Center for the Genetics of Host Defense

Research Output 1999 2019

2015
22 Citations (Scopus)

Overlapping functions of the MAP4K family kinases Hppy and Msn in Hippo signaling

Li, S., Cho, Y. S., Yue, T., Ip, Y. T. & Jiang, J., Nov 24 2015, In : Cell Discovery. 1, 15038.

Research output: Contribution to journalArticle

Drosophila
Phosphotransferases
Imaginal Discs
Organ Size
Cytoskeleton
28 Citations (Scopus)

Real-time resolution of point mutations that cause phenovariance in mice

Wang, T., Zhan, X., Bua, C. H., Lyona, S., Pratta, D., Hildebrand, S., Choi, J. H., Zhang, Z., Zeng, M., Wang, K. W., Turer, E. E., Chen, Z., Zhang Ph.D., D-W., Yue, T., Wang, Y., Shi, H-X., Wang, J., Sun, L., SoRelle, J., McAlpine, W. & 28 others, Hutchins, N., Zhan, X., Fin, M., Gobert, R., Quan, J., Kreutzer, M., Arnett, S., Hawkins, K., Leach, A., Tate, C., Daniel, C., Reyna, C., Prince, L., Davis, S., Purrington, J., Bearden, R., Weatherly, J., White, D., Russell, J. L., Sun, Q., Tang, M., Li, X., Scott, L., Moresco, E. M. Y., McInerney, G. M., Karlsson Hedestam, G. B., Xie, Y. & Beutler, B. A., Feb 3 2015, In : Proceedings of the National Academy of Sciences of the United States of America. 112, 5, p. E440-E449

Research output: Contribution to journalArticle

Point Mutation
Mutation
Ethylnitrosourea
Phenotype
High-Throughput Nucleotide Sequencing
2014
42 Citations (Scopus)

An epigenetic switch induced by Shh signalling regulates gene activation during development and medulloblastoma growth

Shi, X., Zhang, Z., Zhan, X., Cao, M., Satoh, T., Akira, S., Shpargel, K., Magnuson, T., Li, Q., Wang, R., Wang, C., Ge, K. & Wu, J., 2014, In : Nature Communications. 5, 6425.

Research output: Contribution to journalArticle

Medulloblastoma
Methyltransferases
Growth and Development
Epigenomics
genes
72 Citations (Scopus)

MAVS, cGAS, and endogenous retroviruses in T-independent B cell responses

Zeng, M., Hu, Z., Shi, X., Li, X., Zhan, X., Li, X. D., Wang, J., Choi, J. H., Wang, K. W., Purrington, T., Tang, M., Fina, M., DeBerardinis, R. J., Moresco, E. M. Y., Pedersen, G., McInerney, G. M., Hedestam, G. B. K., Chen, Z. J. & Beutler, B., Dec 19 2014, In : Science. 346, 6216, p. 1486-1492 7 p.

Research output: Contribution to journalArticle

Endogenous Retroviruses
Antiviral Agents
B-Lymphocytes
RNA
Antibody Formation
14 Citations (Scopus)

Mutation of mouse Samd4 causes leanness, myopathy, uncoupled mitochondrial respiration, and dysregulated mTORC1 signaling

Chen, Z., Holland, W., Shelton, J. M., Ali, A., Zhan, X., Won, S., Tomisato, W., Liu, C., Li, X., Moresco, E. M. Y. & Beutler, B., May 20 2014, In : Proceedings of the National Academy of Sciences of the United States of America. 111, 20, p. 7367-7372 6 p.

Research output: Contribution to journalArticle

Mitochondrial Myopathies
Thinness
Respiration
Mutation
Proteins
6 Citations (Scopus)

Regulator of G-protein signaling 19 (RGS19) and its partner Gα-inhibiting activity polypeptide 3 (GNAI3) are required for zVAD-induced autophagy and cell death in L929 cells

Wu, T., Li, Y., Huang, D., Han, F., Zhang, Y. Y., Zhang, D. W. & Han, J., Apr 21 2014, In : PLoS One. 9, 4, e94634.

