Research Output

Article

dHAND-Cre transgenic mice reveal specific potential functions of dHAND during craniofacial development

Ruest, L. B., Dager, M., Yanagisawa, H., Charité, J., Hammer, R. E., Olson, E. N., Yanagisawa, M. & Clouthier, D. E., May 15 2003, In : Developmental Biology. 257, 2, p. 263-277 15 p.

Research output: Contribution to journalArticle

34 Scopus citations

DHHC5 interacts with PDZ domain 3 of post-synaptic density-95 (PSD-95) protein and plays a role in learning and memory

Li, Y., Hu, J., Höfer, K., Wong, A. M. S., Cooper, J. D., Birnbaum, S. G., Hammer, R. E. & Hofmann, S. L., Apr 23 2010, In : Journal of Biological Chemistry. 285, 17, p. 13022-13031 10 p.

Research output: Contribution to journalArticle

50 Scopus citations

Diet-induced hypercholesterolemia in mice: Prevention by overexpression of LDL receptors

Yokode, M., Hammer, R. E., Ishibashi, S., Brown, M. S. & Goldstein, J. L., Jan 1 1990, In : Science. 250, 4985, p. 1273-1275 3 p.

Research output: Contribution to journalArticle

140 Scopus citations

Differential expression of α-fetoprotein genes on the inactive X chromosome in extraembryonic and somatic tissues of a transgenic mouse line

Krumlauf, R., Chapman, V. M., Hammer, R. E., Brinster, R. & Tilghman, S. M., Dec 1 1986, In : Nature. 319, 6050, p. 224-226 3 p.

Research output: Contribution to journalArticle

42 Scopus citations

Differential regulation of ERK1/2 and mTORC1 through T1R1/T1R3 in MIN6 cells

Wauson, E. M., Guerra, M. L., Dyachok, J., McGlynn, K., Giles, J., Ross, E. M. & Cobb, M. H., Jul 31 2015, In : Molecular Endocrinology. 29, 8, p. 1114-1122 9 p.

Research output: Contribution to journalArticle

10 Scopus citations
Open Access
44 Scopus citations

Differential splicing and glycosylation of Apoer2 alters synaptic plasticity and fear learning

Wasser, C. R., Masiulis, I., Durakoglugil, M. S., Lane-Donovan, C., Xian, X., Beffert, U., Agarwala, A., Hammer, R. E. & Herz, J., Nov 25 2014, In : Science signaling. 7, 353, ra113.

Research output: Contribution to journalArticle

21 Scopus citations

Dihydrostreptomycin Directly Binds to, Modulates, and Passes through the MscL Channel Pore

Wray, R., Iscla, I., Gao, Y., Li, H., Wang, J. & Blount, P., Jun 9 2016, In : PLoS biology. 14, 6, e1002473.

Research output: Contribution to journalArticle

13 Scopus citations
466 Scopus citations

Direct demonstration of an intramolecular SH2Ôphosphotyrosine interaction in the Crk protein

Rosen, M. K., Yamazaki, T., Gish, G. D., Kay, C. M., Pawson, T. & Kay, L. E., Mar 30 1995, In : Nature. 374, 6521, p. 477-479 3 p.

Research output: Contribution to journalArticle

116 Scopus citations

Directional allosteric regulation of protein filament length

Jermyn, A. S., Cao, W., Elam, W. A., De La Cruz, E. M. & Lin, M. M., Mar 2020, In : Physical Review E. 101, 3, 032409.

Research output: Contribution to journalArticle

Discovery, Modeling, and Human Pharmacokinetics of N-(2-Acetyl-4,6-dimethylphenyl)-3-(3,4-dimethylisoxazol-5-ylsulfamoyl) -thiophene-2-carboxamide (TBC3711), a Second Generation, ETA Selective, and Orally Bioavailable Endothelin Antagonist

Wu, C., Decker, E. R., Blok, N., Bui, H., You, T. J., Wang, J., Bourgoyne, A. R., Knowles, V., Berens, K. L., Holland, G. W., Brock, T. A. & Dixon, R. A. F., Apr 8 2004, In : Journal of Medicinal Chemistry. 47, 8, p. 1969-1986 18 p.

Research output: Contribution to journalArticle

94 Scopus citations

Disruption of Abcg5 and Abcg8 in mice reveals their crucial role in biliary cholesterol secretion

Yu, L., Hammer, R. E., Li-Hawkins, J., Von Bergmann, K., Lutjohann, D., Cohen, J. C. & Hobbs, H. H., Dec 10 2002, In : Proceedings of the National Academy of Sciences of the United States of America. 99, 25, p. 16237-16242 6 p.

