Center for the Genetics of Host Defense

Research Output

2016

K+ Efflux-Independent NLRP3 Inflammasome Activation by Small Molecules Targeting Mitochondria

Groß, C. J., Mishra, R., Schneider, K. S., Médard, G., Wettmarshausen, J., Dittlein, D. C., Shi, H., Gorka, O., Koenig, P. A., Fromm, S., Magnani, G., Ćiković, T., Hartjes, L., Smollich, J., Robertson, A. A. B., Cooper, M. A., Schmidt-Supprian, M., Schuster, M., Schroder, K., Broz, P. & 7 others, Traidl-Hoffmann, C., Beutler, B., Kuster, B., Ruland, J., Schneider, S., Perocchi, F. & Groß, O., Oct 18 2016, In : Immunity. 45, 4, p. 761-773 13 p.

Research output: Contribution to journalArticle

94 Scopus citations

K63-Ubiquitylation and TRAF6 Pathways Regulate Mammalian P-Body Formation and mRNA Decapping

Tenekeci, U., Poppe, M., Beuerlein, K., Buro, C., Müller, H., Weiser, H., Kettner-Buhrow, D., Porada, K., Newel, D., Xu, M., Chen, Z. J., Busch, J., Schmitz, M. L. & Kracht, M., Jun 16 2016, In : Molecular Cell. 62, 6, p. 943-957 15 p.

Research output: Contribution to journalArticle

11 Scopus citations

Mps1Mph1 Kinase Phosphorylates Mad3 to Inhibit Cdc20Slp1-APC/C and Maintain Spindle Checkpoint Arrests

Zich, J., May, K., Paraskevopoulos, K., Sen, O., Syred, H. M., van der Sar, S., Patel, H., Moresco, J. J., Sarkeshik, A., Yates, J. R., Rappsilber, J. & Hardwick, K. G., Feb 2016, In : PLoS genetics. 12, 2, e1005834.

Research output: Contribution to journalArticle

Open Access
7 Scopus citations

Mutation of Fnip1 is associated with B-cell deficiency, cardiomyopathy, and elevated AMPK activity

Siggs, O. M., Stockenhuber, A., Deobagkar-Lele, M., Bull, K. R., Crockford, T. L., Kingston, B. L., Crawford, G., Anzilotti, C., Steeples, V., Ghaffari, S., Czibik, G., Bellahcene, M., Watkins, H., Ashrafian, H., Davies, B., Woods, A., Carling, D., Yavari, A., Beutler, B. & Cornall, R. J., Jun 28 2016, In : Proceedings of the National Academy of Sciences of the United States of America. 113, 26, p. E3706-E3715

Research output: Contribution to journalArticle

18 Scopus citations

Pathogens, commensals, and immunity: From the perspective of the urinary bladder

Beutler, B., Jan 7 2016, In : Pathogens. 5, 1, p. 1-3 3 p.

Research output: Contribution to journalEditorial

1 Scopus citations

Regulation of Smoothened Trafficking and Hedgehog Signaling by the SUMO Pathway

Ma, G., Li, S., Han, Y., Li, S., Yue, T., Wang, B. & Jiang, J., Nov 21 2016, In : Developmental Cell. 39, 4, p. 438-451 14 p.

Research output: Contribution to journalArticle

25 Scopus citations

Streptococci engage TLR13 on myeloid cells in a site-specific fashion

Kolter, J., Feuerstein, R., Spoeri, E., Gharun, K., Elling, R., Trieu-Cuot, P., Goldmann, T., Waskow, C., Chen, Z. J., Kirschning, C. J., Deshmukh, S. D. & Henneke, P., Mar 15 2016, In : Journal of Immunology. 196, 6, p. 2733-2741 9 p.