Research output: Contribution to journalArticle

autophagy
Autophagy
Cell death
G-proteins
cell death
2013
139 Citations (Scopus)

A Role of RIP3-Mediated Macrophage Necrosis in Atherosclerosis Development

Lin, J., Li, H., Yang, M., Ren, J., Huang, Z., Han, F., Huang, J., Ma, J., Zhang, D., Zhang, Z., Wu, J., Huang, D., Qiao, M., Jin, G., Wu, Q., Huang, Y., Du, J. & Han, J., Jan 31 2013, In : Cell Reports. 3, 1, p. 200-210 11 p.

Research output: Contribution to journalArticle

Macrophages
Atherosclerosis
Necrosis
Bone
Receptor-Interacting Protein Serine-Threonine Kinases
21 Citations (Scopus)

Going forward with genetics: Recent technological advances and forward genetics in mice

Moresco, E. M. Y., Li, X. & Beutler, B., May 2013, In : American Journal of Pathology. 182, 5, p. 1462-1473 12 p.

Research output: Contribution to journalArticle

DNA Sequence Analysis
Biological Phenomena
High-Throughput Nucleotide Sequencing
Induced Pluripotent Stem Cells
Haploidy
2012
40 Citations (Scopus)

A forward genetic screen reveals roles for Nfkbid, Zeb1, and Ruvbl2 in humoral immunity

Arnold, C. N., Pirie, E., Dosenovic, P., McInerney, G. M., Xia, Y., Wang, N., Li, X., Siggs, O. M., Karlsson Hedestam, G. B. & Beutler, B., Jul 31 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 31, p. 12286-12293 8 p.

Research output: Contribution to journalArticle

Humoral Immunity
Mutation
Antibody Formation
B-Lymphocytes
Cellophane
16 Citations (Scopus)

Coupling hippocampal neurogenesis to brain ph through proneurogenic small molecules that regulate proton sensing G protein-coupled receptors

Schneider, J. W., Goetsch, S. C., Leng, X., Ludwig, S. M., Russell, J. L., Yang, C. P. & Zhang, Q. J., Jul 18 2012, In : ACS Chemical Neuroscience. 3, 7, p. 557-568 12 p.

Research output: Contribution to journalArticle

Neurogenesis
G-Protein-Coupled Receptors
Protons
Brain
Neural Stem Cells
30 Citations (Scopus)

ENU-induced phenovariance in mice: Inferences from 587 mutations

Arnold, C. N., Barnes, M. J., Berger, M., Blasius, A. L., Brandl, K., Croker, B., Crozat, K., Du, X., Eidenschenk, C., Georgel, P., Hoebe, K., Huang, H., Jiang, Z., Krebs, P., La Vine, D., Li, X., Lyon, S., Moresco, E. M. Y., Murray, A. R., Popkin, D. L. & 11 others, Rutschmann, S., Siggs, O. M., Smart, N. G., Sun, L., Tabeta, K., Webster, V., Tomisato, W., Won, S., Xia, Y., Xiao, N. & Beutler, B., 2012, In : BMC Research Notes. 5, 577.

Research output: Contribution to journalArticle

Amino Acids
Substitution reactions
Mutation
Genes
Amino Acid Substitution
73 Citations (Scopus)

Hedgehog-regulated ubiquitination controls smoothened trafficking and cell surface expression in Drosophila

Li, S., Chen, Y., Shi, Q., Yue, T., Wang, B. & Jiang, J., Jan 2012, In : PLoS Biology. 10, 1, e1001239.

Research output: Contribution to journalArticle

Hedgehogs
Erinaceidae
Ubiquitination
Drosophila
Phosphorylation
8 Citations (Scopus)

Hypopigmentation and Maternal-Zygotic Embryonic Lethality Caused by a Hypomorphic Mbtps1 Mutation in Mice

Rutschmann, S., Crozat, K., Li, X., Du, X., Hanselman, J. C., Shigeoka, A. A., Brandl, K., Popkin, D. L., McKay, D. B., Xia, Y., Moresco, E. M. Y. & Beutler, B., Apr 2012, In : G3: Genes, Genomes, Genetics. 2, 4, p. 499-504 6 p.

