Center for the Genetics of Host Defense

Research Output

A critical role for dorsal progenitors in cortical myelination

Yue, T., Xian, K., Hurlock, E., Xin, M., Kernie, S. G., Parada, L. F. & Lu, Q. R., Jan 25 2006, In : Journal of Neuroscience. 26, 4, p. 1275-1280 6 p.

Research output: Contribution to journalArticle

62 Scopus citations

Activation of cyclic GMP-AMP synthase by self-DNA causes autoimmune diseases

Gao, D., Li, T., Li, X. D., Chen, X., Li, Q. Z., Wight-Carter, M. & Chen, Z. J., Oct 20 2015, In : Proceedings of the National Academy of Sciences of the United States of America. 112, 42, p. E5699-E5705

Research output: Contribution to journalArticle

210 Scopus citations

Adjuvant effect of the novel TLR1/TLR2 agonist Diprovocim synergizes with anti–PD-L1 to eliminate melanoma in mice

Wang, Y., Su, L., Morin, M. D., Jones, B. T., Mifune, Y., Shi, H., Wang, K. W., Zhan, X., Liu, A., Wang, J., Li, X., Tang, M., Ludwig, S., Hildebrand, S., Zhou, K., Siegwart, D. J., Moresco, E. M. Y., Zhang, H., Boger, D. L. & Beutler, B., Sep 11 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 37, p. E8698-E8706

Research output: Contribution to journalArticle

23 Scopus citations

A dynamic notch injury response activates epicardium and contributes to fibrosis repair.

Russell, J. L., Goetsch, S. C., Gaiano, N. R., Hill, J. A., Olson, E. N. & Schneider, J. W., Jan 7 2011, In : Circulation research. 108, 1, p. 51-59 9 p.

Research output: Contribution to journalArticle

102 Scopus citations

A forward genetic screen reveals roles for Nfkbid, Zeb1, and Ruvbl2 in humoral immunity

Arnold, C. N., Pirie, E., Dosenovic, P., McInerney, G. M., Xia, Y., Wang, N., Li, X., Siggs, O. M., Karlsson Hedestam, G. B. & Beutler, B., Jul 31 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 31, p. 12286-12293 8 p.

Research output: Contribution to journalArticle

46 Scopus citations

An ankyrin repeat-containing protein, characterized as a ubiquitin ligase, is closely associated with membrane-enclosed organelles and required for pollen germination and pollen tube growth in lily

Huang, J., Chen, F., Del Casino, C., Autino, A., Shen, M., Yuan, S., Peng, J., Shi, H., Wang, C., Cresti, M. & Li, Y., Apr 2006, In : Plant Physiology. 140, 4, p. 1374-1383 10 p.

Research output: Contribution to journalArticle

27 Scopus citations

An epigenetic switch induced by Shh signalling regulates gene activation during development and medulloblastoma growth

Shi, X., Zhang, Z., Zhan, X., Cao, M., Satoh, T., Akira, S., Shpargel, K., Magnuson, T., Li, Q., Wang, R., Wang, C., Ge, K. & Wu, J., 2014, In : Nature communications. 5, 5425.

Research output: Contribution to journalArticle

47 Scopus citations

ANKRD16 prevents neuron loss caused by an editing-defective tRNA synthetase

Vo, M. N., Terrey, M., Lee, J. W., Roy, B., Moresco, J. J., Sun, L., Fu, H., Liu, Q., Weber, T. G., Yates, J. R., Fredrick, K., Schimmel, P. & Ackerman, S. L., May 24 2018, In : Nature. 557, 7706, p. 510-515 6 p.

