Research Output

2012

Huntington disease and the huntingtin protein

Zheng, Z. & Diamond, M. I., 2012, In : Progress in Molecular Biology and Translational Science. 107, p. 189-214 26 p.

Research output: Contribution to journalArticle

58 Scopus citations

Protein phosphatase 1 dephosphorylates profilin-1 at ser-137

Shao, J. & Diamond, M. I., Mar 30 2012, In : PloS one. 7, 3, e32802.

Research output: Contribution to journalArticle

11 Scopus citations

Trans-cellular propagation of Tau aggregation by fibrillar species

Kfoury, N., Holmes, B. B., Jiang, H., Holtzman, D. M. & Diamond, M. I., Jun 1 2012, In : Journal of Biological Chemistry. 287, 23, p. 19440-19451 12 p.

Research output: Contribution to journalArticle

315 Scopus citations
2011

In vivo microdialysis reveals age-dependent decrease of brain interstitial fluid tau levels in P301S human tau transgenic mice

Yamada, K., Cirrito, J. R., Stewart, F. R., Jiang, H., Finn, M. B., Holmes, B. B., Binder, L. I., Mandelkow, E. M., Diamond, M. I., Lee, V. M. Y. & Holtzman, D. M., Sep 14 2011, In : Journal of Neuroscience. 31, 37, p. 13110-13117 8 p.

Research output: Contribution to journalArticle

206 Scopus citations
2010

F-actin binding regions on the androgen receptor and huntingtin increase aggregation and alter aggregate characteristics

Angeli, S., Shao, J. & Diamond, M. I., Feb 4 2010, In : PloS one. 5, 2, e9053.

Research output: Contribution to journalArticle

21 Scopus citations

Interaction with polyglutamine aggregates reveals a Q/N-rich domain in TDP-43

Fuentealba, R. A., Udan, M., Bell, S., Wegorzewska, I., Shao, J., Diamond, M. I., Weihl, C. C. & Baloh, R. H., Aug 20 2010, In : Journal of Biological Chemistry. 285, 34, p. 26304-26314 11 p.

Research output: Contribution to journalArticle

111 Scopus citations

Prion-like mechanisms in neurodegenerative diseases

Frost, B. & Diamond, M. I., Mar 1 2010, In : Nature Reviews Neuroscience. 11, 3, p. 155-159 5 p.

Research output: Contribution to journalReview article

452 Scopus citations
2009

AR inhibitors identified by high-throughput microscopy detection of conformational change and subcellular localization

Jones, J. O., An, W. F. & Diamond, M. I., Mar 20 2009, In : ACS chemical biology. 4, 3, p. 199-208 10 p.

Research output: Contribution to journalArticle

22 Scopus citations

AR inhibitors identified by high-throughput microscopy detection of conformational change and subcellular localization.

Jones, J. O., An, W. F. & Diamond, M. I., Mar 20 2009, In : ACS chemical biology. 4, 3, p. 191-197 7 p.

Research output: Contribution to journalArticle

4 Scopus citations

Conformational diversity of wild-type tau fibrils specified by templated conformation change

Frost, B., Ollesch, J., Wille, H. & Diamond, M. I., Feb 6 2009, In : Journal of Biological Chemistry. 284, 6, p. 3546-3551 6 p.

Research output: Contribution to journalArticle

142 Scopus citations

Discovery of selective glucocorticoid receptor modulators by multiplexed reporter screening

Gerber, A. N., Masuno, K. & Diamond, M. I., Mar 24 2009, In : Proceedings of the National Academy of Sciences of the United States of America. 106, 12, p. 4929-4934 6 p.

Research output: Contribution to journalArticle

20 Scopus citations

Non-competitive androgen receptor inhibition in vitro and in vivo

Jones, J. O., Bolton, E. C., Huang, Y., Feau, C., Guy, R. K., Yamamoto, K. R., Hann, B. & Diamond, M. I., Apr 28 2009, In : Proceedings of the National Academy of Sciences of the United States of America. 106, 17, p. 7233-7238 6 p.

Research output: Contribution to journalArticle

67 Scopus citations

Propagation of Tau misfolding from the outside to the inside of a cell

Frost, B., Jacks, R. L. & Diamond, M. I., May 8 2009, In : Journal of Biological Chemistry. 284, 19, p. 12845-12852 8 p.

Research output: Contribution to journalArticle

682 Scopus citations

The expanding realm of prion phenomena in neurodegenerative disease

Frost, B. & Diamond, M. I., 2009, In : Prion. 3, 2, p. 74-77 4 p.

Research output: Contribution to journalComment/debate

Open Access
25 Scopus citations

The expanding realm of prion phenomena in neurodegenerative disease

Frost, B. & Diamond, M. I., Apr 2009, In : Prion. 3, 2, p. 23-26 4 p.

Research output: Contribution to journalArticle

Y-27632 improves rotarod performance and reduces huntingtin levels in R6/2 mice

Li, M., Huang, Y., Ma, A. A. K., Lin, E. & Diamond, M. I., Dec 1 2009, In : Neurobiology of Disease. 36, 3, p. 413-420 8 p.

Research output: Contribution to journalArticle

50 Scopus citations
2008

A cellular conformation-based screen for androgen receptor inhibitors

Jones, J. O. & Diamond, M. I., Jul 18 2008, In : ACS chemical biology. 3, 7, p. 412-418 7 p.

Research output: Contribution to journalArticle

26 Scopus citations

A common motif targets huntingtin and the androgen receptor to the proteasome

Chandra, S., Shao, J., Li, J. X., Li, M., Longo, F. M. & Diamond, M. I., Aug 29 2008, In : Journal of Biological Chemistry. 283, 35, p. 23950-23955 6 p.

