Research Output

Article

Crystal structure of DNA photolyase from Escherichia coli

Park, H. W., Kim, S. T., Sancar, A. & Deisenhofer, J., Jan 1 1995, In : Science. 268, 5219, p. 1866-1872 7 p.

Research output: Contribution to journalArticle

453 Scopus citations

Crystal structure of hemoprotein domain of P450BM-3, a prototype for microsomal P450's

Ravichandran, K. G., Boddupalli, S. S., Hasemann, C. A., Peterson, J. A. & Deisenhofer, J., Jan 1 1993, In : Science. 261, 5122, p. 731-736 6 p.

Research output: Contribution to journalArticle

881 Scopus citations

Crystal structure of porcine ribonuclease inhibitor, a protein with leucine-rich repeats

Kobe, B. & Delsenhofer, J., Jan 1 1993, In : Nature. 366, 6457, p. 751-756 6 p.

Research output: Contribution to journalArticle

513 Scopus citations

Crystal structure of Rab geranylgeranyltransferase at 2.0 Å resolution

Zhang, H., Seabra, M. C. & Deisenhofer, J., Mar 1 2000, In : Structure. 8, 3, p. 241-251 11 p.

Research output: Contribution to journalArticle

94 Scopus citations

Crystal structure of Spot 14, a modulator of fatty acid synthesis

Colbert, C. L., Kim, C. W., Moon, Y. A., Henry, L., Palnitkar, M., McKean, W. B., Fitzgerald, K., Deisenhofer, J., Horton, J. D. & Kwon, H. J., Nov 2 2010, In : Proceedings of the National Academy of Sciences of the United States of America. 107, 44, p. 18820-18825 6 p.

Research output: Contribution to journalArticle

39 Scopus citations

Crystal structure of the catalytic portion of human HMG-CoA reductase: Insights into regulation of activity and catalysis

Istvan, E. S., Palnitkar, M., Buchanan, S. K. & Deisenhofer, J., Mar 1 2000, In : EMBO Journal. 19, 5, p. 819-830 12 p.

Research output: Contribution to journalArticle

211 Scopus citations

Crystal structure of the cytochrome bc1 complex from bovine heart mitochondria

Xia, D., Yu, C. A., Kim, H., Xia, J. Z., Kachurin, A. M., Zhang, L., Yu, L. & Deisenhofer, J., Jul 4 1997, In : Science. 277, 5322, p. 60-66 7 p.

Research output: Contribution to journalArticle

813 Scopus citations

Crystal structure of the DNA nucleotide excision repair enzyme UvrB from Thermus thermophilus

Machius, M., Henry, L., Palnitkar, M. & Deisenhofer, J., Oct 12 1999, In : Proceedings of the National Academy of Sciences of the United States of America. 96, 21, p. 11717-11722 6 p.

Research output: Contribution to journalArticle

90 Scopus citations

Crystal structure of the formin mDIA1 in autoinhibited conformation

Otomo, T., Tomchick, D. R., Otomo, C., Machius, M. & Rosen, M. K., Nov 1 2010, In : PloS one. 5, 9, p. 1-13 13 p., e12896.

Research output: Contribution to journalArticle

29 Scopus citations

Crystal structure of the human sterol transporter ABCG5/ABCG8

Lee, J. Y., Kinch, L. N., Borek, D. M., Wang, J., Wang, J., Urbatsch, I. L., Xie, X. S., Grishin, N. V., Cohen, J. C., Otwinowski, Z., Hobbs, H. H. & Rosenbaum, D. M., May 4 2016, In : Nature. 533, 7604, p. 561-564 4 p.

Research output: Contribution to journalArticle

114 Scopus citations

Crystal structure of the MHC class Ib molecule H2-M3

Wang, C. R., Fischer Lindahl, K. & Deisenhofer, J., Jan 1 1996, In : Research in Immunology. 147, 5, p. 313-321 9 p.