Research output: Contribution to journalArticle

Hypopigmentation
Pigmentation
Sterol Regulatory Element Binding Proteins
Activating Transcription Factors
Mothers
45 Citations (Scopus)

iRhom2 is required for the secretion of mouse TNFα

Siggs, O. M., Xiao, N., Wang, Y., Shi, H., Tomisato, W., Li, X., Xia, Y. & Beutler, B., Jun 14 2012, In : Blood. 119, 24, p. 5769-5771 3 p.

Research output: Contribution to journalArticle

Dextran Sulfate
Gene encoding
Macrophages
Toll-Like Receptors
Missense Mutation
27 Citations (Scopus)

Regulated expression of pH sensing G protein-coupled receptor-68 identified through chemical biology defines a new drug target for ischemic heart disease

Russell, J. L., Goetsch, S. C., Aguilar, H. R., Coe, H., Luo, X., Liu, N., Van Rooij, E., Frantz, D. E. & Schneider, J. W., Jun 15 2012, In : ACS Chemical Biology. 7, 6, p. 1077-1083 7 p.

Research output: Contribution to journalArticle

Isoxazoles
Myocardial Ischemia
Pericardium
Pharmaceutical Preparations
Protons
30 Citations (Scopus)

Targeting native adult heart progenitors with cardiogenic small molecules

Russell, J. L., Goetsch, S. C., Aguilar, H. R., Frantz, D. E. & Schneider, J. W., Jun 15 2012, In : ACS Chemical Biology. 7, 6, p. 1067-1076 10 p.

Research output: Contribution to journalArticle

Isoxazoles
Molecules
Muscle
Pericardium
Gene expression
58 Citations (Scopus)

The Cell Adhesion Molecule Echinoid Functions as a Tumor Suppressor and Upstream Regulator of the Hippo Signaling Pathway

Yue, T., Tian, A. & Jiang, J., Feb 14 2012, In : Developmental Cell. 22, 2, p. 255-267 13 p.

Research output: Contribution to journalArticle

Cell Adhesion Molecules
Tumors
Drosophila
Neoplasms
Phosphotransferases
18 Citations (Scopus)

Yip1 domain family, member 6 (Yipf6) mutation induces spontaneous intestinal inflammation in mice

Brandl, K., Tomisato, W., Li, X., Neppl, C., Pirie, E., Falk, W., Xia, Y., Moresco, E. M. Y., Baccala, R., Theofilopoulos, A. N., Schnabl, B. & Beutler, B., Jul 31 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 31, p. 12650-12655 6 p.

Research output: Contribution to journalArticle

Colitis
Inflammation
Mutation
Homeostasis
Ileitis
20 Citations (Scopus)

ZBTB1 is a determinant of lymphoid development

Siggs, O. M., Li, X., Xia, Y. & Beutler, A. B., Jan 2012, In : Journal of Experimental Medicine. 209, 1, p. 19-27 9 p.

Research output: Contribution to journalArticle

Lymphopoiesis
T-Lymphocytes
Mutation
Zinc Fingers
Vertebrates
2011
97 Citations (Scopus)

A dynamic notch injury response activates epicardium and contributes to fibrosis repair.

Russell, J. L., Goetsch, S. C., Gaiano, N. R., Hill, J. A., Olson, E. N. & Schneider, J. W., Jan 7 2011, In : Circulation Research. 108, 1, p. 51-59 9 p.

