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CRI-Lab Sihan Wu

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  • 2023

    Extrachromosomal DNA in the cancerous transformation of Barrett’s oesophagus

    Luebeck, J., Ng, A. W. T., Galipeau, P. C., Li, X., Sanchez, C. A., Katz-Summercorn, A. C., Kim, H., Jammula, S., He, Y., Lippman, S. M., Verhaak, R. G. W., Maley, C. C., Alexandrov, L. B., Reid, B. J., Fitzgerald, R. C., Paulson, T. G., Chang, H. Y., Wu, S., Bafna, V. & Mischel, P. S., Apr 27 2023, In: Nature. 616, 7958, p. 798-805 8 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    12 Scopus citations
  • 2022

    Systematic discovery and functional dissection of enhancers needed for cancer cell fitness and proliferation

    Chen, P. B., Fiaux, P. C., Zhang, K., Li, B., Kubo, N., Jiang, S., Hu, R., Rooholfada, E., Wu, S., Wang, M., Wang, W., McVicker, G., Mischel, P. S. & Ren, B., Nov 8 2022, In: Cell Reports. 41, 6, 111630.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    3 Scopus citations

  • The evolutionary dynamics of extrachromosomal DNA in human cancers

    Lange, J. T., Rose, J. C., Chen, C. Y., Pichugin, Y., Xie, L., Tang, J., Hung, K. L., Yost, K. E., Shi, Q., Erb, M. L., Rajkumar, U., Wu, S., Taschner-Mandl, S., Bernkopf, M., Swanton, C., Liu, Z., Huang, W., Chang, H. Y., Bafna, V., Henssen, A. G., & 2 othersWerner, B. & Mischel, P. S., Oct 2022, In: Nature genetics. 54, 10, p. 1527-1533 7 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    26 Scopus citations
  • 2021

    ecDNA hubs drive cooperative intermolecular oncogene expression

    Hung, K. L., Yost, K. E., Xie, L., Shi, Q., Helmsauer, K., Luebeck, J., Schöpflin, R., Lange, J. T., Chamorro González, R., Weiser, N. E., Chen, C., Valieva, M. E., Wong, I. T. L., Wu, S., Dehkordi, S. R., Duffy, C. V., Kraft, K., Tang, J., Belk, J. A., Rose, J. C., & 14 othersCorces, M. R., Granja, J. M., Li, R., Rajkumar, U., Friedlein, J., Bagchi, A., Satpathy, A. T., Tjian, R., Mundlos, S., Bafna, V., Henssen, A. G., Mischel, P. S., Liu, Z. & Chang, H. Y., Dec 23 2021, In: Nature. 600, 7890, p. 731-736 6 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    99 Scopus citations

  • Extrachromosomal DNA: An Emerging Hallmark in Human Cancer

    Wu, S., Bafna, V., Chang, H. Y. & Mischel, P. S., 2021, In: Annual Review of Pathology: Mechanisms of Disease. 17, p. 367-386 20 p.

    Research output: Contribution to journal › Review article › peer-review

    Open Access
    36 Scopus citations

  • Targeting glioblastoma signaling and metabolism with a re-purposed brain-penetrant drug

    Bi, J., Khan, A., Tang, J., Armando, A. M., Wu, S., Zhang, W., Gimple, R. C., Reed, A., Jing, H., Koga, T., Wong, I. T. L., Gu, Y., Miki, S., Yang, H., Prager, B., Curtis, E. J., Wainwright, D. A., Furnari, F. B., Rich, J. N., Cloughesy, T. F., & 5 othersKornblum, H. I., Quehenberger, O., Rzhetsky, A., Cravatt, B. F. & Mischel, P. S., Nov 2 2021, In: Cell Reports. 37, 5, 109957.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    35 Scopus citations