Research Output

Article

A cellular conformation-based screen for androgen receptor inhibitors

Jones, J. O. & Diamond, M. I., Jul 18 2008, In : ACS chemical biology. 3, 7, p. 412-418 7 p.

Research output: Contribution to journalArticle

26 Scopus citations

A common motif targets huntingtin and the androgen receptor to the proteasome

Chandra, S., Shao, J., Li, J. X., Li, M., Longo, F. M. & Diamond, M. I., Aug 29 2008, In : Journal of Biological Chemistry. 283, 35, p. 23950-23955 6 p.

Research output: Contribution to journalArticle

15 Scopus citations

An aggregation sensing reporter identifies leflunomide and teriflunomide as polyglutamine aggregate inhibitors

Fuentealba, R. A., Marasa, J., Diamond, M. I., Piwnica-Worms, D. & Weihl, C. C., Feb 1 2012, In : Human molecular genetics. 21, 3, p. 664-680 17 p., ddr500.

Research output: Contribution to journalArticle

29 Scopus citations

An N-terminal nuclear export signal regulates trafficking and aggregation of huntingtin (Htt) protein exon 1

Zheng, Z., Li, A., Holmes, B. B., Marasa, J. C. & Diamond, M. I., Mar 1 2013, In : Journal of Biological Chemistry. 288, 9, p. 6063-6071 9 p.

Research output: Contribution to journalArticle

42 Scopus citations

Anti-tau antibodies that block tau aggregate seeding invitro markedly decrease pathology and improve cognition in vivo

Yanamandra, K., Kfoury, N., Jiang, H., Mahan, T. E., Ma, S., Maloney, S. E., Wozniak, D. F., Diamond, M. I. & Holtzman, D. M., Oct 16 2013, In : Neuron. 80, 2, p. 402-414 13 p.

Research output: Contribution to journalArticle

313 Scopus citations

A rapid cellular FRET assay of polyglutamine aggregation identifies a novel inhibitor

Pollitt, S. K., Pallos, J., Shao, J., Desai, U. A., Ma, A. A. K., Thompson, L. M., Marsh, J. L. & Diamond, M. I., Nov 13 2003, In : Neuron. 40, 4, p. 685-694 10 p.

Research output: Contribution to journalArticle

121 Scopus citations

AR inhibitors identified by high-throughput microscopy detection of conformational change and subcellular localization

Jones, J. O., An, W. F. & Diamond, M. I., Mar 20 2009, In : ACS chemical biology. 4, 3, p. 199-208 10 p.

Research output: Contribution to journalArticle

22 Scopus citations

AR inhibitors identified by high-throughput microscopy detection of conformational change and subcellular localization.

Jones, J. O., An, W. F. & Diamond, M. I., Mar 20 2009, In : ACS chemical biology. 4, 3, p. 191-197 7 p.

Research output: Contribution to journalArticle

4 Scopus citations

A synthetic heparinoid blocks Tau aggregate cell uptake and amplification

Stopschinski, B. E., Thomas, T. L., Nadji, S., Darvish, E., Fan, L., Holmes, B. B., Modi, A. R., Finnell, J. G., Kashmer, O. M., Estill-Terpack, S., Mirbaha, H., Luu, H. S. & Diamond, M. I., Mar 6 2020, In : Journal of Biological Chemistry. 295, 10, p. 2974-2983 10 p.

Research output: Contribution to journalArticle

2 Scopus citations

Biologically active molecules that reduce polyglutamine aggregation and toxicity

Desai, U. A., Pallos, J., Ma, A. A. K., Stockwell, B. R., Thompson, L. M., Marsh, J. L. & Diamond, M. I., Jul 2006, In : Human molecular genetics. 15, 13, p. 2114-2124 11 p.

Research output: Contribution to journalArticle

61 Scopus citations

Cellular models for the study of prions

Holmes, B. B. & Diamond, M. I., Feb 1 2017, In : Cold Spring Harbor perspectives in medicine. 7, 2, a024026.

