Research Output

2019

Nuclear envelope–localized torsinA-LAP1 complex regulates hepatic VLDL secretion and steatosis

Shin, J. Y., Hernandez-Ono, A., Fedotova, T., Östlund, C., Lee, M. J., Gibeley, S. B., Liang, C. C., Dauer, W. T., Ginsberg, H. N. & Worman, H. J., Jan 1 2019, In : Journal of Clinical Investigation. 129, 11, p. 4885-4900 16 p.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations
2018

Model-based and model-free machine learning techniques for diagnostic prediction and classification of clinical outcomes in Parkinson's disease

Gao, C., Sun, H., Wang, T., Tang, M., Bohnen, N. I., Müller, M. L. T. M., Herman, T., Giladi, N., Kalinin, A., Spino, C., Dauer, W., Hausdorff, J. M. & Dinov, I. D., Dec 1 2018, In : Scientific reports. 8, 1, 7129.

Research output: Contribution to journalArticle

Open Access
17 Scopus citations

Regional vesicular acetylcholine transporter distribution in human brain: A [18F]fluoroethoxybenzovesamicol positron emission tomography study

Albin, R. L., Bohnen, N. I., Muller, M. L. T. M., Dauer, W. T., Sarter, M., Frey, K. A. & Koeppe, R. A., Dec 1 2018, In : Journal of Comparative Neurology. 526, 17, p. 2884-2897 14 p.

Research output: Contribution to journalArticle

3 Scopus citations

Targeting the pedunculopontine nucleus in Parkinson's disease: Time to go back to the drawing board

Albin, R. L., Surmeier, D. J., Tubert, C., Sarter, M., Müller, M. L. T. M., Bohnen, N. I. & Dauer, W. T., Dec 2018, In : Movement Disorders. 33, 12, p. 1871-1875 5 p.

Research output: Contribution to journalArticle

4 Scopus citations

TorsinA dysfunction causes persistent neuronal nuclear pore defects

Pappas, S. S., Liang, C. C., Kim, S., Rivera, C. A. O. & Dauer, W. T., Feb 1 2018, In : Human molecular genetics. 27, 3, p. 407-420 14 p.

Research output: Contribution to journalArticle

Open Access
7 Scopus citations
2017

Current Opinions and Areas of Consensus on the Role of the Cerebellum in Dystonia

Shakkottai, V. G., Batla, A., Bhatia, K., Dauer, W. T., Dresel, C., Niethammer, M., Eidelberg, D., Raike, R. S., Smith, Y., Jinnah, H. A., Hess, E. J., Meunier, S., Hallett, M., Fremont, R., Khodakhah, K., LeDoux, M. S., Popa, T., Gallea, C., Lehericy, S., Bostan, A. C. & 1 others, Strick, P. L., Apr 1 2017, In : Cerebellum. 16, 2, p. 577-594 18 p.

Research output: Contribution to journalReview article

68 Scopus citations

Eighth international chorea-acanthocytosis symposium: Summary of workshop discussion and action points

Pappas, S. S., Bonifacino, J., Danek, A., Dauer, W. T., De, M., De Franceschi, L., DiPaolo, G., Fuller, R., Haucke, V., Hermann, A., Kornmann, B., Landwehrmeyer, B., Levin, J., Neiman, A. M., Rudnicki, D. D., Sibon, O., Velayos-Baeza, A., Vonk, J. J., Walker, R. H., Weisman, L. S. & 1 others, Albin, R. L., Jan 1 2017, In : Tremor and Other Hyperkinetic Movements. 7

Research output: Contribution to journalArticle

4 Scopus citations

Forebrain knock-out of torsinA reduces striatal free-water and impairs whole-brain functional connectivity in a symptomatic mouse model of DYT1 dystonia

DeSimone, J. C., Pappas, S. S., Febo, M., Burciu, R. G., Shukla, P., Colon-Perez, L. M., Dauer, W. T. & Vaillancourt, D. E., Oct 2017, In : Neurobiology of Disease. 106, p. 124-132 9 p.

Research output: Contribution to journalArticle

4 Scopus citations
2016

Predictive big data analytics: A study of Parkinson's disease using large, complex, heterogeneous, incongruent, multi-source and incomplete observations

Dinov, I. D., Heavner, B., Tang, M., Glusman, G., Chard, K., Darcy, M., Madduri, R., Pa, J., Spino, C., Kesselman, C., Foster, I., Deutsch, E. W., Price, N. D., Van Horn, J. D., Ames, J., Clark, K., Hood, L., Hampstead, B. M., Dauer, W. & Toga, A. W., Aug 2016, In : PloS one. 11, 8, e0157077.

Research output: Contribution to journalArticle

Open Access
38 Scopus citations
2014

Author response.