Research output: Contribution to journalArticle

9 Scopus citations

Crystal structure of the outer membrane active transporter FepA from Escherichia coli

Buchanan, S. K., Smith, B. S., Venkatramani, L., Xia, D., Esser, L., Palnitkar, M., Chakraborty, R., Van Der Helm, D. & Deisenhofer, J., May 27 1999, In : Nature Structural Biology. 6, 1, p. 56-63 8 p.

Research output: Contribution to journalArticle

458 Scopus citations

Crystal structure of the receptor-binding domain of adenovirus type 5 fiberprotein at 1.7 Å resolution

Xia, D., Henry, L. J., Gerard, R. D. & Deisenhofer, J., Dec 1994, In : Structure. 2, 12, p. 1259-1270 12 p.

Research output: Contribution to journalArticle

229 Scopus citations

Crystal Structures of Human Orexin 2 Receptor Bound to the Subtype-Selective Antagonist EMPA

Suno, R., Kimura, K. T., Nakane, T., Yamashita, K., Wang, J., Fujiwara, T., Yamanaka, Y., Im, D., Horita, S., Tsujimoto, H., Tawaramoto, M. S., Hirokawa, T., Nango, E., Tono, K., Kameshima, T., Hatsui, T., Joti, Y., Yabashi, M., Shimamoto, K., Yamamoto, M. & 4 others, Rosenbaum, D. M., Iwata, S., Shimamura, T. & Kobayashi, T., Jan 2 2018, In : Structure. 26, 1, p. 7-19.e5

Research output: Contribution to journalArticle

22 Scopus citations

Crystal structures of mitochondrial processing peptidase reveal the mode for specific cleavage of import signal sequences

Taylor, A. B., Smith, B. S., Kitada, S., Kojima, K., Miyaura, H., Otwinowski, Z., Ito, A. & Deisenhofer, J., Aug 11 2001, In : Structure. 9, 7, p. 615-625 11 p.

Research output: Contribution to journalArticle

164 Scopus citations

C-terminal binding domain of Rho GDP-dissociation inhibitor directs N- terminal inhibitory peptide to GTPases

Gosser, Y. Q., Nomanbhoy, T. K., Aghazadeh, B., Manor, D., Combs, C., Cerione, R. A. & Rosen, M. K., Jun 19 1997, In : Nature. 387, 6635, p. 814-819 6 p.

Research output: Contribution to journalArticle

139 Scopus citations

C-terminal ECFP fusion impairs synaptotagmin 1 function: Crowding out synaptotagmin 1

Han, W., Rhee, J. S., Maximov, A., Lin, W., Hammer, R. E., Rosenmund, C. & Südhof, T. C., Feb 11 2005, In : Journal of Biological Chemistry. 280, 6, p. 5089-5100 12 p.

Research output: Contribution to journalArticle

25 Scopus citations

Cytochrome c1 of baker's yeast. I. Isolation and properties

Ross, E. & Schatz, G., Jan 1 1976, In : Journal of Biological Chemistry. 251, 7, p. 1991-1996 6 p.

Research output: Contribution to journalArticle

46 Scopus citations
37 Scopus citations

Cytoplasmic sequence required for basolateral targeting of LDL receptor in livers of transgenic mice

Yokode, M., Pathak, R. K., Hammer, R. E., Brown, M. S., Goldstein, J. L. & Anderson, R. G. W., May 11 1992, In : Journal of Cell Biology. 117, 1, p. 39-46 8 p.

Research output: Contribution to journalArticle

Open Access
63 Scopus citations

Cytoskeletal waves in the absence of molecular motors

Doubrovinski, K. & Kruse, K., Jul 1 2008, In : EPL. 83, 1, 18003.

Research output: Contribution to journalArticle

39 Scopus citations

Cytosolic calcium transients: Spatial localization and role in drosophila photoreceptor cell function

Ranganathan, R., Bacskai, B. J., Tsien, R. Y. & Zuker, C. S., Oct 1994, In : Neuron. 13, 4, p. 837-848 12 p.

