Research Output

2020

A synthetic heparinoid blocks Tau aggregate cell uptake and amplification

Stopschinski, B. E., Thomas, T. L., Nadji, S., Darvish, E., Fan, L., Holmes, B. B., Modi, A. R., Finnell, J. G., Kashmer, O. M., Estill-Terpack, S., Mirbaha, H., Luu, H. S. & Diamond, M. I., Mar 6 2020, In : Journal of Biological Chemistry. 295, 10, p. 2974-2983 10 p.

Research output: Contribution to journalArticle

1 Scopus citations

Site-Specific Hyperphosphorylation Inhibits, Rather than Promotes, Tau Fibrillization, Seeding Capacity, and Its Microtubule Binding

Haj-Yahya, M., Gopinath, P., Rajasekhar, K., Mirbaha, H., Diamond, M. I. & Lashuel, H. A., Mar 2 2020, In : Angewandte Chemie - International Edition. 59, 10, p. 4059-4067 9 p.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations
2019

Parkinson’s disease and multiple system atrophy have distinct -synuclein seed characteristics

Yamasaki, T. R., Holmes, B. B., Furman, J. L., Dhavale, D. D., Su, B. W., Song, E. S., Cairns, N. J., Kotzbauer, P. T. & Diamond, M. I., Jan 18 2019, In : Journal of Biological Chemistry. 294, 3, p. 1045-1058 14 p.

Research output: Contribution to journalArticle

32 Scopus citations

Propagation of protein aggregation in neurodegenerative diseases

Vaquer-Alicea, J. & Diamond, M. I., Jun 20 2019, In : Annual review of biochemistry. 88, p. 785-810 26 p.

Research output: Contribution to journalArticle

19 Scopus citations

Tau local structure shields an amyloid-forming motif and controls aggregation propensity

Chen, D., Drombosky, K. W., Hou, Z., Sari, L., Kashmer, O. M., Ryder, B. D., Perez, V. A., Woodard, D. N. R., Lin, M. M., Diamond, M. I. & Joachimiak, L. A., Dec 1 2019, In : Nature communications. 10, 1, 2493.

Research output: Contribution to journalArticle

Open Access
8 Scopus citations
2018

Inert and seed-competent tau monomers suggest structural origins of aggregation

Mirbaha, H., Chen, D., Morazova, O. A., Ruff, K. M., Sharma, A. M., Liu, X., Goodarzi, M., Pappu, R. V., Colby, D. W., Mirzaei, H., Joachimiak, L. A. & Diamond, M. I., Jul 10 2018, In : eLife. 7, e36584.

Research output: Contribution to journalArticle

48 Scopus citations

Profilin reduces aggregation and phase separation of huntingtin N-terminal fragments by preferentially binding to soluble monomers and oligomers

Posey, A. E., Ruff, K. M., Harmon, T. S., Crick, S. L., Li, A., Diamond, M. I. & Pappu, R. V., Mar 9 2018, In : Journal of Biological Chemistry. 293, 10, p. 3734-3746 13 p.

Research output: Contribution to journalArticle

28 Scopus citations

Rebuttal to Drs. Grinberg and Heinsen

Kaufman, S. K., Del Tredici, K., Braak, H. & Diamond, M. I., Nov 1 2018, In : Acta Neuropathologica. 136, 5, 1 p.

Research output: Contribution to journalLetter

Specific glycosaminoglycan chain length and sulfation patterns are required for cell uptake of tau versus -synuclein and -amyloid aggregates

Stopschinski, B. E., Holmes, B. B., Miller, G. M., Manon, V. A., Vaquer-Alicea, J., Prueitt, W. L., Hsieh-Wilson, L. C. & Diamond, M. I., Jul 6 2018, In : Journal of Biological Chemistry. 293, 27, p. 10826-10840 15 p.

