Research Output

Defining the spermatogonial stem cell

Hamra, F. K., Schultz, N., Chapman, K. M., Grellhesl, D. M., Cronkhite, J. T., Hammer, R. E. & Garbers, D. L., May 15 2004, In : Developmental Biology. 269, 2, p. 393-410 18 p.

Research output: Contribution to journalArticle

114 Scopus citations

Defocused orientation and position imaging (DOPI) of myosin V

Toprak, E., Enderlein, J., Syed, S., McKinney, S. A., Petschek, R. G., Ha, T., Goldman, Y. E. & Selvin, P. R., Apr 25 2006, In : Proceedings of the National Academy of Sciences of the United States of America. 103, 17, p. 6495-6499 5 p.

Research output: Contribution to journalArticle

164 Scopus citations

Delayed commitment to evolutionary fate in antibiotic resistance fitness landscapes

Palmer, A. C., Toprak, E., Baym, M., Kim, S., Veres, A., Bershtein, S. & Kishony, R., Jun 10 2015, In : Nature Communications. 6, 7385.

Research output: Contribution to journalArticle

60 Scopus citations

Deletion of ELOVL5 leads to fatty liver through activation of SREBP-1c in mice

Moon, Y. A., Hammer, R. E. & Horton, J. D., Apr 1 2009, In : Journal of lipid research. 50, 3, p. 412-423 12 p.

Research output: Contribution to journalArticle

109 Scopus citations

Deletion of ELOVL6 blocks the synthesis of oleic acid but does not prevent the development of fatty liver or insulin resistance

Moon, Y. A., Ochoa, C. R., Mitsche, M. A., Hammer, R. E. & Horton, J. D., Jan 1 2015, In : Journal of lipid research. 55, 12, p. 2597-2605 9 p., A16.

Research output: Contribution to journalArticle

37 Scopus citations

Dependence of Mouse Embryonic Stem Cells on Threonine Catabolism

Wang, J., Alexander, P., Wu, L., Hammer, R. E., Cleaver, O. & McKnight, S. L., Jul 24 2009, In : Science. 325, 5939, p. 435-439 5 p.

Research output: Contribution to journalArticle

215 Scopus citations

Deranged calcium signaling and neurodegeneration in spinocerebellar ataxia type 3

Chen, X., Tang, T. S., Tu, H., Nelson, O., Pook, M., Hammer, R. E., Nukina, N. & Bezprozvanny, I., Nov 26 2008, In : Journal of Neuroscience. 28, 48, p. 12713-12724 12 p.

Research output: Contribution to journalArticle

147 Scopus citations

Detection of very weak side chain-main chain hydrogen bonding interactions in medium-size 13C/15N-labeled proteins by sensitivity- enhanced NMR spectroscopy

Liu, A., Hu, W., Majumdar, A., Rosen, M. K. & Patel, D. J., Jan 1 2000, In : Journal of Biomolecular NMR. 17, 1, p. 79-82 4 p.

Research output: Contribution to journalArticle

14 Scopus citations

Detergent structure in crystals of a bacterial photosynthetic reaction centre

Roth, M., Lewit-Bentley, A., Michel, H., Deisenhofer, J., Huber, R. & Oesterhelt, D., Jan 1 1989, In : Nature. 340, 6235, p. 659-662 4 p.

Research output: Contribution to journalArticle

183 Scopus citations

Determination of protein complex stoichiometry through multisignal sedimentation velocity experiments

Padrick, S. B., Deka, R. K., Chuang, J. L., Wynn, R. M., Chuang, D. T., Norgard, M. V., Rosen, M. K. & Brautigam, C. A., Dec 2010, In : Analytical biochemistry. 407, 1, p. 89-103 15 p.

Research output: Contribution to journalArticle

31 Scopus citations

Determining the secondary structure and orientation of EmrE, a multi-drug transporter, indicates a transmembrane four-helix bundle

Arkin, I. T., Russ, W. P., Lebendiker, M. & Schuldiner, S., Jun 4 1996, In : Biochemistry. 35, 22, p. 7235-7238 4 p.

Research output: Contribution to journalArticle

98 Scopus citations

Develop and test a solvent accessible surface area-based model in conformational entropy calculations

Wang, J. & Hou, T., May 25 2012, In : Journal of Chemical Information and Modeling. 52, 5, p. 1199-1212 14 p.