Research output: Contribution to journalArticle

121 Scopus citations

DAPLE protein inhibits nucleotide exchange on Gαs and Gαq via the same motif that activates Gαi

Marivin, A., Maziarz, M., Zhao, J., DiGiacomo, V., Calvo, I. O., Mann, E. A., Ear, J., Blanco-Canosa, J. B., Ross, E. M., Ghosh, P. & Garcia-Marcos, M., Feb 21 2020, In : Journal of Biological Chemistry. 295, 8, p. 2270-2284 15 p.

Research output: Contribution to journalArticle

Data publication with the structural biology data grid supports live analysis

Meyer, P. A., Socias, S., Key, J., Ransey, E., Tjon, E. C., Buschiazzo, A., Lei, M., Botka, C., Withrow, J., Neau, D., Rajashankar, K., Anderson, K. S., Baxter, R. H., Blacklow, S. C., Boggon, T. J., Bonvin, A. M. J. J., Borek, D., Brett, T. J., Caflisch, A., Chang, C. I. & 50 others, Chazin, W. J., Corbett, K. D., Cosgrove, M. S., Crosson, S., Dhe-Paganon, S., Di Cera, E., Drennan, C. L., Eck, M. J., Eichman, B. F., Fan, Q. R., Ferré-D'Amaré, A. R., Fromme, J. C., Garcia, K. C., Gaudet, R., Gong, P., Harrison, S. C., Heldwein, E. E., Jia, Z., Keenan, R. J., Kruse, A. C., Kvansakul, M., McLellan, J. S., Modis, Y., Nam, Y., Otwinowski, Z., Pai, E. F., Pereira, P. J. B., Petosa, C., Raman, C. S., Rapoport, T. A., Roll-Mecak, A., Rosen, M. K., Rudenko, G., Schlessinger, J., Schwartz, T. U., Shamoo, Y., Sondermann, H., Tao, Y. J., Tolia, N. H., Tsodikov, O. V., Westover, K. D., Wu, H., Foster, I., Fraser, J. S., Maia, F. R. N. C., Gonen, T., Kirchhausen, T., Diederichs, K., Crosas, M. & Sliz, P., Mar 7 2016, In : Nature communications. 7, 10882.

Research output: Contribution to journalArticle

64 Scopus citations

Deconstruction of the ras switching cycle through saturation mutagenesis

Bandaru, P., Shah, N. H., Bhattacharyya, M., Barton, J. P., Kondo, Y., Cofsky, J. C., Gee, C. L., Chakraborty, A. K., Kortemme, T., Ranganathan, R. & Kuriyan, J., Jul 7 2017, In : eLife. 6, e27810.

Research output: Contribution to journalArticle

23 Scopus citations

Decreased IRS-2 and increased SREBP-1c lead to mixed insulin resistance and sensitivity in livers of lipodystrophic and ob/ob mice

Shimomura, I., Matsuda, M., Hammer, R. E., Bashmakov, Y., Brown, M. S. & Goldstein, J. L., Jan 1 2000, In : Molecular cell. 6, 1, p. 77-86 10 p.

Research output: Contribution to journalArticle

Open Access
651 Scopus citations
176 Scopus citations

Decreased plasma cholesterol and hypersensitivity to statins in mice lacking Pcsk9

Rashid, S., Curtis, D. E., Garuti, R., Anderson, N. H., Bashmakov, Y., Ho, Y. K., Hammer, R. E., Moon, Y. A. & Horton, J. D., Apr 12 2005, In : Proceedings of the National Academy of Sciences of the United States of America. 102, 15, p. 5374-5379 6 p.

Research output: Contribution to journalArticle

483 Scopus citations

Defective dendritic cell (DC) function in a HLA-B27 transgenic rat model of spondyloarthropathy (SpA)

Stagg, A. J., Breban, M., Hammer, R. E., Knight, S. C. & Taurog, J. D., Jan 1 1995, In : Advances in experimental medicine and biology. 378, p. 557-559 3 p.

