. T., Mifune, Y., Shi, H., Wang, K. W., Zhan, X., Liu, A., Wang, J., Li, X., Tang, M., Ludwig, S., Hildebrand, S., Zhou, K., Siegwart, D. J., Moresco, E. M. Y., Zhang, H., Boger, D. L. & Beutler, B., Sep 11 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 37, p. E8698-E8706

Research output: Contribution to journalArticle

Melanoma
Cytotoxic T-Lymphocytes
Immunization
Toll-Like Receptor 1
Neoplasms
1 Citation (Scopus)

A viable hypomorphic Arnt2 mutation causes hyperphagic obesity, diabetes and hepatic steatosis

Turer, E. E., San Miguel, M., Wang, K. W., McAlpine, W., Ou, F., Li, X., Tang, M., Zang, Z., Wang, J., Hayse, B., Evers, B., Zhan, X., Russell, J. L. & Beutler, B. A., Dec 18 2018, In : Disease models & mechanisms. 11, 12

Research output: Contribution to journalArticle

Aryl Hydrocarbon Receptor Nuclear Translocator
Medical problems
Clustered Regularly Interspaced Short Palindromic Repeats
Obesity
Mutation
1 Citation (Scopus)

B-1a Cell Development in Splenectomized Neonatal Mice

Pedersen, G. K., Li, X., Khoenkhoen, S., Ádori, M., Beutler, B. & Karlsson Hedestam, G. B., Jan 1 2018, In : Frontiers in immunology. 9, 1 p.

Research output: Contribution to journalArticle

Open Access
Spleen
Splenectomy
Bone Marrow
B-Lymphocyte Subsets
B-Lymphoid Precursor Cells
3 Citations (Scopus)

Diprovocims: A New and Exceptionally Potent Class of Toll-like Receptor Agonists

Morin, M. D., Wang, Y., Jones, B. T., Mifune, Y., Su, L., Shi, H-X., Moresco, E. M. Y., Zhang, H., Beutler, B. A. & Boger, D. L., Jan 1 2018, (Accepted/In press) In : Journal of the American Chemical Society.

Research output: Contribution to journalArticle

Dimerization
Toll-Like Receptors
Screening
Toll-Like Receptor 2
Macrophages
2 Citations (Scopus)

Excessive endosomal TLR signaling causes inflammatory disease in mice with defective SMCR8-WDR41-C9ORF72 complex function

McAlpine, W., Sun, L., Wang, K. W., Liu, A., Jain, R., Miguel, M. S., Wang, J., Zhang, Z., Hayse, B., McAlpine, S. G., Choi, J. H., Zhong, X., Ludwig, S., Russell, J. L., Zhan, X., Choi, M., Li, X., Tang, M., Moresco, E. M. Y., Beutler, B. A. & 1 others, Turer, E. E., Dec 4 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 49, p. E11523-E11531

Research output: Contribution to journalArticle

Toll-Like Receptors
Autoimmunity
Ligands
Phagosomes
Dextran Sulfate
7 Citations (Scopus)

Intracellular lipid metabolism impairs β cell compensation during diet-induced obesity

Ye, R., Gordillo, R., Shao, M., Onodera, T., Chen, Z., Chen, S., Lin, X., SoRelle, J. A., Li, X., Tang, M., Keller, M. P., Kuliawat, R., Attie, A. D., Gupta, R. K., Holland, W. L., Beutler, B. A., Herz, J. & Scherer, P. E., Mar 1 2018, In : Journal of Clinical Investigation. 128, 3, p. 1178-1189 12 p.

Research output: Contribution to journalArticle

Low Density Lipoprotein Receptor-Related Protein-1
Lipid Metabolism
Obesity
Insulin
Diet
3 Citations (Scopus)

Large-scale forward genetics screening identifies Trpa1 as a chemosensor for predator odor-evoked innate fear behaviors

Wang, Y., Cao, L., Lee, C. Y., Matsuo, T., Wu, K., Asher, G., Tang, L., Saitoh, T., Russell, J. L., Klewe-Nebenius, D., Wang, L., Soya, S., Hasegawa, E., Chérasse, Y., Zhou, J., Li, Y., Wang, T., Zhan, X., Miyoshi, C., Irukayama, Y. & 13 others, Cao, J., Meeks, J., Gautron, L., Wang, Z., Sakurai, K., Funato, H., Sakurai, T., Yanagisawa, M., Nagase, H., Kobayakawa, R., Kobayakawa, K., Beutler, B. A. & Liu, Q., Dec 1 2018, In : Nature Communications. 9, 1, 4324.

