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2020

Site-Specific Hyperphosphorylation Inhibits, Rather than Promotes, Tau Fibrillization, Seeding Capacity, and Its Microtubule Binding

Haj-Yahya, M., Gopinath, P., Rajasekhar, K., Mirbaha, H., Diamond, M. I. & Lashuel, H. A., Mar 2 2020, In : Angewandte Chemie - International Edition. 59, 10, p. 4059-4067 9 p.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations
2019

Parkinson’s disease and multiple system atrophy have distinct -synuclein seed characteristics

Yamasaki, T. R., Holmes, B. B., Furman, J. L., Dhavale, D. D., Su, B. W., Song, E. S., Cairns, N. J., Kotzbauer, P. T. & Diamond, M. I., Jan 18 2019, In : Journal of Biological Chemistry. 294, 3, p. 1045-1058 14 p.

Research output: Contribution to journalArticle

21 Scopus citations

Propagation of protein aggregation in neurodegenerative diseases

Vaquer-Alicea, J. & Diamond, M. I., Jun 20 2019, In : Annual Review of Biochemistry. 88, p. 785-810 26 p.

Research output: Contribution to journalArticle

14 Scopus citations

Tau local structure shields an amyloid-forming motif and controls aggregation propensity

Chen, D., Drombosky, K. W., Hou, Z., Sari, L., Kashmer, O. M., Ryder, B. D., Perez, V. A., Woodard, D. N. R., Lin, M. M., Diamond, M. I. & Joachimiak, L. A., Dec 1 2019, In : Nature communications. 10, 1, 2493.

Research output: Contribution to journalArticle

Open Access
6 Scopus citations
2018

Inert and seed-competent tau monomers suggest structural origins of aggregation

Mirbaha, H., Chen, D., Morazova, O. A., Ruff, K. M., Sharma, A. M., Liu, X., Goodarzi, M., Pappu, R. V., Colby, D. W., Mirzaei, H., Joachimiak, L. A. & Diamond, M. I., Jul 10 2018, In : eLife. 7, e36584.

Research output: Contribution to journalArticle

41 Scopus citations

Profilin reduces aggregation and phase separation of huntingtin N-terminal fragments by preferentially binding to soluble monomers and oligomers

Posey, A. E., Ruff, K. M., Harmon, T. S., Crick, S. L., Li, A., Diamond, M. I. & Pappu, R. V., Mar 9 2018, In : Journal of Biological Chemistry. 293, 10, p. 3734-3746 13 p.

Research output: Contribution to journalArticle

25 Scopus citations

Specific glycosaminoglycan chain length and sulfation patterns are required for cell uptake of tau versus -synuclein and -amyloid aggregates

Stopschinski, B. E., Holmes, B. B., Miller, G. M., Manon, V. A., Vaquer-Alicea, J., Prueitt, W. L., Hsieh-Wilson, L. C. & Diamond, M. I., Jul 6 2018, In : Journal of Biological Chemistry. 293, 27, p. 10826-10840 15 p.

Research output: Contribution to journalArticle

29 Scopus citations

Tau monomer encodes strains

Sharma, A. M., Thomas, T. L., Woodard, D. N. R., Kashmer, O. M. & Diamond, M. I., Dec 11 2018, In : eLife. 7

Research output: Contribution to journalArticle

14 Scopus citations

Tau seeding activity begins in the transentorhinal/entorhinal regions and anticipates phospho-tau pathology in Alzheimer’s disease and PART

Kaufman, S. K., Del Tredici, K., Thomas, T. L., Braak, H. & Diamond, M. I., May 11 2018, (Accepted/In press) In : Acta Neuropathologica. p. 1-11 11 p.

Research output: Contribution to journalArticle

37 Scopus citations
2017

Cellular models for the study of prions

Holmes, B. B. & Diamond, M. I., Feb 1 2017, In : Cold Spring Harbor perspectives in medicine. 7, 2, a024026.

Research output: Contribution to journalArticle

9 Scopus citations

Characterization of tau prion seeding activity and strains from formaldehyde-fixed tissue

Kaufman, S. K., Thomas, T. L., Del Tredici, K., Braak, H. & Diamond, M. I., Jun 7 2017, In : Acta neuropathologica communications. 5, 1, 1 p.