Research output: Contribution to journalArticle

23 Scopus citations

Defective forebrain development in mice lacking gp330/megalin

Willnow, T. E., Hilpert, J., Armstrong, S. A., Rohlmann, A., Hammer, R. E., Burns, D. K. & Herz, J., Aug 6 1996, In : Proceedings of the National Academy of Sciences of the United States of America. 93, 16, p. 8460-8464 5 p.

Research output: Contribution to journalArticle

383 Scopus citations

Defining the spermatogonial stem cell

Hamra, F. K., Schultz, N., Chapman, K. M., Grellhesl, D. M., Cronkhite, J. T., Hammer, R. E. & Garbers, D. L., May 15 2004, In : Developmental Biology. 269, 2, p. 393-410 18 p.

Research output: Contribution to journalArticle

114 Scopus citations

Defocused orientation and position imaging (DOPI) of myosin V

Toprak, E., Enderlein, J., Syed, S., McKinney, S. A., Petschek, R. G., Ha, T., Goldman, Y. E. & Selvin, P. R., Apr 25 2006, In : Proceedings of the National Academy of Sciences of the United States of America. 103, 17, p. 6495-6499 5 p.

Research output: Contribution to journalArticle

164 Scopus citations

Delayed commitment to evolutionary fate in antibiotic resistance fitness landscapes

Palmer, A. C., Toprak, E., Baym, M., Kim, S., Veres, A., Bershtein, S. & Kishony, R., Jun 10 2015, In : Nature Communications. 6, 7385.

Research output: Contribution to journalArticle

60 Scopus citations

Deletion of ELOVL5 leads to fatty liver through activation of SREBP-1c in mice

Moon, Y. A., Hammer, R. E. & Horton, J. D., Apr 1 2009, In : Journal of lipid research. 50, 3, p. 412-423 12 p.

Research output: Contribution to journalArticle

109 Scopus citations

Deletion of ELOVL6 blocks the synthesis of oleic acid but does not prevent the development of fatty liver or insulin resistance

Moon, Y. A., Ochoa, C. R., Mitsche, M. A., Hammer, R. E. & Horton, J. D., Jan 1 2015, In : Journal of lipid research. 55, 12, p. 2597-2605 9 p., A16.

Research output: Contribution to journalArticle

37 Scopus citations

Dependence of Mouse Embryonic Stem Cells on Threonine Catabolism

Wang, J., Alexander, P., Wu, L., Hammer, R. E., Cleaver, O. & McKnight, S. L., Jul 24 2009, In : Science. 325, 5939, p. 435-439 5 p.

Research output: Contribution to journalArticle

215 Scopus citations

Deranged calcium signaling and neurodegeneration in spinocerebellar ataxia type 3

Chen, X., Tang, T. S., Tu, H., Nelson, O., Pook, M., Hammer, R. E., Nukina, N. & Bezprozvanny, I., Nov 26 2008, In : Journal of Neuroscience. 28, 48, p. 12713-12724 12 p.

Research output: Contribution to journalArticle

147 Scopus citations

Detection of very weak side chain-main chain hydrogen bonding interactions in medium-size 13C/15N-labeled proteins by sensitivity- enhanced NMR spectroscopy

Liu, A., Hu, W., Majumdar, A., Rosen, M. K. & Patel, D. J., Jan 1 2000, In : Journal of Biomolecular NMR. 17, 1, p. 79-82 4 p.

Research output: Contribution to journalArticle

14 Scopus citations

Detergent structure in crystals of a bacterial photosynthetic reaction centre

Roth, M., Lewit-Bentley, A., Michel, H., Deisenhofer, J., Huber, R. & Oesterhelt, D., Jan 1 1989, In : Nature. 340, 6235, p. 659-662 4 p.

