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2017

Racial and Ethnic Disparities in Parental Refusal of Consent in a Large, Multisite Pediatric Critical Care Clinical Trial

Natale, J. E., Lebet, R., Joseph, J. G., Ulysse, C., Ascenzi, J., Wypij, D., Curley, M. A. Q., Curley, M. A. Q., Wypij, D., Allen, G. L., Angus, D. C., Asaro, L. A., Ascenzi, J. A., Bateman, S. T., Borasino, S., Bowens, C. D., Bysani, G. K., Cheifetz, I. M., Cowl, A. S., Dodson, B. L. & 27 others, Faustino, E. V. S., Fineman, L. D., Flori, H. R., Franck, L. S., Gedeit, R. G., Grant, M. J. C., Harabin, A. L., Haskins-Kiefer, C., Hertzog, J. H., Hutchins, L., Kirby, A. L., Lebet, R. M., Matthay, M. A., McLaughlin, G. E., Natale, J. E., Oren, P. P., Polavarapu, N., Schneider, J. B., Schwarz, A. J., Shanley, T. P., Simone, S., Singer, L. P., Sorce, L. R., Truemper, E. J., Vander Heyden, M. A., Watson, R. S. & Wells, C. R., May 1 2017, In : Journal of Pediatrics. 184, p. 204-208.e1

Research output: Contribution to journalArticle

4 Scopus citations

Therapeutic Hypothermia after In-Hospital Cardiac Arrest in Children

THAPCA Trial Investigators, Jan 26 2017, In : New England Journal of Medicine. 376, 4, p. 318-329 12 p.

Research output: Contribution to journalArticle

105 Scopus citations

Tight glycemic control in critically Ill children

Agus, M. S. D., Wypij, D., Hirshberg, E. L., Srinivasan, V., Faustino, E. V., Luckett, P. M., Alexander, J. L., Asaro, L. A., Curley, M. A. Q., Steil, G. M. & Nadkarni, V. M., Feb 23 2017, In : New England Journal of Medicine. 376, 8, p. 729-741 13 p.

Research output: Contribution to journalArticle

54 Scopus citations
2016

A common genetic variant in TLR1 enhances human neutrophil priming and impacts length of intensive care stay in pediatric sepsis

Whitmore, L. C., Hook, J. S., Philiph, A. R., Hilkin, B. M., Bing, X., Ahn, C., Wong, H. R., Ferguson, P. J. & Moreland, J. G., Feb 1 2016, In : Journal of Immunology. 196, 3, p. 1376-1386 11 p.

Research output: Contribution to journalArticle

10 Scopus citations

Craniectomy and Traumatic Brain Injury in Children on Extracorporeal Membrane Oxygenation Support: Case Report and Review of the Literature

Anton-Martin, P., Braga, B., Megison, S., Journeycake, J. & Moreland, J., Oct 4 2016, (Accepted/In press) In : Pediatric Emergency Care.

Research output: Contribution to journalArticle

2 Scopus citations

Developing a Tool to Assess Placement of Central Venous Catheters in Pediatrics Patients

Fleming, G. M., Mink, R. B., Hornik, C., Emke, A. R., Green, M. L., Mason, K., Petrillo, T., Schuette, J., Tcharmtchi, M. H., Winkler, M. & Turner, D. A., Jul 1 2016, In : Journal of graduate medical education. 8, 3, p. 346-352 7 p.

Research output: Contribution to journalArticle

5 Scopus citations

Interferon Regulatory factor 6 has a protective role in the host response to endotoxic shock

Joly, S., Rhea, L., Volk, P., Moreland, J. G. & Dunnwald, M., Apr 2016, In : PloS one. 11, 4, e0152385.

Research output: Contribution to journalArticle

6 Scopus citations

Management of pediatric trauma

Committee on Pediatric Emergency Medicine, Council on Injury, Violence, and Poison Prevention, Section on Critical Care, Section on Orthopaedics, Section on Surgery, Section on Transport Medicine, Pediatric Trauma Society & Society of Trauma Nurses, Pediatric Committee, Aug 2016, In : Pediatrics. 138, 2, e20161569.

Research output: Contribution to journalArticle

8 Scopus citations

Neutrophil azurophilic granule exocytosis is primed by TNF-α and partially regulated by NADPH oxidase

Potera, R. M., Jensen, M. J., Hilkin, B. M., South, G. K., Hook, J. S., Gross, E. A. & Moreland, J. G., Nov 1 2016, In : Innate Immunity. 22, 8, p. 635-646 12 p.