Research output: Contribution to journalArticle

12 Scopus citations

TLR4/MD-2 activation by a synthetic agonist with no similarity to LPS

Wang, Y., Su, L., Morin, M. D., Jones, B. T., Whitby, L. R., Surakattula, M. M. R. P., Huang, H., Shi, H., Choi, J. H., Wang, K. W., Moresco, E. M. Y., Berger, M., Zhan, X., Zhang, H., Boger, D. L. & Beutler, B., Feb 16 2016, In : Proceedings of the National Academy of Sciences of the United States of America. 113, 7, p. E884-E893

Research output: Contribution to journalArticle

56 Scopus citations

What Lies Ahead? Scientists Look into Their Crystal Balls: Forward Genetics and Viral Pathogenesis

Beutler, B., 2016, Viral Pathogenesis: From Basics to Systems Biology: Third Edition. Elsevier Inc., p. 319-320 2 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

2015

Activation of cyclic GMP-AMP synthase by self-DNA causes autoimmune diseases

Gao, D., Li, T., Li, X. D., Chen, X., Li, Q. Z., Wight-Carter, M. & Chen, Z. J., Oct 20 2015, In : Proceedings of the National Academy of Sciences of the United States of America. 112, 42, p. E5699-E5705

Research output: Contribution to journalArticle

210 Scopus citations
4 Scopus citations

Casein kinase II promotes target silencing by miRISC through direct phosphorylation of the DEAD-box RNA helicase CGH-1

Alessi, A. F., Khivansara, V., Han, T., Freeberg, M. A., Moresco, J. J., Tu, P. G., Montoye, E., Yates, J. R., Karp, X. & Kim, J. K., Dec 29 2015, In : Proceedings of the National Academy of Sciences of the United States of America. 112, 52, p. E7213-E7222

Research output: Contribution to journalArticle

Open Access
6 Scopus citations

Comparison of predicted and actual consequences of missense mutations

Miosge, L. A., Field, M. A., Sontani, Y., Cho, V., Johnson, S., Palkova, A., Balakishnan, B., Liang, R., Zhang, Y., Lyon, S., Beutler, B., Whittle, B., Bertram, E. M., Enders, A., Goodnow, C. C. & Andrewsa, T. D., Sep 15 2015, In : Proceedings of the National Academy of Sciences of the United States of America. 112, 37, p. E5189-E5198

Research output: Contribution to journalArticle

101 Scopus citations

Current strategies for mutation detection in phenotype-driven screens utilising next generation sequencing

Simon, M. M., Moresco, E. M. Y., Bull, K. R., Kumar, S., Mallon, A. M., Beutler, B. & Potter, P. K., Oct 1 2015, In : Mammalian Genome. 26, 9-10, p. 486-500 15 p.

Research output: Contribution to journalArticle

15 Scopus citations

DNA damage shifts circadian clock time via Hausp-dependent Cry1 stabilization

Papp, S. J., Huber, A. L., Jordan, S. D., Kriebs, A., Nguyen, M., Moresco, J. J., Yates, J. R. & Lamia, K. A., 2015, In : eLife. 4, e04883.

Research output: Contribution to journalArticle

Open Access
15 Scopus citations

Endosomal recognition of Lactococcus lactis G121 and its RNA by dendritic cells is key to its allergy-protective effects

Stein, K., Brand, S., Jenckel, A., Sigmund, A., Chen, Z. J., Kirschning, C. J., Kauth, M. & Heine, H., Sep 23 2015, (Accepted/In press) In : Journal of Allergy and Clinical Immunology.

Research output: Contribution to journalArticle

10 Scopus citations

Erratum: Plant and animal sensors of conserved microbial signatures (Science (2015) 330:6007 (1061-1064))

Ronald, P. C. & Beutler, B., Sep 11 2015, In : Science. 349, 6253, 3218.

Research output: Contribution to journalComment/debate

Generation of BAF53b-Cre transgenic mice with pan-neuronal Cre activities

Zhan, X., Cao, M., Yoo, A. S., Zhang, Z., Chen, L., Crabtree, G. R. & Wu, J. I., Jul 1 2015, In : Genesis. 53, 7, p. 440-448 9 p.