Research output: Contribution to journalArticle

10 Scopus citations

Characterization of tau prion seeding activity and strains from formaldehyde-fixed tissue

Kaufman, S. K., Thomas, T. L., Del Tredici, K., Braak, H. & Diamond, M. I., Jun 7 2017, In : Acta neuropathologica communications. 5, 1, 1 p.

Research output: Contribution to journalArticle

35 Scopus citations

Conformational diversity of wild-type tau fibrils specified by templated conformation change

Frost, B., Ollesch, J., Wille, H. & Diamond, M. I., Feb 6 2009, In : Journal of Biological Chemistry. 284, 6, p. 3546-3551 6 p.

Research output: Contribution to journalArticle

142 Scopus citations

Discovery of selective glucocorticoid receptor modulators by multiplexed reporter screening

Gerber, A. N., Masuno, K. & Diamond, M. I., Mar 24 2009, In : Proceedings of the National Academy of Sciences of the United States of America. 106, 12, p. 4929-4934 6 p.

Research output: Contribution to journalArticle

20 Scopus citations

Distinct tau prion strains propagate in cells and mice and define different tauopathies

Sanders, D. W., Kaufman, S. K., DeVos, S. L., Sharma, A. M., Mirbaha, H., Li, A., Barker, S. J., Foley, A. C., Thorpe, J. R., Serpell, L. C., Miller, T. M., Grinberg, L. T., Seeley, W. W. & Diamond, M. I., Jun 18 2014, In : Neuron. 82, 6, p. 1271-1288 18 p.

Research output: Contribution to journalArticle

441 Scopus citations

Distinct therapeutic mechanisms of Tau antibodies: Promoting microglial clearance versus blocking neuronal uptake

Funk, K. E., Mirbaha, H., Jiang, H., Holtzman, D. M. & Diamond, M. I., Aug 28 2015, In : Journal of Biological Chemistry. 290, 35, p. 21652-21662 11 p.

Research output: Contribution to journalArticle

58 Scopus citations

DNA length polymorphism 5′ to the myelin basic protein gene is associated with multiple sclerosis

Boylan, K. B., Takahashi, N., Paty, D. W., Sadovnick, A. D., Diamond, M., Hood, L. E. & Prusiner, S. B., Mar 1990, In : Annals of Neurology. 27, 3, p. 291-297 7 p.

Research output: Contribution to journalArticle

62 Scopus citations

DNA length polymorphism located 5' to the human myelin basic protein gene

Boylan, K. B., Takahashi, N., Diamond, M., Hood, L. E. & Prusiner, S. B., Sep 2 1987, In : American Journal of Human Genetics. 40, 5, p. 387-400 14 p.

Research output: Contribution to journalArticle

14 Scopus citations

F-actin binding regions on the androgen receptor and huntingtin increase aggregation and alter aggregate characteristics

Angeli, S., Shao, J. & Diamond, M. I., Feb 4 2010, In : PloS one. 5, 2, e9053.

Research output: Contribution to journalArticle

21 Scopus citations
21 Scopus citations

Heparan sulfate proteoglycans mediate Aβ-induced oxidative stress and hypercontractility in cultured vascular smooth muscle cells

Reynolds, M. R., Singh, I., Azad, T. D., Holmes, B. B., Verghese, P. B., Dietrich, H. H., Diamond, M., Bu, G., Han, B. H. & Zipfel, G. J., Jan 22 2016, In : Molecular neurodegeneration. 11, 1, 9.