Research output: Contribution to journalArticle

15 Scopus citations

Inhibitory effects of nordihydroguaiaretic acid (NDGA) on the IGF-1 receptor and androgen dependent growth of LAPC-4 prostate cancer cells

Ryan, C. J., Zavodovskaya, M., Youngren, J. F., Campbell, M., Diamond, M., Jones, J., Shiry, L., Allan, G., Maddux, B. A. & Goldfine, I. D., Aug 1 2008, In : Prostate. 68, 11, p. 1232-1240 9 p.

Research output: Contribution to journalArticle

19 Scopus citations

Phosphorylation of profilin by ROCK1 regulates polyglutamine aggregation

Shao, J., Welch, W. J., DiProspero, N. A. & Diamond, M. I., Sep 1 2008, In : Molecular and cellular biology. 28, 17, p. 5196-5208 13 p.

Research output: Contribution to journalArticle

94 Scopus citations

ROCK and PRK-2 mediate the inhibitory effect of Y-27632 on polyglutamine aggregation

Shao, J., Welch, W. J. & Diamond, M. I., May 28 2008, In : FEBS Letters. 582, 12, p. 1637-1642 6 p.

Research output: Contribution to journalArticle

22 Scopus citations
2007

Design and implementation of cell-based assays to model human disease

Jones, J. O. & Diamond, M. I., Nov 1 2007, In : ACS chemical biology. 2, 11, p. 718-724 7 p.

Research output: Contribution to journalReview article

18 Scopus citations

Polyglutamine diseases: Emerging concepts in pathogenesis and therapy

Shao, J. & Diamond, M. I., Oct 15 2007, In : Human molecular genetics. 16, R2, p. R115-R123

Research output: Contribution to journalReview article

192 Scopus citations

Selective activation of estrogen receptor-β transcriptional pathways by an herbal extract

Cvoro, A., Paruthiyil, S., Jones, J. O., Tzagarakis-Foster, C., Clegg, N. J., Tatomer, D., Medina, R. T., Tagliaferri, M., Schaufele, F., Scanlan, T. S., Diamond, M. I., Cohen, I. & Leitman, D. C., Feb 2007, In : Endocrinology. 148, 2, p. 538-547 10 p.

Research output: Contribution to journalArticle

61 Scopus citations

Soluble androgen receptor oligomers underlie pathology in a mouse model of spinobulbar muscular atrophy

Li, M., Chevalier-Larsen, E. S., Merry, D. E. & Diamond, M. I., Jan 2 2007, In : Journal of Biological Chemistry. 282, 5, p. 3157-3164 8 p.

Research output: Contribution to journalArticle

77 Scopus citations
2006

Biologically active molecules that reduce polyglutamine aggregation and toxicity

Desai, U. A., Pallos, J., Ma, A. A. K., Stockwell, B. R., Thompson, L. M., Marsh, J. L. & Diamond, M. I., Jul 2006, In : Human molecular genetics. 15, 13, p. 2114-2124 11 p.

Research output: Contribution to journalArticle

61 Scopus citations
2005

The structural basis of androgen receptor activation: Intramolecular and intermolecular amino-carboxy interactions

Schaufele, F., Carbonell, X., Guerbadot, M., Borngraeber, S., Chapman, M. S., Ma, A. A. K., Miner, J. N. & Diamond, M. I., Jul 12 2005, In : Proceedings of the National Academy of Sciences of the United States of America. 102, 28, p. 9802-9807 6 p.

Research output: Contribution to journalArticle

153 Scopus citations
2003

A rapid cellular FRET assay of polyglutamine aggregation identifies a novel inhibitor

Pollitt, S. K., Pallos, J., Shao, J., Desai, U. A., Ma, A. A. K., Thompson, L. M., Marsh, J. L. & Diamond, M. I., Nov 13 2003, In : Neuron. 40, 4, p. 685-694 10 p.

Research output: Contribution to journalArticle

121 Scopus citations

Polyglutamine protein aggregation and toxicity are linked to the cellular stress response

Cowan, K. J., Diamond, M. I. & Welch, W. J., Jun 15 2003, In : Human molecular genetics. 12, 12, p. 1377-1391 15 p.

Research output: Contribution to journalArticle

62 Scopus citations
2001
21 Scopus citations
2000
59 Scopus citations
1991
103 Scopus citations
1990

DNA length polymorphism 5′ to the myelin basic protein gene is associated with multiple sclerosis

Boylan, K. B., Takahashi, N., Paty, D. W., Sadovnick, A. D., Diamond, M., Hood, L. E. & Prusiner, S. B., Mar 1990, In : Annals of Neurology. 27, 3, p. 291-297 7 p.

Research output: Contribution to journalArticle

62 Scopus citations

Transcription factor interactions: Selectors of positive or negative regulation from a single DNA element

Diamond, M. I., Miner, J. N., Yoshinaga, S. K. & Yamamoto, K. R., Jan 1 1990, In : Science. 249, 4974, p. 1266-1272 7 p.

Research output: Contribution to journalArticle

1035 Scopus citations
1987

DNA length polymorphism located 5' to the human myelin basic protein gene

Boylan, K. B., Takahashi, N., Diamond, M., Hood, L. E. & Prusiner, S. B., Sep 2 1987, In : American Journal of Human Genetics. 40, 5, p. 387-400 14 p.

Research output: Contribution to journalArticle

14 Scopus citations