Research output: Contribution to journalArticle

Pericardium
Fibrosis
Wounds and Injuries
Severe Combined Immunodeficiency
Epithelial-Mesenchymal Transition
20 Citations (Scopus)

A small molecule differentiation inducer increases insulin production by pancreatic β cells

Dioum, E. M., Osborne, J. K., Goetsch, S., Russell, J., Schneider, J. W. & Cobb, M. H., Dec 20 2011, In : Proceedings of the National Academy of Sciences of the United States of America. 108, 51, p. 20713-20718 6 p.

Research output: Contribution to journalArticle

Isoxazoles
Insulin
Histones
Transferases
Histone Deacetylases
44 Citations (Scopus)
Chromatin Assembly and Disassembly
Hedgehogs
Activator Appliances
Genes
Telencephalon
34 Citations (Scopus)

Lethal mitochondrial cardiomyopathy in a hypomorphic Med30 mouse mutant is ameliorated by ketogenic diet

Krebs, P., Fan, W., Chen, Y. H., Tobita, K., Downes, M. R., Wood, M. R., Sun, L., Li, X., Xia, Y., Ding, N., Spaeth, J. M., Moresco, E. M. Y., Boyer, T. G., Lo, C. W. Y., Yen, J., Evans, R. M. & Beutler, B., Dec 6 2011, In : Proceedings of the National Academy of Sciences of the United States of America. 108, 49, p. 19678-19682 5 p.

Research output: Contribution to journalArticle

Ketogenic Diet
Oxidative Phosphorylation
Cardiomyopathies
Mediator Complex
Missense Mutation
36 Citations (Scopus)

Mitochondrial ubiquitin ligase MARCH5 promotes TLR7 signaling by attenuating TANK action

Shi, H. X., Liu, X., Wang, Q., Tang, P. P., Liu, X. Y., Shan, Y. F. & Wang, C., May 1 2011, In : PLoS Pathogens. 7, 5, e1002057.

Research output: Contribution to journalArticle

Ligases
Ubiquitin
Toll-Like Receptors
Mitochondria
imiquimod
39 Citations (Scopus)

Multiple death pathways in TNF-treated fibroblasts: RIP3-and RIP1-dependent and independent routes

Zhang, D. W., Zheng, M., Zhao, J., Li, Y. Y., Huang, Z., Li, Z. & Han, J., Feb 1 2011, In : Cell Research. 21, 2, p. 368-371 4 p.

Research output: Contribution to journalLetter

Receptor-Interacting Protein Serine-Threonine Kinases
GTPase-Activating Proteins
Oligopeptides
Cycloheximide
RNA Interference
209 Citations (Scopus)

Programmed necrosis: Backup to and competitor with apoptosis in the immune system

Han, J., Zhong, C. Q. & Zhang, D. W., Dec 1 2011, In : Nature Immunology. 12, 12, p. 1143-1149 7 p.

Research output: Contribution to journalReview article

Immune System
Cell Death
Necrosis
Apoptosis
Caspases
109 Citations (Scopus)

Sonic Hedgehog dependent Phosphorylation by CK1α and GRK2 is required for Ciliary Accumulation and Activation of Smoothened

Chen, Y., Sasai, N., Ma, G., Yue, T., Jia, J., Briscoe, J. & Jiang, J., Jun 2011, In : PLoS Biology. 9, 6, e1001083.

Research output: Contribution to journalArticle

Phosphorylation
Hedgehogs
Erinaceidae
phosphorylation
Chemical activation
2010
50 Citations (Scopus)

An Slfn2 mutation causes lymphoid and myeloid immunodeficiency due to loss of immune cell quiescence

Berger, M., Krebs, P., Crozat, K., Li, X., Croker, B. A., Siggs, O. M., Popkin, D., Du, X., Lawson, B. R., Theofilopoulos, A. N., Xia, Y., Khovananth, K., Moresco, E. M. Y., Satoh, T., Takeuchi, O., Akira, S. & Beutler, B., 2010, In : Nature Immunology. 11, 4, p. 335-343 9 p.

