Children's Medical Center Research Institute At Ut Southwestern

Research output

Research output per year 1994 2011 2012 2014 2015 2016 2017 2019 2020 2021 2022 2023 2024

• 662 Article
• 95 Review article
• 35 Comment/debate
• 19 Short survey
• 37 More
  • 11 Letter
  • 10 Conference contribution
  • 9 Chapter
  • 7 Editorial

Research output per year

Research output per year

Search results

• 2024

  Deciphering and disrupting PIEZO1-TMEM16F interplay in hereditary xerocytosis

  Liang, P., Zhang, Y., Wan, Y. C. S., Ma, S., Dong, P., Lowry, A. J., Francis, S. J., Khandelwal, S., Delahunty, M., Telen, M. J., Strouse, J. J., Arepally, G. M. & Yang, H., Jan 25 2024, In: Blood. 143, 4, p. 357-369 13 p.

  Research output: Contribution to journal › Article › peer-review

  • Hereditary Xerocytosis 100%
  • Erythrocytes 40%
  • Red 35%
  • Phosphatidylserines 34%
  • Phospholipid Transfer Proteins 33%
  1 Scopus citations

• Eclosion muscles secrete ecdysteroids to initiate asymmetric intestinal stem cell division in Drosophila

  Zhang, S., Wu, S., Yao, R., Wei, X., Ohlstein, B. & Guo, Z., Jan 8 2024, In: Developmental cell. 59, 1, p. 125-140.e12

  Research output: Contribution to journal › Article › peer-review

  • Ecdysteroids 100%
  • Ecdysone 97%
  • Abdominal Oblique Muscles 93%
  • Ecdysteroid 92%
  • Asymmetric Cell Division 90%

• Hepatic malonyl-CoA synthesis restrains gluconeogenesis by suppressing fat oxidation, pyruvate carboxylation, and amino acid availability

  Deja, S., Fletcher, J., Kim, C-W., Kucejova, B., Fu, X., Mizerska, M., Villegas, M., Pudelko-Malik, N., Browder, N., Inigo-Vollmer, M., Menezes, C. J., Mishra, P., Berglund, E. D., Browning, J. D., Thyfault, J. P., Young, J. D., Horton, J. D. & Burgess, S. C., 2024, (Accepted/In press) In: Cell Metabolism.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Malonyl Coenzyme A 100%
  • Acetyl-CoA Carboxylase 89%
  • Gluconeogenesis 80%
  • Pyruvic Acid 71%
  • Fats 49%

• Metabolic signatures of thymomas: potential biomarkers and treatment targets

  Miller, J. W., Faubert, B. M., Mathews, T. P., Waters, J. K., DeBerardinis, R. J. & Kernstine, K. H., Feb 1 2024, In: European Journal of Cardio-thoracic Surgery. 65, 2, ezad394.

  Research output: Contribution to journal › Article › peer-review

  • Thymoma 100%
  • Biomarkers 53%
  • Glucose 28%
  • Thymus Gland 26%
  • Lactic Acid 24%
  1 Scopus citations

• Schistosome Infection Impacts Hematopoiesis

  Wijshake, T., Rose, J., Wang, J., Zielke, J., Marlar-Pave, M., Chen, W., Collins, J. J. & Agathocleous, M., Feb 1 2024, In: Journal of Immunology. 212, 4, p. 607-616 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Hematopoiesis 100%
  • Hematopoietic Stem Cells 60%
  • Schistosomiasis 54%
  • Erythropoiesis 53%
  • Infections 43%

• Severely polarized extracellular acidity around tumour cells

  Feng, Q., Bennett, Z., Grichuk, A., Pantoja, R., Huang, T., Faubert, B., Huang, G., Chen, M., DeBerardinis, R. J., Sumer, B. D. & Gao, J., 2024, (Accepted/In press) In: Nature Biomedical Engineering.