Research output: Contribution to journalArticle

10 Scopus citations

A non-dicer RNase III and four other novel factors required for RNAi-Mediated transposon suppression in the human pathogenic yeast cryptococcus neoformans

Burke, J. E., Longhurst, A. D., Natarajan, P., Rao, B., Liu, J., Sales-Lee, J., Mortensen, Y., Moresco, J. J., Diedrich, J. K., Yates, J. R. & Madhani, H. D., Jul 1 2019, In : G3: Genes, Genomes, Genetics. 9, 7, p. 2235-2244 10 p.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

An Slfn2 mutation causes lymphoid and myeloid immunodeficiency due to loss of immune cell quiescence

Berger, M., Krebs, P., Crozat, K., Li, X., Croker, B. A., Siggs, O. M., Popkin, D., Du, X., Lawson, B. R., Theofilopoulos, A. N., Xia, Y., Khovananth, K., Moresco, E. M. Y., Satoh, T., Takeuchi, O., Akira, S. & Beutler, B., Mar 2 2010, In : Nature immunology. 11, 4, p. 335-343 9 p.

Research output: Contribution to journalArticle

54 Scopus citations
4 Scopus citations
3 Scopus citations

ARF differentially modulates apoptosis induced by E2F1 and Myc

Russell, J. L., Powers, J. T., Rounbehler, R. J., Rogers, P. M., Conti, C. J. & Johnson, D. G., Feb 26 2002, In : Molecular and Cellular Biology. 22, 5, p. 1360-1368 9 p.

Research output: Contribution to journalArticle

67 Scopus citations

A Role of RIP3-Mediated Macrophage Necrosis in Atherosclerosis Development

Lin, J., Li, H., Yang, M., Ren, J., Huang, Z., Han, F., Huang, J., Ma, J., Zhang, D., Zhang, Z., Wu, J., Huang, D., Qiao, M., Jin, G., Wu, Q., Huang, Y., Du, J. & Han, J., Jan 31 2013, In : Cell Reports. 3, 1, p. 200-210 11 p.

Research output: Contribution to journalArticle

149 Scopus citations

A small molecule differentiation inducer increases insulin production by pancreatic β cells

Dioum, E. M., Osborne, J. K., Goetsch, S., Russell, J., Schneider, J. W. & Cobb, M. H., Dec 20 2011, In : Proceedings of the National Academy of Sciences of the United States of America. 108, 51, p. 20713-20718 6 p.

Research output: Contribution to journalArticle

23 Scopus citations
10 Scopus citations

A viable hypomorphic Arnt2 mutation causes hyperphagic obesity, diabetes and hepatic steatosis

Turer, E. E., San Miguel, M., Wang, K. W., McAlpine, W., Ou, F., Li, X., Tang, M., Zang, Z., Wang, J., Hayse, B., Evers, B., Zhan, X., Russell, J. L. & Beutler, B. A., Dec 18 2018, In : Disease models & mechanisms. 11, 12

Research output: Contribution to journalArticle

2 Scopus citations

B-1a Cell Development in Splenectomized Neonatal Mice

Pedersen, G. K., Li, X., Khoenkhoen, S., Ádori, M., Beutler, B. & Karlsson Hedestam, G. B., 2018, In : Frontiers in immunology. 9, 1 p., 1738.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Binding of munc 18-1 to synaptobrevin and to the SNARE four-helix bundle

Xu, Y., Su, L. & Rizot, J., Mar 2 2010, In : Biochemistry. 49, 8, p. 1568-1576 9 p.

Research output: Contribution to journalArticle

70 Scopus citations

Casein kinase 2 promotes Hedgehog signaling by regulating both smoothened and Cubitus interruptus

Jia, H., Liu, Y., Xia, R., Tong, C., Yue, T., Jiang, J. & Jia, J., Nov 26 2010, In : Journal of Biological Chemistry. 285, 48, p. 37218-37226 9 p.

Research output: Contribution to journalArticle

53 Scopus citations

Casein kinase II promotes target silencing by miRISC through direct phosphorylation of the DEAD-box RNA helicase CGH-1

Alessi, A. F., Khivansara, V., Han, T., Freeberg, M. A., Moresco, J. J., Tu, P. G., Montoye, E., Yates, J. R., Karp, X. & Kim, J. K., Dec 29 2015, In : Proceedings of the National Academy of Sciences of the United States of America. 112, 52, p. E7213-E7222

Research output: Contribution to journalArticle

Open Access
6 Scopus citations

CCDC11 is a novel centriolar satellite protein essential for ciliogenesis and establishment of left-right asymmetry

Silva, E., Betleja, E., John, E., Spear, P., Moresco, J. J., Zhang, S., Yates, J. R., Mitchell, B. J. & Mahjoub, M. R., Jan 1 2016, In : Molecular biology of the cell. 27, 1, p. 48-63 16 p.