Research output: Contribution to journalArticle

T-Lymphocytes
Mutation
Monocytes
Ethylnitrosourea
Virus Diseases

Binding of munc 18-1 to synaptobrevin and to the SNARE four-helix bundle

Xu, Y., Su, L. & Rizot, J., Mar 2 2010, In : Biochemistry. 49, 8, p. 1568-1576 9 p.

Research output: Contribution to journalArticle

Munc18 Proteins
R-SNARE Proteins
Magnetic resonance spectroscopy
SNARE Proteins
Cell membranes
52 Citations (Scopus)

Casein kinase 2 promotes Hedgehog signaling by regulating both smoothened and Cubitus interruptus

Jia, H., Liu, Y., Xia, R., Tong, C., Yue, T., Jiang, J. & Jia, J., Nov 26 2010, In : Journal of Biological Chemistry. 285, 48, p. 37218-37226 9 p.

Research output: Contribution to journalArticle

Casein Kinase II
RNA Interference
Gene expression
Serine
Gene Expression
18 Citations (Scopus)

Epithelial p38α controls immune cell recruitment in the colonic mucosa

Kang, Y. J., Otsuka, M., van den Berg, A., Hong, L., Huang, Z., Wu, X., Zhang, D. W., Vallance, B. A., Tobias, P. S. & Han, J., Jun 1 2010, In : PLoS Pathogens. 6, 6

Research output: Contribution to journalArticle

Mucous Membrane
Epithelial Cells
Chemokines
Citrobacter rodentium
T-Lymphocytes
182 Citations (Scopus)

Hippo signaling regulates Drosophila intestine stem cell proliferation through multiple pathways

Ren, F., Wang, B., Yue, T., Yun, E. Y., Ip, Y. T. & Jiang, J., Dec 7 2010, In : Proceedings of the National Academy of Sciences of the United States of America. 107, 49, p. 21064-21069 6 p.

Research output: Contribution to journalArticle

Drosophila
Intestines
Stem Cells
Cell Proliferation
Epithelial Cells

Interferon regulatory factor 3, a pivotal transcription factor for host antiviral responses

Liu, X., Shi, H. X. & Wang, C., Aug 1 2010, In : Progress in Biochemistry and Biophysics. 37, 8, p. 817-825 9 p.

Research output: Contribution to journalReview article

Interferon Regulatory Factor-3
Antiviral Agents
Transcription Factors
Interferon Type I
Interferon Regulatory Factor-7
113 Citations (Scopus)

MyD88 signaling in nonhematopoietic cells protects mice against induced colitis by regulating specific EGF receptor ligands

Brandl, K., Sun, L., Neppl, C., Siggs, O. M., Le Gall, S. M., Tomisato, W., Li, X., Du, X., Maennel, D. N., Blobel, C. P. & Beutler, B., Nov 16 2010, In : Proceedings of the National Academy of Sciences of the United States of America. 107, 46, p. 19967-19972 6 p.

Research output: Contribution to journalArticle

Dextran Sulfate
Toll-Like Receptors
Colitis
Inflammation
Mutation
119 Citations (Scopus)

Positive regulation of interferon regulatory factor 3 activation by Herc5 via ISG15 modification

Shi, H. X., Yang, K., Liu, X., Liu, X. Y., Wei, B., Shan, Y. F., Zhu, L. H. & Wang, C., May 1 2010, In : Molecular and Cellular Biology. 30, 10, p. 2424-2436 13 p.

Research output: Contribution to journalArticle

Interferon Regulatory Factor-3
Antiviral Agents
Virus Diseases
Ubiquitins
Sendai virus
90 Citations (Scopus)

Receptor-interacting protein (RIP) kinase family

Zhang, D., Lin, J. & Han, J., Jul 1 2010, In : Cellular and Molecular Immunology. 7, 4, p. 243-249 7 p.