Research output: Contribution to journalArticle

fear
Instinct
odors
predators
Genetic Testing
10 Citations (Scopus)

Probability of phenotypically detectable protein damage by ENU-induced mutations in the Mutagenetix database

Wang, T., Bu, C. H., Hildebrand, S., Jia, G., Siggs, O. M., Lyon, S., Pratt, D., Scott, L., Russell, J., Ludwig, S., Murray, A. R., Moresco, E. M. Y. & Beutler, B., Dec 1 2018, In : Nature Communications. 9, 1, 441.

Research output: Contribution to journalArticle

mutations
Genes
Databases
damage
proteins

The class i myosin MYO1D binds to lipid and protects against colitis

McAlpine, W., Wang, K. W., Choi, J. H., Miguel, M. S., McAlpine, S. G., Russell, J., Ludwig, S., Li, X., Tang, M., Zhan, X., Choi, M., Wang, T., Bu, C. H., Murray, A. R., Moresco, E. M. Y., Turer, E. E. & Beutler, B., Sep 1 2018, In : DMM Disease Models and Mechanisms. 11, 9, dmm035923.

Research output: Contribution to journalArticle

Dextran Sulfate
Colitis
Myosins
Myosin Type I
Ethylnitrosourea
2017
16 Citations (Scopus)

Creatine maintains intestinal homeostasis and protects against colitis

Turer, E. E., McAlpine, W., Wang, K. W., Lu, T., Li, X., Tang, M., Zhan, X., Wang, T., Zhan, X., Bu, C. H., Murray, A. R. & Beutler, B. A., Feb 14 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 7, p. E1273-E1281

Research output: Contribution to journalArticle

Creatine
Colitis
Dextran Sulfate
Homeostasis
Clustered Regularly Interspaced Short Palindromic Repeats

Erratum: The genetic architecture of heterochrony as a quantitative trait: Lessons from a computational model [Briefings in Bioinformatics, (2017)] doi: 10.1093/bib/bbx056

Lidan, S., Mengmeng, S., Chenfei, Z., Dongyang, W., Hexin, S., Kaiyue, L., Yanfang, G., Tangren, C., Qixiang, Z. & Rongling, W., Nov 1 2017, In : Briefings in Bioinformatics. 18, 6, 1 p.

Research output: Contribution to journalComment/debate

Bioinformatics
Computational Biology
6 Citations (Scopus)

HCFC2 is needed for IRF1- and IRF2-dependent Tlr3 transcription and for survival during viral infections

Sun, L., Jiang, Z., Acosta-Rodriguez, V. A., Berger, M., Du, X., Choi, J. H., Wang, J., Wang, K. W., Kilaru, G. K., Mohawk, J. A., Quan, J., Scott, L., Hildebrand, S., Li, X., Tang, M., Zhan, X., Murray, A. R., Vine, D. L., Moresco, E. M. Y., Takahashi, J. S. & 1 others, Beutler, B., Nov 1 2017, In : Journal of Experimental Medicine. 214, 11, p. 3263-3277 15 p.

Research output: Contribution to journalArticle

Interferon Regulatory Factor-1
Toll-Like Receptor 3
Virus Diseases
Double-Stranded RNA
Interferons
19 Citations (Scopus)

Human Adaptive Immunity Rescues an Inborn Error of Innate Immunity

Israel, L., Wang, Y., Bulek, K., Della Mina, E., Zhang, Z., Pedergnana, V., Chrabieh, M., Lemmens, N. A., Sancho-Shimizu, V., Descatoire, M., Lasseau, T., Israelsson, E., Lorenzo, L., Yun, L., Belkadi, A., Moran, A., Weisman, L. E., Vandenesch, F., Batteux, F., Weller, S. & 14 others, Levin, M., Herberg, J., Abhyankar, A., Prando, C., Itan, Y., van Wamel, W. J. B., Picard, C., Abel, L., Chaussabel, D., Li, X., Beutler, B., Arkwright, P. D., Casanova, J. L. & Puel, A., Feb 23 2017, In : Cell. 168, 5, p. 789-800.e10

Research output: Contribution to journalArticle

Adaptive Immunity
Innate Immunity
Penetrance
Toll-Like Receptor 1
Interleukin-1 Receptor-Associated Kinases
13 Citations (Scopus)

