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2019

Nuclear envelope–localized torsinA-LAP1 complex regulates hepatic VLDL secretion and steatosis

Shin, J. Y., Hernandez-Ono, A., Fedotova, T., Östlund, C., Lee, M. J., Gibeley, S. B., Liang, C. C., Dauer, W. T., Ginsberg, H. N. & Worman, H. J., Jan 1 2019, In : Journal of Clinical Investigation. 129, 11, p. 4885-4900 16 p.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations
2018

Model-based and model-free machine learning techniques for diagnostic prediction and classification of clinical outcomes in Parkinson's disease

Gao, C., Sun, H., Wang, T., Tang, M., Bohnen, N. I., Müller, M. L. T. M., Herman, T., Giladi, N., Kalinin, A., Spino, C., Dauer, W., Hausdorff, J. M. & Dinov, I. D., Dec 1 2018, In : Scientific reports. 8, 1, 7129.

Research output: Contribution to journalArticle

Open Access
17 Scopus citations

Regional vesicular acetylcholine transporter distribution in human brain: A [18F]fluoroethoxybenzovesamicol positron emission tomography study

Albin, R. L., Bohnen, N. I., Muller, M. L. T. M., Dauer, W. T., Sarter, M., Frey, K. A. & Koeppe, R. A., Dec 1 2018, In : Journal of Comparative Neurology. 526, 17, p. 2884-2897 14 p.

Research output: Contribution to journalArticle

3 Scopus citations

Targeting the pedunculopontine nucleus in Parkinson's disease: Time to go back to the drawing board

Albin, R. L., Surmeier, D. J., Tubert, C., Sarter, M., Müller, M. L. T. M., Bohnen, N. I. & Dauer, W. T., Dec 2018, In : Movement Disorders. 33, 12, p. 1871-1875 5 p.

Research output: Contribution to journalArticle

4 Scopus citations

TorsinA dysfunction causes persistent neuronal nuclear pore defects

Pappas, S. S., Liang, C. C., Kim, S., Rivera, C. A. O. & Dauer, W. T., Feb 1 2018, In : Human molecular genetics. 27, 3, p. 407-420 14 p.

Research output: Contribution to journalArticle

Open Access
7 Scopus citations
2017

Eighth international chorea-acanthocytosis symposium: Summary of workshop discussion and action points

Pappas, S. S., Bonifacino, J., Danek, A., Dauer, W. T., De, M., De Franceschi, L., DiPaolo, G., Fuller, R., Haucke, V., Hermann, A., Kornmann, B., Landwehrmeyer, B., Levin, J., Neiman, A. M., Rudnicki, D. D., Sibon, O., Velayos-Baeza, A., Vonk, J. J., Walker, R. H., Weisman, L. S. & 1 others, Albin, R. L., Jan 1 2017, In : Tremor and Other Hyperkinetic Movements. 7

Research output: Contribution to journalArticle

4 Scopus citations

Forebrain knock-out of torsinA reduces striatal free-water and impairs whole-brain functional connectivity in a symptomatic mouse model of DYT1 dystonia

DeSimone, J. C., Pappas, S. S., Febo, M., Burciu, R. G., Shukla, P., Colon-Perez, L. M., Dauer, W. T. & Vaillancourt, D. E., Oct 2017, In : Neurobiology of Disease. 106, p. 124-132 9 p.

Research output: Contribution to journalArticle

4 Scopus citations
2016

Predictive big data analytics: A study of Parkinson's disease using large, complex, heterogeneous, incongruent, multi-source and incomplete observations

Dinov, I. D., Heavner, B., Tang, M., Glusman, G., Chard, K., Darcy, M., Madduri, R., Pa, J., Spino, C., Kesselman, C., Foster, I., Deutsch, E. W., Price, N. D., Van Horn, J. D., Ames, J., Clark, K., Hood, L., Hampstead, B. M., Dauer, W. & Toga, A. W., Aug 2016, In : PloS one. 11, 8, e0157077.

Research output: Contribution to journalArticle

Open Access
38 Scopus citations
2014

Depletion of lamina-associated polypeptide 1 from cardiomyocytes causes cardiac dysfunction in mice

Shin, J. Y., Le Dour, C., Sera, F., Iwata, S., Homma, S., Joseph, L. C., Morrow, J. P., Dauer, W. T. & Worman, H. J., May 23 2014, In : Nucleus (United States). 5, 3

Research output: Contribution to journalArticle

Open Access
8 Scopus citations

Nuclear envelope breakdown induced by herpes simplex virus type 1 involves the activity of viral fusion proteins

Maric, M., Haugo, A. C., Dauer, W., Johnson, D. & Roller, R. J., Jul 2014, In : Virology. 460-461, 1, p. 128-137 10 p.