  Research output: Contribution to journal › Article › peer-review

  • Acidity 100%
  • Tumors 74%
  • Cells 70%
  • Nanoprobes 65%
  • Chemical activation 32%
• 2023

  (R)-2-Hydroxyglutarate Inhibits KDM5 Histone Lysine Demethylases to Drive Transformation in IDH-Mutant Cancers

  Gunn, K., Myllykoski, M., Cao, J. Z., Ahmed, M., Huang, B., Rouaisnel, B., Diplas, B. H., Levitt, M. M., Looper, R., Doench, J. G., Ligon, K. L., Ligon, K. L., McBrayer, S. K., Yan, H., Duy, C., Godley, L. A., Koivunen, P. & Losman, J. A., 2023, In: Cancer discovery. 13, 6, p. 1478-1497 20 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • alpha-hydroxyglutarate 100%
  • Histone Demethylases 90%
  • Acute Myeloid Leukemia 44%
  • Glioma 43%
  • Histones 29%
  3 Scopus citations

• A comparative study of neuroendocrine heterogeneity in small cell lung cancer and neuroblastoma

  Cai, L., De Berardinis, R. J., Xie, Y., Minna, J. D. & Xiao, G., Aug 1 2023, In: Molecular Cancer Research. 21, 8, p. 795-807 13 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Small Cell Lung Carcinoma 100%
  • Neuroblastoma 89%
  • myc Genes 22%
  • Cell Line 21%
  • Drug Resistance 16%

• A concurrent dual analysis of genomic data augments diagnoses: Experiences of 2 clinical sites in the Undiagnosed Diseases Network

  Undiagnosed Diseases Network & Undiagnosed Diseases Network, Apr 2023, In: Genetics in Medicine. 25, 4, 100353.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Undiagnosed Diseases 100%
  • Data Analysis 48%
  • High-Throughput Nucleotide Sequencing 35%
  • Genes 22%
  • National Institutes of Health (U.S.) 9%
  1 Scopus citations

• Adipocytes reprogram cancer cell metabolism by diverting glucose towards glycerol-3-phosphate thereby promoting metastasis

  Mukherjee, A., Bezwada, D., Greco, F., Zandbergen, M., Shen, T., Chiang, C. Y., Tasdemir, M., Fahrmann, J., Grapov, D., La Frano, M. R., Vu, H. S., Faubert, B., Newman, J. W., McDonnell, L. A., Nezi, L., Fiehn, O., DeBerardinis, R. J. & Lengyel, E., Sep 2023, In: Nature Metabolism. 5, 9, p. 1563-1577 15 p.

  Research output: Contribution to journal › Article › peer-review

  • alpha-glycerophosphoric acid 100%
  • Adipocytes 65%
  • Glucose 43%
  • Tumor Microenvironment 43%
  • Neoplasm Metastasis 42%
  3 Scopus citations

• A live-imaging protocol for tracking intestinal stem cell divisions in the Drosophila melanogaster pupal midgut

  Wu, S., Tang, R., Ohlstein, B. & Guo, Z., Dec 15 2023, In: STAR Protocols. 4, 4, 102749.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • caN protocol 100%
  • Drosophila melanogaster 88%
  • Intestinal Mucosa 85%
  • Cell Division 76%
  • Drosophila 75%