IgD class switching is initiated by microbiota and limited to mucosa-associated lymphoid tissue in mice

Choi, J. H., Wang, K. W., Zhang Ph.D., D-W., Zhan, X., Wang, T., Bu, C. H., Behrendt, C. L., Zeng, M., Wang, Y., Misawa, T., Li, X., Tang, M., Zhan, X., Scott, L., Hildebrand, S., Murray, A. R., Moresco, E. M. Y., Hooper, L. V. & Beutler, B. A., Feb 14 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 7, p. E1196-E1204

Research output: Contribution to journalArticle

Immunoglobulin Class Switching
Immunoglobulin D
Microbiota
Lymphoid Tissue
Mucous Membrane
6 Citations (Scopus)

Skin-specific regulation of SREBP processing & lipid biosynthesis by glycerol kinase 5

Zhang, D., Tomisato, W., Su, L., Sun, L., Choi, J. H., Zhang, Z., Wang, K. W., Zhan, X., Choi, M., Li, X., Tang, M., Castro-Perez, J. M., Hildebrand, S., Murray, A. R., Moresco, E. M. Y. & Beutler, B., Jun 27 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 26, p. E5197-E5206

Research output: Contribution to journalArticle

Sterol Regulatory Element Binding Proteins
Glycerol Kinase
Hair
Lipids
Skin
1 Citation (Scopus)

The ESRP1-GPR137 axis contributes to intestinal pathogenesis

Mager, L. F., Koelzer, V. H., Stuber, R., Thoo, L., Keller, I., Koeck, I., Langenegger, M., Simillion, C., Pfister, S. P., Faderl, M., Genitsch, V., Tcymbarevich, I., Juillerat, P., Li, X., Xia, Y., Karamitopoulou, E., Lyck, R., Zlobec, I., Hapfelmeier, S., Bruggmann, R. & 5 others, McCoy, K. D., Macpherson, A. J., Müller, C., Beutler, B. & Krebs, P., Oct 4 2017, In : eLife. 6, e28366.

Research output: Contribution to journalArticle

Protein Splicing
Colorectal Neoplasms
Proteins
Protein Isoforms
Wnt Signaling Pathway
2016
8 Citations (Scopus)
MEF2 Transcription Factors
Autistic Disorder
Synapses
Chromatin
Genes
11 Citations (Scopus)

Discovery and Structure-Activity Relationships of the Neoseptins: A New Class of Toll-like Receptor-4 (TLR4) Agonists

Morin, M. D., Wang, Y., Jones, B. T., Su, L., Surakattula, M. M. R. P., Berger, M., Huang, H., Beutler, E. K., Zhang, H., Beutler, B. & Boger, D. L., May 26 2016, In : Journal of Medicinal Chemistry. 59, 10, p. 4812-4830 19 p.

Research output: Contribution to journalArticle

Toll-Like Receptor 4
Structure-Activity Relationship
Libraries
Lipopolysaccharides
Mouse Tlr4 protein
3 Citations (Scopus)

Erratum: TLR4/MD-2 activation by a synthetic agonist with no similarity to LPS (Proceedings of the National Academy of Sciences of the United States of America (2016) 113 (E884-E893))

Wang, Y., Su, L., Morin, M. D., Jones, B. T., Whitby, L. R., Surakattula, M. M. R. P., Huang, H., Shi, H., Choi, J. H., Wang, K. W., Moresco, E. M. Y., Berger, M., Zhan, X., Zhang, H., Boger, D. L. & Beutler, B., Apr 5 2016, In : Proceedings of the National Academy of Sciences of the United States of America. 113, 14, p. E2096

Research output: Contribution to journalArticle

2 Citations (Scopus)

Heterozygous mutation in IκBNS leads to reduced levels of natural IgM antibodies and impaired responses to T-independent type 2 antigens

Pederse, G. K., Ádor, M., Star, J. M., Khoenkhoe, S., Arnold, C., Beutler, B. & Karlsson Hedestam, G. B., Mar 1 2016, In : Frontiers in Immunology. 7, MAR, 65.

