Research Output

2018

Erratum: The Polyploid State Plays a Tumor-Suppressive Role in the Liver (Developmental Cell (2018) 44(4) (447–459.e5), (S1534580718300108) (10.1016/j.devcel.2018.01.010))

Zhang, S., Zhou, K., Luo, X., Li, L., Tu, H. C., Sehgal, A., Nguyen, L. H., Zhang, Y., Gopal, P., Tarlow, B. D., Siegwart, D. J. & Zhu, H., Nov 5 2018, In : Developmental cell. 47, 3, p. 390 1 p.

Research output: Contribution to journalComment/debate

2 Scopus citations

Gain-of-function variants in the ODC1 gene cause a syndromic neurodevelopmental disorder associated with macrocephaly, alopecia, dysmorphic features, and neuroimaging abnormalities

Rodan, L. H., Anyane-Yeboa, K., Chong, K., Klein Wassink-Ruiter, J. S., Wilson, A., Smith, L., Kothare, S. V., Rajabi, F., Blaser, S., Ni, M., DeBerardinis, R. J., Poduri, A. & Berry, G. T., Jan 1 2018, (Accepted/In press) In : American Journal of Medical Genetics, Part A.

Research output: Contribution to journalArticle

4 Scopus citations

GATA/Heme Multi-omics Reveals a Trace Metal-Dependent Cellular Differentiation Mechanism

Tanimura, N., Liao, R., Wilson, G. M., Dent, M. R., Cao, M., Burstyn, J. N., Hematti, P., Liu, X., Zhang, Y., Zheng, Y., Keles, S., Xu, J., Coon, J. J. & Bresnick, E. H., Sep 10 2018, In : Developmental cell. 46, 5, p. 581-594.e4

Research output: Contribution to journalArticle

3 Scopus citations

Histone variant H3.3–mediated chromatin remodeling is essential for paternal genome activation in mouse preimplantation embryos

Kong, Q., Banaszynski, L. A., Geng, F., Zhang, X., Zhang, J., Zhang, H., O’Neill, C. L., Yan, P., Liu, Z., Shido, K., Palermo, G. D., David Allis, C., Rafii, S., Rosenwaks, Z. & Wen, D., Mar 9 2018, In : Journal of Biological Chemistry. 293, 10, p. 3829-3838 10 p.

Research output: Contribution to journalArticle

15 Scopus citations

Inosine Monophosphate Dehydrogenase Dependence in a Subset of Small Cell Lung Cancers

Huang, F., Ni, M., Chalishazar, M. D., Huffman, K. E., Kim, J., Cai, L., Shi, X., Cai, F., Zacharias, L. G., Ireland, A. S., Li, K., Gu, W., Kaushik, A. K., Liu, X., Gazdar, A. F., Oliver, T. G., Minna, J. D., Hu, Z. & DeBerardinis, R. J., Jan 1 2018, (Accepted/In press) In : Cell Metabolism.

Research output: Contribution to journalArticle

28 Scopus citations

Knockdown of Anillin Actin Binding Protein Blocks Cytokinesis in Hepatocytes and Reduces Liver Tumor Development in Mice Without Affecting Regeneration

Zhang, S., Nguyen, L. H., Zhou, K., Tu, H. C., Sehgal, A., Nassour, I., Li, L., Gopal, P., Goodman, J., Singal, A. G., Yopp, A., Zhang, Y., Siegwart, D. J. & Zhu, H., Apr 2018, In : Gastroenterology. 154, 5, p. 1421-1434 14 p.