• Apoptotic cell death in disease—Current understanding of the NCCD 2023

  Vitale, I., Pietrocola, F., Guilbaud, E., Aaronson, S. A., Abrams, J. M., Adam, D., Agostini, M., Agostinis, P., Alnemri, E. S., Altucci, L., Amelio, I., Andrews, D. W., Aqeilan, R. I., Arama, E., Baehrecke, E. H., Balachandran, S., Bano, D., Barlev, N. A., Bartek, J., Bazan, N. G., & 208 othersBecker, C., Bernassola, F., Bertrand, M. J. M., Bianchi, M. E., Blagosklonny, M. V., Blander, J. M., Blandino, G., Blomgren, K., Borner, C., Bortner, C. D., Bove, P., Boya, P., Brenner, C., Broz, P., Brunner, T., Damgaard, R. B., Calin, G. A., Campanella, M., Candi, E., Carbone, M., Carmona-Gutierrez, D., Cecconi, F., Chan, F. K. M., Chen, G. Q., Chen, Q., Chen, Y. H., Cheng, E. H., Chipuk, J. E., Cidlowski, J. A., Ciechanover, A., Ciliberto, G., Conrad, M., Cubillos-Ruiz, J. R., Czabotar, P. E., D’Angiolella, V., Daugaard, M., Dawson, T. M., Dawson, V. L., De Maria, R., De Strooper, B., Debatin, K. M., Deberardinis, R. J., Degterev, A., Del Sal, G., Deshmukh, M., Di Virgilio, F., Diederich, M., Dixon, S. J., Dynlacht, B. D., El-Deiry, W. S., Elrod, J. W., Engeland, K., Fimia, G. M., Galassi, C., Ganini, C., Garcia-Saez, A. J., Garg, A. D., Garrido, C., Gavathiotis, E., Gerlic, M., Ghosh, S., Green, D. R., Greene, L. A., Gronemeyer, H., Häcker, G., Hajnóczky, G., Hardwick, J. M., Haupt, Y., He, S., Heery, D. M., Hengartner, M. O., Hetz, C., Hildeman, D. A., Ichijo, H., Inoue, S., Jäättelä, M., Janic, A., Joseph, B., Jost, P. J., Kanneganti, T. D., Karin, M., Kashkar, H., Kaufmann, T., Kelly, G. L., Kepp, O., Kimchi, A., Kitsis, R. N., Klionsky, D. J., Kluck, R., Krysko, D. V., Kulms, D., Kumar, S., Lavandero, S., Lavrik, I. N., Lemasters, J. J., Liccardi, G., Linkermann, A., Lipton, S. A., Lockshin, R. A., López-Otín, C., Luedde, T., MacFarlane, M., Madeo, F., Malorni, W., Manic, G., Mantovani, R., Marchi, S., Marine, J. C., Martin, S. J., Martinou, J. C., Mastroberardino, P. G., Medema, J. P., Mehlen, P., Meier, P., Melino, G., Melino, S., Miao, E. A., Moll, U. M., Muñoz-Pinedo, C., Murphy, D. J., Niklison-Chirou, M. V., Novelli, F., Núñez, G., Oberst, A., Ofengeim, D., Opferman, J. T., Oren, M., Pagano, M., Panaretakis, T., Pasparakis, M., Penninger, J. M., Pentimalli, F., Pereira, D. M., Pervaiz, S., Peter, M. E., Pinton, P., Porta, G., Prehn, J. H. M., Puthalakath, H., Rabinovich, G. A., Rajalingam, K., Ravichandran, K. S., Rehm, M., Ricci, J. E., Rizzuto, R., Robinson, N., Rodrigues, C. M. P., Rotblat, B., Rothlin, C. V., Rubinsztein, D. C., Rudel, T., Rufini, A., Ryan, K. M., Sarosiek, K. A., Sawa, A., Sayan, E., Schroder, K., Scorrano, L., Sesti, F., Shao, F., Shi, Y., Sica, G. S., Silke, J., Simon, H. U., Sistigu, A., Stephanou, A., Stockwell, B. R., Strapazzon, F., Strasser, A., Sun, L., Sun, E., Sun, Q., Szabadkai, G., Tait, S. W. G., Tang, D., Tavernarakis, N., Troy, C. M., Turk, B., Urbano, N., Vandenabeele, P., Vanden Berghe, T., Vander Heiden, M. G., Vanderluit, J. L., Verkhratsky, A., Villunger, A., von Karstedt, S., Voss, A. K., Vousden, K. H., Vucic, D., Vuri, D., Wagner, E. F., Walczak, H., Wallach, D., Wang, R., Wang, Y., Weber, A., Wood, W., Yamazaki, T., Yang, H. T., Zakeri, Z., Zawacka-Pankau, J. E., Zhang, L., Zhang, H., Zhivotovsky, B., Zhou, W., Piacentini, M., Kroemer, G. & Galluzzi, L., May 2023, In: Cell Death and Differentiation. 30, 5, p. 1097-1154 58 p.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  • Terminology 100%
  • Cell Death 75%
  • Apoptosis 60%
  • Regulated Cell Death 51%
  • Homeostasis 48%
  66 Scopus citations

• Bi-allelic variants in INTS11 are associated with a complex neurological disorder

  Undiagnosed Diseases Network, May 4 2023, In: American Journal of Human Genetics. 110, 5, p. 774-789 16 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Nervous System Diseases 100%
  • RNA 74%
  • Small Nuclear RNA 31%
  • Language Development Disorders 28%
  • Endonucleases 25%
  5 Scopus citations

• Biallelic variants in NUDCD2 associated with a multiple malformation syndrome with cholestasis and renal failure

  Scheuerle, A. E., Ni, M., Ahmad, A. A., Timmons, C. F., Rakheja, D., Gordon, E. E. & Boothe, M., Sep 2023, In: American Journal of Medical Genetics, Part A. 191, 9, p. 2324-2328 5 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Cholestasis 100%
  • Renal Insufficiency 77%
  • Ciliopathies 32%
  • Proteins 32%
  • cohesins 31%
  1 Scopus citations

