Center for the Genetics of Host Defense

Research Output 1999 2019

Article
59 Citations (Scopus)

A critical role for dorsal progenitors in cortical myelination

Yue, T., Xian, K., Hurlock, E., Xin, M., Kernie, S. G., Parada, L. F. & Lu, Q. R., Jan 25 2006, In : Journal of Neuroscience. 26, 4, p. 1275-1280 6 p.

Research output: Contribution to journalArticle

Oligodendroglia
Basic Helix-Loop-Helix Transcription Factors
Telencephalon
Rhombencephalon
Spinal Cord
169 Citations (Scopus)

Activation of cyclic GMP-AMP synthase by self-DNA causes autoimmune diseases

Gao, D., Li, T., Li, X. D., Chen, X., Li, Q. Z., Wight-Carter, M. & Chen, Z. J., Oct 20 2015, In : Proceedings of the National Academy of Sciences of the United States of America. 112, 42, p. E5699-E5705

Research output: Contribution to journalArticle

GMP synthase (glutamine-hydrolyzing)
Autoimmune Diseases
DNA
Phenotype
Interferons
10 Citations (Scopus)

Adjuvant effect of the novel TLR1/TLR2 agonist Diprovocim synergizes with anti–PD-L1 to eliminate melanoma in mice

Wang, Y., Su, L., Morin, M. D., Jones, B. T., Mifune, Y., Shi, H., Wang, K. W., Zhan, X., Liu, A., Wang, J., Li, X., Tang, M., Ludwig, S., Hildebrand, S., Zhou, K., Siegwart, D. J., Moresco, E. M. Y., Zhang, H., Boger, D. L. & Beutler, B., Sep 11 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 37, p. E8698-E8706

Research output: Contribution to journalArticle

Melanoma
Cytotoxic T-Lymphocytes
Immunization
Toll-Like Receptor 1
Neoplasms
97 Citations (Scopus)

A dynamic notch injury response activates epicardium and contributes to fibrosis repair.

Russell, J. L., Goetsch, S. C., Gaiano, N. R., Hill, J. A., Olson, E. N. & Schneider, J. W., Jan 7 2011, In : Circulation Research. 108, 1, p. 51-59 9 p.

Research output: Contribution to journalArticle

Pericardium
Fibrosis
Wounds and Injuries
Severe Combined Immunodeficiency
Epithelial-Mesenchymal Transition
41 Citations (Scopus)

A forward genetic screen reveals roles for Nfkbid, Zeb1, and Ruvbl2 in humoral immunity

Arnold, C. N., Pirie, E., Dosenovic, P., McInerney, G. M., Xia, Y., Wang, N., Li, X., Siggs, O. M., Karlsson Hedestam, G. B. & Beutler, B., Jul 31 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 31, p. 12286-12293 8 p.

Research output: Contribution to journalArticle

Humoral Immunity
Mutation
Antibody Formation
B-Lymphocytes
Cellophane
26 Citations (Scopus)

An ankyrin repeat-containing protein, characterized as a ubiquitin ligase, is closely associated with membrane-enclosed organelles and required for pollen germination and pollen tube growth in lily

Huang, J., Chen, F., Del Casino, C., Autino, A., Shen, M., Yuan, S., Peng, J., Shi, H., Wang, C., Cresti, M. & Li, Y., Apr 1 2006, In : Plant Physiology. 140, 4, p. 1374-1383 10 p.

Research output: Contribution to journalArticle

Lilium
Ankyrin Repeat
Pollen Tube
ankyrins
pollen germination
42 Citations (Scopus)

An epigenetic switch induced by Shh signalling regulates gene activation during development and medulloblastoma growth

Shi, X., Zhang, Z., Zhan, X., Cao, M., Satoh, T., Akira, S., Shpargel, K., Magnuson, T., Li, Q., Wang, R., Wang, C., Ge, K. & Wu, J., 2014, In : Nature Communications. 5, 6425.