Bohnen, N., Sarter, M., Muller, M., Dauer, W. & Albin, R., Apr 29 2014, In : Neurology. 82, 17, p. 1568-1569 2 p.

Research output: Contribution to journalComment/debate

Depletion of lamina-associated polypeptide 1 from cardiomyocytes causes cardiac dysfunction in mice

Shin, J. Y., Le Dour, C., Sera, F., Iwata, S., Homma, S., Joseph, L. C., Morrow, J. P., Dauer, W. T. & Worman, H. J., May 23 2014, In : Nucleus (United States). 5, 3

Research output: Contribution to journalArticle

Open Access
8 Scopus citations

Inherited Isolated Dystonia: Clinical Genetics and Gene Function

Dauer, W., Oct 18 2014, In : Neurotherapeutics. 11, 4, p. 807-816 10 p.

Research output: Contribution to journalReview article

16 Scopus citations

Lamina-associated polypeptide 1: Protein interactions and tissue-selective functions

Shin, J. Y., Dauer, W. T. & Worman, H. J., May 2014, In : Seminars in Cell and Developmental Biology. 29, p. 164-168 5 p.

Research output: Contribution to journalReview article

12 Scopus citations

Magic shotgun for Parkinson's disease?

Albin, R. L. & Dauer, W. T., May 2014, In : Brain. 137, 5, p. 1274-1275 2 p.

Research output: Contribution to journalComment/debate

Open Access
3 Scopus citations

Mouse models of neurodevelopmental disease of the basal ganglia and associated circuits

Pappas, S. S., Leventhal, D. K., Albin, R. L. & Dauer, W. T., 2014, Current Topics in Developmental Biology. Academic Press Inc., p. 97-169 73 p. (Current Topics in Developmental Biology; vol. 109).

Research output: Chapter in Book/Report/Conference proceedingChapter

20 Scopus citations

Multiplying messages LRRK beneath parkinson disease

Dauer, W. T. & Guo, M., Apr 10 2014, In : Cell. 157, 2, p. 291-293 3 p.

Research output: Contribution to journalShort survey

Open Access

Neurogenetic Disease: Genes, Mechanisms, and Future Promise

Dauer, W. T., Oct 18 2014, In : Neurotherapeutics. 11, 4, p. 697-698 2 p.

Research output: Contribution to journalEditorial

1 Scopus citations

Nuclear envelope breakdown induced by herpes simplex virus type 1 involves the activity of viral fusion proteins

Maric, M., Haugo, A. C., Dauer, W., Johnson, D. & Roller, R. J., Jul 2014, In : Virology. 460-461, 1, p. 128-137 10 p.

Research output: Contribution to journalArticle

Open Access
12 Scopus citations

Parkinsons disease: What role do pedunculopontine cholinergic neurons play?

Bohnen, N. I., Müller, M. L., Dauer, W. T. & Albin, R. L., Jan 1 2014, In : Future Neurology. 9, 1, p. 5-8 4 p.

Research output: Contribution to journalReview article

3 Scopus citations

The Nuclear Envelope: An Intriguing Focal Point for Neurogenetic Disease

Worman, H. J. & Dauer, W. T., Oct 18 2014, In : Neurotherapeutics. 11, 4, p. 764-772 9 p.

Research output: Contribution to journalReview article

12 Scopus citations

TorsinA hypofunction causes abnormal twisting movements and sensorimotor circuit neurodegeneration

Liang, C. C., Tanabe, L. M., Jou, S., Chi, F. & Dauer, W. T., Jul 1 2014, In : Journal of Clinical Investigation. 124, 7, p. 3080-3092 13 p.

Research output: Contribution to journalArticle

Open Access
73 Scopus citations
2013

Emerging common molecular pathways for primary dystonia

Ledoux, M. S., Dauer, W. T. & Warner, T. T., Jun 15 2013, In : Movement Disorders. 28, 7, p. 968-981 14 p.

Research output: Contribution to journalReview article

26 Scopus citations

Interplay of LRRK2 with chaperone-mediated autophagy

Orenstein, S. J., Kuo, S. H., Tasset, I., Arias, E., Koga, H., Fernandez-Carasa, I., Cortes, E., Honig, L. S., Dauer, W., Consiglio, A., Raya, A., Sulzer, D. & Cuervo, A. M., Apr 1 2013, In : Nature neuroscience. 16, 4, p. 394-406 13 p.

Research output: Contribution to journalArticle

305 Scopus citations

Lamina-associated polypeptide-1 interacts with the muscular dystrophy protein emerin and is essential for skeletal muscle maintenance

Shin, J. Y., Méndez-López, I., Wang, Y., Hays, A. P., Tanji, K., Lefkowitch, J. H., Schulze, P. C., Worman, H. J. & Dauer, W. T., Sep 30 2013, In : Developmental cell. 26, 6, p. 591-603 13 p.