• Biallelic variants in ribonuclease inhibitor (RNH1), an inflammasome modulator, are associated with a distinctive subtype of acute, necrotizing encephalopathy

  Undiagnosed Diseases Network, Sep 2023, In: Genetics in Medicine. 25, 9, 100897.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Inflammasomes 100%
  • Ribonucleases 93%
  • Brain Diseases 79%
  • Acute Febrile Encephalopathy 48%
  • Child 36%

• Career pathways, part 11

  Hoxhaj, G. & Reznik, E., May 2023, In: Nature Metabolism. 5, 5, p. 716-719 4 p.

  Research output: Contribution to journal › Comment/debate › peer-review

• Clinical and molecular characteristics associated with Vitamin C deficiency in myeloid malignancies; real world data from a prospective cohort

  Premnath, N., Chung, S. S., Weinberg, O. K., Ikpefan, R., Pandey, M., Kaur, G., Geethakumari, P. R., Afrough, A., Awan, F. T., Anderson, L. D., Vusirikala, M., Collins, R. H., Chen, W., Agathocleous, M. & Madanat, Y. F., Feb 2023, In: Leukemia Research. 125, 107001.

  Research output: Contribution to journal › Letter › peer-review

  • Ascorbic Acid Deficiency 100%
  • Ascorbic Acid 63%
  • Neoplasms 20%
  • Cell Self Renewal 6%
  • Mutation 5%
  3 Scopus citations

• Comprehensive isotopomer analysis of glutamate and aspartate in small tissue samples

  Cai, F., Bezwada, D., Cai, L., Mahar, R., Wu, Z., Chang, M. C., Pachnis, P., Yang, C., Kelekar, S., Gu, W., Brooks, B., Ko, B., Vu, H. S., Mathews, T. P., Zacharias, L. G., Martin-Sandoval, M., Do, D., Oaxaca, K. C., Jin, E. S., Margulis, V., & 3 othersMalloy, C. R., Merritt, M. E. & DeBerardinis, R. J., Oct 3 2023, In: Cell Metabolism. 35, 10, p. 1830-1843.e5

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Aspartic Acid 100%
  • Mass Spectrometry 86%
  • Glutamic Acid 84%
  • Magnetic Resonance Spectroscopy 64%
  • Isotope Labeling 56%

• Continuing a search for a diagnosis: the impact of adolescence and family dynamics

  Undiagnosed Disease Network, Dec 2023, In: Orphanet Journal of Rare Diseases. 18, 1, 6.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Family Relations 100%
  • Undiagnosed Diseases 52%
  • Child 34%
  • Parents 34%
  • Interviews 15%
  2 Scopus citations

• Critical role of antioxidant programs in enzalutamide-resistant prostate cancer

  Blatt, E. B., Parra, K., Neeb, A., Buroni, L., Bogdan, D., Yuan, W., Gao, Y., Gilbreath, C., Paschalis, A., Carreira, S., DeBerardinis, R. J., Mani, R. S., de Bono, J. S. & Raj, G. V., Jul 21 2023, In: Oncogene. 42, 30, p. 2347-2359 13 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • MDV 3100 100%
  • Prostatic Neoplasms 53%
  • Antioxidants 50%
  • Glutamine 23%
  • Glutaminase 21%
  1 Scopus citations

• Deep-Learning-Based Hepatic Ploidy Quantification Using H&E Histopathology Images

  Wen, Z., Lin, Y. H., Wang, S., Fujiwara, N., Rong, R., Jin, K. W., Yang, D. M., Yao, B., Yang, S., Wang, T., Xie, Y., Hoshida, Y., Zhu, H. & Xiao, G., Apr 2023, In: Genes. 14, 4, 921.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Deep Learning 100%
  • Ploidies 87%
  • Hematoxylin 72%
  • Eosine Yellowish-(YS) 72%
  • Liver 37%
  1 Scopus citations

• De novo missense variants in phosphatidylinositol kinase PIP5KIγ underlie a neurodevelopmental syndrome associated with altered phosphoinositide signaling

  Undiagnosed Diseases Network & Telethon Undiagnosed Diseases Program, Aug 3 2023, In: American Journal of Human Genetics. 110, 8, p. 1377-1393 17 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • 1-phosphatidylinositol-4-phosphate 5-kinase 100%
  • Phosphatidylinositols 64%
  • Phosphotransferases 46%
  • Neurodevelopmental Disorders 17%
  • Endosomes 16%