Research output: Contribution to journalArticle

Medulloblastoma
Methyltransferases
Growth and Development
Epigenomics
genes
51 Citations (Scopus)

An Slfn2 mutation causes lymphoid and myeloid immunodeficiency due to loss of immune cell quiescence

Berger, M., Krebs, P., Crozat, K., Li, X., Croker, B. A., Siggs, O. M., Popkin, D., Du, X., Lawson, B. R., Theofilopoulos, A. N., Xia, Y., Khovananth, K., Moresco, E. M. Y., Satoh, T., Takeuchi, O., Akira, S. & Beutler, B., 2010, In : Nature Immunology. 11, 4, p. 335-343 9 p.

Research output: Contribution to journalArticle

T-Lymphocytes
Mutation
Monocytes
Ethylnitrosourea
Virus Diseases
3 Citations (Scopus)
Medulloblastoma
Protein-Tyrosine Kinases
Tyrosine
Neoplasms
src-Family Kinases
2 Citations (Scopus)
Hedgehogs
Zinc Fingers
Transcription
Proteomics
Modulators
66 Citations (Scopus)

ARF differentially modulates apoptosis induced by E2F1 and Myc

Russell, J. L., Powers, J. T., Rounbehler, R. J., Rogers, P. M., Conti, C. J. & Johnson, D. G., Feb 26 2002, In : Molecular and Cellular Biology. 22, 5, p. 1360-1368 9 p.

Research output: Contribution to journalArticle

Apoptosis
E2F1 Transcription Factor
S Phase
Epidermis
Neoplasms
140 Citations (Scopus)

A Role of RIP3-Mediated Macrophage Necrosis in Atherosclerosis Development

Lin, J., Li, H., Yang, M., Ren, J., Huang, Z., Han, F., Huang, J., Ma, J., Zhang, D., Zhang, Z., Wu, J., Huang, D., Qiao, M., Jin, G., Wu, Q., Huang, Y., Du, J. & Han, J., Jan 31 2013, In : Cell Reports. 3, 1, p. 200-210 11 p.

Research output: Contribution to journalArticle

Macrophages
Atherosclerosis
Necrosis
Bone
Receptor-Interacting Protein Serine-Threonine Kinases
21 Citations (Scopus)

A small molecule differentiation inducer increases insulin production by pancreatic β cells

Dioum, E. M., Osborne, J. K., Goetsch, S., Russell, J., Schneider, J. W. & Cobb, M. H., Dec 20 2011, In : Proceedings of the National Academy of Sciences of the United States of America. 108, 51, p. 20713-20718 6 p.

Research output: Contribution to journalArticle

Isoxazoles
Insulin
Histones
Transferases
Histone Deacetylases
9 Citations (Scopus)
MEF2 Transcription Factors
Autistic Disorder
Synapses
Chromatin
Genes
1 Citation (Scopus)

A viable hypomorphic Arnt2 mutation causes hyperphagic obesity, diabetes and hepatic steatosis

Turer, E. E., San Miguel, M., Wang, K. W., McAlpine, W., Ou, F., Li, X., Tang, M., Zang, Z., Wang, J., Hayse, B., Evers, B., Zhan, X., Russell, J. L. & Beutler, B. A., Dec 18 2018, In : Disease models & mechanisms. 11, 12

Research output: Contribution to journalArticle

Aryl Hydrocarbon Receptor Nuclear Translocator
Medical problems
Clustered Regularly Interspaced Short Palindromic Repeats
Obesity
Mutation
1 Citation (Scopus)

B-1a Cell Development in Splenectomized Neonatal Mice

Pedersen, G. K., Li, X., Khoenkhoen, S., Ádori, M., Beutler, B. & Karlsson Hedestam, G. B., Jan 1 2018, In : Frontiers in immunology. 9, 1 p.