Research output: Contribution to journalArticle

16 Scopus citations

Nlrp12 mutation causes C57BL/6J strain-specific defect in neutrophil recruitment

Ulland, T. K., Jain, N., Hornick, E. E., Elliott, E. I., Clay, G. M., Sadler, J. J., Mills, K. A. M., Janowski, A. M., Volk, A. P. D., Wang, K., Legge, K. L., Gakhar, L., Bourdi, M., Ferguson, P. J., Wilson, M. E., Cassel, S. L. & Sutterwala, F. S., Oct 25 2016, In : Nature communications. 7, 13180.

Research output: Contribution to journalArticle

18 Scopus citations

Perinatal chronic hypoxia induces cortical inflammation, hypomyelination, and peripheral myelin-specific t cell autoreactivity

Ortega, S. B., Kong, X., Venkataraman, R., Savedra, A. M., Kernie, S. G., Stowe, A. M. & Raman, L., Jan 1 2016, In : Journal of Leukocyte Biology. 99, 1, p. 21-29 9 p.

Research output: Contribution to journalArticle

10 Scopus citations

Pharmacokinetics and Safety of Micafungin in Infants Supported with Extracorporeal Membrane Oxygenation

Autmizguine, J., Hornik, C. P., Benjamin, D. K., Brouwer, K. L. R., Hupp, S. R., Cohen-Wolkowiez, M. & Watt, K. M., Nov 1 2016, In : Pediatric Infectious Disease Journal. 35, 11, p. 1204-1210 7 p.

Research output: Contribution to journalArticle

12 Scopus citations

Predicting outcome after pediatric traumatic brain injury by early magnetic resonance imaging lesion location and volume

Smitherman, E., Hernandez, A., Stavinoha, P. L., Huang, R., Kernie, S. G., Diaz-Arrastia, R. & Miles, D. K., Jan 1 2016, In : Journal of Neurotrauma. 33, 1, p. 35-48 14 p.

Research output: Contribution to journalArticle

14 Scopus citations

Regional cerebral abnormalities measured by frequency-domain near-infrared spectroscopy in pediatric patients during extracorporeal membrane oxygenation

Tian, F., Jenks, C., Potter, D., Miles, D. & Raman, L., Dec 2 2016, (Accepted/In press) In : ASAIO Journal.

Research output: Contribution to journalArticle

4 Scopus citations
1 Scopus citations

Use of continuous renal replacement therapy in salicylate toxicity: A case report and review of the literature

Papacostas, M. F., Hoge, M., Baum, M. & Davila, S. Z., Sep 1 2016, In : Heart and Lung: Journal of Acute and Critical Care. 45, 5, p. 460-463 4 p.

Research output: Contribution to journalArticle

2 Scopus citations

Year in review 2015: Extracorporeal membrane oxygenation

Raman, L. & Dalton, H. J., Jul 1 2016, In : Respiratory care. 61, 7, p. 986-991 6 p.

Research output: Contribution to journalArticle

13 Scopus citations
2015

Aspirin resistance in single-ventricle physiology: Aspirin prophylaxis is not adequate to inhibit platelets in the immediate postoperative period

Mir, A., Frank, S., Journeycake, J., Wolovitis, J., Guleserian, K., Heistein, L. & Lemler, M., Jun 1 2015, In : Annals of Thoracic Surgery. 99, 6, p. 2158-2164 7 p.

Research output: Contribution to journalArticle

14 Scopus citations

Early fluid accumulation in children with shock and ICU mortality: a matched case–control study

Bhaskar, P., Dhar, A. V., Thompson, M., Quigley, R. & Modem, V., Aug 24 2015, In : Intensive Care Medicine. 41, 8, p. 1445-1453 9 p.

Research output: Contribution to journalArticle

33 Scopus citations

Erythropoietin-mediated neuroprotection in a pediatric mouse model of chronic hypoxia

Chung, E., Kong, X., Goldberg, M. P., Stowe, A. M. & Raman, L., Jun 5 2015, In : Neuroscience Letters. 597, p. 54-59 6 p.

Research output: Contribution to journalArticle

7 Scopus citations

Evaluation of hematologic composition in newborn C57/BL6 mice up to day 35

White, J. R., Gong, H., Colaizy, T. T., Moreland, J. G., Flaherty, H. & Mcelroy, S. J., 2015, (Accepted/In press) In : Veterinary Clinical Pathology.