Research output: Contribution to journalArticle

31 Scopus citations

MIRO-1 Determines Mitochondrial Shape Transition upon GPCR Activation and Ca2+ Stress

Nemani, N., Carvalho, E., Tomar, D., Dong, Z., Ketschek, A., Breves, S. L., Jaña, F., Worth, A. M., Heffler, J., Palaniappan, P., Tripathi, A., Subbiah, R., Riitano, M. F., Seelam, A., Manfred, T., Itoh, K., Meng, S., Sesaki, H., Craigen, W. J., Rajan, S. & 9 others, Shanmughapriya, S., Caplan, J., Prosser, B. L., Gill, D. L., Stathopulos, P. B., Gallo, G., Chan, D. C., Mishra, P. & Madesh, M., Apr 24 2018, In : Cell Reports. 23, 4, p. 1005-1019 15 p.

Research output: Contribution to journalArticle

19 Scopus citations

Quantitative integration of epigenomic variation and transcription factor binding using MAmotif toolkit identifies an important role of IRF2 as transcription activator at gene promoters

Sun, H., Wang, J., Gong, Z., Yao, J., Wang, Y., Xu, J., Yuan, G. C., Zhang, Y. & Shao, Z., Dec 1 2018, In : Cell Discovery. 4, 1, 38.

Research output: Contribution to journalLetter

4 Scopus citations

Regulation of embryonic haematopoietic multipotency by EZH1

Vo, L. T., Kinney, M. A., Liu, X., Zhang, Y., Barragan, J., Sousa, P. M., Jha, D. K., Han, A., Cesana, M., Shao, Z., North, T. E., Orkin, S. H., Doulatov, S., Xu, J. & Daley, G. Q., Jan 25 2018, In : Nature. 553, 7689, p. 506-510 5 p.

Research output: Contribution to journalArticle

23 Scopus citations

The Polyploid State Plays a Tumor-Suppressive Role in the Liver

Zhang, S., Zhou, K., Luo, X., Li, L., Tu, H. C., Sehgal, A., Nguyen, L. H., Zhang, Y., Gopal, P., Tarlow, B. D., Siegwart, D. J. & Zhu, H., Jan 1 2018, (Accepted/In press) In : Developmental Cell.

Research output: Contribution to journalArticle

36 Scopus citations

Transmembrane Protease TMPRSS11B Promotes Lung Cancer Growth by Enhancing Lactate Export and Glycolytic Metabolism

Updegraff, B. L., Zhou, X., Guo, Y., Padanad, M. S., Chen, P. H., Yang, C., Sudderth, J., Rodriguez-Tirado, C., Girard, L., Minna, J. D., Mishra, P., DeBerardinis, R. J. & O'Donnell-Mendell, K. A., Jan 1 2018, (Accepted/In press) In : Cell Reports.

Research output: Contribution to journalArticle

7 Scopus citations
2017
11 Scopus citations

Adult haematopoietic stem cell niches

Crane, G. M., Jeffery, E. & Morrison, S. J., Sep 1 2017, In : Nature Reviews Immunology. 17, 9, p. 573-590 18 p.

Research output: Contribution to journalReview article

192 Scopus citations

Arid1a Has Context-Dependent Oncogenic and Tumor Suppressor Functions in Liver Cancer

Sun, X., Wang, S. C., Wei, Y., Luo, X., Jia, Y., Li, L., Gopal, P., Zhu, M., Nassour, I., Chuang, J. C., Maples, T., Celen, C., Nguyen, L. H., Wu, L., Fu, S., Li, W., Hui, L., Tian, F., Ji, Y., Zhang, S. & 8 others, Sorouri, M., Hwang, T. H., Letzig, L., James, L., Wang, Z., Yopp, A. C., Singal, A. G. & Zhu, H., Nov 13 2017, In : Cancer Cell. 32, 5, p. 574-589.e6

Research output: Contribution to journalArticle

42 Scopus citations

Arid1b haploinsufficient mice reveal neuropsychiatric phenotypes and reversible causes of growth impairment

Celen, C., Chuang, J. C., Luo, X., Nijem, N., Walker, A. K., Chen, F., Zhang, S., Chung, A. S., Nguyen, L. H., Nassour, I., Budhipramono, A., Sun, X., Bok, L. A., McEntagart, M., Gevers, E. F., Birnbaum, S. G., Eisch, A. J., Powell, C. M., Ge, W. P., Santen, G. W. E. & 2 others, Chahrour, M. & Zhu, H., Jul 11 2017, In : eLife. 6, e25730.