Research output: Contribution to journalArticle

Open Access
Spleen
Splenectomy
Bone Marrow
B-Lymphocyte Subsets
B-Lymphoid Precursor Cells
67 Citations (Scopus)

Binding of munc 18-1 to synaptobrevin and to the SNARE four-helix bundle

Xu, Y., Su, L. & Rizot, J., Mar 2 2010, In : Biochemistry. 49, 8, p. 1568-1576 9 p.

Research output: Contribution to journalArticle

Vesicle-Associated Membrane Protein 1
R-SNARE Proteins
Syntaxin 1
Membrane Fusion
Fusion reactions
52 Citations (Scopus)

Casein kinase 2 promotes Hedgehog signaling by regulating both smoothened and Cubitus interruptus

Jia, H., Liu, Y., Xia, R., Tong, C., Yue, T., Jiang, J. & Jia, J., Nov 26 2010, In : Journal of Biological Chemistry. 285, 48, p. 37218-37226 9 p.

Research output: Contribution to journalArticle

Casein Kinase II
RNA Interference
Gene expression
Serine
Gene Expression
91 Citations (Scopus)

Comparison of predicted and actual consequences of missense mutations

Miosge, L. A., Field, M. A., Sontani, Y., Cho, V., Johnson, S., Palkova, A., Balakishnan, B., Liang, R., Zhang, Y., Lyon, S., Beutler, B., Whittle, B., Bertram, E. M., Enders, A., Goodnow, C. C. & Andrewsa, T. D., Sep 15 2015, In : Proceedings of the National Academy of Sciences of the United States of America. 112, 37, p. E5189-E5198

Research output: Contribution to journalArticle

Missense Mutation
Phenotype
Mutation
Homozygote
Genome
17 Citations (Scopus)

Coupling hippocampal neurogenesis to brain ph through proneurogenic small molecules that regulate proton sensing G protein-coupled receptors

Schneider, J. W., Goetsch, S. C., Leng, X., Ludwig, S. M., Russell, J. L., Yang, C. P. & Zhang, Q. J., Jul 18 2012, In : ACS Chemical Neuroscience. 3, 7, p. 557-568 12 p.

Research output: Contribution to journalArticle

Neurogenesis
G-Protein-Coupled Receptors
Protons
Brain
Neural Stem Cells
16 Citations (Scopus)

Creatine maintains intestinal homeostasis and protects against colitis

Turer, E. E., McAlpine, W., Wang, K. W., Lu, T., Li, X., Tang, M., Zhan, X., Wang, T., Zhan, X., Bu, C. H., Murray, A. R. & Beutler, B. A., Feb 14 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 7, p. E1273-E1281

Research output: Contribution to journalArticle

Creatine
Colitis
Dextran Sulfate
Homeostasis
Clustered Regularly Interspaced Short Palindromic Repeats
14 Citations (Scopus)

Current strategies for mutation detection in phenotype-driven screens utilising next generation sequencing

Simon, M. M., Moresco, E. M. Y., Bull, K. R., Kumar, S., Mallon, A. M., Beutler, B. & Potter, P. K., Oct 1 2015, In : Mammalian Genome. 26, 9-10, p. 486-500 15 p.

Research output: Contribution to journalArticle

Ethylnitrosourea
Phenotype
Mutation
Mutagenesis
Genome
27 Citations (Scopus)

Determinants that control the distinct subcellular localization of p38α-PRAK and p38β-PRAK complexes

Li, Q., Zhang, N., Zhang, D., Wang, Y., Lin, T., Wang, Y., Zhou, H., Ye, Z., Zhang, F., Lin, S. C. & Han, J., Apr 18 2008, In : Journal of Biological Chemistry. 283, 16, p. 11014-11023 10 p.

Research output: Contribution to journalArticle

Karyopherins
Protein Kinases
Nuclear Localization Signals
p38 Mitogen-Activated Protein Kinases
Cytosol
89 Citations (Scopus)

Differential modulation of E. coli mRNA abundance by inhibitory proteins that alter the composition of the degradosome

Gao, J., Lee, K., Zhao, M., Qiu, J., Zhan, X., Saxena, A., Moore, C. J., Cohen, S. N. & Georgiou, G., Jul 2006, In : Molecular Microbiology. 61, 2, p. 394-406 13 p.