Research output: Contribution to journalArticle

41 Scopus citations

Developmental regulation of α-fetoprotein genes in transgenic mice

Krumlauf, R., Hammer, R. E., Tilghman, S. M. & Brinster, R. L., 1985, In : Molecular and cellular biology. 5, 7, p. 1639-1648 10 p.

Research output: Contribution to journalArticle

Open Access
76 Scopus citations

Development and testing of a general Amber force field

Wang, J., Wolf, R. M., Caldwell, J. W., Kollman, P. A. & Case, D. A., Jul 15 2004, In : Journal of Computational Chemistry. 25, 9, p. 1157-1174 18 p.

Research output: Contribution to journalArticle

7936 Scopus citations

Development of polarizable models for molecular mechanical calculations. 3. polarizable water models conforming to thole polarization screening schemes

Wang, J., Cieplak, P., Cai, Q., Hsieh, M. J., Wang, J., Duan, Y. & Luo, R., Jul 19 2012, In : Journal of Physical Chemistry B. 116, 28, p. 7999-8008 10 p.

Research output: Contribution to journalArticle

34 Scopus citations

Development of polarizable models for molecular mechanical calculations. 4. van der waals parametrization

Wang, J., Cieplak, P., Li, J., Cai, Q., Hsieh, M. J., Luo, R. & Duan, Y., Jun 21 2012, In : Journal of Physical Chemistry B. 116, 24, p. 7088-7101 14 p.

Research output: Contribution to journalArticle

29 Scopus citations

Development of polarizable models for molecular mechanical calculations I: Parameterization of atomic polarizability

Wang, J., Cieplak, P., Li, J., Hou, T., Luo, R. & Duan, Y., Mar 31 2011, In : Journal of Physical Chemistry B. 115, 12, p. 3091-3099 9 p.

Research output: Contribution to journalArticle

90 Scopus citations

Development of polarizable models for molecular mechanical calculations II: Induced dipole models significantly improve accuracy of intermolecular interaction energies

Wang, J., Cieplak, P., Li, J., Wang, J., Cai, Q., Hsieh, M., Lei, H., Luo, R. & Duan, Y., Mar 31 2011, In : Journal of Physical Chemistry B. 115, 12, p. 3100-3111 12 p.

Research output: Contribution to journalArticle

90 Scopus citations

Development of porcine ova that were centrifuged to permit visualization of pronuclei and nuclei.

Wall, R. J., Pursel, V. G., Hammer, R. E. & Brinster, R. L., Apr 1985, In : Biology of reproduction. 32, 3, p. 645-651 7 p.

Research output: Contribution to journalArticle

Open Access
100 Scopus citations

Development of reliable aqueous solubility models and their application in druglike analysis

Wang, J., Krudy, G., Hou, T., Zhang, W., Holland, G. & Xu, X., Jul 1 2007, In : Journal of Chemical Information and Modeling. 47, 4, p. 1395-1404 10 p.

Research output: Contribution to journalArticle

74 Scopus citations

dHAND-Cre transgenic mice reveal specific potential functions of dHAND during craniofacial development

Ruest, L. B., Dager, M., Yanagisawa, H., Charité, J., Hammer, R. E., Olson, E. N., Yanagisawa, M. & Clouthier, D. E., May 15 2003, In : Developmental Biology. 257, 2, p. 263-277 15 p.

Research output: Contribution to journalArticle

34 Scopus citations

DHHC5 interacts with PDZ domain 3 of post-synaptic density-95 (PSD-95) protein and plays a role in learning and memory

Li, Y., Hu, J., Höfer, K., Wong, A. M. S., Cooper, J. D., Birnbaum, S. G., Hammer, R. E. & Hofmann, S. L., Apr 23 2010, In : Journal of Biological Chemistry. 285, 17, p. 13022-13031 10 p.

Research output: Contribution to journalArticle

50 Scopus citations

Diet-induced hypercholesterolemia in mice: Prevention by overexpression of LDL receptors

Yokode, M., Hammer, R. E., Ishibashi, S., Brown, M. S. & Goldstein, J. L., Jan 1 1990, In : Science. 250, 4985, p. 1273-1275 3 p.

Research output: Contribution to journalArticle

140 Scopus citations

Differential expression of α-fetoprotein genes on the inactive X chromosome in extraembryonic and somatic tissues of a transgenic mouse line

Krumlauf, R., Chapman, V. M., Hammer, R. E., Brinster, R. & Tilghman, S. M., Dec 1 1986, In : Nature. 319, 6050, p. 224-226 3 p.