Research output: Contribution to journalArticle

540 Scopus citations

Disruption of ECE-1 and ECE-2 reveals a role for endothelin-converting enzyme-2 in murine cardiac development

Yanagisawa, H., Hammer, R. E., Richardson, J. A., Emoto, N., Clay Williams, S., Takeda, S. I., Clouthier, D. E. & Yanagisawa, M., May 2000, In : Journal of Clinical Investigation. 105, 10, p. 1373-1382 10 p.

Research output: Contribution to journalArticle

Open Access
163 Scopus citations

Disruption of PPT1 or PPT2 causes neuronal ceroid lipofuscinosis in knockout mice

Gupta, P., Soyombo, A. A., Atashband, A., Wisniewski, K. E., Shelton, J. M., Richardson, J. A., Hammer, R. E. & Hofmann, S. L., Nov 20 2001, In : Proceedings of the National Academy of Sciences of the United States of America. 98, 24, p. 13566-13571 6 p.

Research output: Contribution to journalArticle

205 Scopus citations

Distinct Interactions Select and Maintain a Specific Cell Fate

Doncic, A., Falleur-Fettig, M. & Skotheim, J. M., Aug 19 2011, In : Molecular cell. 43, 4, p. 528-539 12 p.

Research output: Contribution to journalArticle

81 Scopus citations

Distinct narcolepsy syndromes in orexin receptor-2 and orexin null mice: Molecular genetic dissection of non-REM and REM sleep regulatory processes

Willie, J. T., Chemelli, R. M., Sinton, C. M., Tokita, S., Williams, S. C., Kisanuki, Y. Y., Marcus, J. N., Lee, C., Elmquist, J. K., Kohlmeier, K. A., Leonard, C. S., Richardson, J. A., Hammer, R. E. & Yanagisawa, M., Jun 5 2003, In : Neuron. 38, 5, p. 715-730 16 p.

Research output: Contribution to journalArticle

473 Scopus citations

Diversity of Alpha-Fetoprotein gene expression in mice is generated by a combination of separate enhancer elements

Hammer, R. E., Krumlauf, R., Camper, S. A., Brinster, R. L. & Tilghman, S. M., Jan 1 1987, In : Science. 235, 4784, p. 53-58 6 p.

Research output: Contribution to journalArticle

169 Scopus citations

Dlx5/6-Enhancer Directed Expression of Cre Recombinase in the Pharyngeal Arches and Brain

Ruest, L. B., Hammer, R. E., Yanagisawa, M. & Clouthier, D. E., Dec 1 2003, In : Genesis. 37, 4, p. 188-194 7 p.

Research output: Contribution to journalArticle

22 Scopus citations

DNA photolyases and cryptochromes

Deisenhofer, J., Aug 30 2000, In : Mutation Research - DNA Repair. 460, 3-4, p. 143-149 7 p.

Research output: Contribution to journalArticle

64 Scopus citations

Dominance of misfolded intermediates in the dynamics of α-helix folding

Lin, M. M., Shorokhov, D. & Zewail, A. H., Oct 7 2014, In : Proceedings of the National Academy of Sciences of the United States of America. 111, 40, p. 14424-14429 6 p.

Research output: Contribution to journalArticle

13 Scopus citations

Double-knockout mice for α- and β-synucleins: Effect on synaptic functions

Chandra, S., Fornai, F., Kwon, H. B., Yazdani, U., Atasoy, D., Liu, X., Hammer, R. E., Battaglia, G., German, D. C., Castillo, P. E. & Südhof, T. C., Oct 12 2004, In : Proceedings of the National Academy of Sciences of the United States of America. 101, 41, p. 14966-14971 6 p.

Research output: Contribution to journalArticle

288 Scopus citations

Dramatic growth of mice that develop from eggs microinjected with metallothionein-growth hormone fusion genes

Palmiter, R. D., Brinster, R. L., Hammer, R. E., Trumbauer, M. E., Rosenfeld, M. G., Birnberg, N. C. & Evans, R. M., Dec 1 1982, In : Nature. 300, 5893, p. 611-615 5 p.

Research output: Contribution to journalArticle

831 Scopus citations

Dramatic growth of mice that develop from eggs microinjected with metallothionein-growth hormone fusion genes. 1982.

