Research Output

Article

Local F-actin network links synapse formation and axon branching

Chia, P. H., Chen, B., Li, P., Rosen, M. K. & Shen, K., Jan 27 2014, In : Cell. 156, 1-2, p. 208-220 13 p.

Research output: Contribution to journalArticle

64 Scopus citations

Loss of Dis3l2 partially phenocopies perlman syndrome in mice and results in upregulation of Igf2 in nephron progenitor cells

Hunter, R. W., Liu, Y., Manjunath, H., Acharya, A., Jones, B. T., Zhang, H., Chen, B., Ramalingam, H., Hammer, R. E., Xie, Y., Richardson, J. A., Rakheja, D., Carroll, T. J. & Mendell, J. T., Jul 1 2018, In : Genes and Development. 32, 13-14, p. 903-908 6 p.

Research output: Contribution to journalArticle

12 Scopus citations

Loss-of-Function Analysis of EphA Receptors in Retinotectal Mapping

Feldheim, D. A., Nakamoto, M., Osterfield, M., Gale, N. W., DeChiara, T. M., Rohatgi, R., Yancopoulos, G. D. & Flanagan, J. G., Mar 10 2004, In : Journal of Neuroscience. 24, 10, p. 2542-2550 9 p.

Research output: Contribution to journalArticle

Open Access
116 Scopus citations

Low blood pressure in endothelial cell-specific endothelin 1 knockout mice

Kisanuki, Y. Y., Emoto, N., Ohuchi, T., Widyantoro, B., Yagi, K., Nakayama, K., Kedzierski, R. M., Hammer, R. E., Yanagisawa, H., Williams, S. C., Richardson, J. A., Suzuki, T. & Yanagisawa, M., Jul 1 2010, In : Hypertension. 56, 1, p. 121-128 8 p.

Research output: Contribution to journalArticle

77 Scopus citations
116 Scopus citations

LRH-1 and PTF1-L coregulate an exocrine pancreas-specific transcriptional network for digestive function

Holmstrom, S. R., Deering, T., Swift, G. H., Poelwijk, F. J., Mangelsdorf, D. J., Kliewer, S. A. & Macdonald, R. J., Aug 15 2011, In : Genes and Development. 25, 16, p. 1674-1679 6 p.

Research output: Contribution to journalArticle

65 Scopus citations

LRP1 integrates murine macrophage cholesterol homeostasis and inflammatory responses in atherosclerosis

Xian, X., Ding, Y., Dieckmann, M., Zhou, L., Plattner, F., Liu, M., Parks, J. S., Hammer, R. E., Boucher, P., Tsai, S. & Herz, J., Nov 16 2017, In : eLife. 6, e29292.

Research output: Contribution to journalArticle

19 Scopus citations

Lrp4 domains differentially regulate limb/brain development and synaptic plasticity

Pohlkamp, T., Durakoglugil, M. S., Lane-Donovan, C., Xian, X., Johnson, E. B., Hammer, R. E. & Herz, J., Feb 17 2015, In : PloS one. 10, 2, e0116701.

Research output: Contribution to journalArticle

10 Scopus citations

'MAD'ly phasing the extracellular domain of the LDL receptor: A medium-sized protein, large tungsten clusters and multiple non-isomorphous crystals

Rudenko, G., Henry, L., Vonrhein, C., Bricogne, G. & Deisenhofer, J., Nov 1 2003, In : Acta Crystallographica - Section D Biological Crystallography. 59, 11, p. 1978-1986 9 p.

Research output: Contribution to journalArticle

18 Scopus citations

Male and female germline specific expression of an EGFP reporter gene in a unique strain of transgenic rats

Cronkhite, J. T., Norlander, C., Furth, J. K., Levan, G., Garbers, D. L. & Hammer, R. E., Aug 1 2005, In : Developmental Biology. 284, 1, p. 171-183 13 p.

Research output: Contribution to journalArticle

30 Scopus citations

Mapping of the mastoparan-binding site on G proteins: Cross-linking of [125I-Tyr3,Cys11]mastoparan to G(o)

Higashijima, T. & Ross, E. M., Sep 23 1991, In : Journal of Biological Chemistry. 266, 19, p. 12655-12661 7 p.

Research output: Contribution to journalArticle

78 Scopus citations

Mastoparan, a peptide toxin from wasp venom, mimics receptors by activating GTP-binding regulatory proteins (G proteins)

Higashijima, T., Uzu, S., Nakajima, T. & Ross, E. M., Jan 1 1988, In : Journal of Biological Chemistry. 263, 14, p. 6491-6494 4 p.