Research output: Contribution to journalArticle

34 Scopus citations

Novel human neuronal tau model exhibiting neurofibrillary tangles and transcellular propagation

Reilly, P., Winston, C. N., Baron, K. R., Trejo, M., Rockenstein, E. M., Akers, J. C., Kfoury, N., Diamond, M., Masliah, E., Rissman, R. A. & Yuan, S. H., Oct 1 2017, In : Neurobiology of Disease. 106, p. 222-234 13 p.

Research output: Contribution to journalArticle

16 Scopus citations

Tau reduction prevents neuronal loss and reverses pathological tau deposition and seeding in mice with tauopathy

DeVos, S. L., Miller, R. L., Schoch, K. M., Holmes, B. B., Kebodeaux, C. S., Wegener, A. J., Chen, G., Shen, T., Tran, H., Nichols, B., Zanardi, T. A., Kordasiewicz, H. B., Swayze, E. E., Bennett, C. F., Diamond, M. I. & Miller, T. M., Jan 25 2017, In : Science Translational Medicine. 9, 374, eaag0481.

Research output: Contribution to journalArticle

100 Scopus citations

The CNS in inbred transgenic models of 4-repeat Tauopathy develops consistent tau seeding capacity yet focal and diverse patterns of protein deposition

Eskandari-Sedighi, G., Daude, N., Gapeshina, H., Sanders, D. W., Kamali-Jamil, R., Yang, J., Shi, B., Wille, H., Ghetti, B., Diamond, M. I., Janus, C. & Westaway, D., Oct 4 2017, In : Molecular Neurodegeneration. 12, 1, 72.

Research output: Contribution to journalArticle

1 Scopus citations

Ultrasensitive and selective detection of 3-repeat tau seeding activity in Pick disease brain and cerebrospinal fluid

Saijo, E., Ghetti, B., Zanusso, G., Oblak, A., Furman, J. L., Diamond, M. I., Kraus, A. & Caughey, B., May 1 2017, In : Acta Neuropathologica. 133, 5, p. 751-765 15 p.

Research output: Contribution to journalArticle

38 Scopus citations

Widespread tau seeding activity at early Braak stages

Furman, J. L., Vaquer-Alicea, J., White, C. L., Cairns, N. J., Nelson, P. T. & Diamond, M. I., Jan 1 2017, In : Acta Neuropathologica. 133, 1, p. 91-100 10 p.

Research output: Contribution to journalArticle

37 Scopus citations
2016

Heparan sulfate proteoglycans mediate Aβ-induced oxidative stress and hypercontractility in cultured vascular smooth muscle cells

Reynolds, M. R., Singh, I., Azad, T. D., Holmes, B. B., Verghese, P. B., Dietrich, H. H., Diamond, M., Bu, G., Han, B. H. & Zipfel, G. J., Jan 22 2016, In : Molecular Neurodegeneration. 11, 1, 9.

Research output: Contribution to journalArticle

12 Scopus citations

Neuronal activity enhances tau propagation and tau pathology in vivo

Wu, J. W., Hussaini, S. A., Bastille, I. M., Rodriguez, G. A., Mrejeru, A., Rilett, K., Sanders, D. W., Cook, C., Fu, H., Boonen, R. A. C. M., Herman, M., Nahmani, E., Emrani, S., Figueroa, Y. H., Diamond, M. I., Clelland, C. L., Wray, S. & Duff, K. E., Aug 1 2016, In : Nature Neuroscience. 19, 8, p. 1085-1092 8 p.

Research output: Contribution to journalArticle

179 Scopus citations

Prions and Protein Assemblies that Convey Biological Information in Health and Disease

Sanders, D. W., Kaufman, S. K., Holmes, B. B. & Diamond, M. I., Feb 3 2016, In : Neuron. 89, 3, p. 433-448 16 p.