Research output: Contribution to journalArticle

12 Scopus citations

Heparan sulfate proteoglycans mediate internalization and propagation of specific proteopathic seeds

Holmes, B. B., DeVos, S. L., Kfoury, N., Li, M., Jacks, R., Yanamandra, K., Ouidja, M. O., Brodsky, F. M., Marasa, J., Bagchi, D. P., Kotzbauer, P. T., Miller, T. M., Papy-Garcia, D. & Diamond, M. I., Aug 13 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 33, p. E3138-E3147

Research output: Contribution to journalArticle

350 Scopus citations

Huntington disease and the huntingtin protein

Zheng, Z. & Diamond, M. I., 2012, In : Progress in Molecular Biology and Translational Science. 107, p. 189-214 26 p.

Research output: Contribution to journalArticle

58 Scopus citations

Inert and seed-competent tau monomers suggest structural origins of aggregation

Mirbaha, H., Chen, D., Morazova, O. A., Ruff, K. M., Sharma, A. M., Liu, X., Goodarzi, M., Pappu, R. V., Colby, D. W., Mirzaei, H., Joachimiak, L. A. & Diamond, M. I., Jul 10 2018, In : eLife. 7, e36584.

Research output: Contribution to journalArticle

50 Scopus citations

Inhibition of the androgen receptor by mineralocorticoids at levels physiologically achieved in serum in patients treated with abiraterone acetate

Kim, W., Jones, J. O., Diamond, M., Haqq, C., Molina, A., Small, E. J. & Ryan, C. J., Jul 2014, In : Prostate Cancer and Prostatic Diseases. 17, 3, p. 292-299 8 p.

Research output: Contribution to journalArticle

6 Scopus citations

Inhibitory effects of nordihydroguaiaretic acid (NDGA) on the IGF-1 receptor and androgen dependent growth of LAPC-4 prostate cancer cells

Ryan, C. J., Zavodovskaya, M., Youngren, J. F., Campbell, M., Diamond, M., Jones, J., Shiry, L., Allan, G., Maddux, B. A. & Goldfine, I. D., Aug 1 2008, In : Prostate. 68, 11, p. 1232-1240 9 p.

Research output: Contribution to journalArticle

19 Scopus citations

Interaction with polyglutamine aggregates reveals a Q/N-rich domain in TDP-43

Fuentealba, R. A., Udan, M., Bell, S., Wegorzewska, I., Shao, J., Diamond, M. I., Weihl, C. C. & Baloh, R. H., Aug 20 2010, In : Journal of Biological Chemistry. 285, 34, p. 26304-26314 11 p.

Research output: Contribution to journalArticle

111 Scopus citations

Intravitreal Administration of HA-1077, a ROCK Inhibitor, Improves Retinal Function in a Mouse Model of Huntington Disease

Li, M., Yasumura, D., Ma, A. A. K., Matthes, M. T., Yang, H., Nielson, G., Huang, Y., Szoka, F. C., LaVail, M. M. & Diamond, M. I., Feb 11 2013, In : PloS one. 8, 2, e56026.

Research output: Contribution to journalArticle

30 Scopus citations

In vivo microdialysis reveals age-dependent decrease of brain interstitial fluid tau levels in P301S human tau transgenic mice

Yamada, K., Cirrito, J. R., Stewart, F. R., Jiang, H., Finn, M. B., Holmes, B. B., Binder, L. I., Mandelkow, E. M., Diamond, M. I., Lee, V. M. Y. & Holtzman, D. M., Sep 14 2011, In : Journal of Neuroscience. 31, 37, p. 13110-13117 8 p.

Research output: Contribution to journalArticle

206 Scopus citations

N17 Modifies Mutant Huntingtin Nuclear Pathogenesis and Severity of Disease in HD BAC Transgenic Mice

Gu, X., Cantle, J. P., Greiner, E. R., Lee, C. Y. D., Barth, A. M., Gao, F., Park, C. S., Zhang, Z., Sandoval-Miller, S., Zhang, R. L., Diamond, M., Mody, I., Coppola, G. & Yang, X. W., Feb 18 2015, In : Neuron. 85, 4, p. 726-741 16 p.