Research output: Contribution to journalArticle

42 Scopus citations

Differential regulation of ERK1/2 and mTORC1 through T1R1/T1R3 in MIN6 cells

Wauson, E. M., Guerra, M. L., Dyachok, J., McGlynn, K., Giles, J., Ross, E. M. & Cobb, M. H., Jul 31 2015, In : Molecular Endocrinology. 29, 8, p. 1114-1122 9 p.

Research output: Contribution to journalArticle

10 Scopus citations
Open Access
44 Scopus citations

Differential splicing and glycosylation of Apoer2 alters synaptic plasticity and fear learning

Wasser, C. R., Masiulis, I., Durakoglugil, M. S., Lane-Donovan, C., Xian, X., Beffert, U., Agarwala, A., Hammer, R. E. & Herz, J., Nov 25 2014, In : Science signaling. 7, 353, ra113.

Research output: Contribution to journalArticle

21 Scopus citations

Dihydrostreptomycin Directly Binds to, Modulates, and Passes through the MscL Channel Pore

Wray, R., Iscla, I., Gao, Y., Li, H., Wang, J. & Blount, P., Jun 9 2016, In : PLoS biology. 14, 6, e1002473.

Research output: Contribution to journalArticle

13 Scopus citations
466 Scopus citations

Direct demonstration of an intramolecular SH2Ôphosphotyrosine interaction in the Crk protein

Rosen, M. K., Yamazaki, T., Gish, G. D., Kay, C. M., Pawson, T. & Kay, L. E., Mar 30 1995, In : Nature. 374, 6521, p. 477-479 3 p.

Research output: Contribution to journalArticle

116 Scopus citations

Directional allosteric regulation of protein filament length

Jermyn, A. S., Cao, W., Elam, W. A., De La Cruz, E. M. & Lin, M. M., Mar 2020, In : Physical Review E. 101, 3, 032409.

Research output: Contribution to journalArticle

Discovery, Modeling, and Human Pharmacokinetics of N-(2-Acetyl-4,6-dimethylphenyl)-3-(3,4-dimethylisoxazol-5-ylsulfamoyl) -thiophene-2-carboxamide (TBC3711), a Second Generation, ETA Selective, and Orally Bioavailable Endothelin Antagonist

Wu, C., Decker, E. R., Blok, N., Bui, H., You, T. J., Wang, J., Bourgoyne, A. R., Knowles, V., Berens, K. L., Holland, G. W., Brock, T. A. & Dixon, R. A. F., Apr 8 2004, In : Journal of Medicinal Chemistry. 47, 8, p. 1969-1986 18 p.

Research output: Contribution to journalArticle

94 Scopus citations

Disregulated glyceroneogenesis: PCK1 as a candidate diabetes and obesity gene

Beale, E. G., Hammer, R. E., Antoine, B. & Forest, C., Apr 2004, In : Trends in Endocrinology and Metabolism. 15, 3, p. 129-135 7 p.

Research output: Contribution to journalReview article

80 Scopus citations

Disruption of Abcg5 and Abcg8 in mice reveals their crucial role in biliary cholesterol secretion

Yu, L., Hammer, R. E., Li-Hawkins, J., Von Bergmann, K., Lutjohann, D., Cohen, J. C. & Hobbs, H. H., Dec 10 2002, In : Proceedings of the National Academy of Sciences of the United States of America. 99, 25, p. 16237-16242 6 p.

Research output: Contribution to journalArticle

540 Scopus citations

Disruption of ECE-1 and ECE-2 reveals a role for endothelin-converting enzyme-2 in murine cardiac development

Yanagisawa, H., Hammer, R. E., Richardson, J. A., Emoto, N., Clay Williams, S., Takeda, S. I., Clouthier, D. E. & Yanagisawa, M., May 2000, In : Journal of Clinical Investigation. 105, 10, p. 1373-1382 10 p.

Research output: Contribution to journalArticle

Open Access
163 Scopus citations

Disruption of PPT1 or PPT2 causes neuronal ceroid lipofuscinosis in knockout mice

Gupta, P., Soyombo, A. A., Atashband, A., Wisniewski, K. E., Shelton, J. M., Richardson, J. A., Hammer, R. E. & Hofmann, S. L., Nov 20 2001, In : Proceedings of the National Academy of Sciences of the United States of America. 98, 24, p. 13566-13571 6 p.

Research output: Contribution to journalArticle

205 Scopus citations

Distinct Interactions Select and Maintain a Specific Cell Fate

Doncic, A., Falleur-Fettig, M. & Skotheim, J. M., Aug 19 2011, In : Molecular cell. 43, 4, p. 528-539 12 p.