Research output: Contribution to journalArticle

Open Access
16 Scopus citations

CDK7 regulates organ size and tumor growth by safeguarding the Hippo pathway effector Yki/Yap/Taz in the nucleus

Cho, Y. S., Li, S., Wang, X., Zhu, J., Zhuo, S., Han, Y., Yue, T., Yang, Y. & Jiang, J., Jan 1 2020, In : Genes & development. 34, 1-2, p. 53-71 19 p.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

Census 2: Isobaric labeling data analysis

Park, S. K. R., Aslanian, A., Mcclatchy, D. B., Han, X., Shah, H., Singh, M., Rauniyar, N., Moresco, J. J., Pinto, A. F. M., Diedrich, J. K., Delahunty, C. & Yates, J. R., Aug 1 2014, In : Bioinformatics. 30, 15, p. 2208-2209 2 p.

Research output: Contribution to journalArticle

Open Access
22 Scopus citations

CK2-dependent phosphorylation is required to maintain Pax7 protein levels in proliferating muscle progenitors

González, N., Moresco, J. J., Cabezas, F., de la Vega, E., Bustos, F., Yates, J. R. & Olguín, H. C., May 2016, In : PloS one. 11, 5, e0154919.

Research output: Contribution to journalArticle

Open Access
9 Scopus citations

Comparison of predicted and actual consequences of missense mutations

Miosge, L. A., Field, M. A., Sontani, Y., Cho, V., Johnson, S., Palkova, A., Balakishnan, B., Liang, R., Zhang, Y., Lyon, S., Beutler, B., Whittle, B., Bertram, E. M., Enders, A., Goodnow, C. C. & Andrewsa, T. D., Sep 15 2015, In : Proceedings of the National Academy of Sciences of the United States of America. 112, 37, p. E5189-E5198

Research output: Contribution to journalArticle

101 Scopus citations

Corrigendum: The 4D nucleome project (Nature (2017) 549 (219-226) DOI: 10.1038/nature23884)

4D Nucleome Network, Dec 14 2017, In : Nature. 552, 7684, 1 p.

Research output: Contribution to journalComment/debate

Open Access
2 Scopus citations

Coupling hippocampal neurogenesis to brain ph through proneurogenic small molecules that regulate proton sensing G protein-coupled receptors

Schneider, J. W., Goetsch, S. C., Leng, X., Ludwig, S. M., Russell, J. L., Yang, C. P. & Zhang, Q. J., Jul 18 2012, In : ACS Chemical Neuroscience. 3, 7, p. 557-568 12 p.

Research output: Contribution to journalArticle

18 Scopus citations

Creatine maintains intestinal homeostasis and protects against colitis

Turer, E. E., McAlpine, W., Wang, K. W., Lu, T., Li, X., Tang, M., Zhan, X., Wang, T., Zhan, X., Bu, C. H., Murray, A. R. & Beutler, B. A., Feb 14 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 7, p. E1273-E1281

Research output: Contribution to journalArticle

18 Scopus citations

Current strategies for mutation detection in phenotype-driven screens utilising next generation sequencing

Simon, M. M., Moresco, E. M. Y., Bull, K. R., Kumar, S., Mallon, A. M., Beutler, B. & Potter, P. K., Oct 1 2015, In : Mammalian Genome. 26, 9-10, p. 486-500 15 p.

Research output: Contribution to journalArticle

15 Scopus citations

Deoxycytidine kinase augments ATM-mediated DNA repair and contributes to radiation resistance

Bunimovich, Y. L., Nair-Gill, E., Riedinger, M., McCracken, M. N., Cheng, D., McLaughlin, J., Radu, C. G. & Witte, O. N., Aug 7 2014, In : PloS one. 9, 8, e104125.