Research output: Contribution to journalArticle

36 Scopus citations

Neuronal activity enhances tau propagation and tau pathology in vivo

Wu, J. W., Hussaini, S. A., Bastille, I. M., Rodriguez, G. A., Mrejeru, A., Rilett, K., Sanders, D. W., Cook, C., Fu, H., Boonen, R. A. C. M., Herman, M., Nahmani, E., Emrani, S., Figueroa, Y. H., Diamond, M. I., Clelland, C. L., Wray, S. & Duff, K. E., Aug 1 2016, In : Nature Neuroscience. 19, 8, p. 1085-1092 8 p.

Research output: Contribution to journalArticle

198 Scopus citations

Non-competitive androgen receptor inhibition in vitro and in vivo

Jones, J. O., Bolton, E. C., Huang, Y., Feau, C., Guy, R. K., Yamamoto, K. R., Hann, B. & Diamond, M. I., Apr 28 2009, In : Proceedings of the National Academy of Sciences of the United States of America. 106, 17, p. 7233-7238 6 p.

Research output: Contribution to journalArticle

67 Scopus citations

Novel human neuronal tau model exhibiting neurofibrillary tangles and transcellular propagation

Reilly, P., Winston, C. N., Baron, K. R., Trejo, M., Rockenstein, E. M., Akers, J. C., Kfoury, N., Diamond, M., Masliah, E., Rissman, R. A. & Yuan, S. H., Oct 2017, In : Neurobiology of Disease. 106, p. 222-234 13 p.

Research output: Contribution to journalArticle

18 Scopus citations

Parkinson’s disease and multiple system atrophy have distinct -synuclein seed characteristics

Yamasaki, T. R., Holmes, B. B., Furman, J. L., Dhavale, D. D., Su, B. W., Song, E. S., Cairns, N. J., Kotzbauer, P. T. & Diamond, M. I., Jan 18 2019, In : Journal of Biological Chemistry. 294, 3, p. 1045-1058 14 p.

Research output: Contribution to journalArticle

36 Scopus citations

Phosphorylation of profilin by ROCK1 regulates polyglutamine aggregation

Shao, J., Welch, W. J., DiProspero, N. A. & Diamond, M. I., Sep 1 2008, In : Molecular and cellular biology. 28, 17, p. 5196-5208 13 p.

Research output: Contribution to journalArticle

94 Scopus citations

Photo-activatable Cre recombinase regulates gene expression in vivo

Schindler, S. E., McCall, J. G., Yan, P., Hyrc, K. L., Li, M., Tucker, C. L., Lee, J. M., Bruchas, M. R. & Diamond, M. I., Sep 9 2015, In : Scientific reports. 5, 13627.

Research output: Contribution to journalArticle

42 Scopus citations

Polyglutamine protein aggregation and toxicity are linked to the cellular stress response

Cowan, K. J., Diamond, M. I. & Welch, W. J., Jun 15 2003, In : Human molecular genetics. 12, 12, p. 1377-1391 15 p.

Research output: Contribution to journalArticle

62 Scopus citations

Prion-like nuclear aggregation of TDP-43 during heat shock is regulated by HSP40/70 chaperones

Udan-Johns, M., Bengoechea, R., Bell, S., Shao, J., Diamond, M. I., True, H. L., Weihl, C. C. & Baloh, R. H., Jan 2014, In : Human molecular genetics. 23, 1, p. 157-170 14 p., ddt408.

Research output: Contribution to journalArticle

55 Scopus citations

Prions and Protein Assemblies that Convey Biological Information in Health and Disease

Sanders, D. W., Kaufman, S. K., Holmes, B. B. & Diamond, M. I., Feb 3 2016, In : Neuron. 89, 3, p. 433-448 16 p.