Research output: Contribution to journalArticle

Receptor-Interacting Protein Serine-Threonine Kinases
Protein Kinases
Biological Phenomena
Protein-Serine-Threonine Kinases
Innate Immunity
106 Citations (Scopus)

Slc15a4, AP-3, and Hermansky-Pudlak syndrome proteins are required for Toll-like receptor signaling in plasmacytoid dendritic cells

Blasius, A. L., Arnold, C. N., Georgel, P., Rutschmann, S., Xia, Y., Lin, P., Ross, C., Li, X., Smart, N. G. & Beutler, B., Nov 16 2010, In : Proceedings of the National Academy of Sciences of the United States of America. 107, 46, p. 19973-19978 6 p.

Research output: Contribution to journalArticle

Hermanski-Pudlak Syndrome
Toll-Like Receptors
Dendritic Cells
Proteins
Mutation
57 Citations (Scopus)

Tom70 mediates activation of interferon regulatory factor 3 on mitochondria

Liu, X. Y., Wei, B., Shi, H. X., Shan, Y. F. & Wang, C., Sep 1 2010, In : Cell Research. 20, 9, p. 994-1011 18 p.

Research output: Contribution to journalArticle

Interferon Regulatory Factor-3
Mitochondria
Phosphotransferases
Membranes
RNA Virus Infections
2009
93 Citations (Scopus)

Enhanced sensitivity to DSS colitis caused by a hypomorphic Mbtps1 mutation disrupting the ATF6-driven unfolded protein response

Brandl, K., Rutschmann, S., Li, X., Du, X., Xiao, N., Schnabl, B., Brenner, D. A. & Beutler, B., Mar 3 2009, In : Proceedings of the National Academy of Sciences of the United States of America. 106, 9, p. 3300-3305 6 p.

Research output: Contribution to journalArticle

Unfolded Protein Response
Dextran Sulfate
Colitis
Sterol Regulatory Element Binding Proteins
Activating Transcription Factors
38 Citations (Scopus)

Hippo signaling pathway and organ size control

Zhang, L., Yue, T. & Jiang, J., Jan 2009, In : Fly. 3, 1, p. 68-73 6 p.

Research output: Contribution to journalArticle

carcinogenesis
cell growth
cell proliferation
Drosophila
apoptosis
15 Citations (Scopus)

Monoclonal antibodies against IREM-1: Potential for targeted therapy of AML

Korver, W., Zhao, X., Singh, S., Pardoux, C., Zhao, J., Guzman, M. L., Sen, S., Yonkovich, S., Liu, S., Zhan, X., Tomasevic, N., Zhou, C., Gros, D., Jordan, C. T., Gotlib, J., Hsi, E. D. & Abo, A., Sep 2009, In : Leukemia. 23, 9, p. 1587-1597 11 p.

Research output: Contribution to journalArticle

Acute Myeloid Leukemia
Monoclonal Antibodies
Myeloid Cells
Therapeutics
Cell Line
80 Citations (Scopus)

Multiple Ser/Thr-rich degrons mediate the degradation of Ci/Gli by the Cul3-HIB/SPOP E3 ubiquitin ligase

Zhang, Q., Shi, Q., Chen, Y., Yue, T., Li, S., Wang, B. & Jiang, J., Dec 15 2009, In : Proceedings of the National Academy of Sciences of the United States of America. 106, 50, p. 21191-21196 6 p.

Research output: Contribution to journalArticle

Ubiquitin-Protein Ligases
Proteins
Transcription Factors
Binding Sites
Genome
1029 Citations (Scopus)

RIP3, an energy metabolism regulator that switches TNF-induced cell death from apoptosis to necrosis

Zhang, D. W., Shao, J., Lin, J., Zhang, N., Lu, B. J., Lin, S. C., Dong, M. Q. & Han, J., Jul 17 2009, In : Science. 325, 5938, p. 332-336 5 p.