Palmiter, R. D., Brinster, R. L., Hammer, R. E., Trumbauer, M. E., Rosenfeld, M. G., Birnberg, N. C. & Evans, R. M., Jan 1 1992, In : Biotechnology (Reading, Mass.). 24, p. 429-433 5 p.

Research output: Contribution to journalArticle

15 Scopus citations

Dramatic pituitary hyperplasia in transgenic mice expressing a human growth hormone-releasing factor gene

Mayo, K. E., Hammer, R. E., Swanson, L. W., Brinster, R. L., Rosenfeld, M. G. & Evans, R. M., Jul 1988, In : Molecular Endocrinology. 2, 7, p. 606-612 7 p.

Research output: Contribution to journalArticle

Open Access
159 Scopus citations

Drug and Drug candidate building block analysis

Wang, J. & Hou, T., Jan 25 2010, In : Journal of Chemical Information and Modeling. 50, 1, p. 55-67 13 p.

Research output: Contribution to journalArticle

66 Scopus citations

Drug-likeness analysis of traditional chinese medicines: Prediction of drug-likeness using machine learning approaches

Tian, S., Wang, J., Li, Y., Xu, X. & Hou, T., Dec 3 2012, In : Molecular Pharmaceutics. 9, 10, p. 2875-2886 12 p.

Research output: Contribution to journalArticle

59 Scopus citations
31 Scopus citations
22 Scopus citations

Dual genetic pathways of endothelin-mediated intercellular signaling revealed by targeted disruption of endothelin converting enzyme-1 gene

Yanagisawa, H., Yanagisawa, M., Kapur, R. P., Richardson, J. A., Williams, S. C., Clouthier, D. E., De Wit, D., Emoto, N. & Hammer, R. E., Apr 11 1998, In : Development. 125, 5, p. 825-836 12 p.

Research output: Contribution to journalArticle

410 Scopus citations

Dynamic regulation of RGS2 suggests a novel mechanism in G-protein signaling and neuronal plasticity

Ingi, T., Krumins, A. M., Chidiac, P., Brothers, G. M., Chung, S., Snow, B. E., Barnes, C. A., Lanahan, A. A., Siderovski, D. P., Ross, E. M., Gilman, A. G. & Worley, P. F., Sep 15 1998, In : Journal of Neuroscience. 18, 18, p. 7178-7188 11 p.

Research output: Contribution to journalArticle

Open Access
250 Scopus citations

Dynamic Scaffolding in a G Protein-Coupled Signaling System

Mishra, P., Socolich, M., Wall, M. A., Graves, J., Wang, Z. & Ranganathan, R., Oct 5 2007, In : Cell. 131, 1, p. 80-92 13 p.

Research output: Contribution to journalArticle

73 Scopus citations

Dynamics of a random laser above threshold

Van Soest, G., Poelwijk, F. J., Sprik, R. & Lagendijk, A., Feb 19 2001, In : Physical Review Letters. 86, 8, p. 1522-1525 4 p.

Research output: Contribution to journalArticle

72 Scopus citations
53 Scopus citations

Dynamin regulates the dynamics and mechanical strength of the actin cytoskeleton as a multifilament actin-bundling protein

Zhang, R., Lee, D. M., Jimah, J. R., Gerassimov, N., Yang, C., Kim, S., Luvsanjav, D., Winkelman, J., Mettlen, M., Abrams, M. E., Kalia, R., Keene, P., Pandey, P., Ravaux, B., Kim, J. H., Ditlev, J. A., Zhang, G., Rosen, M. K., Frost, A., Alto, N. M. & 5 others, Gardel, M., Schmid, S. L., Svitkina, T. M., Hinshaw, J. E. & Chen, E. H., Jun 1 2020, In : Nature cell biology. 22, 6, p. 674-688 15 p.

Research output: Contribution to journalArticle

E6 and E7 expression from the HPV 18 LCR: Development of genital hyperplasia and neoplasia in transgenic mice

Comerford, S. A., Maika, S. D., Laimins, L. A., Messing, A., Elsasser, H. P. & Hammer, R. E., Jan 1 1995, In : Oncogene. 10, 3, p. 587-597 11 p.

Research output: Contribution to journalArticle

21 Scopus citations

Effect of Al3+ plus F- on the Catecholamine-Stimulated GTPase Activity of Purified and Reconstituted Gs

Brandt, D. R. & Ross, E. M., Nov 1986, In : Biochemistry. 25, 22, p. 7036-7041 6 p.