Research output: Contribution to journalArticle

Open Access
43 Scopus citations

The Nuclear Envelope Protein, LAP1B, Is a Novel Protein Phosphatase 1 Substrate

Santos, M., Rebelo, S., Van Kleeff, P. J. M., Kim, C. E., Dauer, W. T., Fardilha, M., da Cruz e Silva, O. A. & da Cruz e Silva, E. F., Oct 7 2013, In : PloS one. 8, 10, e76788.

Research output: Contribution to journalArticle

Open Access
16 Scopus citations
2012

Genetic background modulates the phenotype of a mouse model of dyt1 dystonia

Tanabe, L. M., Martin, C. & Dauer, W. T., Feb 29 2012, In : PloS one. 7, 2, e32245.

Research output: Contribution to journalArticle

Open Access
33 Scopus citations

Laminopathies

Dauer, W. T. & Worman, H. J., Jan 1 2012, New-Opathies: An Emerging Molecular Reclassification of Human Disease. World Scientific Publishing Co., p. 1-21 21 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Leucine-rich repeat kinase 2 for beginners: Six key questions

Kett, L. R. & Dauer, W. T., Mar 2012, In : Cold Spring Harbor Perspectives in Medicine. 2, 3

Research output: Contribution to journalArticle

Open Access
22 Scopus citations

LRRK2 Parkinson disease mutations enhance its microtubule association

Kett, L. R., Boassa, D., Ho, C. C. Y., Rideout, H. J., Hu, J., Terada, M., Ellisman, M. & Dauer, W. T., Feb 1 2012, In : Human molecular genetics. 21, 4, p. 890-899 10 p., ddr526.

Research output: Contribution to journalArticle

Open Access
87 Scopus citations

Parkinson syndrome: Heterogeneity of etiology; heterogeneity of pathogenesis?

Albin, R. L. & Dauer, W. T., Jul 17 2012, In : Neurology. 79, 3, p. 202-203 2 p.

Research output: Contribution to journalEditorial

9 Scopus citations
2011

Cerebellothalamocortical pathway abnormalities in torsinA DYT1 knock-in mice

Uluǧ, A. M., Vo, A., Argyelan, M., Tanabe, L., Schiffer, W. K., Dewey, S., Dauer, W. T. & Eidelberg, D., Apr 19 2011, In : Proceedings of the National Academy of Sciences of the United States of America. 108, 16, p. 6638-6643 6 p.

Research output: Contribution to journalArticle

Open Access
77 Scopus citations

Lethal toxicity caused by expression of shRNA in the mouse striatum: Implications for therapeutic design

Martin, J. N., Wolken, N., Brown, T., Dauer, W. T., Ehrlich, M. E. & Gonzalez-Alegre, P., Jul 1 2011, In : Gene Therapy. 18, 7, p. 666-673 8 p.

Research output: Contribution to journalArticle

Open Access
64 Scopus citations

Targeted disruption of neuronal 19S proteasome subunits induces the formation of ubiquitinated inclusions in the absence of cell death

Droggiti, A., Ho, C. C. Y., Stefanis, L., Dauer, W. T. & Rideout, H. J., Nov 1 2011, In : Journal of Neurochemistry. 119, 3, p. 630-643 14 p.

Research output: Contribution to journalArticle

5 Scopus citations
2010

A molecular mechanism underlying the neural-specific defect in torsinA mutant mice

Kim, C. E., Perez, A., Perkins, G., Ellisman, M. H. & Dauer, W. T., May 25 2010, In : Proceedings of the National Academy of Sciences of the United States of America. 107, 21, p. 9861-9866 6 p.

Research output: Contribution to journalArticle

86 Scopus citations

Contextual automated 3D analysis of subcellular organelles adapted to high-content screening

Dorval, T., Ogier, A., Genovesio, A., Hye Kuyon Lim, K. L., Do Yoon Kwon, Y. K., Lee, J. H., Worman, H. J., Dauer, W. & Grailhe, R., Aug 1 2010, In : Journal of Biomolecular Screening. 15, 7, p. 847-857 11 p.

Research output: Contribution to journalArticle

11 Scopus citations

New messages in the nuclear envelope.

Dauer, W. T. & Worman, H. J., Feb 1 2010, In : Cell cycle (Georgetown, Tex.). 9, 4, p. 645-646 2 p.