Research output: Contribution to journalArticle

39 Scopus citations

Profilin reduces aggregation and phase separation of huntingtin N-terminal fragments by preferentially binding to soluble monomers and oligomers

Posey, A. E., Ruff, K. M., Harmon, T. S., Crick, S. L., Li, A., Diamond, M. I. & Pappu, R. V., Mar 9 2018, In : Journal of Biological Chemistry. 293, 10, p. 3734-3746 13 p.

Research output: Contribution to journalArticle

33 Scopus citations

Propagation of prions causing synucleinopathies in cultured cells

Woerman, A. L., Stöhr, J., Aoyagi, A., Rampersaud, R., Krejciova, Z., Watts, J. C., Ohyama, T., Patel, S., Widjaja, K., Oehler, A., Sanders, D. W., Diamond, M. I., Seeley, W. W., Middleton, L. T., Gentleman, S. M., Mordes, D. A., Südhof, T. C., Giles, K. & Prusiner, S. B., Sep 1 2015, In : Proceedings of the National Academy of Sciences of the United States of America. 112, 35, p. E4949-E4958

Research output: Contribution to journalArticle

107 Scopus citations

Propagation of protein aggregation in neurodegenerative diseases

Vaquer-Alicea, J. & Diamond, M. I., Jun 20 2019, In : Annual review of biochemistry. 88, p. 785-810 26 p.

Research output: Contribution to journalArticle

28 Scopus citations

Propagation of Tau misfolding from the outside to the inside of a cell

Frost, B., Jacks, R. L. & Diamond, M. I., May 8 2009, In : Journal of Biological Chemistry. 284, 19, p. 12845-12852 8 p.

Research output: Contribution to journalArticle

682 Scopus citations

Protein phosphatase 1 dephosphorylates profilin-1 at ser-137

Shao, J. & Diamond, M. I., Mar 30 2012, In : PloS one. 7, 3, e32802.

Research output: Contribution to journalArticle

11 Scopus citations

Proteopathic tau seeding predicts tauopathy in vivo

Holmes, B. B., Furman, J. L., Mahan, T. E., Yamasaki, T. R., Mirbaha, H., Eades, W. C., Belaygorod, L., Cairns, N. J., Holtzman, D. M. & Diamond, M. I., Oct 14 2014, In : Proceedings of the National Academy of Sciences of the United States of America. 111, 41, p. E4376-E4385

Research output: Contribution to journalArticle

179 Scopus citations
59 Scopus citations

ROCK and PRK-2 mediate the inhibitory effect of Y-27632 on polyglutamine aggregation

Shao, J., Welch, W. J. & Diamond, M. I., May 28 2008, In : FEBS Letters. 582, 12, p. 1637-1642 6 p.

Research output: Contribution to journalArticle

22 Scopus citations

Selective activation of estrogen receptor-β transcriptional pathways by an herbal extract

Cvoro, A., Paruthiyil, S., Jones, J. O., Tzagarakis-Foster, C., Clegg, N. J., Tatomer, D., Medina, R. T., Tagliaferri, M., Schaufele, F., Scanlan, T. S., Diamond, M. I., Cohen, I. & Leitman, D. C., Feb 2007, In : Endocrinology. 148, 2, p. 538-547 10 p.

Research output: Contribution to journalArticle

61 Scopus citations

Sensitive detection of proteopathic seeding activity with FRET flow cytometry

Furman, J. L., Holmes, B. B. & Diamond, M. I., Dec 8 2015, In : Journal of Visualized Experiments. 2015, 106, e53205.

Research output: Contribution to journalArticle

21 Scopus citations

Site-Specific Hyperphosphorylation Inhibits, Rather than Promotes, Tau Fibrillization, Seeding Capacity, and Its Microtubule Binding

Haj-Yahya, M., Gopinath, P., Rajasekhar, K., Mirbaha, H., Diamond, M. I. & Lashuel, H. A., Mar 2 2020, In : Angewandte Chemie - International Edition. 59, 10, p. 4059-4067 9 p.

Research output: Contribution to journalArticle

Open Access
5 Scopus citations