Research output: Contribution to journalArticle

Receptor-Interacting Protein Serine-Threonine Kinases
Energy Metabolism
Cell Death
Necrosis
Tumor Necrosis Factor-alpha
15 Citations (Scopus)

The first propeller domain of LRP6 regulates sensitivity to DKK1

Binnerts, M. E., Tomasevic, N., Bright, J. M., Leung, J., Ahn, V. E., Kim, K. A., Zhan, X., Liu, S., Yonkovich, S., Williams, J., Zhou, M., Gros, D., Dixon, M., Korver, W., Weis, W. I. & Abo, A., Aug 1 2009, In : Molecular Biology of the Cell. 20, 15, p. 3552-3560 9 p.

Research output: Contribution to journalArticle

Monoclonal Antibodies
105 Citations (Scopus)

TRIM21 is essential to sustain IFN regulatory factor 3 activation during antiviral response

Yang, K., Shi, H. X., Liu, X. Y., Shan, Y. F., Wei, B., Chen, S. & Wang, C., Mar 15 2009, In : Journal of Immunology. 182, 6, p. 3782-3792 11 p.

Research output: Contribution to journalArticle

Interferon Regulatory Factor-3
Antiviral Agents
RNA Virus Infections
Ubiquitination
Virus Diseases
2008
27 Citations (Scopus)

Determinants that control the distinct subcellular localization of p38α-PRAK and p38β-PRAK complexes

Li, Q., Zhang, N., Zhang, D., Wang, Y., Lin, T., Wang, Y., Zhou, H., Ye, Z., Zhang, F., Lin, S. C. & Han, J., Apr 18 2008, In : Journal of Biological Chemistry. 283, 16, p. 11014-11023 10 p.

Research output: Contribution to journalArticle

Karyopherins
Protein Kinases
Nuclear Localization Signals
p38 Mitogen-Activated Protein Kinases
Cytosol
11 Citations (Scopus)

Mouse RING finger protein Rnf133 is a testis-specific endoplasmic reticulum-associated E3 ubiquitin ligase

Nian, H., Zhang, W., Shi, H., Zhao, Q., Xie, Q., Liao, S., Zhang, Y., Zhang, Z., Wang, C. & Han, C., Jul 1 2008, In : Cell Research. 18, 7, p. 800-802 3 p.

Research output: Contribution to journalLetter

Ubiquitin-Protein Ligases
Spermatogenesis
Tertiary Protein Structure
Endoplasmic Reticulum
Testis
191 Citations (Scopus)

R-Spondin family members regulate the Wnt pathway by a common mechanism

Kim, K. A., Wagle, M., Tran, K., Zhan, X., Dixon, M. A., Liu, S., Gros, D., Korver, W., Yonkovich, S., Tomasevic, N., Binnerts, M. & Abo, A., Jun 2008, In : Molecular Biology of the Cell. 19, 6, p. 2588-2596 9 p.

Research output: Contribution to journalArticle

Wnt Signaling Pathway
Proteins
Furin
Ligands
Knockout Mice
2007
72 Citations (Scopus)

Mouse R-spondin2 is required for apical ectodermal ridge maintenance in the hindlimb

Nam, J. S., Park, E., Turcotte, T. J., Palencia, S., Zhan, X., Lee, J., Yun, K., Funk, W. D. & Yoon, J. K., Nov 1 2007, In : Developmental Biology. 311, 1, p. 124-135 12 p.

Research output: Contribution to journalArticle

Catenins
Hindlimb
Maintenance
Fibroblast Growth Factor 8
Developmental Genes
191 Citations (Scopus)

R-Spondin1 regulates Wnt signaling by inhibiting internalization of LRP6

Binnerts, M. E., Kim, K. A., Bright, J. M., Patel, S. M., Tran, K., Zhou, M., Leung, J. M., Liu, Y., Lomas, W. E., Dixon, M., Hazell, S. A., Wagle, M., Nie, W. S., Tomasevic, N., Williams, J., Zhan, X., Levy, M. D., Funk, W. D. & Abo, A., Sep 11 2007, In : Proceedings of the National Academy of Sciences of the United States of America. 104, 37, p. 14700-14705 6 p.

Research output: Contribution to journalArticle

Wnt Signaling Pathway
Ligands
Catenins
Proteins
Epithelium