Research output: Contribution to journalArticle

81 Scopus citations

Distinct narcolepsy syndromes in orexin receptor-2 and orexin null mice: Molecular genetic dissection of non-REM and REM sleep regulatory processes

Willie, J. T., Chemelli, R. M., Sinton, C. M., Tokita, S., Williams, S. C., Kisanuki, Y. Y., Marcus, J. N., Lee, C., Elmquist, J. K., Kohlmeier, K. A., Leonard, C. S., Richardson, J. A., Hammer, R. E. & Yanagisawa, M., Jun 5 2003, In : Neuron. 38, 5, p. 715-730 16 p.

Research output: Contribution to journalArticle

473 Scopus citations

Diversity of Alpha-Fetoprotein gene expression in mice is generated by a combination of separate enhancer elements

Hammer, R. E., Krumlauf, R., Camper, S. A., Brinster, R. L. & Tilghman, S. M., Jan 1 1987, In : Science. 235, 4784, p. 53-58 6 p.

Research output: Contribution to journalArticle

169 Scopus citations

Dlx5/6-Enhancer Directed Expression of Cre Recombinase in the Pharyngeal Arches and Brain

Ruest, L. B., Hammer, R. E., Yanagisawa, M. & Clouthier, D. E., Dec 1 2003, In : Genesis. 37, 4, p. 188-194 7 p.

Research output: Contribution to journalArticle

22 Scopus citations

DNA photolyases and cryptochromes

Deisenhofer, J., Aug 30 2000, In : Mutation Research - DNA Repair. 460, 3-4, p. 143-149 7 p.

Research output: Contribution to journalArticle

64 Scopus citations

Dominance of misfolded intermediates in the dynamics of α-helix folding

Lin, M. M., Shorokhov, D. & Zewail, A. H., Oct 7 2014, In : Proceedings of the National Academy of Sciences of the United States of America. 111, 40, p. 14424-14429 6 p.

Research output: Contribution to journalArticle

13 Scopus citations

Double-knockout mice for α- and β-synucleins: Effect on synaptic functions

Chandra, S., Fornai, F., Kwon, H. B., Yazdani, U., Atasoy, D., Liu, X., Hammer, R. E., Battaglia, G., German, D. C., Castillo, P. E. & Südhof, T. C., Oct 12 2004, In : Proceedings of the National Academy of Sciences of the United States of America. 101, 41, p. 14966-14971 6 p.

Research output: Contribution to journalArticle

288 Scopus citations

Dramatic growth of mice that develop from eggs microinjected with metallothionein-growth hormone fusion genes

Palmiter, R. D., Brinster, R. L., Hammer, R. E., Trumbauer, M. E., Rosenfeld, M. G., Birnberg, N. C. & Evans, R. M., Dec 1 1982, In : Nature. 300, 5893, p. 611-615 5 p.

Research output: Contribution to journalArticle

831 Scopus citations

Dramatic growth of mice that develop from eggs microinjected with metallothionein-growth hormone fusion genes. 1982.

Palmiter, R. D., Brinster, R. L., Hammer, R. E., Trumbauer, M. E., Rosenfeld, M. G., Birnberg, N. C. & Evans, R. M., Jan 1 1992, In : Biotechnology (Reading, Mass.). 24, p. 429-433 5 p.

Research output: Contribution to journalArticle

15 Scopus citations

Dramatic pituitary hyperplasia in transgenic mice expressing a human growth hormone-releasing factor gene

Mayo, K. E., Hammer, R. E., Swanson, L. W., Brinster, R. L., Rosenfeld, M. G. & Evans, R. M., Jul 1988, In : Molecular Endocrinology. 2, 7, p. 606-612 7 p.

Research output: Contribution to journalArticle

Open Access
159 Scopus citations

Drug and Drug candidate building block analysis

Wang, J. & Hou, T., Jan 25 2010, In : Journal of Chemical Information and Modeling. 50, 1, p. 55-67 13 p.

Research output: Contribution to journalArticle

66 Scopus citations

Drug-likeness analysis of traditional chinese medicines: Prediction of drug-likeness using machine learning approaches

Tian, S., Wang, J., Li, Y., Xu, X. & Hou, T., Dec 3 2012, In : Molecular Pharmaceutics. 9, 10, p. 2875-2886 12 p.

Research output: Contribution to journalArticle

59 Scopus citations
31 Scopus citations
22 Scopus citations