Research output: Contribution to journalArticle

25 Scopus citations

Ascorbate regulates haematopoietic stem cell function and leukaemogenesis

Agathocleous, M., Meacham, C. E., Burgess, R. J., Piskounova, E., Zhao, Z., Crane, G. M., Cowin, B. L., Bruner, E., Murphy, M. M., Chen, W., Spangrude, G. J., Hu, Z., DeBerardinis, R. J. & Morrison, S. J., Sep 28 2017, In : Nature. 549, 7673, p. 476-481 6 p.

Research output: Contribution to journalArticle

148 Scopus citations

Bone marrow adipocytes promote the regeneration of stem cells and haematopoiesis by secreting SCF

Zhou, B. O., Yu, H., Yue, R., Zhao, Z., Rios, J. J., Naveiras, O. & Morrison, S. J., Aug 1 2017, In : Nature Cell Biology. 19, 8, p. 891-903 13 p.

Research output: Contribution to journalArticle

116 Scopus citations

CD4 is expressed on a heterogeneous subset of hematopoietic progenitors, which persistently harbor CXCR4 and CCR5-tropic HIV proviral genomes in vivo

Sebastian, N. T., Zaikos, T. D., Terry, V., Taschuk, F., McNamara, L. A., Onafuwa-Nuga, A., Yucha, R., Signer, R. A. J., Riddell, J., Bixby, D., Markowitz, N., Morrison, S. J. & Collins, K. L., Jul 2017, In : PLoS pathogens. 13, 7, e1006509.

Research output: Contribution to journalArticle

14 Scopus citations

Checks and Balances: Rpd3 Issues Executive Orders in Developmental Enhancer Regulation

Martire, S. & Banaszynski, L., Feb 27 2017, In : Developmental Cell. 40, 4, p. 325-326 2 p.

Research output: Contribution to journalShort survey

CPS1 maintains pyrimidine pools and DNA synthesis in KRAS/LKB1-mutant lung cancer cells

Kim, J., Hu, Z., Cai, L., Li, K., Choi, E., Faubert, B., Bezwada, D., Rodriguez-Canales, J., Villalobos, P., Lin, Y. F., Ni, M., Huffman, K. E., Girard, L., Byers, L. A., Unsal-Kacmaz, K., Peña, C. G., Heymach, J. V., Wauters, E., Vansteenkiste, J., Castrillon, D. H. & 6 others, Chen, B. P. C., Wistuba, I., Lambrechts, D., Xu, J., Minna, J. D. & Deberardinis, R. J., Jun 1 2017, In : Nature. 546, 7656, p. 168-172 5 p.

Research output: Contribution to journalArticle

71 Scopus citations

Digoxin Plus Trametinib Therapy Achieves Disease Control in BRAF Wild-Type Metastatic Melanoma Patients

Frankel, A. E., Eskiocak, U., Gill, J. G., Yuan, S., Ramesh, V., Froehlich, T. W., Ahn, C. & Morrison, S. J., Apr 1 2017, In : Neoplasia (United States). 19, 4, p. 255-260 6 p.

Research output: Contribution to journalArticle

9 Scopus citations

Distinct Brca1 Mutations Differentially Reduce Hematopoietic Stem Cell Function

Mgbemena, V. E., Signer, R. A. J., Wijayatunge, R., Laxson, T., Morrison, S. J. & Ross, T. S., Jan 24 2017, In : Cell Reports. 18, 4, p. 947-960 14 p.

Research output: Contribution to journalArticle

8 Scopus citations

Identification of hair shaft progenitors that create a niche for hair pigmentation

Liao, C. P., Booker, R. C., Morrison, S. J. & Le, L. Q., Apr 15 2017, In : Genes and Development. 31, 8, p. 744-756 13 p.