Research output: Contribution to journalArticle

37 Scopus citations

Tau Prion Strains Dictate Patterns of Cell Pathology, Progression Rate, and Regional Vulnerability In Vivo

Kaufman, S. K., Sanders, D. W., Thomas, T. L., Ruchinskas, A. J., Vaquer-Alicea, J., Sharma, A. M., Miller, T. M. & Diamond, M. I., Nov 23 2016, In : Neuron. 92, 4, p. 796-812 17 p.

Research output: Contribution to journalArticle

128 Scopus citations
2015

Distinct therapeutic mechanisms of Tau antibodies: Promoting microglial clearance versus blocking neuronal uptake

Funk, K. E., Mirbaha, H., Jiang, H., Holtzman, D. M. & Diamond, M. I., Aug 28 2015, In : Journal of Biological Chemistry. 290, 35, p. 21652-21662 11 p.

Research output: Contribution to journalArticle

53 Scopus citations

N17 Modifies Mutant Huntingtin Nuclear Pathogenesis and Severity of Disease in HD BAC Transgenic Mice

Gu, X., Cantle, J. P., Greiner, E. R., Lee, C. Y. D., Barth, A. M., Gao, F., Park, C. S., Zhang, Z., Sandoval-Miller, S., Zhang, R. L., Diamond, M., Mody, I., Coppola, G. & Yang, X. W., Feb 18 2015, In : Neuron. 85, 4, p. 726-741 16 p.

Research output: Contribution to journalArticle

34 Scopus citations

Photo-activatable Cre recombinase regulates gene expression in vivo

Schindler, S. E., McCall, J. G., Yan, P., Hyrc, K. L., Li, M., Tucker, C. L., Lee, J. M., Bruchas, M. R. & Diamond, M. I., Sep 9 2015, In : Scientific Reports. 5, 13627.

Research output: Contribution to journalArticle

41 Scopus citations

Propagation of prions causing synucleinopathies in cultured cells

Woerman, A. L., Stöhr, J., Aoyagi, A., Rampersaud, R., Krejciova, Z., Watts, J. C., Ohyama, T., Patel, S., Widjaja, K., Oehler, A., Sanders, D. W., Diamond, M. I., Seeley, W. W., Middleton, L. T., Gentleman, S. M., Mordes, D. A., Südhof, T. C., Giles, K. & Prusiner, S. B., Sep 1 2015, In : Proceedings of the National Academy of Sciences of the United States of America. 112, 35, p. E4949-E4958

Research output: Contribution to journalArticle

98 Scopus citations

Sensitive detection of proteopathic seeding activity with FRET flow cytometry

Furman, J. L., Holmes, B. B. & Diamond, M. I., Dec 8 2015, In : Journal of Visualized Experiments. 2015, 106, e53205.

Research output: Contribution to journalArticle

20 Scopus citations

Subcellular localization and Ser-137 phosphorylation regulate tumor-suppressive activity of Profilin-1

Diamond, M. I., Cai, S., Boudreau, A., Carey, C. J., Lyle, N., Pappu, R. V., Swamidass, S. J., Bissell, M., Piwnica-Worms, H. & Shao, J., Apr 3 2015, In : Journal of Biological Chemistry. 290, 14, p. 9075-9086 12 p.

Research output: Contribution to journalArticle

7 Scopus citations

Tau trimers are the minimal propagation unit spontaneously internalized to seed intracellular aggregation

Mirbaha, H., Holmes, B. B., Sanders, D. W., Bieschke, J. & Diamond, M. I., Jun 12 2015, In : Journal of Biological Chemistry. 290, 24, p. 14893-14903 11 p.

Research output: Contribution to journalArticle

90 Scopus citations

The green tea polyphenol (-)-epigallocatechin gallate prevents the aggregation of tau protein into toxic oligomers at substoichiometric ratios

Wobst, H. J., Sharma, A., Diamond, M. I., Wanker, E. E. & Bieschke, J., Feb 2 2015, In : FEBS Letters. 589, 1, p. 77-83 7 p.