Research output: Contribution to journalArticle

Open Access
12 Scopus citations

TorsinA hypofunction causes abnormal twisting movements and sensorimotor circuit neurodegeneration

Liang, C. C., Tanabe, L. M., Jou, S., Chi, F. & Dauer, W. T., Jul 1 2014, In : Journal of Clinical Investigation. 124, 7, p. 3080-3092 13 p.

Research output: Contribution to journalArticle

Open Access
73 Scopus citations
2013

Interplay of LRRK2 with chaperone-mediated autophagy

Orenstein, S. J., Kuo, S. H., Tasset, I., Arias, E., Koga, H., Fernandez-Carasa, I., Cortes, E., Honig, L. S., Dauer, W., Consiglio, A., Raya, A., Sulzer, D. & Cuervo, A. M., Apr 1 2013, In : Nature neuroscience. 16, 4, p. 394-406 13 p.

Research output: Contribution to journalArticle

305 Scopus citations

Lamina-associated polypeptide-1 interacts with the muscular dystrophy protein emerin and is essential for skeletal muscle maintenance

Shin, J. Y., Méndez-López, I., Wang, Y., Hays, A. P., Tanji, K., Lefkowitch, J. H., Schulze, P. C., Worman, H. J. & Dauer, W. T., Sep 30 2013, In : Developmental cell. 26, 6, p. 591-603 13 p.

Research output: Contribution to journalArticle

Open Access
43 Scopus citations

The Nuclear Envelope Protein, LAP1B, Is a Novel Protein Phosphatase 1 Substrate

Santos, M., Rebelo, S., Van Kleeff, P. J. M., Kim, C. E., Dauer, W. T., Fardilha, M., da Cruz e Silva, O. A. & da Cruz e Silva, E. F., Oct 7 2013, In : PloS one. 8, 10, e76788.

Research output: Contribution to journalArticle

Open Access
16 Scopus citations
2012

Genetic background modulates the phenotype of a mouse model of dyt1 dystonia

Tanabe, L. M., Martin, C. & Dauer, W. T., Feb 29 2012, In : PloS one. 7, 2, e32245.

Research output: Contribution to journalArticle

Open Access
33 Scopus citations

Leucine-rich repeat kinase 2 for beginners: Six key questions

Kett, L. R. & Dauer, W. T., Mar 2012, In : Cold Spring Harbor Perspectives in Medicine. 2, 3

Research output: Contribution to journalArticle

Open Access
22 Scopus citations

LRRK2 Parkinson disease mutations enhance its microtubule association

Kett, L. R., Boassa, D., Ho, C. C. Y., Rideout, H. J., Hu, J., Terada, M., Ellisman, M. & Dauer, W. T., Feb 1 2012, In : Human molecular genetics. 21, 4, p. 890-899 10 p., ddr526.

Research output: Contribution to journalArticle

Open Access
87 Scopus citations
2011

Cerebellothalamocortical pathway abnormalities in torsinA DYT1 knock-in mice

Uluǧ, A. M., Vo, A., Argyelan, M., Tanabe, L., Schiffer, W. K., Dewey, S., Dauer, W. T. & Eidelberg, D., Apr 19 2011, In : Proceedings of the National Academy of Sciences of the United States of America. 108, 16, p. 6638-6643 6 p.

Research output: Contribution to journalArticle

Open Access
77 Scopus citations

Lethal toxicity caused by expression of shRNA in the mouse striatum: Implications for therapeutic design

Martin, J. N., Wolken, N., Brown, T., Dauer, W. T., Ehrlich, M. E. & Gonzalez-Alegre, P., Jul 1 2011, In : Gene Therapy. 18, 7, p. 666-673 8 p.

Research output: Contribution to journalArticle

Open Access
64 Scopus citations

Targeted disruption of neuronal 19S proteasome subunits induces the formation of ubiquitinated inclusions in the absence of cell death

Droggiti, A., Ho, C. C. Y., Stefanis, L., Dauer, W. T. & Rideout, H. J., Nov 1 2011, In : Journal of Neurochemistry. 119, 3, p. 630-643 14 p.

Research output: Contribution to journalArticle

5 Scopus citations
2010

A molecular mechanism underlying the neural-specific defect in torsinA mutant mice

Kim, C. E., Perez, A., Perkins, G., Ellisman, M. H. & Dauer, W. T., May 25 2010, In : Proceedings of the National Academy of Sciences of the United States of America. 107, 21, p. 9861-9866 6 p.

Research output: Contribution to journalArticle

86 Scopus citations

Contextual automated 3D analysis of subcellular organelles adapted to high-content screening

Dorval, T., Ogier, A., Genovesio, A., Hye Kuyon Lim, K. L., Do Yoon Kwon, Y. K., Lee, J. H., Worman, H. J., Dauer, W. & Grailhe, R., Aug 1 2010, In : Journal of Biomolecular Screening. 15, 7, p. 847-857 11 p.