Research output: Contribution to journalArticle

15 Scopus citations

In Situ Capture of Chromatin Interactions by Biotinylated dCas9

Liu, X., Zhang, Y., Chen, Y., Li, M., Zhou, F., Li, K., Cao, H., Ni, M., Liu, Y., Gu, Z., Dickerson, K. E., Xie, S., Hon, G. C., Xuan, Z., Zhang, M. Q., Shao, Z. & Xu, J., Aug 24 2017, In : Cell. 170, 5, p. 1028-1043.e19

Research output: Contribution to journalArticle

84 Scopus citations

Lactate Metabolism in Human Lung Tumors

Faubert, B., Li, K. Y., Cai, L., Hensley, C. T., Kim, J., Zacharias, L. G., Yang, C., Do, Q. N., Doucette, S., Burguete, D., Li, H., Huet, G., Yuan, Q., Wigal, T., Butt, Y., Ni, M., Torrealba, J., Oliver, D., Lenkinski, R. E., Malloy, C. R. & 4 others, Wachsmann, J. W., Young, J. D., Kernstine, K. & DeBerardinis, R. J., Oct 5 2017, In : Cell. 171, 2, p. 358-371.e9

Research output: Contribution to journalArticle

273 Scopus citations

Non-Viral CRISPR/Cas Gene Editing In Vitro and In Vivo Enabled by Synthetic Nanoparticle Co-Delivery of Cas9 mRNA and sgRNA

Miller, J. B., Zhang, S., Kos, P., Xiong, H., Zhou, K., Perelman, S. S., Zhu, H. & Siegwart, D. J., Jan 19 2017, In : Angewandte Chemie - International Edition. 56, 4, p. 1059-1063 5 p.

Research output: Contribution to journalArticle

174 Scopus citations

OPA1 Isoforms in the Hierarchical Organization of Mitochondrial Functions

Del Dotto, V., Mishra, P., Vidoni, S., Fogazza, M., Maresca, A., Caporali, L., McCaffery, J. M., Cappelletti, M., Baruffini, E., Lenaers, G., Chan, D., Rugolo, M., Carelli, V. & Zanna, C., Jun 20 2017, In : Cell Reports. 19, 12, p. 2557-2571 15 p.

Research output: Contribution to journalArticle

54 Scopus citations

Peroxisomal protein PEX13 functions in selective autophagy

Lee, M. Y., Sumpter, R., Zou, Z., Sirasanagandla, S., Wei, Y., Mishra, P., Rosewich, H., Crane, D. I. & Levine, B., Jan 1 2017, In : EMBO Reports. 18, 1, p. 48-60 13 p.

Research output: Contribution to journalArticle

19 Scopus citations

Prdm16 is required for the maintenance of neural stem cells in the postnatal forebrain and their differentiation into ependymal cells

Shimada, I. S., Acar, M., Burgess, R. J., Zhao, Z. & Morrison, S. J., 2017, In : Genes and Development. 31, 11, p. 1134-1146 13 p.

Research output: Contribution to journalArticle

17 Scopus citations

Prohibitin 2 Is an Inner Mitochondrial Membrane Mitophagy Receptor

Wei, Y., Chiang, W. C., Sumpter, R., Mishra, P. & Levine, B., Jan 12 2017, In : Cell. 168, 1-2, p. 224-238.e10

Research output: Contribution to journalArticle

208 Scopus citations

Quantitative metabolic flux analysis reveals an unconventional pathway of fatty acid synthesis in cancer cells deficient for the mitochondrial citrate transport protein

Jiang, L., Boufersaoui, A., Yang, C., Ko, B., Rakheja, D., Guevara, G., Hu, Z. & DeBerardinis, R. J., Sep 2017, In : Metabolic Engineering. 43, p. 198-207 10 p.