Research output: Contribution to journalArticle

9 Scopus citations

Feasibility Study Evaluating Therapeutic Hypothermia for Refractory Status Epilepticus in Children

Buttram, S. D. W., Au, A. K., Koch, J., Lidsky, K., McBain, K., O'Brien, N., Zielinski, B. A. & Bell, M. J., Dec 1 2015, In : Therapeutic hypothermia and temperature management. 5, 4, p. 198-202 5 p.

Research output: Contribution to journalArticle

4 Scopus citations
8 Scopus citations

The association of congenital heart disease with necrotizing enterocolitis in preterm infants: A birth cohort study

Motta, C., Scott, W., Mahony, L., Koch, J., Wyckoff, M., Reisch, J., Burchfield, P. J. & Brion, L. P., Nov 1 2015, In : Journal of Perinatology. 35, 11, p. 949-953 5 p.

Research output: Contribution to journalArticle

15 Scopus citations

Therapeutic hypothermia after out-of-hospital cardiac arrest in children

Moler, F. W., Silverstein, F. S., Holubkov, R., Slomine, B. S., Christensen, J. R., Nadkarni, V. M., Meert, K. L., Clark, A. E., Browning, B., Pemberton, V. L., Page, K., Shankaran, S., Hutchison, J. S., Newth, C. J. L., Bennett, K. S., Berger, J. T., Topjian, A., Pineda, J. A., Koch, J. D., Schleien, C. L. & 25 others, Dalton, H. J., Ofori-Amanfo, G., Goodman, D. M., Fink, E. L., McQuillen, P., Zimmerman, J. J., Thomas, N. J., Van Der Jagt, E. W., Porter, M. B., Meyer, M. T., Harrison, R., Pham, N., Schwarz, A. J., Nowak, J. E., Alten, J., Wheeler, D. S., Bhalala, U. S., Lidsky, K., Lloyd, E., Mathur, M., Shah, S., Wu, T., Theodorou, A. A., Sanders, R. C. & Dean, J. M., May 14 2015, In : New England Journal of Medicine. 372, 20, p. 1898-1908 11 p.

Research output: Contribution to journalArticle

222 Scopus citations

Use of nesiritide in critically ill children with biventricular dysfunction suffering from oliguria despite standard heart-failure management

Das, B. B., Koch, J., Dimas, V., Guleserian, K. & Nugent, A., Dec 23 2015, (Accepted/In press) In : Cardiology in the Young. p. 1-5 5 p.

Research output: Contribution to journalArticle

1 Scopus citations
2014

Acute upper-airway obstruction by a lingual thyroglossal duct cyst and implications for advanced airway management

Zimmerman, K. O., Hupp, S. R., Bourguet-Vincent, A., Bressler, E. A., Raynor, E. M., Turner, D. A. & Rehder, K. J., Jul 1 2014, In : Respiratory care. 59, 7, p. e98-e102

Research output: Contribution to journalArticle

4 Scopus citations

Inpatient bronchiolitis guideline implementation and resource utilization

Mittal, V., Bowens, C. D., Walsh, B., Mehta, A., Badawy, M. K., Morse, R. B., Pop, R., Tidwell, J., Sheehan, M., McDermott, S., Cannon, C. & Kahn, J., Jan 1 2014, In : Pediatrics. 133, 3, p. e730-e737

Research output: Contribution to journalArticle

48 Scopus citations

NOX2 protects against progressive lung injury and multiple organ dysfunction syndrome

Whitmore, L. C., Goss, K. L., Newell, E. A., Hilkin, B. M., Hook, J. S. & Moreland, J. G., Jul 1 2014, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 307, 1, p. L71-L82

Research output: Contribution to journalArticle

14 Scopus citations

The oxygen-rich postnatal environment induces cardiomyocyte cell-cycle arrest through DNA damage response

Puente, B. N., Kimura, W., Muralidhar, S. A., Moon, J., Amatruda, J. F., Phelps, K. L., Grinsfelder, D., Rothermel, B. A., Chen, R., Garcia, J. A., Santos, C. X., Thet, S., Mori, E., Kinter, M. T., Rindler, P. M., Zacchigna, S., Mukherjee, S., Chen, D. J., Mahmoud, A. I., Giacca, M. & 5 others, Rabinovitch, P. S., Aroumougame, A., Shah, A. M., Szweda, L. I. & Sadek, H. A., Apr 24 2014, In : Cell. 157, 3, p. 565-579 15 p.