Research output: Contribution to journalComment/debate

4 Scopus citations

The biology and pathology of the familial Parkinson's disease protein LRRK2

Dauer, W. & Ho, C. C. Y., Dec 20 2010, In : Movement Disorders. 25, SUPPL. 1, p. S40-S43

Research output: Contribution to journalArticle

17 Scopus citations
2009

Primary dystonia: Molecules and mechanisms

Tanabe, L. M., Kim, C. E., Alagem, N. & Dauer, W. T., Oct 14 2009, In : Nature Reviews Neurology. 5, 11, p. 598-609 12 p.

Research output: Contribution to journalReview article

108 Scopus citations

The Nuclear Envelope as a Signaling Node in Development and Disease

Dauer, W. T. & Worman, H. J., Nov 17 2009, In : Developmental cell. 17, 5, p. 626-638 13 p.

Research output: Contribution to journalReview article

Open Access
151 Scopus citations

The Parkinson disease protein leucine-rich repeat kinase 2 transduces death signals via Fas-associated protein with death domain and caspase-8 in a cellular model of neurodegeneration

Ho, C. C. Y., Rideout, H. J., Ribe, E., Troy, C. M. & Dauer, W. T., Jan 28 2009, In : Journal of Neuroscience. 29, 4, p. 1011-1016 6 p.

Research output: Contribution to journalArticle

Open Access
117 Scopus citations

The WD40 domain is required for LRRK2 neurotoxicity

Jorgensen, N. D., Peng, Y., Ho, C. C. Y., Rideout, H. J., Petrey, D., Liu, P. & Dauer, W. T., Dec 1 2009, In : PloS one. 4, 12, e8463.

Research output: Contribution to journalArticle

Open Access
70 Scopus citations

Transcriptional and proteomic profiling in a cellular model of DYT1 dystonia

Martin, J. N., Bair, T. B., Bode, N., Dauer, W. T. & Gonzalez-Alegre, P., Dec 1 2009, In : Neuroscience. 164, 2, p. 563-572 10 p.

Research output: Contribution to journalArticle

17 Scopus citations
2008

A critical evaluation of the Braak staging scheme for Parkinson's disease

Burke, R. E., Dauer, W. T. & Vonsattel, J. P. G., Nov 1 2008, In : Annals of Neurology. 64, 5, p. 485-491 7 p.

Research output: Contribution to journalReview article

221 Scopus citations

Dopamine-modified α-synuclein blocks chaperone-mediated autophagy

Martinez-Vicente, M., Talloczy, Z., Kaushik, S., Massey, A. C., Mazzulli, J., Mosharov, E. V., Hodara, R., Fredenburg, R., Wu, D. C., Follenzi, A., Dauer, W., Przedborski, S., Ischiropoulos, H., Lansbury, P. T., Sulzer, D. & Cuervo, A. M., Feb 1 2008, In : Journal of Clinical Investigation. 118, 2, p. 777-778 2 p.

Research output: Contribution to journalArticle

Open Access
431 Scopus citations

Overview: Rodent and fish models of Parkinson's disease

Dauer, W., Dec 1 2008, Parkinson's Disease. Elsevier Inc., p. 219-223 5 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

The kinase domain of mitochondrial PINK1 faces the cytoplasm

Zhou, C., Huang, Y., Shao, Y., May, J., Prou, D., Perier, C., Dauer, W., Schon, E. A. & Przedborski, S., Aug 19 2008, In : Proceedings of the National Academy of Sciences of the United States of America. 105, 33, p. 12022-12027 6 p.

Research output: Contribution to journalArticle

Open Access
237 Scopus citations

Thymidine kinase 2 (H126N) knockin mice show the essential role of balanced deoxynucleotide pools for mitochondrial DNA maintenance

Akman, H. O., Dorado, B., López, L. C., García-Cazorla, Á., Vilà, M. R., Tanabe, L. M., Dauer, W. T., Bonilla, E., Tanji, K. & Hirano, M., Aug 1 2008, In : Human molecular genetics. 17, 16, p. 2433-2440 8 p.

Research output: Contribution to journalArticle

Open Access
74 Scopus citations
2007
4 Scopus citations

The roles of kinases in familial Parkinson's disease

Cookson, M. R., Dauer, W., Dawson, T., Fon, E. A., Guo, M. & Shen, J., Oct 31 2007, In : Journal of Neuroscience. 27, 44, p. 11865-11868 4 p.

Research output: Contribution to journalArticle

Open Access
40 Scopus citations

α-Synuclein involvement in hippocampal synaptic plasticity: Role of NO, cGMP, cGK and CaMKII

Liu, S., Fa, M., Ninan, I., Trinchese, F., Dauer, W. & Arancio, O., Jun 1 2007, In : European Journal of Neuroscience. 25, 12, p. 3583-3596 14 p.

Research output: Contribution to journalArticle

29 Scopus citations