Research output: Contribution to journalArticle

Escherichia coli
Messenger RNA
Endonucleases
Proteins
RNA Cleavage
4 Citations (Scopus)

Diprovocims: A New and Exceptionally Potent Class of Toll-like Receptor Agonists

Morin, M. D., Wang, Y., Jones, B. T., Mifune, Y., Su, L., Shi, H-X., Moresco, E. M. Y., Zhang, H., Beutler, B. A. & Boger, D. L., Jan 1 2018, (Accepted/In press) In : Journal of the American Chemical Society.

Research output: Contribution to journalArticle

Dimerization
Toll-Like Receptors
Screening
Toll-Like Receptor 2
Macrophages
12 Citations (Scopus)

Discovery and Structure-Activity Relationships of the Neoseptins: A New Class of Toll-like Receptor-4 (TLR4) Agonists

Morin, M. D., Wang, Y., Jones, B. T., Su, L., Surakattula, M. M. R. P., Berger, M., Huang, H., Beutler, E. K., Zhang, H., Beutler, B. & Boger, D. L., May 26 2016, In : Journal of Medicinal Chemistry. 59, 10, p. 4812-4830 19 p.

Research output: Contribution to journalArticle

Toll-Like Receptor 4
Structure-Activity Relationship
Libraries
Lipopolysaccharides
Mouse Tlr4 protein
44 Citations (Scopus)
Chromatin Assembly and Disassembly
Hedgehogs
Activator Appliances
Genes
Telencephalon
130 Citations (Scopus)

E2F1 has both oncogenic and tumor-suppressive properties in a transgenic model

Pierce, A. M., Schneider-Broussard, R., Gimenez-Conti, I. B., Russell, J. L., Conti, C. J. & Johnson, D. G., Jan 1 1999, In : Molecular and Cellular Biology. 19, 9, p. 6408-6414 7 p.

Research output: Contribution to journalArticle

Keratin-5
Transgenic Mice
Skin
Carcinogenesis
Neoplasms
10 Citations (Scopus)

E2F1 suppresses skin carcinogenesis via the ARF-p53 pathway

Russell, J. L., Weaks, R. L., Berton, T. R. & Johnson, D. G., Feb 9 2006, In : Oncogene. 25, 6, p. 867-876 10 p.

Research output: Contribution to journalArticle

Carcinogenesis
Skin
Transgenic Mice
Neoplasms
E2F1 Transcription Factor
77 Citations (Scopus)

E2F4 and E2F1 have similar proliferative properties but different apoptotic and oncogenic properties in vivo

Wang, D., Russell, J. L. & Johnson, D. G., May 1 2000, In : Molecular and Cellular Biology. 20, 10, p. 3417-3424 8 p.

Research output: Contribution to journalArticle

Transgenic Mice
Retinoblastoma
Keratin-5
Carcinogenesis
Neoplasms
10 Citations (Scopus)

Endosomal recognition of Lactococcus lactis G121 and its RNA by dendritic cells is key to its allergy-protective effects

Stein, K., Brand, S., Jenckel, A., Sigmund, A., Chen, Z. J., Kirschning, C. J., Kauth, M. & Heine, H., Sep 23 2015, (Accepted/In press) In : Journal of Allergy and Clinical Immunology.

Research output: Contribution to journalArticle

Lactococcus lactis
Dendritic Cells
Hypersensitivity
RNA
Bone Marrow
94 Citations (Scopus)

Enhanced sensitivity to DSS colitis caused by a hypomorphic Mbtps1 mutation disrupting the ATF6-driven unfolded protein response

Brandl, K., Rutschmann, S., Li, X., Du, X., Xiao, N., Schnabl, B., Brenner, D. A. & Beutler, B., Mar 3 2009, In : Proceedings of the National Academy of Sciences of the United States of America. 106, 9, p. 3300-3305 6 p.