Research output: Contribution to journalArticle

293 Scopus citations

Timing of continuous renal replacement therapy and mortality in critically ill children

Modem, V., Thompson, M., Gollhofer, D., Dhar, A. V. & Quigley, R., Apr 2014, In : Critical care medicine. 42, 4, p. 943-953 11 p.

Research output: Contribution to journalArticle

47 Scopus citations
2013

Comparison of success rates using video laryngoscopy versus direct laryngoscopy by residents during a simulated pediatric emergency

Sylvia, M. J., Maranda, L., Harris, K. L., Thompson, J. & Walsh, B. M., Jun 1 2013, In : Simulation in Healthcare. 8, 3, p. 155-161 7 p.

Research output: Contribution to journalArticle

14 Scopus citations

Differences in medical therapy goals for children with severe traumatic brain injury - An international study

Bell, M. J., Adelson, P. D., Hutchison, J. S., Kochanek, P. M., Tasker, R. C., Vavilala, M. S., Beers, S. R., Fabio, A., Kelsey, S. F., Wisniewski, S. R., Loftis, L., Morris, K., LaRovere, K., Meyer, P., Walson, K., Exo, J., Sarnaik, A., Kilbaugh, T., Miles, D., Wainwright, M. & 26 others, Dean, N., Chima, R., Biagas, K., Peters, M., Balcells, J., Del Toledo, J. S., Robertson, C., Bailey, D., Piper, L., Tsai, W., Ragheb, J., Agbeko, R., O'Brien, N., Young, A., Thomas, N., Buttram, S., Borasino, S., Natale, J., Giza, C., Shellington, D., Stein, D., Clark, R., Au, A., Zimmerman, J., Pineda, J. & Ferrazzano, P., Oct 2013, In : Pediatric Critical Care Medicine. 14, 8, p. 811-818 8 p.

Research output: Contribution to journalArticle

47 Scopus citations

NOX2 protects against prolonged inflammation, lung injury, and mortality following systemic insults

Whitmore, L. C., Hilkin, B. M., Goss, K. L., Wahle, E. M., Colaizy, T. T., Boggiatto, P. M., Varga, S. M., Miller, F. J. & Moreland, J. G., Nov 1 2013, In : Journal of innate immunity. 5, 6, p. 565-580 16 p.

Research output: Contribution to journalArticle

21 Scopus citations

Pharmacological inhibition of the mTOR pathway impairs hippocampal development in mice

Raman, L., Kong, X. & Kernie, S. G., Apr 29 2013, In : Neuroscience Letters. 541, p. 9-14 6 p.

Research output: Contribution to journalArticle

14 Scopus citations

Tolvaptan increases serum sodium in pediatric patients with heart failure

Regen, R. B., Gonzalez, A., Zawodniak, K., Leonard, D., Quigley, R., Barnes, A. P. & Koch, J. D., Aug 1 2013, In : Pediatric Cardiology. 34, 6, p. 1463-1468 6 p.

Research output: Contribution to journalArticle

17 Scopus citations

Transepithelial migration of neutrophils into the lung requires TREM-1

Klesney-Tait, J., Keck, K., Li, X., Gilfillan, S., Otero, K., Baruah, S., Meyerholz, D. K., Varga, S. M., Knudson, C. J., Moninger, T. O., Moreland, J., Zabner, J. & Colonna, M., Jan 2 2013, In : Journal of Clinical Investigation. 123, 1, p. 138-149 12 p.

Research output: Contribution to journalArticle

86 Scopus citations
2012

Development of a bedside tool to predict time to death after withdrawal of life-sustaining therapies in infants and children

Shore, P. M., Huang, R., Roy, L., Darnell, C., Grein, H., Robertson, T. & Thompson, L., Jul 1 2012, In : Pediatric Critical Care Medicine. 13, 4, p. 415-422 8 p.

Research output: Contribution to journalArticle

14 Scopus citations

Endotoxin priming of neutrophils requires endocytosis and NADPH oxidase-dependent endosomal reactive oxygen species

Lamb, F. S., Hook, J. S., Hilkin, B. M., Huber, J. N., Volk, A. P. D. & Moreland, J. G., Apr 6 2012, In : Journal of Biological Chemistry. 287, 15, p. 12395-12404 10 p.