Research output: Contribution to journalArticle

11 Scopus citations

The biology and pathology of the familial Parkinson's disease protein LRRK2

Dauer, W. & Ho, C. C. Y., Dec 20 2010, In : Movement Disorders. 25, SUPPL. 1, p. S40-S43

Research output: Contribution to journalArticle

17 Scopus citations
2009

The Parkinson disease protein leucine-rich repeat kinase 2 transduces death signals via Fas-associated protein with death domain and caspase-8 in a cellular model of neurodegeneration

Ho, C. C. Y., Rideout, H. J., Ribe, E., Troy, C. M. & Dauer, W. T., Jan 28 2009, In : Journal of Neuroscience. 29, 4, p. 1011-1016 6 p.

Research output: Contribution to journalArticle

Open Access
117 Scopus citations

The WD40 domain is required for LRRK2 neurotoxicity

Jorgensen, N. D., Peng, Y., Ho, C. C. Y., Rideout, H. J., Petrey, D., Liu, P. & Dauer, W. T., Dec 1 2009, In : PloS one. 4, 12, e8463.

Research output: Contribution to journalArticle

Open Access
70 Scopus citations

Transcriptional and proteomic profiling in a cellular model of DYT1 dystonia

Martin, J. N., Bair, T. B., Bode, N., Dauer, W. T. & Gonzalez-Alegre, P., Dec 1 2009, In : Neuroscience. 164, 2, p. 563-572 10 p.

Research output: Contribution to journalArticle

17 Scopus citations
2008

Dopamine-modified α-synuclein blocks chaperone-mediated autophagy

Martinez-Vicente, M., Talloczy, Z., Kaushik, S., Massey, A. C., Mazzulli, J., Mosharov, E. V., Hodara, R., Fredenburg, R., Wu, D. C., Follenzi, A., Dauer, W., Przedborski, S., Ischiropoulos, H., Lansbury, P. T., Sulzer, D. & Cuervo, A. M., Feb 1 2008, In : Journal of Clinical Investigation. 118, 2, p. 777-778 2 p.

Research output: Contribution to journalArticle

Open Access
431 Scopus citations

The kinase domain of mitochondrial PINK1 faces the cytoplasm

Zhou, C., Huang, Y., Shao, Y., May, J., Prou, D., Perier, C., Dauer, W., Schon, E. A. & Przedborski, S., Aug 19 2008, In : Proceedings of the National Academy of Sciences of the United States of America. 105, 33, p. 12022-12027 6 p.

Research output: Contribution to journalArticle

Open Access
237 Scopus citations

Thymidine kinase 2 (H126N) knockin mice show the essential role of balanced deoxynucleotide pools for mitochondrial DNA maintenance

Akman, H. O., Dorado, B., López, L. C., García-Cazorla, Á., Vilà, M. R., Tanabe, L. M., Dauer, W. T., Bonilla, E., Tanji, K. & Hirano, M., Aug 1 2008, In : Human molecular genetics. 17, 16, p. 2433-2440 8 p.

Research output: Contribution to journalArticle

Open Access
74 Scopus citations
2007
4 Scopus citations

The roles of kinases in familial Parkinson's disease

Cookson, M. R., Dauer, W., Dawson, T., Fon, E. A., Guo, M. & Shen, J., Oct 31 2007, In : Journal of Neuroscience. 27, 44, p. 11865-11868 4 p.

Research output: Contribution to journalArticle

Open Access
40 Scopus citations

α-Synuclein involvement in hippocampal synaptic plasticity: Role of NO, cGMP, cGK and CaMKII

Liu, S., Fa, M., Ninan, I., Trinchese, F., Dauer, W. & Arancio, O., Jun 1 2007, In : European Journal of Neuroscience. 25, 12, p. 3583-3596 14 p.

Research output: Contribution to journalArticle

29 Scopus citations
2006

Cortical 5-HT2A receptor signaling modulates anxiety-like behaviors in mice

Weisstaub, N. V., Zhou, M., Lira, A., Lambe, E., González-Maeso, J., Hornung, J. P., Sibille, E., Underwood, M., Itohara, S., Dauer, W. T., Ansorge, M. S., Morelli, E., Mann, J. J., Toth, M., Aghajanian, G., Sealfon, S. C., Hen, R. & Gingrich, J. A., Jul 28 2006, In : Science. 313, 5786, p. 536-540 5 p.

Research output: Contribution to journalArticle

287 Scopus citations
2005

Loss of the dystonia-associated protein torsinA selectively disrupts the neuronal nuclear envelope

Goodchild, R. E., Kim, C. E. & Dauer, W. T., Dec 22 2005, In : Neuron. 48, 6, p. 923-932 10 p.