Research output: Contribution to journalArticle

4 Scopus citations

Helsinki alert of biodiversity and health

Von Hertzen, L., Beutler, B., Bienenstock, J., Blaser, M., Cani, P. D., Eriksson, J., Färkkilä, M., Haahtela, T., Hanski, I., Jenmalm, M. C., Kere, J., Knip, M., Kontula, K., Koskenvuo, M., Ling, C., Mandrup-Poulsen, T., Von Mutius, E., Mäkelä, M. J., Paunio, T., Pershagen, G. & 6 others, Renz, H., Rook, G., Saarela, M., Vaarala, O., Veldhoen, M. & De Vos, W. M., May 1 2015, In : Annals of Medicine. 47, 3, p. 218-225 8 p.

Research output: Contribution to journalReview article

51 Scopus citations

IL-33 signaling contributes to the pathogenesis of myeloproliferative neoplasms

Mager, L. F., Riether, C., Schürch, C. M., Banz, Y., Wasmer, M. H., Stuber, R., Theocharides, A. P., Li, X., Xia, Y., Saito, H., Nakae, S., Baerlocher, G. M., Manz, M. G., McCoy, K. D., Macpherson, A. J., Ochsenbein, A. F., Beutler, B. & Krebs, P., Jul 1 2015, In : Journal of Clinical Investigation. 125, 7, p. 2579-2591 13 p.

Research output: Contribution to journalArticle

54 Scopus citations
23 Scopus citations

Mutation of the ER retention receptor KDELR1 leads to cell-intrinsic lymphopenia and a failure to control chronic viral infection

Siggs, O. M., Popkin, D. L., Krebs, P., Li, X., Tang, M., Zhan, X., Zeng, M., Lin, P., Xia, Y., Oldstone, M. B. A., Cornall, R. J. & Beutler, B., Oct 20 2015, In : Proceedings of the National Academy of Sciences of the United States of America. 112, 42, p. E5706-E5714

Research output: Contribution to journalArticle

7 Scopus citations

NLRP3 activation and mitosis are mutually exclusive events coordinated by NEK7, a new inflammasome component

Shi, H., Wang, Y., Li, X., Zhan, X., Tang, M., Fina, M., Su, L., Pratt, D., Bu, C. H., Hildebrand, S., Lyon, S., Scott, L., Quan, J., Sun, Q., Russell, J., Arnett, S., Jurek, P., Chen, D., Kravchenko, V. V., Mathison, J. C. & 4 others, Moresco, E. M. Y., Monson, N. L., Ulevitch, R. J. & Beutler, B., Dec 7 2015, (Accepted/In press) In : Nature Immunology.

Research output: Contribution to journalArticle

195 Scopus citations

Noncanoncial signal recognition particle RNAs in a major eukaryotic phylum revealed by purification of SRP from the human pathogen Cryptococcus neoformans

Dumesic, P. A., Rosenblad, M. A., Samuelsson, T., Nguyen, T., Moresco, J. J., Yates, J. R. & Madhani, H. D., 2015, In : Nucleic acids research. 43, 18, p. 9017-9027 11 p.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Overlapping functions of the MAP4K family kinases Hppy and Msn in Hippo signaling

Li, S., Cho, Y. S., Yue, T., Ip, Y. T. & Jiang, J., Nov 24 2015, In : Cell Discovery. 1, 15038.