Research output: Contribution to journalArticle

29 Scopus citations

Paragonimus kellicotti Fluke infections in Missouri, USA

Lane, M. A., Marcos, L. A., Onen, N. F., Demertzis, L. M., Hayes, E. V., Davila, S. Z., Nurutdinova, D. R., Bailey, T. C. & Weil, G. J., Aug 1 2012, In : Emerging Infectious Diseases. 18, 8, p. 1263-1267 5 p.

Research output: Contribution to journalArticle

20 Scopus citations

The use of extracorporeal life support in adolescent amlodipine overdose

Persad, E. A., Raman, L., Thompson, M. T. & Sheeran, P. W., Oct 1 2012, In : Indian Journal of Critical Care Medicine. 16, 4, p. 204-206 3 p.

Research output: Contribution to journalArticle

6 Scopus citations
2011

A trial of methadone tapering schedules in pediatric intensive care unit patients exposed to prolonged sedative infusions

Bowens, C. D., Thompson, J. A., Thompson, M. T., Breitzka, R. L., Thompson, D. G. & Sheeran, P. W., Sep 2011, In : Pediatric Critical Care Medicine. 12, 5, p. 504-511 8 p.

Research output: Contribution to journalArticle

29 Scopus citations

Chronic hypoxia impairs murine hippocampal development and depletes the postnatal progenitor pool by attenuating mammalian target of rapamycin signaling

Raman, L., Kong, X., Gilley, J. A. & Kernie, S. G., Aug 2011, In : Pediatric Research. 70, 2, p. 159-165 7 p.

Research output: Contribution to journalArticle

13 Scopus citations

Current recommended parenteral protein intakes do not support protein synthesis in critically ill septic, insulin-resistant adolescents with tight glucose control

Verbruggen, S. C. A. T., Coss-Bu, J., Wu, M., Schierbeek, H., Joosten, K. F. M., Dhar, A., Van Goudoever, J. B. & Castillo, L., Nov 2011, In : Critical care medicine. 39, 11, p. 2518-2525 8 p.

Research output: Contribution to journalArticle

39 Scopus citations

Electrical activity of the diaphragm during extubation readiness testing in critically ill children

Wolf, G. K., Walsh, B. K., Green, M. L. & Arnold, J. H., Nov 2011, In : Pediatric Critical Care Medicine. 12, 6, p. e220-e224

Research output: Contribution to journalArticle

26 Scopus citations

Electrocardiographic guidance for the placement of gastric feeding tubes: A pediatric case series

Green, M. L., Walsh, B. K., Wolf, G. K. & Arnold, J. H., Apr 2011, In : Respiratory care. 56, 4, p. 467-471 5 p.

Research output: Contribution to journalArticle

7 Scopus citations

Potential for liver and kidney donation after circulatory death in infants and children

Shore, P. M., Huang, R., Roy, L., Darnell, C., Grein, H., Robertson, T. & Thompson, L., Sep 1 2011, In : Pediatrics. 128, 3, p. e631-e638

Research output: Contribution to journalArticle

13 Scopus citations

Priming of neutrophils and differentiated PLB-985 cells by pathophysiological concentrations of TNF-α is partially oxygen dependent

Volk, A. P. D., Barber, B. M., Goss, K. L., Ruff, J. G., Heise, C. K., Hook, J. S. & Moreland, J. G., Apr 1 2011, In : Journal of innate immunity. 3, 3, p. 298-314 17 p.

Research output: Contribution to journalArticle

25 Scopus citations

Thigh abscess due to haemophilus influenzae type f in a human immunodeficiency virus-positive child

Watson, M. E., Davila, S. Z., Burnham, C. A. D., Nguyen, V., Nelson, K. L., Smith, A. L. & Storch, G. A., Nov 1 2011, In : Infectious Diseases in Clinical Practice. 19, 6, p. e21-e23

Research output: Contribution to journalArticle

1 Scopus citations
2010

Activation of swelling-activated chloride current by tumor necrosis factor-α requires ClC-3-dependent endosomal reactive oxygen production

Matsuda, J. J., Filali, M. S., Moreland, J. G., Miller, F. J. & Lamb, F. S., Jul 23 2010, In : Journal of Biological Chemistry. 285, 30, p. 22864-22873 10 p.

Research output: Contribution to journalArticle

42 Scopus citations