Research output: Contribution to journalArticle

Open Access
17 Scopus citations

Determinants that control the distinct subcellular localization of p38α-PRAK and p38β-PRAK complexes

Li, Q., Zhang, N., Zhang, D., Wang, Y., Lin, T., Wang, Y., Zhou, H., Ye, Z., Zhang, F., Lin, S. C. & Han, J., Apr 18 2008, In : Journal of Biological Chemistry. 283, 16, p. 11014-11023 10 p.

Research output: Contribution to journalArticle

27 Scopus citations

Differential modulation of E. coli mRNA abundance by inhibitory proteins that alter the composition of the degradosome

Gao, J., Lee, K., Zhao, M., Qiu, J., Zhan, X., Saxena, A., Moore, C. J., Cohen, S. N. & Georgiou, G., Jul 1 2006, In : Molecular Microbiology. 61, 2, p. 394-406 13 p.

Research output: Contribution to journalArticle

92 Scopus citations

Diprovocims: A New and Exceptionally Potent Class of Toll-like Receptor Agonists

Morin, M. D., Wang, Y., Jones, B. T., Mifune, Y., Su, L., Shi, H-X., Moresco, E. M. Y., Zhang, H., Beutler, B. A. & Boger, D. L., Jan 1 2018, (Accepted/In press) In : Journal of the American Chemical Society.

Research output: Contribution to journalArticle

8 Scopus citations

Discovery and Structure-Activity Relationships of the Neoseptins: A New Class of Toll-like Receptor-4 (TLR4) Agonists

Morin, M. D., Wang, Y., Jones, B. T., Su, L., Surakattula, M. M. R. P., Berger, M., Huang, H., Beutler, E. K., Zhang, H., Beutler, B. & Boger, D. L., May 26 2016, In : Journal of Medicinal Chemistry. 59, 10, p. 4812-4830 19 p.

Research output: Contribution to journalArticle

14 Scopus citations

DNA damage shifts circadian clock time via Hausp-dependent Cry1 stabilization

Papp, S. J., Huber, A. L., Jordan, S. D., Kriebs, A., Nguyen, M., Moresco, J. J., Yates, J. R. & Lamia, K. A., 2015, In : eLife. 4, e04883.

Research output: Contribution to journalArticle

Open Access
15 Scopus citations
46 Scopus citations

E2F1 has both oncogenic and tumor-suppressive properties in a transgenic model

Pierce, A. M., Schneider-Broussard, R., Gimenez-Conti, I. B., Russell, J. L., Conti, C. J. & Johnson, D. G., Jan 1 1999, In : Molecular and Cellular Biology. 19, 9, p. 6408-6414 7 p.

Research output: Contribution to journalArticle

130 Scopus citations

E2F1 suppresses skin carcinogenesis via the ARF-p53 pathway

Russell, J. L., Weaks, R. L., Berton, T. R. & Johnson, D. G., Feb 9 2006, In : Oncogene. 25, 6, p. 867-876 10 p.

Research output: Contribution to journalArticle

10 Scopus citations

E2F4 and E2F1 have similar proliferative properties but different apoptotic and oncogenic properties in vivo

Wang, D., Russell, J. L. & Johnson, D. G., May 1 2000, In : Molecular and Cellular Biology. 20, 10, p. 3417-3424 8 p.

Research output: Contribution to journalArticle

77 Scopus citations

Endosomal recognition of Lactococcus lactis G121 and its RNA by dendritic cells is key to its allergy-protective effects

Stein, K., Brand, S., Jenckel, A., Sigmund, A., Chen, Z. J., Kirschning, C. J., Kauth, M. & Heine, H., Sep 23 2015, (Accepted/In press) In : Journal of Allergy and Clinical Immunology.