Research output: Contribution to journalArticle

28 Scopus citations

Regulation of mitochondrial biogenesis in erythropoiesis by mTORC1-mediated protein translation

Liu, X., Zhang, Y., Ni, M., Cao, H., Signer, R. A. J., Li, D., Li, M., Gu, Z., Hu, Z., Dickerson, K. E., Weinberg, S. E., Chandel, N. S., Deberardinis, R. J., Zhou, F., Shao, Z. & Xu, J., May 31 2017, In : Nature cell biology. 19, 6, p. 626-638 13 p.

Research output: Contribution to journalArticle

45 Scopus citations

Temporal dynamics of cardiac hypertrophic growth in response to pressure overload

Wang, Y., Zhang, Y., Ding, G., May, H. I., Xu, J., Gillette, T. G., Wang, H. & Wang, Z. V., Dec 2017, In : American Journal of Physiology - Heart and Circulatory Physiology. 313, 6, p. H1119-H1129

Research output: Contribution to journalArticle

9 Scopus citations
15 Scopus citations

The glutamate/cystine xCT antiporter antagonizes glutamine metabolism and reduces nutrient flexibility

Shin, C. S., Mishra, P., Watrous, J. D., Carelli, V., D'Aurelio, M., Jain, M. & Chan, D. C., 2017, In : Nature communications. 8, 15074.

Research output: Contribution to journalArticle

54 Scopus citations

The mitochondrial respiratory chain is essential for haematopoietic stem cell function

Ansó, E., Weinberg, S. E., Diebold, L. P., Thompson, B. J., Malinge, S., Schumacker, P. T., Liu, X., Zhang, Y., Shao, Z., Steadman, M., Marsh, K. M., Xu, J., Crispino, J. D. & Chandel, N. S., May 31 2017, In : Nature cell biology. 19, 6, p. 614-625 12 p.

Research output: Contribution to journalArticle

79 Scopus citations

Transcription pausing regulates mouse embryonic stem cell differentiation

Tastemel, M., Gogate, A. A., Malladi, V. S., Nguyen, K., Mitchell, C., Banaszynski, L. A. & Bai, X., Dec 2017, In : Stem Cell Research. 25, p. 250-255 6 p.

Research output: Contribution to journalArticle

3 Scopus citations

Valosin-containing protein (VCP/p97) inhibitors relieve mitofusin-dependent mitochondrial defects due to VCP disease mutants

Zhang, T., Mishra, P., Hay, B. A., Chan, D. & Guo, M., Mar 21 2017, In : eLife. 6, e17834.

Research output: Contribution to journalArticle

23 Scopus citations
Open Access
10 Scopus citations
2016

AACR Cancer Progress Report 2016

Davidson, N. E., Armstrong, S. A., Coussens, L. M., Cruz-Correa, M. R., DeBerardinis, R. J., Doroshow, J. H., Foti, M., Hwu, P., Kensler, T. W., Morrow, M., Mulligan, C. G., Pao, W., Platz, E. A., Smith, T. J. & Willman, C. L., Oct 1 2016, In : Clinical cancer research : an official journal of the American Association for Cancer Research. 22, p. S1-S137

Research output: Contribution to journalArticle

Open Access
23 Scopus citations
23 Scopus citations

Bcl11a Deficiency Leads to Hematopoietic Stem Cell Defects with an Aging-like Phenotype

Luc, S., Huang, J., McEldoon, J. L., Somuncular, E., Li, D., Rhodes, C., Mamoor, S., Hou, S., Xu, J. & Orkin, S. H., Sep 20 2016, In : Cell Reports. 16, 12, p. 3181-3194 14 p.

Research output: Contribution to journalArticle

27 Scopus citations

Cancer, oxidative stress, and metastasis

Gill, J. G., Piskounova, E. & Morrison, S. J., 2016, In : Cold Spring Harbor Symposia on Quantitative Biology. 81, 1, p. 163-175 13 p.