Research output: Contribution to journalArticle

69 Scopus citations
2014

Distinct tau prion strains propagate in cells and mice and define different tauopathies

Sanders, D. W., Kaufman, S. K., DeVos, S. L., Sharma, A. M., Mirbaha, H., Li, A., Barker, S. J., Foley, A. C., Thorpe, J. R., Serpell, L. C., Miller, T. M., Grinberg, L. T., Seeley, W. W. & Diamond, M. I., Jun 18 2014, In : Neuron. 82, 6, p. 1271-1288 18 p.

Research output: Contribution to journalArticle

413 Scopus citations

Inhibition of the androgen receptor by mineralocorticoids at levels physiologically achieved in serum in patients treated with abiraterone acetate

Kim, W., Jones, J. O., Diamond, M., Haqq, C., Molina, A., Small, E. J. & Ryan, C. J., Jul 2014, In : Prostate Cancer and Prostatic Diseases. 17, 3, p. 292-299 8 p.

Research output: Contribution to journalArticle

6 Scopus citations

Prion-like nuclear aggregation of TDP-43 during heat shock is regulated by HSP40/70 chaperones

Udan-Johns, M., Bengoechea, R., Bell, S., Shao, J., Diamond, M. I., True, H. L., Weihl, C. C. & Baloh, R. H., Jan 1 2014, In : Human molecular genetics. 23, 1, p. 157-170 14 p., ddt408.

Research output: Contribution to journalArticle

52 Scopus citations

Proteopathic tau seeding predicts tauopathy in vivo

Holmes, B. B., Furman, J. L., Mahan, T. E., Yamasaki, T. R., Mirbaha, H., Eades, W. C., Belaygorod, L., Cairns, N. J., Holtzman, D. M. & Diamond, M. I., Oct 14 2014, In : Proceedings of the National Academy of Sciences of the United States of America. 111, 41, p. E4376-E4385

Research output: Contribution to journalArticle

165 Scopus citations
2013

An N-terminal nuclear export signal regulates trafficking and aggregation of huntingtin (Htt) protein exon 1

Zheng, Z., Li, A., Holmes, B. B., Marasa, J. C. & Diamond, M. I., Mar 1 2013, In : Journal of Biological Chemistry. 288, 9, p. 6063-6071 9 p.

Research output: Contribution to journalArticle

38 Scopus citations

Anti-tau antibodies that block tau aggregate seeding invitro markedly decrease pathology and improve cognition in vivo

Yanamandra, K., Kfoury, N., Jiang, H., Mahan, T. E., Ma, S., Maloney, S. E., Wozniak, D. F., Diamond, M. I. & Holtzman, D. M., Oct 16 2013, In : Neuron. 80, 2, p. 402-414 13 p.

Research output: Contribution to journalArticle

292 Scopus citations

Heparan sulfate proteoglycans mediate internalization and propagation of specific proteopathic seeds

Holmes, B. B., DeVos, S. L., Kfoury, N., Li, M., Jacks, R., Yanamandra, K., Ouidja, M. O., Brodsky, F. M., Marasa, J., Bagchi, D. P., Kotzbauer, P. T., Miller, T. M., Papy-Garcia, D. & Diamond, M. I., Aug 13 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 33, p. E3138-E3147

Research output: Contribution to journalArticle

321 Scopus citations

Intravitreal Administration of HA-1077, a ROCK Inhibitor, Improves Retinal Function in a Mouse Model of Huntington Disease

Li, M., Yasumura, D., Ma, A. A. K., Matthes, M. T., Yang, H., Nielson, G., Huang, Y., Szoka, F. C., LaVail, M. M. & Diamond, M. I., Feb 11 2013, In : PloS one. 8, 2, e56026.

Research output: Contribution to journalArticle

26 Scopus citations
2012

An aggregation sensing reporter identifies leflunomide and teriflunomide as polyglutamine aggregate inhibitors

Fuentealba, R. A., Marasa, J., Diamond, M. I., Piwnica-Worms, D. & Weihl, C. C., Feb 1 2012, In : Human molecular genetics. 21, 3, p. 664-680 17 p., ddr500.

Research output: Contribution to journalArticle

27 Scopus citations

Huntington disease and the huntingtin protein

Zheng, Z. & Diamond, M. I., 2012, In : Progress in Molecular Biology and Translational Science. 107, p. 189-214 26 p.