Research output: Contribution to journalArticle

Unfolded Protein Response
Dextran Sulfate
Colitis
Sterol Regulatory Element Binding Proteins
Activating Transcription Factors

Enhanced susceptibility to chemically induced colitis caused by excessive endosomal TLR signaling in LRBA-deficient mice

Wang, K. W., Zhan, X., McAlpine, W., Zhang, Z., Choi, J. H., Shi, H., Misawa, T., Yue, T., Zhang Ph.D., D-W., Wang, Y., Ludwig, S., Russell, J., Tang, M., Li, X., Murray, A. R., Moresco, E. M. Y., Turer, E. E. & Beutler, B., Jan 1 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 166, 23, p. 11380-11389 10 p.

Research output: Contribution to journalArticle

Dextran Sulfate
Toll-Like Receptors
Regulatory T-Lymphocytes
Colitis
Dendritic Cells
30 Citations (Scopus)

ENU-induced phenovariance in mice: Inferences from 587 mutations

Arnold, C. N., Barnes, M. J., Berger, M., Blasius, A. L., Brandl, K., Croker, B., Crozat, K., Du, X., Eidenschenk, C., Georgel, P., Hoebe, K., Huang, H., Jiang, Z., Krebs, P., La Vine, D., Li, X., Lyon, S., Moresco, E. M. Y., Murray, A. R., Popkin, D. L. & 11 others, Rutschmann, S., Siggs, O. M., Smart, N. G., Sun, L., Tabeta, K., Webster, V., Tomisato, W., Won, S., Xia, Y., Xiao, N. & Beutler, B., 2012, In : BMC Research Notes. 5, 577.

Research output: Contribution to journalArticle

Amino Acids
Substitution reactions
Mutation
Genes
Amino Acid Substitution
18 Citations (Scopus)

Epithelial p38α controls immune cell recruitment in the colonic mucosa

Kang, Y. J., Otsuka, M., van den Berg, A., Hong, L., Huang, Z., Wu, X., Zhang, D. W., Vallance, B. A., Tobias, P. S. & Han, J., Jun 1 2010, In : PLoS Pathogens. 6, 6

Research output: Contribution to journalArticle

Mucous Membrane
Epithelial Cells
Chemokines
Citrobacter rodentium
T-Lymphocytes
3 Citations (Scopus)

Erratum: TLR4/MD-2 activation by a synthetic agonist with no similarity to LPS (Proceedings of the National Academy of Sciences of the United States of America (2016) 113 (E884-E893))

Wang, Y., Su, L., Morin, M. D., Jones, B. T., Whitby, L. R., Surakattula, M. M. R. P., Huang, H., Shi, H., Choi, J. H., Wang, K. W., Moresco, E. M. Y., Berger, M., Zhan, X., Zhang, H., Boger, D. L. & Beutler, B., Apr 5 2016, In : Proceedings of the National Academy of Sciences of the United States of America. 113, 14, p. E2096

Research output: Contribution to journalArticle

2 Citations (Scopus)

Excessive endosomal TLR signaling causes inflammatory disease in mice with defective SMCR8-WDR41-C9ORF72 complex function

McAlpine, W., Sun, L., Wang, K. W., Liu, A., Jain, R., Miguel, M. S., Wang, J., Zhang, Z., Hayse, B., McAlpine, S. G., Choi, J. H., Zhong, X., Ludwig, S., Russell, J. L., Zhan, X., Choi, M., Li, X., Tang, M., Moresco, E. M. Y., Beutler, B. A. & 1 others, Turer, E. E., Dec 4 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 49, p. E11523-E11531

Research output: Contribution to journalArticle

Toll-Like Receptors
Autoimmunity
Ligands
Phagosomes
Dextran Sulfate
24 Citations (Scopus)

Facilitating the formation of disulfide bonds in the Escherichia coli periplasm via coexpression of yeast protein disulfide isomerase

Zhan, X., Schwaller, M., Gilbert, H. F. & Georgiou, G., Nov 1999, In : Biotechnology Progress. 15, 6, p. 1033-1038 6 p.