Research output: Contribution to journalArticle

T Independent Antigens
Antibody Formation
Immunoglobulin M
Mutation
B-Lymphocytes
52 Citations (Scopus)

HSV-1 ICP27 targets the TBK1-activated STING signalsome to inhibit virus-induced type I IFN expression

Christensen, M. H., Jensen, S. B., Miettinen, J. J., Luecke, S., Prabakaran, T., Reinert, L. S., Mettenleiter, T., Chen, Z. J., Knipe, D. M., Sandri-Goldin, R. M., Enquist, L. W., Hartmann, R., Mogensen, T. H., Rice, S. A., Nyman, T. A., Matikainen, S. & Paludan, S. R., Jul 1 2016, In : EMBO Journal. 35, 13, p. 1385-1399 15 p.

Research output: Contribution to journalArticle

Macrophages
Human Herpesvirus 1
Viruses
Herpesviridae
Viral Proteins
6 Citations (Scopus)

Inhibiting TLR9 and other UNC93B1-dependent TLRs paradoxically increases accumulation of MYD88L265P plasmablasts in vivo

Wang, J. Q., Beutler, B., Goodnow, C. C. & Horikawa, K., 2016, In : Blood. 128, 12, p. 1604-1608 5 p.

Research output: Contribution to journalArticle

B-Lymphocytes
Cells
Toll-Like Receptors
Waldenstrom Macroglobulinemia
Cell proliferation
10 Citations (Scopus)

Insulin resistance and diabetes caused by genetic or diet-induced KBTBD2 deficiency in mice

Zhang, Z., Turer, E., Li, X., Zhan, X., Choi, M., Tang, M., Press, A., Smith, S. R., Divoux, A., Moresco, E. M. Y. & Beutler, B., Oct 18 2016, In : Proceedings of the National Academy of Sciences of the United States of America. 113, 42, p. E6418-E6426

Research output: Contribution to journalArticle

Insulin Resistance
Insulin
Diet
Clustered Regularly Interspaced Short Palindromic Repeats
Cullin Proteins
71 Citations (Scopus)

K+ Efflux-Independent NLRP3 Inflammasome Activation by Small Molecules Targeting Mitochondria

Groß, C. J., Mishra, R., Schneider, K. S., Médard, G., Wettmarshausen, J., Dittlein, D. C., Shi, H., Gorka, O., Koenig, P. A., Fromm, S., Magnani, G., Ćiković, T., Hartjes, L., Smollich, J., Robertson, A. A. B., Cooper, M. A., Schmidt-Supprian, M., Schuster, M., Schroder, K., Broz, P. & 7 others, Traidl-Hoffmann, C., Beutler, B., Kuster, B., Ruland, J., Schneider, S., Perocchi, F. & Groß, O., Oct 18 2016, In : Immunity. 45, 4, p. 761-773 13 p.

Research output: Contribution to journalArticle

imiquimod
Inflammasomes
Mitochondria
Toll-Like Receptor 7
Skin Neoplasms
10 Citations (Scopus)

K63-Ubiquitylation and TRAF6 Pathways Regulate Mammalian P-Body Formation and mRNA Decapping

Tenekeci, U., Poppe, M., Beuerlein, K., Buro, C., Müller, H., Weiser, H., Kettner-Buhrow, D., Porada, K., Newel, D., Xu, M., Chen, Z. J., Busch, J., Schmitz, M. L. & Kracht, M., Jun 16 2016, In : Molecular Cell. 62, 6, p. 943-957 15 p.

Research output: Contribution to journalArticle

TNF Receptor-Associated Factor 6
Ubiquitination
RNA Stability
Messenger RNA
Ubiquitin
10 Citations (Scopus)

Mutation of Fnip1 is associated with B-cell deficiency, cardiomyopathy, and elevated AMPK activity

Siggs, O. M., Stockenhuber, A., Deobagkar-Lele, M., Bull, K. R., Crockford, T. L., Kingston, B. L., Crawford, G., Anzilotti, C., Steeples, V., Ghaffari, S., Czibik, G., Bellahcene, M., Watkins, H., Ashrafian, H., Davies, B., Woods, A., Carling, D., Yavari, A., Beutler, B. & Cornall, R. J., Jun 28 2016, In : Proceedings of the National Academy of Sciences of the United States of America. 113, 26, p. E3706-E3715

Research output: Contribution to journalArticle

AMP-Activated Protein Kinases
Cardiomyopathies
B-Lymphocytes
Mutation
Estrone
1 Citation (Scopus)

Pathogens, commensals, and immunity: From the perspective of the urinary bladder

Beutler, B., Jan 7 2016, In : Pathogens. 5, 1, p. 1-3 3 p.