Research output: Contribution to journalArticle

35 Scopus citations

Tau monomer encodes strains

Sharma, A. M., Thomas, T. L., Woodard, D. N. R., Kashmer, O. M. & Diamond, M. I., Dec 11 2018, In : eLife. 7

Research output: Contribution to journalArticle

16 Scopus citations

Tau seeding activity begins in the transentorhinal/entorhinal regions and anticipates phospho-tau pathology in Alzheimer’s disease and PART

Kaufman, S. K., Del Tredici, K., Thomas, T. L., Braak, H. & Diamond, M. I., May 11 2018, (Accepted/In press) In : Acta Neuropathologica. p. 1-11 11 p.

Research output: Contribution to journalArticle

37 Scopus citations
2017

Cellular models for the study of prions

Holmes, B. B. & Diamond, M. I., Feb 1 2017, In : Cold Spring Harbor perspectives in medicine. 7, 2, a024026.

Research output: Contribution to journalArticle

9 Scopus citations

Characterization of tau prion seeding activity and strains from formaldehyde-fixed tissue

Kaufman, S. K., Thomas, T. L., Del Tredici, K., Braak, H. & Diamond, M. I., Jun 7 2017, In : Acta neuropathologica communications. 5, 1, 1 p.

Research output: Contribution to journalArticle

35 Scopus citations

FRET and flow cytometry assays to measure proteopathic seeding activity in biological samples

Furman, J. L. & Diamond, M. I., 2017, Methods in Molecular Biology. Humana Press Inc., Vol. 1523. p. 349-359 11 p. (Methods in Molecular Biology; vol. 1523).

Research output: Chapter in Book/Report/Conference proceedingChapter

4 Scopus citations

Novel human neuronal tau model exhibiting neurofibrillary tangles and transcellular propagation

Reilly, P., Winston, C. N., Baron, K. R., Trejo, M., Rockenstein, E. M., Akers, J. C., Kfoury, N., Diamond, M., Masliah, E., Rissman, R. A. & Yuan, S. H., Oct 1 2017, In : Neurobiology of Disease. 106, p. 222-234 13 p.

Research output: Contribution to journalArticle

16 Scopus citations

Tau reduction prevents neuronal loss and reverses pathological tau deposition and seeding in mice with tauopathy

DeVos, S. L., Miller, R. L., Schoch, K. M., Holmes, B. B., Kebodeaux, C. S., Wegener, A. J., Chen, G., Shen, T., Tran, H., Nichols, B., Zanardi, T. A., Kordasiewicz, H. B., Swayze, E. E., Bennett, C. F., Diamond, M. I. & Miller, T. M., Jan 25 2017, In : Science Translational Medicine. 9, 374, eaag0481.

Research output: Contribution to journalArticle

106 Scopus citations

The CNS in inbred transgenic models of 4-repeat Tauopathy develops consistent tau seeding capacity yet focal and diverse patterns of protein deposition

Eskandari-Sedighi, G., Daude, N., Gapeshina, H., Sanders, D. W., Kamali-Jamil, R., Yang, J., Shi, B., Wille, H., Ghetti, B., Diamond, M. I., Janus, C. & Westaway, D., Oct 4 2017, In : Molecular Neurodegeneration. 12, 1, 72.

Research output: Contribution to journalArticle

1 Scopus citations

The prion model for progression and diversity of neurodegenerative diseases

Stopschinski, B. E. & Diamond, M. I., Apr 1 2017, In : The Lancet Neurology. 16, 4, p. 323-332 10 p.

Research output: Contribution to journalReview article

61 Scopus citations

Ultrasensitive and selective detection of 3-repeat tau seeding activity in Pick disease brain and cerebrospinal fluid

Saijo, E., Ghetti, B., Zanusso, G., Oblak, A., Furman, J. L., Diamond, M. I., Kraus, A. & Caughey, B., May 1 2017, In : Acta Neuropathologica. 133, 5, p. 751-765 15 p.

Research output: Contribution to journalArticle

40 Scopus citations

Widespread tau seeding activity at early Braak stages

Furman, J. L., Vaquer-Alicea, J., White, C. L., Cairns, N. J., Nelson, P. T. & Diamond, M. I., Jan 1 2017, In : Acta Neuropathologica. 133, 1, p. 91-100 10 p.