Research output: Contribution to journalArticle

protein disulfide-isomerase
Protein Disulfide-Isomerases
Periplasm
Fungal Proteins
disulfide bonds
2 Citations (Scopus)

Generation of BAF53b-Cre transgenic mice with pan-neuronal Cre activities

Zhan, X., Cao, M., Yoo, A. S., Zhang, Z., Chen, L., Crabtree, G. R. & Wu, J. I., Jul 1 2015, In : Genesis. 53, 7, p. 440-448 9 p.

Research output: Contribution to journalArticle

Transgenic Mice
Neurons
Artificial Chromosomes
Genes
Chromatin Assembly and Disassembly
10 Citations (Scopus)

Genetic Analysis of Disulfide Isomerization in Escherichia coli: Expression of DsbC Is Modulated by RNase E-Dependent mRNA Processing

Zhan, X., Gao, J., Jain, C., Cieslewicz, M. J., Swartz, J. R. & Georgiou, G., Feb 2004, In : Journal of Bacteriology. 186, 3, p. 654-660 7 p.

Research output: Contribution to journalArticle

Protein Disulfide-Isomerases
Tissue Plasminogen Activator
Disulfides
4-Aminobenzoic Acid
Periplasm
22 Citations (Scopus)

Going forward with genetics: Recent technological advances and forward genetics in mice

Moresco, E. M. Y., Li, X. & Beutler, B., May 2013, In : American Journal of Pathology. 182, 5, p. 1462-1473 12 p.

Research output: Contribution to journalArticle

DNA Sequence Analysis
Biological Phenomena
High-Throughput Nucleotide Sequencing
Induced Pluripotent Stem Cells
Haploidy
7 Citations (Scopus)

HCFC2 is needed for IRF1- and IRF2-dependent Tlr3 transcription and for survival during viral infections

Sun, L., Jiang, Z., Acosta-Rodriguez, V. A., Berger, M., Du, X., Choi, J. H., Wang, J., Wang, K. W., Kilaru, G. K., Mohawk, J. A., Quan, J., Scott, L., Hildebrand, S., Li, X., Tang, M., Zhan, X., Murray, A. R., Vine, D. L., Moresco, E. M. Y., Takahashi, J. S. & 1 others, Beutler, B., Nov 1 2017, In : Journal of Experimental Medicine. 214, 11, p. 3263-3277 15 p.

Research output: Contribution to journalArticle

Interferon Regulatory Factor-1
Toll-Like Receptor 3
Virus Diseases
Double-Stranded RNA
Interferons
74 Citations (Scopus)

Hedgehog-regulated ubiquitination controls smoothened trafficking and cell surface expression in Drosophila

Li, S., Chen, Y., Shi, Q., Yue, T., Wang, B. & Jiang, J., Jan 2012, In : PLoS Biology. 10, 1, e1001239.

Research output: Contribution to journalArticle

Hedgehogs
Erinaceidae
Ubiquitination
Drosophila
Phosphorylation
44 Citations (Scopus)

Helsinki alert of biodiversity and health

Von Hertzen, L., Beutler, B., Bienenstock, J., Blaser, M., Cani, P. D., Eriksson, J., Färkkilä, M., Haahtela, T., Hanski, I., Jenmalm, M. C., Kere, J., Knip, M., Kontula, K., Koskenvuo, M., Ling, C., Mandrup-Poulsen, T., Von Mutius, E., Mäkelä, M. J., Paunio, T., Pershagen, G. & 6 others, Renz, H., Rook, G., Saarela, M., Vaarala, O., Veldhoen, M. & De Vos, W. M., May 1 2015, In : Annals of Medicine. 47, 3, p. 218-225 8 p.