• De novo variants in MRTFB have gain-of-function activity in Drosophila and are associated with a novel neurodevelopmental phenotype with dysmorphic features

  Undiagnosed Diseases Network, Jun 2023, In: Genetics in Medicine. 25, 6, 100833.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • myocardin 100%
  • Drosophila 59%
  • Transcription Factors 47%
  • Phenotype 38%
  • Diptera 27%
  2 Scopus citations

• Disabling Uncompetitive Inhibition of Oncogenic IDH Mutations Drives Acquired Resistance

  Lyu, J., Liu, Y., Gong, L., Chen, M., Madanat, Y. F., Zhang, Y., Cai, F., Gu, Z., Cao, H., Kaphle, P., Kim, Y. J., Kalkan, F. N., Stephens, H., Dickerson, K. E., Ni, M., Chen, W., Patel, P., Mims, A. S., Borate, U., Burd, A., & 8 othersCai, S. F., Yin, C. C., You, M. J., Chung, S. S., Collins, R. H., DeBerardinis, R. J., Liu, X. & Xu, J., Jan 9 2023, In: Cancer discovery. 13, 1, p. 170-193 24 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Mutation 100%
  • Acute Myeloid Leukemia 73%
  • NADP 55%
  • Leukemia 41%
  • Amino Acids 35%
  5 Scopus citations

• Dissecting Locus-Specific Chromatin Interactions by CRISPR CAPTURE

  Botten, G. A., Lee, M. & Xu, J., 2023, Methods in Molecular Biology. Humana Press Inc., p. 69-97 29 p. (Methods in Molecular Biology; vol. 2599).

  Research output: Chapter in Book/Report/Conference proceeding › Chapter

  Open Access

  • Clustered Regularly Interspaced Short Palindromic Repeats 100%
  • Chromatin 77%
  • CRISPR-Associated Protein 9 45%
  • Macromolecular Substances 40%
  • Guide RNA 40%
  1 Scopus citations

• Dissecting molecular, pathological, and clinical features associated with tumor neural/neuroendocrine heterogeneity

  Cai, L., DeBerardinis, R. J., Xiao, G., Minna, J. D. & Xie, Y., Jun 16 2023, In: iScience. 26, 6, 106983.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Neuroendocrine Tumors 100%
  • Neoplasms 28%
  • Datasets 15%

• DNA damage in IDH-mutant gliomas: mechanisms and clinical implications

  Shi, D. D., Anand, S., Abdullah, K. & McBrayer, S. K., May 2023, In: Journal of Neuro-Oncology. 162, 3, p. 515-523 9 p.

  Research output: Contribution to journal › Review article › peer-review

  • Glioma 100%
  • DNA Damage 94%
  • Mutation 50%
  • Alkylating Agents 42%
  • Brain Neoplasms 33%
  5 Scopus citations

• Dominant-negative variant in SLC1A4 causes an autosomal dominant epilepsy syndrome

  University of Washington Center for Mendelian Genomics (UW-CMG), Undiagnosed Diseases Network (UDN), Jun 2023, In: Annals of Clinical and Translational Neurology. 10, 6, p. 1046-1053 8 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • monoethylglycinexylidide 100%
  • Epileptic Syndromes 74%
  • Microcephaly 70%
  • Serine 56%
  • Neutral Amino Acid Transport Systems 48%

• Emerging roles of nucleotide metabolism in cancer

  Shi, D. D., Savani, M. R., Abdullah, K. G. & McBrayer, S. K., Aug 2023, In: Trends in Cancer. 9, 8, p. 624-635 12 p.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  • Nucleotides 100%
  • Neoplasms 40%
  • Transcriptome 19%
  • Homeostasis 15%
  • RNA 14%
  3 Scopus citations

• Endothelial and Leptin Receptor⁺ cells promote the maintenance of stem cells and hematopoiesis in early postnatal murine bone marrow

  Kara, N., Xue, Y., Zhao, Z., Murphy, M. M., Comazzetto, S., Lesser, A., Du, L. & Morrison, S. J., Mar 13 2023, In: Developmental cell. 58, 5, p. 348-360.e6