Research output: Contribution to journalArticle

183 Scopus citations

Determination of protein complex stoichiometry through multisignal sedimentation velocity experiments

Padrick, S. B., Deka, R. K., Chuang, J. L., Wynn, R. M., Chuang, D. T., Norgard, M. V., Rosen, M. K. & Brautigam, C. A., Dec 2010, In : Analytical biochemistry. 407, 1, p. 89-103 15 p.

Research output: Contribution to journalArticle

31 Scopus citations

Determining the secondary structure and orientation of EmrE, a multi-drug transporter, indicates a transmembrane four-helix bundle

Arkin, I. T., Russ, W. P., Lebendiker, M. & Schuldiner, S., Jun 4 1996, In : Biochemistry. 35, 22, p. 7235-7238 4 p.

Research output: Contribution to journalArticle

98 Scopus citations

Develop and test a solvent accessible surface area-based model in conformational entropy calculations

Wang, J. & Hou, T., May 25 2012, In : Journal of Chemical Information and Modeling. 52, 5, p. 1199-1212 14 p.

Research output: Contribution to journalArticle

41 Scopus citations

Developmental regulation of α-fetoprotein genes in transgenic mice

Krumlauf, R., Hammer, R. E., Tilghman, S. M. & Brinster, R. L., 1985, In : Molecular and cellular biology. 5, 7, p. 1639-1648 10 p.

Research output: Contribution to journalArticle

Open Access
76 Scopus citations

Development and testing of a general Amber force field

Wang, J., Wolf, R. M., Caldwell, J. W., Kollman, P. A. & Case, D. A., Jul 15 2004, In : Journal of Computational Chemistry. 25, 9, p. 1157-1174 18 p.

Research output: Contribution to journalArticle

7936 Scopus citations

Development of polarizable models for molecular mechanical calculations. 3. polarizable water models conforming to thole polarization screening schemes

Wang, J., Cieplak, P., Cai, Q., Hsieh, M. J., Wang, J., Duan, Y. & Luo, R., Jul 19 2012, In : Journal of Physical Chemistry B. 116, 28, p. 7999-8008 10 p.

Research output: Contribution to journalArticle

34 Scopus citations

Development of polarizable models for molecular mechanical calculations. 4. van der waals parametrization

Wang, J., Cieplak, P., Li, J., Cai, Q., Hsieh, M. J., Luo, R. & Duan, Y., Jun 21 2012, In : Journal of Physical Chemistry B. 116, 24, p. 7088-7101 14 p.

Research output: Contribution to journalArticle

29 Scopus citations

Development of polarizable models for molecular mechanical calculations I: Parameterization of atomic polarizability

Wang, J., Cieplak, P., Li, J., Hou, T., Luo, R. & Duan, Y., Mar 31 2011, In : Journal of Physical Chemistry B. 115, 12, p. 3091-3099 9 p.

Research output: Contribution to journalArticle

90 Scopus citations

Development of polarizable models for molecular mechanical calculations II: Induced dipole models significantly improve accuracy of intermolecular interaction energies

Wang, J., Cieplak, P., Li, J., Wang, J., Cai, Q., Hsieh, M., Lei, H., Luo, R. & Duan, Y., Mar 31 2011, In : Journal of Physical Chemistry B. 115, 12, p. 3100-3111 12 p.

Research output: Contribution to journalArticle

90 Scopus citations

Development of porcine ova that were centrifuged to permit visualization of pronuclei and nuclei.

Wall, R. J., Pursel, V. G., Hammer, R. E. & Brinster, R. L., Apr 1985, In : Biology of reproduction. 32, 3, p. 645-651 7 p.

Research output: Contribution to journalArticle

Open Access
100 Scopus citations

Development of reliable aqueous solubility models and their application in druglike analysis

Wang, J., Krudy, G., Hou, T., Zhang, W., Holland, G. & Xu, X., Jul 1 2007, In : Journal of Chemical Information and Modeling. 47, 4, p. 1395-1404 10 p.

Research output: Contribution to journalArticle

74 Scopus citations