Research output: Contribution to journalEditorial

Immunity
Urinary Bladder
18 Citations (Scopus)

Regulation of Smoothened Trafficking and Hedgehog Signaling by the SUMO Pathway

Ma, G., Li, S., Han, Y., Li, S., Yue, T., Wang, B. & Jiang, J., Nov 21 2016, In : Developmental Cell. 39, 4, p. 438-451 14 p.

Research output: Contribution to journalArticle

Sumoylation
Phosphorylation
Transducers
Membrane Proteins
Degradation
10 Citations (Scopus)

Streptococci engage TLR13 on myeloid cells in a site-specific fashion

Kolter, J., Feuerstein, R., Spoeri, E., Gharun, K., Elling, R., Trieu-Cuot, P., Goldmann, T., Waskow, C., Chen, Z. J., Kirschning, C. J., Deshmukh, S. D. & Henneke, P., Mar 15 2016, In : Journal of Immunology. 196, 6, p. 2733-2741 9 p.

Research output: Contribution to journalArticle

Streptococcus agalactiae
Microglia
Myeloid Cells
Streptococcus
Monocytes
47 Citations (Scopus)

TLR4/MD-2 activation by a synthetic agonist with no similarity to LPS

Wang, Y., Su, L., Morin, M. D., Jones, B. T., Whitby, L. R., Surakattula, M. M. R. P., Huang, H., Shi, H., Choi, J. H., Wang, K. W., Moresco, E. M. Y., Berger, M., Zhan, X., Zhang, H., Boger, D. L. & Beutler, B., Feb 16 2016, In : Proceedings of the National Academy of Sciences of the United States of America. 113, 7, p. E884-E893

Research output: Contribution to journalArticle

Lipopolysaccharides
Lipid A
Ligands
Peptidomimetics
Toll-Like Receptor 4

What Lies Ahead? Scientists Look into Their Crystal Balls: Forward Genetics and Viral Pathogenesis

Beutler, B., 2016, Viral Pathogenesis: From Basics to Systems Biology: Third Edition. Elsevier Inc., p. 319-320 2 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

2015
166 Citations (Scopus)

Activation of cyclic GMP-AMP synthase by self-DNA causes autoimmune diseases

Gao, D., Li, T., Li, X. D., Chen, X., Li, Q. Z., Wight-Carter, M. & Chen, Z. J., Oct 20 2015, In : Proceedings of the National Academy of Sciences of the United States of America. 112, 42, p. E5699-E5705

Research output: Contribution to journalArticle

GMP synthase (glutamine-hydrolyzing)
Autoimmune Diseases
DNA
Phenotype
Interferons
3 Citations (Scopus)
Medulloblastoma
Protein-Tyrosine Kinases
Tyrosine
Neoplasms
src-Family Kinases
89 Citations (Scopus)

Comparison of predicted and actual consequences of missense mutations

Miosge, L. A., Field, M. A., Sontani, Y., Cho, V., Johnson, S., Palkova, A., Balakishnan, B., Liang, R., Zhang, Y., Lyon, S., Beutler, B., Whittle, B., Bertram, E. M., Enders, A., Goodnow, C. C. & Andrewsa, T. D., Sep 15 2015, In : Proceedings of the National Academy of Sciences of the United States of America. 112, 37, p. E5189-E5198

Research output: Contribution to journalArticle

Missense Mutation
Phenotype
Mutation
Homozygote
Genome
14 Citations (Scopus)

Current strategies for mutation detection in phenotype-driven screens utilising next generation sequencing

Simon, M. M., Moresco, E. M. Y., Bull, K. R., Kumar, S., Mallon, A. M., Beutler, B. & Potter, P. K., Oct 1 2015, In : Mammalian Genome. 26, 9-10, p. 486-500 15 p.

Research output: Contribution to journalArticle

Ethylnitrosourea
Phenotype
Mutation
Mutagenesis
Genome
10 Citations (Scopus)

Endosomal recognition of Lactococcus lactis G121 and its RNA by dendritic cells is key to its allergy-protective effects

Stein, K., Brand, S., Jenckel, A., Sigmund, A., Chen, Z. J., Kirschning, C. J., Kauth, M. & Heine, H., Sep 23 2015, (Accepted/In press) In : Journal of Allergy and Clinical Immunology.