Research output: Contribution to journalArticle

10 Scopus citations

Enhanced sensitivity to DSS colitis caused by a hypomorphic Mbtps1 mutation disrupting the ATF6-driven unfolded protein response

Brandl, K., Rutschmann, S., Li, X., Du, X., Xiao, N., Schnabl, B., Brenner, D. A. & Beutler, B., Mar 3 2009, In : Proceedings of the National Academy of Sciences of the United States of America. 106, 9, p. 3300-3305 6 p.

Research output: Contribution to journalArticle

97 Scopus citations

Enhanced susceptibility to chemically induced colitis caused by excessive endosomal TLR signaling in LRBA-deficient mice

Wang, K. W., Zhan, X., McAlpine, W., Zhang, Z., Choi, J. H., Shi, H., Misawa, T., Yue, T., Zhang, D., Wang, Y., Ludwig, S., Russell, J., Tang, M., Li, X., Murray, A. R., Moresco, E. M. Y., Turer, E. E. & Beutler, B., 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 166, 23, p. 11380-11389 10 p.

Research output: Contribution to journalArticle

1 Scopus citations

ENU-induced phenovariance in mice: Inferences from 587 mutations

Arnold, C. N., Barnes, M. J., Berger, M., Blasius, A. L., Brandl, K., Croker, B., Crozat, K., Du, X., Eidenschenk, C., Georgel, P., Hoebe, K., Huang, H., Jiang, Z., Krebs, P., La Vine, D., Li, X., Lyon, S., Moresco, E. M. Y., Murray, A. R., Popkin, D. L. & 11 others, Rutschmann, S., Siggs, O. M., Smart, N. G., Sun, L., Tabeta, K., Webster, V., Tomisato, W., Won, S., Xia, Y., Xiao, N. & Beutler, B., 2012, In : BMC Research Notes. 5, 577.

Research output: Contribution to journalArticle

33 Scopus citations

Epithelial p38α controls immune cell recruitment in the colonic mucosa

Kang, Y. J., Otsuka, M., van den Berg, A., Hong, L., Huang, Z., Wu, X., Zhang, D. W., Vallance, B. A., Tobias, P. S. & Han, J., Jun 2010, In : PLoS pathogens. 6, 6

Research output: Contribution to journalArticle

18 Scopus citations

Erratum: Plant and animal sensors of conserved microbial signatures (Science (2015) 330:6007 (1061-1064))

Ronald, P. C. & Beutler, B., Sep 11 2015, In : Science. 349, 6253, 3218.

Research output: Contribution to journalComment/debate

Erratum: The genetic architecture of heterochrony as a quantitative trait: Lessons from a computational model [Briefings in Bioinformatics, (2017)] doi: 10.1093/bib/bbx056

Lidan, S., Mengmeng, S., Chenfei, Z., Dongyang, W., Hexin, S., Kaiyue, L., Yanfang, G., Tangren, C., Qixiang, Z. & Rongling, W., Nov 1 2017, In : Briefings in Bioinformatics. 18, 6, 1 p.

Research output: Contribution to journalComment/debate

Erratum: TLR4/MD-2 activation by a synthetic agonist with no similarity to LPS (Proceedings of the National Academy of Sciences of the United States of America (2016) 113 (E884-E893))

Wang, Y., Su, L., Morin, M. D., Jones, B. T., Whitby, L. R., Surakattula, M. M. R. P., Huang, H., Shi, H., Choi, J. H., Wang, K. W., Moresco, E. M. Y., Berger, M., Zhan, X., Zhang, H., Boger, D. L. & Beutler, B., Apr 5 2016, In : Proceedings of the National Academy of Sciences of the United States of America. 113, 14, p. E2096

Research output: Contribution to journalComment/debate

3 Scopus citations

Essential cell-extrinsic requirement for PDIA6 in lymphoid and myeloid development

Choi, J. H., Zhong, X., Zhang, Z., Su, L., McAlpine, W., Misawa, T., Liao, T. C., Zhan, X., Russell, J., Ludwig, S., Li, X., Tang, M., Anderton, P., Moresco, E. M. Y. & Beutler, B., 2020, In : Journal of Experimental Medicine. 217, 4, e20190006.

Research output: Contribution to journalArticle

Open Access