Research output: Contribution to journalArticle

24 Scopus citations

Real-time resolution of point mutations that cause phenovariance in mice

Wang, T., Zhan, X., Bua, C. H., Lyona, S., Pratta, D., Hildebrand, S., Choi, J. H., Zhang, Z., Zeng, M., Wang, K. W., Turer, E. E., Chen, Z., Zhang Ph.D., D-W., Yue, T., Wang, Y., Shi, H-X., Wang, J., Sun, L., SoRelle, J., McAlpine, W. & 28 others, Hutchins, N., Zhan, X., Fin, M., Gobert, R., Quan, J., Kreutzer, M., Arnett, S., Hawkins, K., Leach, A., Tate, C., Daniel, C., Reyna, C., Prince, L., Davis, S., Purrington, J., Bearden, R., Weatherly, J., White, D., Russell, J. L., Sun, Q., Tang, M., Li, X., Scott, L., Moresco, E. M. Y., McInerney, G. M., Karlsson Hedestam, G. B., Xie, Y. & Beutler, B. A., Feb 3 2015, In : Proceedings of the National Academy of Sciences of the United States of America. 112, 5, p. E440-E449

Research output: Contribution to journalArticle

36 Scopus citations
2014

An epigenetic switch induced by Shh signalling regulates gene activation during development and medulloblastoma growth

Shi, X., Zhang, Z., Zhan, X., Cao, M., Satoh, T., Akira, S., Shpargel, K., Magnuson, T., Li, Q., Wang, R., Wang, C., Ge, K. & Wu, J., 2014, In : Nature communications. 5, 5425.

Research output: Contribution to journalArticle

47 Scopus citations

Census 2: Isobaric labeling data analysis

Park, S. K. R., Aslanian, A., Mcclatchy, D. B., Han, X., Shah, H., Singh, M., Rauniyar, N., Moresco, J. J., Pinto, A. F. M., Diedrich, J. K., Delahunty, C. & Yates, J. R., Aug 1 2014, In : Bioinformatics. 30, 15, p. 2208-2209 2 p.

Research output: Contribution to journalArticle

Open Access
22 Scopus citations

Deoxycytidine kinase augments ATM-mediated DNA repair and contributes to radiation resistance

Bunimovich, Y. L., Nair-Gill, E., Riedinger, M., McCracken, M. N., Cheng, D., McLaughlin, J., Radu, C. G. & Witte, O. N., Aug 7 2014, In : PloS one. 9, 8, e104125.

Research output: Contribution to journalArticle

Open Access
17 Scopus citations

MAVS, cGAS, and endogenous retroviruses in T-independent B cell responses

Zeng, M., Hu, Z., Shi, X., Li, X., Zhan, X., Li, X. D., Wang, J., Choi, J. H., Wang, K. W., Purrington, T., Tang, M., Fina, M., DeBerardinis, R. J., Moresco, E. M. Y., Pedersen, G., McInerney, G. M., Hedestam, G. B. K., Chen, Z. J. & Beutler, B., Dec 19 2014, In : Science. 346, 6216, p. 1486-1492 7 p.

Research output: Contribution to journalArticle

77 Scopus citations

Mutation of mouse Samd4 causes leanness, myopathy, uncoupled mitochondrial respiration, and dysregulated mTORC1 signaling

Chen, Z., Holland, W., Shelton, J. M., Ali, A., Zhan, X., Won, S., Tomisato, W., Liu, C., Li, X., Moresco, E. M. Y. & Beutler, B., May 20 2014, In : Proceedings of the National Academy of Sciences of the United States of America. 111, 20, p. 7367-7372 6 p.

Research output: Contribution to journalArticle

17 Scopus citations

Positron emission tomography probe demonstrates a striking concentration of ribose salvage in the liver

Clark, P. M., Flores, G., Evdokimov, N. M., McCracken, M. N., Chai, T., Nair-Gill, E., O'Mahony, F., Beaven, S. W., Faull, K. F., Phelps, M. E., Jung, M. E. & Witte, O. N., Jul 15 2014, In : Proceedings of the National Academy of Sciences of the United States of America. 111, 28, p. E2866-E2874

Research output: Contribution to journalArticle

Open Access
14 Scopus citations

Regulator of G-protein signaling 19 (RGS19) and its partner Gα-inhibiting activity polypeptide 3 (GNAI3) are required for zVAD-induced autophagy and cell death in L929 cells

Wu, T., Li, Y., Huang, D., Han, F., Zhang, Y. Y., Zhang, D. W. & Han, J., Apr 21 2014, In : PloS one. 9, 4, e94634.