Research output: Contribution to journalArticle

37 Scopus citations
2016

Active and passive immunotherapy against tau: Effects and potential mechanisms

Yanamandra, K., Diamond, M. I. & Holtzman, D. M., Jan 1 2016, Methods in Pharmacology and Toxicology. Humana Press Inc., p. 121-138 18 p. (Methods in Pharmacology and Toxicology; vol. PartF1).

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

Heparan sulfate proteoglycans mediate Aβ-induced oxidative stress and hypercontractility in cultured vascular smooth muscle cells

Reynolds, M. R., Singh, I., Azad, T. D., Holmes, B. B., Verghese, P. B., Dietrich, H. H., Diamond, M., Bu, G., Han, B. H. & Zipfel, G. J., Jan 22 2016, In : Molecular neurodegeneration. 11, 1, 9.

Research output: Contribution to journalArticle

12 Scopus citations

Neuronal activity enhances tau propagation and tau pathology in vivo

Wu, J. W., Hussaini, S. A., Bastille, I. M., Rodriguez, G. A., Mrejeru, A., Rilett, K., Sanders, D. W., Cook, C., Fu, H., Boonen, R. A. C. M., Herman, M., Nahmani, E., Emrani, S., Figueroa, Y. H., Diamond, M. I., Clelland, C. L., Wray, S. & Duff, K. E., Aug 1 2016, In : Nature Neuroscience. 19, 8, p. 1085-1092 8 p.

Research output: Contribution to journalArticle

186 Scopus citations

Prions and Protein Assemblies that Convey Biological Information in Health and Disease

Sanders, D. W., Kaufman, S. K., Holmes, B. B. & Diamond, M. I., Feb 3 2016, In : Neuron. 89, 3, p. 433-448 16 p.

Research output: Contribution to journalArticle

37 Scopus citations

Tau Prion Strains Dictate Patterns of Cell Pathology, Progression Rate, and Regional Vulnerability In Vivo

Kaufman, S. K., Sanders, D. W., Thomas, T. L., Ruchinskas, A. J., Vaquer-Alicea, J., Sharma, A. M., Miller, T. M. & Diamond, M. I., Nov 23 2016, In : Neuron. 92, 4, p. 796-812 17 p.

Research output: Contribution to journalArticle

134 Scopus citations
2015

Distinct therapeutic mechanisms of Tau antibodies: Promoting microglial clearance versus blocking neuronal uptake

Funk, K. E., Mirbaha, H., Jiang, H., Holtzman, D. M. & Diamond, M. I., Aug 28 2015, In : Journal of Biological Chemistry. 290, 35, p. 21652-21662 11 p.

Research output: Contribution to journalArticle

58 Scopus citations

N17 Modifies Mutant Huntingtin Nuclear Pathogenesis and Severity of Disease in HD BAC Transgenic Mice

Gu, X., Cantle, J. P., Greiner, E. R., Lee, C. Y. D., Barth, A. M., Gao, F., Park, C. S., Zhang, Z., Sandoval-Miller, S., Zhang, R. L., Diamond, M., Mody, I., Coppola, G. & Yang, X. W., Feb 18 2015, In : Neuron. 85, 4, p. 726-741 16 p.

Research output: Contribution to journalArticle

34 Scopus citations

Photo-activatable Cre recombinase regulates gene expression in vivo

Schindler, S. E., McCall, J. G., Yan, P., Hyrc, K. L., Li, M., Tucker, C. L., Lee, J. M., Bruchas, M. R. & Diamond, M. I., Sep 9 2015, In : Scientific Reports. 5, 13627.

Research output: Contribution to journalArticle

41 Scopus citations

Propagation of prions causing synucleinopathies in cultured cells

Woerman, A. L., Stöhr, J., Aoyagi, A., Rampersaud, R., Krejciova, Z., Watts, J. C., Ohyama, T., Patel, S., Widjaja, K., Oehler, A., Sanders, D. W., Diamond, M. I., Seeley, W. W., Middleton, L. T., Gentleman, S. M., Mordes, D. A., Südhof, T. C., Giles, K. & Prusiner, S. B., Sep 1 2015, In : Proceedings of the National Academy of Sciences of the United States of America. 112, 35, p. E4949-E4958

Research output: Contribution to journalArticle

103 Scopus citations

Sensitive detection of proteopathic seeding activity with FRET flow cytometry

Furman, J. L., Holmes, B. B. & Diamond, M. I., Dec 8 2015, In : Journal of Visualized Experiments. 2015, 106, e53205.

