Center for the Genetics of Host Defense

Research Output

2009

Monoclonal antibodies against IREM-1: Potential for targeted therapy of AML

Korver, W., Zhao, X., Singh, S., Pardoux, C., Zhao, J., Guzman, M. L., Sen, S., Yonkovich, S., Liu, S., Zhan, X., Tomasevic, N., Zhou, C., Gros, D., Jordan, C. T., Gotlib, J., Hsi, E. D. & Abo, A., Sep 2009, In : Leukemia. 23, 9, p. 1587-1597 11 p.

Research output: Contribution to journalArticle

17 Scopus citations

Multiple Ser/Thr-rich degrons mediate the degradation of Ci/Gli by the Cul3-HIB/SPOP E3 ubiquitin ligase

Zhang, Q., Shi, Q., Chen, Y., Yue, T., Li, S., Wang, B. & Jiang, J., Dec 15 2009, In : Proceedings of the National Academy of Sciences of the United States of America. 106, 50, p. 21191-21196 6 p.

Research output: Contribution to journalArticle

82 Scopus citations

RIP3, an energy metabolism regulator that switches TNF-induced cell death from apoptosis to necrosis

Zhang, D. W., Shao, J., Lin, J., Zhang, N., Lu, B. J., Lin, S. C., Dong, M. Q. & Han, J., Jul 17 2009, In : Science. 325, 5938, p. 332-336 5 p.

Research output: Contribution to journalArticle

1089 Scopus citations

The first propeller domain of LRP6 regulates sensitivity to DKK1

Binnerts, M. E., Tomasevic, N., Bright, J. M., Leung, J., Ahn, V. E., Kim, K. A., Zhan, X., Liu, S., Yonkovich, S., Williams, J., Zhou, M., Gros, D., Dixon, M., Korver, W., Weis, W. I. & Abo, A., Aug 1 2009, In : Molecular biology of the cell. 20, 15, p. 3552-3560 9 p.

Research output: Contribution to journalArticle

15 Scopus citations

TRIM21 is essential to sustain IFN regulatory factor 3 activation during antiviral response

Yang, K., Shi, H. X., Liu, X. Y., Shan, Y. F., Wei, B., Chen, S. & Wang, C., Mar 15 2009, In : Journal of Immunology. 182, 6, p. 3782-3792 11 p.

Research output: Contribution to journalArticle

111 Scopus citations
2008

Determinants that control the distinct subcellular localization of p38α-PRAK and p38β-PRAK complexes

Li, Q., Zhang, N., Zhang, D., Wang, Y., Lin, T., Wang, Y., Zhou, H., Ye, Z., Zhang, F., Lin, S. C. & Han, J., Apr 18 2008, In : Journal of Biological Chemistry. 283, 16, p. 11014-11023 10 p.

Research output: Contribution to journalArticle

27 Scopus citations

Mouse RING finger protein Rnf133 is a testis-specific endoplasmic reticulum-associated E3 ubiquitin ligase

Nian, H., Zhang, W., Shi, H., Zhao, Q., Xie, Q., Liao, S., Zhang, Y., Zhang, Z., Wang, C. & Han, C., Jul 1 2008, In : Cell Research. 18, 7, p. 800-802 3 p.

Research output: Contribution to journalLetter

11 Scopus citations

Quantitative mass spectrometry as a tool for nutritional proteomics

Moresco, J. J., Dong, M. Q. & Yates, J. R., Sep 1 2008, In : American Journal of Clinical Nutrition. 88, 3, p. 597-604 8 p.

Research output: Contribution to journalReview article

Open Access
12 Scopus citations

R-Spondin family members regulate the Wnt pathway by a common mechanism

Kim, K. A., Wagle, M., Tran, K., Zhan, X., Dixon, M. A., Liu, S., Gros, D., Korver, W., Yonkovich, S., Tomasevic, N., Binnerts, M. & Abo, A., Jun 1 2008, In : Molecular biology of the cell. 19, 6, p. 2588-2596 9 p.