Research output: Contribution to journalArticle

8 Scopus citations

Effect of the expression of a hepatocyte-specific MHC molecule in transgenic mice on T cell tolerance

Jones-Youngblood, S. L., Wieties, K., Forman D.M.D/Ph.D., J. M. & Hammer, R. E., Jan 1 1990, In : Journal of Immunology. 144, 4, p. 1187-1195 9 p.

Research output: Contribution to journalArticle

31 Scopus citations

Effects of nicotine on conceptus development and oviductal/uterine blood flow in the rat

Hammer, R. E., Mitchell, J. A. & Goldman, H., Jan 1 1979, In : Biology of reproduction. 20, 1 SUPPL, p. no. 81

Research output: Contribution to journalArticle

Effects of nicotine on oviducal blood flow and embryo development in the rat

Mitchell, J. A. & Hammer, R. E., Jan 1 1985, In : Journal of Reproduction and Fertility. 74, 1, p. 71-76 6 p.

Research output: Contribution to journalArticle

Open Access
35 Scopus citations

Effects of nicotine on uterine blood flow and intrauterine oxygen tension in the rat

Hammer, R. E., Goldman, H. & Mitchell, J. A., Jan 1 1981, In : Journal of Reproduction and Fertility. 63, 1, p. 163-168 6 p.

Research output: Contribution to journalArticle

Open Access
29 Scopus citations

Effects of nicotine on zona pellucida loss and blastocyst development in the rat

Hammer, R. E. & Mitchell, J. A., Jan 1 1979, In : Anatomical Record. 194, 4, 1 p.

Research output: Contribution to journalArticle

Effects of the gut microbiota on host adiposity are modulated by the short-chain fatty-acid binding G protein-coupled receptor, Gpr41

Samuel, B. S., Shaito, A., Motoike, T., Rey, F. E., Backhed, F., Manchester, J. K., Hammer, R. E., Williams, S. C., Crowley, J., Yanagisawa, M. & Gordon, J. I., Oct 28 2008, In : Proceedings of the National Academy of Sciences of the United States of America. 105, 43, p. 16767-16772 6 p.

Research output: Contribution to journalArticle

829 Scopus citations

Egg culture: The foundation

Hammer, R. E., Dec 2 1998, In : International Journal of Developmental Biology. 42, 7, p. 833-839 7 p.

Research output: Contribution to journalArticle

10 Scopus citations

Elastase I promoter directs expression of human growth hormone and SV40 T antigen genes to pancreatic acinar cells in transgenic mice

Ornitz, D. M., Palmiter, R. D., Messing, A., Hammer, R. E., Pinkert, C. A. & Brinster, R. L., Jan 1 1985, In : Cold Spring Harbor symposia on quantitative biology. VOL. 50, p. 399-409 11 p.

Research output: Contribution to journalArticle

60 Scopus citations

Electric-field-stimulated protein mechanics

Hekstra, D. R., White, K. I., Socolich, M. A., Henning, R. W., Šrajer, V. & Ranganathan, R., Dec 15 2016, In : Nature. 540, 7633, p. 400-405 6 p.

Research output: Contribution to journalArticle

59 Scopus citations

Electron microscopy of thin-sectioned three-dimensional crystals of SecA protein from Escherichia coli: Structure in projection at 40 Å resolution

Weaver, A. J., McDowall, A. W., Oliver, D. B. & Deisenhofer, J., Jan 1 1992, In : Journal of Structural Biology. 109, 2, p. 87-96 10 p.

Research output: Contribution to journalArticle

15 Scopus citations

Elevated basal slippage mutation rates among the Canidae

Laidlaw, J., Gelfand, Y., Ng, K. W., Garner, H. R., Ranganathan, R., Benson, G. & Fondon, J. W., Sep 10 2007, In : Journal of Heredity. 98, 5, p. 452-460 9 p.

Research output: Contribution to journalArticle

21 Scopus citations
Open Access
327 Scopus citations

Embryonic neuronal death due to neurotrophin and neurotransmitter deprivation occurs independent of Apaf-1

Honarpour, N., Tabuchi, K., Stark, J. M., Hammer, R. E., Südhof, T. C., Parada, L. F., Wang, X., Richardson, J. A. & Herz, J., Sep 6 2001, In : Neuroscience. 106, 2, p. 263-274 12 p.

Research output: Contribution to journalArticle

22 Scopus citations