Research output: Contribution to journalArticle

Biodiversity
Microbiota
Immune Tolerance
Health
Life Style
3 Citations (Scopus)

Heterozygous mutation in IκBNS leads to reduced levels of natural IgM antibodies and impaired responses to T-independent type 2 antigens

Pederse, G. K., Ádor, M., Star, J. M., Khoenkhoe, S., Arnold, C., Beutler, B. & Karlsson Hedestam, G. B., Mar 1 2016, In : Frontiers in Immunology. 7, MAR, 65.

Research output: Contribution to journalArticle

T Independent Antigens
Antibody Formation
Immunoglobulin M
Mutation
B-Lymphocytes
38 Citations (Scopus)

Hippo signaling pathway and organ size control

Zhang, L., Yue, T. & Jiang, J., Jan 2009, In : Fly. 3, 1, p. 68-73 6 p.

Research output: Contribution to journalArticle

carcinogenesis
cell growth
cell proliferation
Drosophila
apoptosis
184 Citations (Scopus)

Hippo signaling regulates Drosophila intestine stem cell proliferation through multiple pathways

Ren, F., Wang, B., Yue, T., Yun, E. Y., Ip, Y. T. & Jiang, J., Dec 7 2010, In : Proceedings of the National Academy of Sciences of the United States of America. 107, 49, p. 21064-21069 6 p.

Research output: Contribution to journalArticle

Drosophila
Intestines
Stem Cells
Cell Proliferation
Epithelial Cells
64 Citations (Scopus)

Hsp90 regulates activation of interferon regulatory factor 3 and TBK-1 stabilization in Sendai virus-infected cells

Yang, K., Shi, H., Qi, R., Sun, S., Tang, Y., Zhang, B. & Wang, C., Mar 1 2006, In : Molecular Biology of the Cell. 17, 3, p. 1461-1471 11 p.

Research output: Contribution to journalArticle

Interferon Regulatory Factor-3
HSP90 Heat-Shock Proteins
Sendai virus
Phosphorylation
Viruses
54 Citations (Scopus)

HSV-1 ICP27 targets the TBK1-activated STING signalsome to inhibit virus-induced type I IFN expression

Christensen, M. H., Jensen, S. B., Miettinen, J. J., Luecke, S., Prabakaran, T., Reinert, L. S., Mettenleiter, T., Chen, Z. J., Knipe, D. M., Sandri-Goldin, R. M., Enquist, L. W., Hartmann, R., Mogensen, T. H., Rice, S. A., Nyman, T. A., Matikainen, S. & Paludan, S. R., Jul 1 2016, In : EMBO Journal. 35, 13, p. 1385-1399 15 p.

Research output: Contribution to journalArticle

Macrophages
Human Herpesvirus 1
Viruses
Herpesviridae
Viral Proteins
20 Citations (Scopus)

Human Adaptive Immunity Rescues an Inborn Error of Innate Immunity

Israel, L., Wang, Y., Bulek, K., Della Mina, E., Zhang, Z., Pedergnana, V., Chrabieh, M., Lemmens, N. A., Sancho-Shimizu, V., Descatoire, M., Lasseau, T., Israelsson, E., Lorenzo, L., Yun, L., Belkadi, A., Moran, A., Weisman, L. E., Vandenesch, F., Batteux, F., Weller, S. & 14 others, Levin, M., Herberg, J., Abhyankar, A., Prando, C., Itan, Y., van Wamel, W. J. B., Picard, C., Abel, L., Chaussabel, D., Li, X., Beutler, B., Arkwright, P. D., Casanova, J. L. & Puel, A., Feb 23 2017, In : Cell. 168, 5, p. 789-800.e10

Research output: Contribution to journalArticle

Adaptive Immunity
Innate Immunity
Penetrance
Toll-Like Receptor 1
Interleukin-1 Receptor-Associated Kinases