Research output: Contribution to journalArticle

56 Scopus citations

Protein phosphatase 1 dephosphorylates profilin-1 at ser-137

Shao, J. & Diamond, M. I., Mar 30 2012, In : PloS one. 7, 3, e32802.

Research output: Contribution to journalArticle

8 Scopus citations

Trans-cellular propagation of Tau aggregation by fibrillar species

Kfoury, N., Holmes, B. B., Jiang, H., Holtzman, D. M. & Diamond, M. I., Jun 1 2012, In : Journal of Biological Chemistry. 287, 23, p. 19440-19451 12 p.

Research output: Contribution to journalArticle

300 Scopus citations
2011

In vivo microdialysis reveals age-dependent decrease of brain interstitial fluid tau levels in P301S human tau transgenic mice

Yamada, K., Cirrito, J. R., Stewart, F. R., Jiang, H., Finn, M. B., Holmes, B. B., Binder, L. I., Mandelkow, E. M., Diamond, M. I., Lee, V. M. Y. & Holtzman, D. M., Sep 14 2011, In : Journal of Neuroscience. 31, 37, p. 13110-13117 8 p.

Research output: Contribution to journalArticle

196 Scopus citations
2010

F-actin binding regions on the androgen receptor and huntingtin increase aggregation and alter aggregate characteristics

Angeli, S., Shao, J. & Diamond, M. I., Feb 4 2010, In : PloS one. 5, 2, e9053.

Research output: Contribution to journalArticle

21 Scopus citations

Interaction with polyglutamine aggregates reveals a Q/N-rich domain in TDP-43

Fuentealba, R. A., Udan, M., Bell, S., Wegorzewska, I., Shao, J., Diamond, M. I., Weihl, C. C. & Baloh, R. H., Aug 20 2010, In : Journal of Biological Chemistry. 285, 34, p. 26304-26314 11 p.

Research output: Contribution to journalArticle

110 Scopus citations
2009

AR inhibitors identified by high-throughput microscopy detection of conformational change and subcellular localization

Jones, J. O., An, W. F. & Diamond, M. I., Mar 20 2009, In : ACS chemical biology. 4, 3, p. 199-208 10 p.

Research output: Contribution to journalArticle

22 Scopus citations

AR inhibitors identified by high-throughput microscopy detection of conformational change and subcellular localization.

Jones, J. O., An, W. F. & Diamond, M. I., Mar 20 2009, In : ACS chemical biology. 4, 3, p. 191-197 7 p.

Research output: Contribution to journalArticle

4 Scopus citations

Conformational diversity of wild-type tau fibrils specified by templated conformation change

Frost, B., Ollesch, J., Wille, H. & Diamond, M. I., Feb 6 2009, In : Journal of Biological Chemistry. 284, 6, p. 3546-3551 6 p.

Research output: Contribution to journalArticle

138 Scopus citations

Discovery of selective glucocorticoid receptor modulators by multiplexed reporter screening

Gerber, A. N., Masuno, K. & Diamond, M. I., Mar 24 2009, In : Proceedings of the National Academy of Sciences of the United States of America. 106, 12, p. 4929-4934 6 p.

Research output: Contribution to journalArticle

20 Scopus citations

Non-competitive androgen receptor inhibition in vitro and in vivo

Jones, J. O., Bolton, E. C., Huang, Y., Feau, C., Guy, R. K., Yamamoto, K. R., Hann, B. & Diamond, M. I., Apr 28 2009, In : Proceedings of the National Academy of Sciences of the United States of America. 106, 17, p. 7233-7238 6 p.

Research output: Contribution to journalArticle

67 Scopus citations

Propagation of Tau misfolding from the outside to the inside of a cell

Frost, B., Jacks, R. L. & Diamond, M. I., May 8 2009, In : Journal of Biological Chemistry. 284, 19, p. 12845-12852 8 p.

Research output: Contribution to journalArticle

659 Scopus citations

The expanding realm of prion phenomena in neurodegenerative disease

Frost, B. & Diamond, M. I., Apr 2009, In : Prion. 3, 2, p. 23-26 4 p.

Research output: Contribution to journalArticle