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Leptin 100%
  • RNA Sequencing 97%
  • Leptin Receptors 75%
  • Hematopoiesis 63%
  • Endothelial Cells 43%
  10 Scopus citations

• Evaluation of the clinical, biochemical, and genetic presentation of neonatal and adult-onset 5,10-methylene tetrahydrofolate reductase (MTHFR) deficiency in patients from Pakistan

  Ahmed, S., Akbar, F., Deberardinis, R. J., Ni, M. & Afroze, B., Aug 1 2023, In: Journal of Pediatric Endocrinology and Metabolism. 36, 8, p. 761-771 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Methylenetetrahydrofolate Reductase (NADPH2) 100%
  • Pakistan 87%
  • Molecular Biology 62%
  • Methylenetetrahydrofolate reductase deficiency 19%
  • Betaine 15%

• Exploiting liver metabolism for tissue-specific cancer targeting

  Wang, Z. & Zhu, H., Mar 2023, In: Nature Cancer. 4, 3, p. 310-311 2 p.

  Research output: Contribution to journal › Comment/debate › peer-review

• Extrachromosomal DNA in the cancerous transformation of Barrett’s oesophagus

  Luebeck, J., Ng, A. W. T., Galipeau, P. C., Li, X., Sanchez, C. A., Katz-Summercorn, A. C., Kim, H., Jammula, S., He, Y., Lippman, S. M., Verhaak, R. G. W., Maley, C. C., Alexandrov, L. B., Reid, B. J., Fitzgerald, R. C., Paulson, T. G., Chang, H. Y., Wu, S., Bafna, V. & Mischel, P. S., Apr 27 2023, In: Nature. 616, 7958, p. 798-805 8 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Barrett Esophagus 100%
  • DNA 46%
  • Biopsy 25%
  • Whole Genome Sequencing 24%
  • Neoplasms 23%
  12 Scopus citations

• FASN deficiency induces a cytosol-to-mitochondria citrate flux to mitigate detachment-induced oxidative stress

  Dai, W., Wang, Z., Wang, G., Wang, Q. A., DeBerardinis, R. & Jiang, L., Aug 29 2023, In: Cell Reports. 42, 8, 112971.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Fatty Acid Synthases 100%
  • Citric Acid 82%
  • Oxidative Stress 75%
  • Cytosol 73%
  • Mitochondria 62%

• FDA approved drugs with antiviral activity against SARS-CoV-2: From structure-based repurposing to host-specific mechanisms

  Ahmed, M. S., Farag, A. B., Boys, I. N., Wang, P., Menendez-Montes, I., Nguyen, N. U. N., Eitson, J. L., Ohlson, M. B., Fan, W., McDougal, M. B., Mar, K., Thet, S., Ortiz, F., Kim, S. Y., Solmonson, A., Williams, N. S., Lemoff, A., DeBerardinis, R. J., Schoggins, J. W. & Sadek, H. A., Jun 2023, In: Biomedicine and Pharmacotherapy. 162, 114614.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Atovaquone 100%
  • SARS Virus 91%
  • Mebendazole 57%
  • Antiviral Agents 53%
  • Inhibitory Concentration 50 35%
  5 Scopus citations

• Features of tumor-microenvironment images predict targeted therapy survival benefit in patients with EGFR-mutant lung cancer

  Wang, S., Rong, R., Yang, D. M., Fujimoto, J., Bishop, J. A., Yan, S., Cai, L., Behrens, C., Berry, L. D., Wilhelm, C., Aisner, D., Sholl, L., Johnson, B. E., Kwiatkowski, D. J., Wistuba, I. I., Bunn, P. A., Minna, J., Xiao, G., Kris, M. G. & Xie, Y., Jan 17 2023, In: Journal of Clinical Investigation. 133, 2, e160330.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Tumor Microenvironment 100%
  • ErbB Receptors 91%
  • Lung Neoplasms 76%
  • Protein-Tyrosine Kinases 68%
  • Survival 53%
  5 Scopus citations

• Glucocorticoid mediated inhibition of LKB1 mutant non-small cell lung cancers

  Huffman, K. E., Li, L. S., Carstens, R., Park, H., Girard, L., Avila, K., Wei, S., Kollipara, R., Timmons, B., Sudderth, J., Bendris, N., Kim, J., Villalobos, P., Fujimoto, J., Schmid, S., Deberardinis, R. J., Wistuba, I., Heymach, J., Kittler, R., Akbay, E. A., & 6 othersPosner, B., Wang, Y., Lam, S., Kliewer, S. A., Mangelsdorf, D. J. & Minna, J. D., 2023, In: Frontiers in Oncology. 13, 1025443.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Glucocorticoids 100%
  • Non-Small Cell Lung Carcinoma 98%
  • Glucocorticoid Receptors 87%
  • Dexamethasone 72%
  • dexamethasone receptor 52%
  2 Scopus citations