Research output: Contribution to journalArticle

202 Scopus citations
2007

Mouse R-spondin2 is required for apical ectodermal ridge maintenance in the hindlimb

Nam, J. S., Park, E., Turcotte, T. J., Palencia, S., Zhan, X., Lee, J., Yun, K., Funk, W. D. & Yoon, J. K., Nov 1 2007, In : Developmental Biology. 311, 1, p. 124-135 12 p.

Research output: Contribution to journalArticle

76 Scopus citations

R-Spondin1 regulates Wnt signaling by inhibiting internalization of LRP6

Binnerts, M. E., Kim, K. A., Bright, J. M., Patel, S. M., Tran, K., Zhou, M., Leung, J. M., Liu, Y., Lomas, W. E., Dixon, M., Hazell, S. A., Wagle, M., Nie, W. S., Tomasevic, N., Williams, J., Zhan, X., Levy, M. D., Funk, W. D. & Abo, A., Sep 11 2007, In : Proceedings of the National Academy of Sciences of the United States of America. 104, 37, p. 14700-14705 6 p.

Research output: Contribution to journalArticle

192 Scopus citations

The lymphoid cell surface receptor NTB-A: A novel monoclonal antibody target for leukaemia and lymphoma therapeutics

Korver, W., Singh, S., Liu, S., Zhao, X., Yonkovich, S., Sweeney, A., Anton, K., Lomas, W. E., Greenwood, R., Smith, A., Tran, D. H., Shinkawa, P., Jimenez, M., Yeung, P., Aguilar, G., Palencia, S., Vatta, P., Mueller, M., Zhan, X., Newton, E. M. & 7 others, Liu, Y., Zhao, J., Emtage, P., Levy, M. D., Hsi, E. D., Funk, W. D. & Abo, A., May 1 2007, In : British Journal of Haematology. 137, 4, p. 307-318 12 p.

Research output: Contribution to journalArticle

11 Scopus citations

UXT is a novel and essential cofactor in the NF-κB transcriptional enhanceosome

Sun, S., Tang, Y., Lou, X., Zhu, L., Yang, K., Zhang, B., Shi, H. & Wang, C., Jul 16 2007, In : Journal of Cell Biology. 178, 2, p. 231-244 14 p.

Research output: Contribution to journalArticle

38 Scopus citations
2006

A critical role for dorsal progenitors in cortical myelination

Yue, T., Xian, K., Hurlock, E., Xin, M., Kernie, S. G., Parada, L. F. & Lu, Q. R., Jan 25 2006, In : Journal of Neuroscience. 26, 4, p. 1275-1280 6 p.

Research output: Contribution to journalArticle

62 Scopus citations

An ankyrin repeat-containing protein, characterized as a ubiquitin ligase, is closely associated with membrane-enclosed organelles and required for pollen germination and pollen tube growth in lily

Huang, J., Chen, F., Del Casino, C., Autino, A., Shen, M., Yuan, S., Peng, J., Shi, H., Wang, C., Cresti, M. & Li, Y., Apr 1 2006, In : Plant Physiology. 140, 4, p. 1374-1383 10 p.

Research output: Contribution to journalArticle

27 Scopus citations

Differential modulation of E. coli mRNA abundance by inhibitory proteins that alter the composition of the degradosome

Gao, J., Lee, K., Zhao, M., Qiu, J., Zhan, X., Saxena, A., Moore, C. J., Cohen, S. N. & Georgiou, G., Jul 1 2006, In : Molecular Microbiology. 61, 2, p. 394-406 13 p.

Research output: Contribution to journalArticle

92 Scopus citations

E2F1 suppresses skin carcinogenesis via the ARF-p53 pathway

Russell, J. L., Weaks, R. L., Berton, T. R. & Johnson, D. G., Feb 9 2006, In : Oncogene. 25, 6, p. 867-876 10 p.