Research output: Contribution to journalArticle

7 Scopus citations

Tls1 regulates splicing of shelterin components to control telomeric heterochromatin assembly and telomere length

Wang, J., Tadeo, X., Hou, H., Andrews, S., Moresco, J. J., Yates, J. R., Nagy, P. L. & Jia, S., Oct 13 2014, In : Nucleic acids research. 42, 18, p. 11419-11432 14 p.

Research output: Contribution to journalArticle

Open Access
7 Scopus citations
2013

A Role of RIP3-Mediated Macrophage Necrosis in Atherosclerosis Development

Lin, J., Li, H., Yang, M., Ren, J., Huang, Z., Han, F., Huang, J., Ma, J., Zhang, D., Zhang, Z., Wu, J., Huang, D., Qiao, M., Jin, G., Wu, Q., Huang, Y., Du, J. & Han, J., Jan 31 2013, In : Cell Reports. 3, 1, p. 200-210 11 p.

Research output: Contribution to journalArticle

149 Scopus citations

Going forward with genetics: Recent technological advances and forward genetics in mice

Moresco, E. M. Y., Li, X. & Beutler, B., May 2013, In : American Journal of Pathology. 182, 5, p. 1462-1473 12 p.

Research output: Contribution to journalArticle

26 Scopus citations

Long-term in vivo monitoring of mouse and human hematopoietic stem cell engraftment with a human positron emission tomography reporter gene

McCracken, M. N., Gschweng, E. H., Nair-Gill, E., McLaughlin, J., Cooper, A. R., Riedinger, M., Cheng, D., Nosala, C., Kohn, D. B. & Witte, O. N., Jan 29 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 5, p. 1857-1862 6 p.

Research output: Contribution to journalArticle

Open Access
29 Scopus citations
2012

A forward genetic screen reveals roles for Nfkbid, Zeb1, and Ruvbl2 in humoral immunity

Arnold, C. N., Pirie, E., Dosenovic, P., McInerney, G. M., Xia, Y., Wang, N., Li, X., Siggs, O. M., Karlsson Hedestam, G. B. & Beutler, B., Jul 31 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 31, p. 12286-12293 8 p.

Research output: Contribution to journalArticle

46 Scopus citations

Coupling hippocampal neurogenesis to brain ph through proneurogenic small molecules that regulate proton sensing G protein-coupled receptors

Schneider, J. W., Goetsch, S. C., Leng, X., Ludwig, S. M., Russell, J. L., Yang, C. P. & Zhang, Q. J., Jul 18 2012, In : ACS Chemical Neuroscience. 3, 7, p. 557-568 12 p.

Research output: Contribution to journalArticle

18 Scopus citations

ENU-induced phenovariance in mice: Inferences from 587 mutations

Arnold, C. N., Barnes, M. J., Berger, M., Blasius, A. L., Brandl, K., Croker, B., Crozat, K., Du, X., Eidenschenk, C., Georgel, P., Hoebe, K., Huang, H., Jiang, Z., Krebs, P., La Vine, D., Li, X., Lyon, S., Moresco, E. M. Y., Murray, A. R., Popkin, D. L. & 11 others, Rutschmann, S., Siggs, O. M., Smart, N. G., Sun, L., Tabeta, K., Webster, V., Tomisato, W., Won, S., Xia, Y., Xiao, N. & Beutler, B., 2012, In : BMC Research Notes. 5, 577.