• GLUT3 promotes macrophage signaling and function via RAS-mediated endocytosis in atopic dermatitis and wound healing

  Yu, D. M., Zhao, J., Lee, E. E., Kim, D., Mahapatra, R., Rose, E. K., Zhou, Z., Hosler, C., El Kurdi, A., Choe, J. Y., Abel, E. D., Hoxhaj, G., Westover, K. D., Cho, R. J., Cheng, J. B. & Wang, R. C., Nov 1 2023, In: Journal of Clinical Investigation. 133, 21, e170706.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Atopic Dermatitis 100%
  • Endocytosis 96%
  • Wound Healing 83%
  • Macrophages 66%
  • Interleukin-4 25%
  2 Scopus citations

• Heme-dependent induction of mitophagy program during differentiation of murine erythroid cells

  Ikeda, M., Kato, H., Shima, H., Matsumoto, M., Furukawa, E., Yan, Y., Liao, R., Xu, J., Muto, A., Fujiwara, T., Harigae, H., Bresnick, E. H. & Igarashi, K., Feb 2023, In: Experimental Hematology. 118, p. 21-30 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Mitophagy 100%
  • Erythroid Cells 92%
  • Heme 81%
  • Mitochondria 37%
  • Erythroblasts 35%

• HNRNPC haploinsufficiency affects alternative splicing of intellectual disability-associated genes and causes a neurodevelopmental disorder

  Genomics England Research Consortium & Undiagnosed Diseases Network, Aug 3 2023, In: American Journal of Human Genetics. 110, 8, p. 1414-1435 22 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Heterogeneous-Nuclear Ribonucleoprotein Group C 100%
  • Haploinsufficiency 67%
  • Neurodevelopmental Disorders 61%
  • Alternative Splicing 57%
  • Intellectual Disability 49%
  2 Scopus citations

• IGFBP2 expressing midlobular hepatocytes preferentially contribute to liver homeostasis and regeneration

  Lin, Y. H., Wei, Y., Zeng, Q., Wang, Y., Pagani, C. A., Li, L., Zhu, M., Wang, Z., Hsieh, M. H., Corbitt, N., Zhang, Y., Sharma, T., Wang, T. & Zhu, H., May 4 2023, In: Cell Stem Cell. 30, 5, p. 665-676.e4

  Research output: Contribution to journal › Article › peer-review

  • Liver Regeneration 100%
  • Hepatocytes 68%
  • Homeostasis 59%
  • 3,5-diethoxycarbonyl-1,4-dihydrocollidine 29%
  • Fasting 26%
  2 Scopus citations

• IL-1β mediates the induction of immune checkpoint regulators IDO1 and PD-L1 in lung adenocarcinoma cells

  Nawas, A. F., Solmonson, A., Gao, B., DeBerardinis, R. J., Minna, J. D., Conacci-Sorrell, M. & Mendelson, C. R., Dec 2023, In: Cell Communication and Signaling. 21, 1, 331.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Indoleamine-Pyrrole 2,3,-Dioxygenase 100%
  • Kynurenine 80%
  • Adenocarcinoma of Lung 78%
  • Interleukin-1 73%
  • Tryptophan 68%
  1 Scopus citations

• Image-based quantification of histological features as a function of spatial location using the Tissue Positioning System

  Rong, R., Wei, Y., Li, L., Wang, T., Zhu, H., Xiao, G. & Wang, Y., Aug 2023, In: EBioMedicine. 94, 104698.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Strain 100%
  • Deep Learning 28%
  • Gene Expression 24%
  • Nephrons 23%
  • Intestinal Mucosa 21%

• Isocitrate dehydrogenase (IDH) mutant gliomas: A Society for Neuro-Oncology (SNO) consensus review on diagnosis, management, and future directions