Research output: Contribution to journalArticle

Lactococcus lactis
Dendritic Cells
Hypersensitivity
RNA
Bone Marrow

Erratum: Plant and animal sensors of conserved microbial signatures (Science (2015) 330:6007 (1061-1064))

Ronald, P. C. & Beutler, B., Sep 11 2015, In : Science. 349, 6253, 3218.

Research output: Contribution to journalComment/debate

2 Citations (Scopus)

Generation of BAF53b-Cre transgenic mice with pan-neuronal Cre activities

Zhan, X., Cao, M., Yoo, A. S., Zhang, Z., Chen, L., Crabtree, G. R. & Wu, J. I., Jul 1 2015, In : Genesis. 53, 7, p. 440-448 9 p.

Research output: Contribution to journalArticle

Transgenic Mice
Neurons
Artificial Chromosomes
Genes
Chromatin Assembly and Disassembly
42 Citations (Scopus)

Helsinki alert of biodiversity and health

Von Hertzen, L., Beutler, B., Bienenstock, J., Blaser, M., Cani, P. D., Eriksson, J., Färkkilä, M., Haahtela, T., Hanski, I., Jenmalm, M. C., Kere, J., Knip, M., Kontula, K., Koskenvuo, M., Ling, C., Mandrup-Poulsen, T., Von Mutius, E., Mäkelä, M. J., Paunio, T., Pershagen, G. & 6 others, Renz, H., Rook, G., Saarela, M., Vaarala, O., Veldhoen, M. & De Vos, W. M., May 1 2015, In : Annals of Medicine. 47, 3, p. 218-225 8 p.

Research output: Contribution to journalArticle

Biodiversity
Microbiota
Immune Tolerance
Health
Life Style
49 Citations (Scopus)

IL-33 signaling contributes to the pathogenesis of myeloproliferative neoplasms

Mager, L. F., Riether, C., Schürch, C. M., Banz, Y., Wasmer, M. H., Stuber, R., Theocharides, A. P., Li, X., Xia, Y., Saito, H., Nakae, S., Baerlocher, G. M., Manz, M. G., McCoy, K. D., Macpherson, A. J., Ochsenbein, A. F., Beutler, B. & Krebs, P., Jul 1 2015, In : Journal of Clinical Investigation. 125, 7, p. 2579-2591 13 p.

Research output: Contribution to journalArticle

Neoplasms
Cytokines
Stem Cells
Myelopoiesis
Animal Diseases
20 Citations (Scopus)
Ligands
Proteins
Protein Conformation
Entropy
Second Messenger Systems
7 Citations (Scopus)

Mutation of the ER retention receptor KDELR1 leads to cell-intrinsic lymphopenia and a failure to control chronic viral infection

Siggs, O. M., Popkin, D. L., Krebs, P., Li, X., Tang, M., Zhan, X., Zeng, M., Lin, P., Xia, Y., Oldstone, M. B. A., Cornall, R. J. & Beutler, B., Oct 20 2015, In : Proceedings of the National Academy of Sciences of the United States of America. 112, 42, p. E5706-E5714

Research output: Contribution to journalArticle

Lymphopenia
Virus Diseases
Endoplasmic Reticulum
Mutation
T-Cell Antigen Receptor
145 Citations (Scopus)

NLRP3 activation and mitosis are mutually exclusive events coordinated by NEK7, a new inflammasome component

Shi, H., Wang, Y., Li, X., Zhan, X., Tang, M., Fina, M., Su, L., Pratt, D., Bu, C. H., Hildebrand, S., Lyon, S., Scott, L., Quan, J., Sun, Q., Russell, J., Arnett, S., Jurek, P., Chen, D., Kravchenko, V. V., Mathison, J. C. & 4 others, Moresco, E. M. Y., Monson, N. L., Ulevitch, R. J. & Beutler, B., Dec 7 2015, (Accepted/In press) In : Nature Immunology.

Research output: Contribution to journalArticle

Inflammasomes
Mitosis
Caspase 1
Interleukin-18
Protein-Serine-Threonine Kinases
22 Citations (Scopus)

Overlapping functions of the MAP4K family kinases Hppy and Msn in Hippo signaling

Li, S., Cho, Y. S., Yue, T., Ip, Y. T. & Jiang, J., Nov 24 2015, In : Cell Discovery. 1, 15038.

Research output: Contribution to journalArticle

Drosophila
Phosphotransferases
Imaginal Discs
Organ Size
Cytoskeleton