Research output: Contribution to journalArticle

62 Scopus citations

Cancer-specific production of n-acetylaspartate via nat8l overexpression in non-small cell lung cancer and its potential as a circulating biomarker

Lou, T. F., Sethuraman, D., Dospoy, P., Srivastva, P., Kim, H. S., Kim, J., Ma, X., Chen, P. H., Huffman, K. E., Frink, R. E., Larsen, J. E., Lewis, C., Um, S. W., Kim, D. H., Ahn, J. M., DeBerardinis, R. J., White, M. A., Minna, J. D. & Yoo, H., Jan 1 2016, In : Cancer Prevention Research. 9, 1, p. 43-52 10 p.

Research output: Contribution to journalArticle

15 Scopus citations

Clec11a/osteolectin is an osteogenic growth factor that promotes the maintenance of the adult skeleton

Yue, R., Shen, B. & Morrison, S. J., Dec 13 2016, In : eLife. 5, DECEMBER2016, p. 27 1 p., e18782.

Research output: Contribution to journalArticle

20 Scopus citations

Cutting Edge: Critical role of glycolysis in human plasmacytoid dendritic cell antiviral responses

Bajwa, G., DeBerardinis, R. J., Shao, B., Hall, B., Farrar, J. D. & Gill, M. A., Mar 1 2016, In : Journal of Immunology. 196, 5, p. 2004-2009 6 p.

Research output: Contribution to journalArticle

28 Scopus citations

Dynamic Control of Enhancer Repertoires Drives Lineage and Stage-Specific Transcription during Hematopoiesis

Huang, J., Liu, X., Li, D., Shao, Z., Cao, H., Zhang, Y., Trompouki, E., Bowman, T. V., Zon, L. I., Yuan, G. C., Orkin, S. H. & Xu, J., Jan 11 2016, In : Developmental Cell. 36, 1, p. 9-23 15 p.

Research output: Contribution to journalArticle

87 Scopus citations

Erratum: NRF2 regulates serine biosynthesis in non-small cell lung cancer (Nat. Genet. (2015) 47 (1475-1481))

Denicola, G. M., Chen, P. H., Mullarky, E., Sudderth, J. A., Hu, Z., Wu, D., Tang, H., Xie, Y., Asara, J. M., Huffman, K. E., Wistuba, I. I., Minna, J. D., Deberardinis, R. J. & Cantley, L. C., Mar 29 2016, In : Nature genetics. 48, 4, 1 p.

Research output: Contribution to journalComment/debate

4 Scopus citations

Evidence of Glycolysis Up-Regulation and Pyruvate Mitochondrial Oxidation Mismatch During Mechanical Unloading of the Failing Human Heart: Implications for Cardiac Reloading and Conditioning

Diakos, N. A., Navankasattusas, S., Abel, E. D., Rutter, J., McCreath, L., Ferrin, P., McKellar, S. H., Miller, D. V., Park, S. Y., Richardson, R. S., Deberardinis, R., Cox, J. E., Kfoury, A. G., Selzman, C. H., Stehlik, J., Fang, J. C., Li, D. Y. & Drakos, S. G., Oct 1 2016, In : JACC: Basic to Translational Science. 1, 6, p. 432-444 13 p.

Research output: Contribution to journalArticle

39 Scopus citations

Fatty Acid Oxidation Mediated by Acyl-CoA Synthetase Long Chain 3 Is Required for Mutant KRAS Lung Tumorigenesis

Padanad, M. S., Konstantinidou, G., Venkateswaran, N., Melegari, M., Rindhe, S., Mitsche, M., Yang, C., Batten, K., Huffman, K. E., Liu, J., Tang, X., Rodriguez-Canales, J., Kalhor, N., Shay, J. W., Minna, J. D., McDonald, J., Wistuba, I. I., DeBerardinis, R. J. & Scaglioni, P. P., Aug 9 2016, In : Cell Reports. 16, 6, p. 1614-1628 15 p.

Research output: Contribution to journalArticle

52 Scopus citations