  Miller, J. J., Gonzalez Castro, L. N., McBrayer, S., Weller, M., Cloughesy, T., Portnow, J., Andronesi, O., Barnholtz-Sloan, J. S., Baumert, B. G., Berger, M. S., Bi, W. L., Bindra, R., Cahill, D. P., Chang, S. M., Costello, J. F., Horbinski, C., Huang, R. Y., Jenkins, R. B., Ligon, K. L., Mellinghoff, I. K., & 11 othersNabors, L. B., Platten, M., Reardon, D. A., Shi, D. D., Schiff, D., Wick, W., Yan, H., von Deimling, A., van den Bent, M., Kaelin, W. G. & Wen, P. Y., Jan 5 2023, In: Neuro-oncology. 25, 1, p. 4-25 22 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Isocitrate Dehydrogenase 100%
  • Glioma 67%
  • Direction compound 53%
  • Molecular Targeted Therapy 49%
  • Brain Neoplasms 34%
  46 Scopus citations

• Isocitrate dehydrogenase mutations in gliomas: A review of current understanding and trials

  Sharma, N., Mallela, A. N., Shi, D. D., Tang, L. W., Abou-Al-Shaar, H., Gersey, Z. C., Zhang, X., Mcbrayer, S. K. & Abdullah, K., Jan 1 2023, In: Neuro-Oncology Advances. 5, 1, vdad053.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  • Isocitrate Dehydrogenase 100%
  • Glioma 67%
  • Mutation 41%
  • Poly(ADP-ribose) Polymerase Inhibitors 24%
  • Subunit Vaccines 22%
  6 Scopus citations

• Itaconate-producing neutrophils regulate local and systemic inflammation following trauma

  Crossley, J. L., Ostashevskaya-Gohstand, S., Comazzetto, S., Hook, J. S., Guo, L., Vishlaghi, N., Juan, C., Xu, L., Horswill, A. R., Hoxhaj, G., Moreland, J. G., Tower, R. J. & Levi, B., Oct 2023, In: JCI Insight. 8, 20, e169208.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • itaconic acid 100%
  • Neutrophils 43%
  • Inflammation 33%
  • Wounds and Injuries 27%
  • Metabolomics 24%
  3 Scopus citations

• L-2-hydroxyglutaric aciduria – review of literature and case series

  Ahmed, S., Siddiqui, A., DeBerardinis, R. J., Ni, M., Lai, W. G., Cai, F., Vu, H. S. & Afroze, B., Apr 1 2023, In: Annals of Medicine and Surgery. 85, 4, p. 712-717 6 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • 2-Hydroxyglutaricaciduria 100%
  • alpha-hydroxyglutarate 22%
  • Pakistan 15%
  • Basal Ganglia 14%
  • Siblings 12%
  1 Scopus citations

• Lactate metabolism is essential in early-onset mitochondrial myopathy

  Chen, Z., Bordieanu, B., Kesavan, R., Lesner, N. P., Venigalla, S. S. K., Shelton, S. D., DeBerardinis, R. J. & Mishra, P., Jan 2023, In: Science Advances. 9, 1, eadd3216.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Mitochondrial Myopathies 100%
  • Electron Transport 74%
  • Lactic Acid 60%
  • Muscles 40%
  • Disease Progression 36%
  1 Scopus citations

• Leptin receptor⁺ cells promote bone marrow innervation and regeneration by synthesizing nerve growth factor

  Gao, X., Murphy, M. M., Peyer, J. G., Ni, Y., Yang, M., Zhang, Y., Guo, J., Kara, N., Embree, C., Tasdogan, A., Ubellacker, J. M., Crane, G. M., Fang, S., Zhao, Z., Shen, B. & Morrison, S. J., Dec 2023, In: Nature cell biology. 25, 12, p. 1746-1757 12 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Leptin Receptors 100%
  • Bone Regeneration 86%
  • Nerve Growth Factor 82%
  • Bone Marrow 56%
  • Regeneration 51%
  4 Scopus citations

• Light-activated macromolecular phase separation modulates transcription by reconfiguring chromatin interactions

  Kim, Y. J., Lee, M., Lee, Y. T., Jing, J., Sanders, J. T., Botten, G. A., He, L., Lyu, J., Zhang, Y., Mettlen, M., Ly, P., Zhou, Y. & Xu, J., Mar 29 2023, In: Science Advances. 9, 13, eadg1123.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Chromatin 100%
  • Light 79%
  • Genes 45%
  • Optogenetics 36%
  • Proteomics 26%
  8 Scopus citations