Research output: Contribution to journalArticle

33 Scopus citations

Hedgehog-regulated ubiquitination controls smoothened trafficking and cell surface expression in Drosophila

Li, S., Chen, Y., Shi, Q., Yue, T., Wang, B. & Jiang, J., Jan 2012, In : PLoS biology. 10, 1, e1001239.

Research output: Contribution to journalArticle

79 Scopus citations

Hypopigmentation and Maternal-Zygotic Embryonic Lethality Caused by a Hypomorphic Mbtps1 Mutation in Mice

Rutschmann, S., Crozat, K., Li, X., Du, X., Hanselman, J. C., Shigeoka, A. A., Brandl, K., Popkin, D. L., McKay, D. B., Xia, Y., Moresco, E. M. Y. & Beutler, B., Apr 1 2012, In : G3: Genes, Genomes, Genetics. 2, 4, p. 499-504 6 p.

Research output: Contribution to journalArticle

8 Scopus citations

iRhom2 is required for the secretion of mouse TNFα

Siggs, O. M., Xiao, N., Wang, Y., Shi, H., Tomisato, W., Li, X., Xia, Y. & Beutler, B., Jun 14 2012, In : Blood. 119, 24, p. 5769-5771 3 p.

Research output: Contribution to journalArticle

52 Scopus citations

Regulated expression of pH sensing G protein-coupled receptor-68 identified through chemical biology defines a new drug target for ischemic heart disease

Russell, J. L., Goetsch, S. C., Aguilar, H. R., Coe, H., Luo, X., Liu, N., Van Rooij, E., Frantz, D. E. & Schneider, J. W., Jun 15 2012, In : ACS Chemical Biology. 7, 6, p. 1077-1083 7 p.

Research output: Contribution to journalArticle

32 Scopus citations

Targeting native adult heart progenitors with cardiogenic small molecules

Russell, J. L., Goetsch, S. C., Aguilar, H. R., Frantz, D. E. & Schneider, J. W., Jun 15 2012, In : ACS Chemical Biology. 7, 6, p. 1067-1076 10 p.

Research output: Contribution to journalArticle

31 Scopus citations

The Cell Adhesion Molecule Echinoid Functions as a Tumor Suppressor and Upstream Regulator of the Hippo Signaling Pathway

Yue, T., Tian, A. & Jiang, J., Feb 14 2012, In : Developmental cell. 22, 2, p. 255-267 13 p.

Research output: Contribution to journalArticle

67 Scopus citations

Yip1 domain family, member 6 (Yipf6) mutation induces spontaneous intestinal inflammation in mice

Brandl, K., Tomisato, W., Li, X., Neppl, C., Pirie, E., Falk, W., Xia, Y., Moresco, E. M. Y., Baccala, R., Theofilopoulos, A. N., Schnabl, B. & Beutler, B., Jul 31 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 31, p. 12650-12655 6 p.

Research output: Contribution to journalArticle

20 Scopus citations

ZBTB1 is a determinant of lymphoid development

Siggs, O. M., Li, X., Xia, Y. & Beutler, A. B., Jan 2012, In : Journal of Experimental Medicine. 209, 1, p. 19-27 9 p.

Research output: Contribution to journalArticle

22 Scopus citations
2011

A dynamic notch injury response activates epicardium and contributes to fibrosis repair.

Russell, J. L., Goetsch, S. C., Gaiano, N. R., Hill, J. A., Olson, E. N. & Schneider, J. W., Jan 7 2011, In : Circulation research. 108, 1, p. 51-59 9 p.

Research output: Contribution to journalArticle

102 Scopus citations

A small molecule differentiation inducer increases insulin production by pancreatic β cells

Dioum, E. M., Osborne, J. K., Goetsch, S., Russell, J., Schneider, J. W. & Cobb, M. H., Dec 20 2011, In : Proceedings of the National Academy of Sciences of the United States of America. 108, 51, p. 20713-20718 6 p.

Research output: Contribution to journalArticle

23 Scopus citations