Research output: Contribution to journalArticle

10 Scopus citations

Hsp90 regulates activation of interferon regulatory factor 3 and TBK-1 stabilization in Sendai virus-infected cells

Yang, K., Shi, H., Qi, R., Sun, S., Tang, Y., Zhang, B. & Wang, C., Mar 1 2006, In : Molecular biology of the cell. 17, 3, p. 1461-1471 11 p.

Research output: Contribution to journalArticle

64 Scopus citations

Molecular signatures define myogenic stem cell populations

Martin, C. M., Russell, J. L., Ferdous, A. & Garry, D. J., Mar 1 2006, In : Stem Cell Reviews. 2, 1, p. 37-42 6 p.

Research output: Contribution to journalReview article

10 Scopus citations
2005

Myelinogenesis and axonal recognition by oligodendrocytes in brain are uncoupled in Olig1-null mice

Xin, M., Yue, T., Ma, Z., Wu, F. F., Gow, A. & Lu, Q. R., Feb 9 2005, In : Journal of Neuroscience. 25, 6, p. 1354-1365 12 p.

Research output: Contribution to journalArticle

190 Scopus citations
2004

Genetic Analysis of Disulfide Isomerization in Escherichia coli: Expression of DsbC Is Modulated by RNase E-Dependent mRNA Processing

Zhan, X., Gao, J., Jain, C., Cieslewicz, M. J., Swartz, J. R. & Georgiou, G., Feb 1 2004, In : Journal of bacteriology. 186, 3, p. 654-660 7 p.

Research output: Contribution to journalArticle

10 Scopus citations
2003

RraA: A protein inhibitor of RNase E activity that globally modulates RNA abundance in E. coli

Lee, K., Zhan, X., Gao, J., Qiu, J., Feng, Y., Meganathan, R., Cohen, S. N. & Georgiou, G., Sep 5 2003, In : Cell. 114, 5, p. 623-634 12 p.

Research output: Contribution to journalArticle

114 Scopus citations

Screening and selection strategies for disulfide isomerase activity.

Lafond, R., Zhan, X. & Georgiou, G., 2003, In : Methods in molecular biology (Clifton, N.J.). 230, p. 239-257 19 p.

Research output: Contribution to journalArticle

4 Scopus citations
2002

ARF differentially modulates apoptosis induced by E2F1 and Myc

Russell, J. L., Powers, J. T., Rounbehler, R. J., Rogers, P. M., Conti, C. J. & Johnson, D. G., Feb 26 2002, In : Molecular and Cellular Biology. 22, 5, p. 1360-1368 9 p.

Research output: Contribution to journalArticle

67 Scopus citations
2000

E2F4 and E2F1 have similar proliferative properties but different apoptotic and oncogenic properties in vivo

Wang, D., Russell, J. L. & Johnson, D. G., May 1 2000, In : Molecular and Cellular Biology. 20, 10, p. 3417-3424 8 p.

Research output: Contribution to journalArticle

77 Scopus citations
1999

E2F1 has both oncogenic and tumor-suppressive properties in a transgenic model

Pierce, A. M., Schneider-Broussard, R., Gimenez-Conti, I. B., Russell, J. L., Conti, C. J. & Johnson, D. G., Jan 1 1999, In : Molecular and Cellular Biology. 19, 9, p. 6408-6414 7 p.

Research output: Contribution to journalArticle

130 Scopus citations

Facilitating the formation of disulfide bonds in the Escherichia coli periplasm via coexpression of yeast protein disulfide isomerase

Zhan, X., Schwaller, M., Gilbert, H. F. & Georgiou, G., Nov 1 1999, In : Biotechnology Progress. 15, 6, p. 1033-1038 6 p.

Research output: Contribution to journalArticle

24 Scopus citations

Increased expression of mutated Ha-ras during premalignant progression in SENCAR mouse skin

Rodriguez-Puebla, M. L., LaCava, M., Bolontrade, M. F., Russell, J. & Conti, C. J., Nov 22 1999, In : Molecular Carcinogenesis. 26, 3, p. 150-156 7 p.

Research output: Contribution to journalArticle

19 Scopus citations