Research output: Contribution to journalArticle

Open Access
253 Scopus citations

The AAA+ protein torsinA interacts with a conserved domain present in LAP1 and a novel ER protein

Goodchild, R. E. & Dauer, W. T., Mar 1 2005, In : Journal of Cell Biology. 168, 6, p. 855-862 8 p.

Research output: Contribution to journalArticle

Open Access
155 Scopus citations
2004

Lack of α-synuclein does not alter apoptosis of neonatal catecholaminergic neurons

Stefanis, L., Wang, Q., Oo, T., Lang-Rollin, I., Burke, R. E. & Dauer, W. T., Oct 1 2004, In : European Journal of Neuroscience. 20, 7, p. 1969-1972 4 p.

Research output: Contribution to journalArticle

7 Scopus citations
Open Access
199 Scopus citations

Regulation of the Development of Mesencephalic Dopaminergic Systems by the Selective Expression of Glial Cell Line-Derived Neurotrophic Factor in Their Targets

Kholodilov, N., Yarygina, O., Oo, T. F., Zhang, H., Sulzer, D., Dauer, W. & Burke, R. E., Mar 24 2004, In : Journal of Neuroscience. 24, 12, p. 3136-3146 11 p.

Research output: Contribution to journalArticle

Open Access
71 Scopus citations

α-synuclein is required for the fibrillar nature of ubiquitinated inclusions induced by proteasomal inhibition in primary neurons

Rideout, H. J., Dietrich, P., Wang, Q., Dauer, W. T. & Stefanis, L., Nov 5 2004, In : Journal of Biological Chemistry. 279, 45, p. 46915-46920 6 p.

Research output: Contribution to journalArticle

Open Access
39 Scopus citations

α-synuclein produces a long-lasting increase in neurotransmitter release

Liu, S., Ninan, I., Antonova, I., Battaglia, F., Trinchese, F., Narasanna, A., Kolodilov, N., Dauer, W., Hawkins, R. D. & Arancio, O., Nov 10 2004, In : EMBO Journal. 23, 22, p. 4506-4516 11 p.

Research output: Contribution to journalArticle

130 Scopus citations
2003

Regulation of α-synuclein by bFGF in cultured ventral midbrain dopaminergic neurons

Rideout, H. J., Dietrich, P., Savalle, M., Dauer, W. T. & Stefanis, L., Feb 1 2003, In : Journal of Neurochemistry. 84, 4, p. 803-813 11 p.

Research output: Contribution to journalArticle

38 Scopus citations
2002

Resistance of α-synuclein null mice to the parkinsonian neurotoxin MPTP

Dauer, W., Kholodilov, N., Vila, M., Trillat, A. C., Goodchild, R., Larsen, K. E., Staal, R., Tieu, K., Schmitz, Y., Yuan, C. A., Rocha, M., Jackson-Lewis, V., Hersch, S., Sulzer, D., Przedborski, S., Burke, R. & Hen, R., Oct 29 2002, In : Proceedings of the National Academy of Sciences of the United States of America. 99, 22, p. 14524-14529 6 p.

Research output: Contribution to journalArticle

451 Scopus citations
1998

The diagnosis and treatment of tardive disorders

Dauer Md, W. T., Fahn Md, S. & Burke Md, R. E., Jul 1 1998, In : Medical Update for Psychiatrists. 3, 4, p. 119-125 7 p.

Research output: Contribution to journalArticle

3 Scopus citations
1994

Coordinate regulation of choline acetyltransferase, tyrosine hydroxylase, and neuropeptide mRNAs by ciliary neurotrophic factor and leukemia inhibitory factor in cultured sympathetic neurons

Lewis, S. E., Rao, M. S., Symes, A. J., Dauer, W. T., Fink, J. S., Landis, S. C. & Hyman, S. E., Aug 1 1994, In : Journal of Neurochemistry. 63, 2, p. 429-438 10 p.

Research output: Contribution to journalArticle

57 Scopus citations

Leukemia inhibitory factor and ciliary neurotrophic factor increase activated Ras in a neuroblastoma cell line and in sympathetic neuron cultures

Schwarzschild, M. A., Dauer, W. T., Lewis, S. E., Hamill, L. K., Fink, J. S. & Hyman, S. E., Oct 1 1994, In : Journal of Neurochemistry. 63, 4, p. 1246-1254 9 p.

Research output: Contribution to journalArticle

17 Scopus citations
1988

The effect of the stereoisomers of butaclamol on neurotensin content in discrete regions of the rat brain

Bissette, G., Dauer, W. T., Kilts, C. D., O'Connor, L. & Nemeroff, C. B., Dec 1 1988, In : Neuropsychopharmacology. 1, 4, p. 329-335 7 p.

Research output: Contribution to journalArticle

19 Scopus citations