Research output: Contribution to journalArticle

21 Scopus citations

Subcellular localization and Ser-137 phosphorylation regulate tumor-suppressive activity of Profilin-1

Diamond, M. I., Cai, S., Boudreau, A., Carey, C. J., Lyle, N., Pappu, R. V., Swamidass, S. J., Bissell, M., Piwnica-Worms, H. & Shao, J., Apr 3 2015, In : Journal of Biological Chemistry. 290, 14, p. 9075-9086 12 p.

Research output: Contribution to journalArticle

8 Scopus citations

Tau trimers are the minimal propagation unit spontaneously internalized to seed intracellular aggregation

Mirbaha, H., Holmes, B. B., Sanders, D. W., Bieschke, J. & Diamond, M. I., Jun 12 2015, In : Journal of Biological Chemistry. 290, 24, p. 14893-14903 11 p.

Research output: Contribution to journalArticle

91 Scopus citations

The green tea polyphenol (-)-epigallocatechin gallate prevents the aggregation of tau protein into toxic oligomers at substoichiometric ratios

Wobst, H. J., Sharma, A., Diamond, M. I., Wanker, E. E. & Bieschke, J., Feb 2 2015, In : FEBS Letters. 589, 1, p. 77-83 7 p.

Research output: Contribution to journalArticle

73 Scopus citations
2014

Distinct tau prion strains propagate in cells and mice and define different tauopathies

Sanders, D. W., Kaufman, S. K., DeVos, S. L., Sharma, A. M., Mirbaha, H., Li, A., Barker, S. J., Foley, A. C., Thorpe, J. R., Serpell, L. C., Miller, T. M., Grinberg, L. T., Seeley, W. W. & Diamond, M. I., Jun 18 2014, In : Neuron. 82, 6, p. 1271-1288 18 p.

Research output: Contribution to journalArticle

425 Scopus citations

Inhibition of the androgen receptor by mineralocorticoids at levels physiologically achieved in serum in patients treated with abiraterone acetate

Kim, W., Jones, J. O., Diamond, M., Haqq, C., Molina, A., Small, E. J. & Ryan, C. J., Jul 2014, In : Prostate Cancer and Prostatic Diseases. 17, 3, p. 292-299 8 p.

Research output: Contribution to journalArticle

6 Scopus citations

Prion-like nuclear aggregation of TDP-43 during heat shock is regulated by HSP40/70 chaperones

Udan-Johns, M., Bengoechea, R., Bell, S., Shao, J., Diamond, M. I., True, H. L., Weihl, C. C. & Baloh, R. H., Jan 1 2014, In : Human molecular genetics. 23, 1, p. 157-170 14 p., ddt408.

Research output: Contribution to journalArticle

53 Scopus citations

Prion-like properties of Tau protein: The importance of extracellular Tau as a therapeutic target

Holmes, B. B. & Diamond, M. I., Jan 1 2014, In : Journal of Biological Chemistry. 289, 29, p. 19855-19861 7 p.

Research output: Contribution to journalShort survey

103 Scopus citations

Proteopathic tau seeding predicts tauopathy in vivo

Holmes, B. B., Furman, J. L., Mahan, T. E., Yamasaki, T. R., Mirbaha, H., Eades, W. C., Belaygorod, L., Cairns, N. J., Holtzman, D. M. & Diamond, M. I., Oct 14 2014, In : Proceedings of the National Academy of Sciences of the United States of America. 111, 41, p. E4376-E4385

Research output: Contribution to journalArticle

174 Scopus citations
2013

Advances in diagnostic testing for Alzheimer disease.

Schindler, S. E., McConathy, J., Ances, B. M. & Diamond, M. I., Jan 1 2013, In : Missouri medicine. 110, 5, p. 401-405 5 p.

Research output: Contribution to journalReview article

5 Scopus citations

An N-terminal nuclear export signal regulates trafficking and aggregation of huntingtin (Htt) protein exon 1

Zheng, Z., Li, A., Holmes, B. B., Marasa, J. C. & Diamond, M. I., Mar 1 2013, In : Journal of Biological Chemistry. 288, 9, p. 6063-6071 9 p.

Research output: Contribution to journalArticle

38 Scopus citations

Anti-tau antibodies that block tau aggregate seeding invitro markedly decrease pathology and improve cognition in vivo

Yanamandra, K., Kfoury, N., Jiang, H., Mahan, T. E., Ma, S., Maloney, S. E., Wozniak, D. F., Diamond, M. I. & Holtzman, D. M., Oct 16 2013, In : Neuron. 80, 2, p. 402-414 13 p.

Research output: Contribution to journalArticle

307 Scopus citations

Erratum to Anti-Tau antibodies that block tau aggregate seeding invitro markedly decrease pathology and improve cognition in vivo [Neuron, 74, (2012), 227-245]

Yanamandra, K., Kfoury, N., Jiang, H., Mahan, T., Ma, S., Maloney, S., Wozniak, D., Diamond, M. & Holtzman, D., Dec 18 2013, In : Neuron. 80, 6, 1 p.

Research output: Contribution to journalComment/debate

Heparan sulfate proteoglycans mediate internalization and propagation of specific proteopathic seeds

Holmes, B. B., DeVos, S. L., Kfoury, N., Li, M., Jacks, R., Yanamandra, K., Ouidja, M. O., Brodsky, F. M., Marasa, J., Bagchi, D. P., Kotzbauer, P. T., Miller, T. M., Papy-Garcia, D. & Diamond, M. I., Aug 13 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 33, p. E3138-E3147

Research output: Contribution to journalArticle

332 Scopus citations

Intravitreal Administration of HA-1077, a ROCK Inhibitor, Improves Retinal Function in a Mouse Model of Huntington Disease

Li, M., Yasumura, D., Ma, A. A. K., Matthes, M. T., Yang, H., Nielson, G., Huang, Y., Szoka, F. C., LaVail, M. M. & Diamond, M. I., Feb 11 2013, In : PloS one. 8, 2, e56026.

Research output: Contribution to journalArticle

27 Scopus citations

Introduction

Diamond, M. I., Jul 1 2013, In : Neurotherapeutics. 10, 3, p. 369-370 2 p.

Research output: Contribution to journalEditorial

Mechanisms of protein seeding in neurodegenerative diseases

Walker, L. C., Diamond, M. I., Duff, K. E. & Hyman, B. T., Mar 2013, In : JAMA Neurology. 70, 3, p. 304-310 7 p.

Research output: Contribution to journalReview article

127 Scopus citations

Prion-Like Propagation of Protein Aggregation and Related Therapeutic Strategies

Kaufman, S. K. & Diamond, M. I., Jul 1 2013, In : Neurotherapeutics. 10, 3, p. 371-382 12 p.

Research output: Contribution to journalReview article

22 Scopus citations
2012

Amyotrophic lateral sclerosis and organ donation: Is there risk of disease transmission?

Holmes, B. B. & Diamond, M. I., Dec 1 2012, In : Annals of Neurology. 72, 6, p. 832-836 5 p.

Research output: Contribution to journalReview article

13 Scopus citations

An aggregation sensing reporter identifies leflunomide and teriflunomide as polyglutamine aggregate inhibitors

Fuentealba, R. A., Marasa, J., Diamond, M. I., Piwnica-Worms, D. & Weihl, C. C., Feb 1 2012, In : Human molecular genetics. 21, 3, p. 664-680 17 p., ddr500.

Research output: Contribution to journalArticle

27 Scopus citations

Cellular mechanisms of protein aggregate propagation

Holmes, B. B. & Diamond, M. I., Dec 1 2012, In : Current opinion in neurology. 25, 6, p. 721-726 6 p.

Research output: Contribution to journalReview article

44 Scopus citations