Research output: Contribution to journalArticle

561 Scopus citations

Measurement of cortical elasticity in Drosophila melanogaster embryos using ferrofluids

Doubrovinski, K., Swan, M., Polyakov, O. & Wieschaus, E. F., Jan 31 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 5, p. 1051-1056 6 p.

Research output: Contribution to journalArticle

27 Scopus citations

Mechanical slowing-down of cytoplasmic diffusion allows in vivo counting of proteins in individual cells

Okumus, B., Landgraf, D., Lai, G. C., Bakhsi, S., Arias-Castro, J. C., Yildiz, S., Huh, D., Fernandez-Lopez, R., Peterson, C. N., Toprak, E., El Karoui, M. & Paulsson, J., May 18 2016, In : Nature communications. 7, 11641.

Research output: Contribution to journalArticle

21 Scopus citations

Mechanism of actin filament nucleation by the bacterial effector VopL

Yu, B., Cheng, H. C., Brautigam, C. A., Tomchick, D. R. & Rosen, M. K., Sep 1 2011, In : Nature Structural and Molecular Biology. 18, 9, p. 1068-1074 7 p.

Research output: Contribution to journalArticle

42 Scopus citations

Mechanism of Rab geranylgeranylation: Formation of the catalytic ternary complex

Anant, J. S., Desnoyers, L., Machius, M., Demeler, B., Hansen, J. C., Westover, K. D., Deisenhofer, J. & Seabra, M. C., Sep 8 1998, In : Biochemistry. 37, 36, p. 12559-12568 10 p.

Research output: Contribution to journalArticle

59 Scopus citations
168 Scopus citations
31 Scopus citations
143 Scopus citations

Mechanistic studies of affinity modulation

Rosen, M. K., Amos, C. D. & Wandless, T. J., Dec 6 2000, In : Journal of the American Chemical Society. 122, 48, p. 11979-11982 4 p.

Research output: Contribution to journalArticle

6 Scopus citations

Mesolimbic neuropeptide W coordinates stress responses under novel environments

Motoike, T., Long, J. M., Tanaka, H., Sinton, C. M., Skach, A., Williams, S. C., Hammer, R. E., Sakurai, T. & Yanagisawa, M., May 24 2016, In : Proceedings of the National Academy of Sciences of the United States of America. 113, 21, p. 6023-6028 6 p.

Research output: Contribution to journalArticle

5 Scopus citations

Metabolic regulation of mitochondrial dynamics

Mishra, P. & Chan, D. C., 2016, In : Journal of Cell Biology. 212, 4, p. 379-387 9 p.

Research output: Contribution to journalArticle

356 Scopus citations

Metallothionein-human GH fusion genes stimulate growth of mice

Palmiter, R. D., Norstedt, G., Gelinas, R. E., Hammer, R. E. & Brinster, R. L., Jan 1 1983, In : Science. 222, 4625, p. 809-814 6 p.

Research output: Contribution to journalArticle

465 Scopus citations

Metallothionein-vasopressin fusion gene expression in transgenic mice. Nephrogenic diabetes insipidus and brain transcripts localized to magnocellular neurons

Habener, J. F., Cwikel, B. J., Hermann, H., Hammer, R. E., Oalmiter, R. D. & Brinster, R. L., Jan 1 1989, In : Journal of Biological Chemistry. 264, 31, p. 18844-18852 9 p.

Research output: Contribution to journalArticle

37 Scopus citations

Methyl labeling and TROSY NMR spectroscopy of proteins expressed in the eukaryote Pichia pastoris

Clark, L., Zahm, J. A., Ali, R., Kukula, M., Bian, L., Patrie, S. M., Gardner, K. H., Rosen, M. & Rosenbaum, D. M., May 30 2015, (Accepted/In press) In : Journal of Biomolecular NMR.

Research output: Contribution to journalArticle

29 Scopus citations

MiR-124 regulates diverse aspects of rhythmic behavior in Drosophila

Garaulet, D. L., Sun, K., Li, W., Wen, J., Panzarino, A. M., O’Neil, J. L., Robin Hiesinger, P., Young, M. W. & Lai, E. C., Mar 23 2016, In : Journal of Neuroscience. 36, 12, p. 3414-3421 8 p.

Research output: Contribution to journalArticle

14 Scopus citations

MiR-192-Mediated Positive Feedback Loop Controls the Robustness of Stress-Induced p53 Oscillations in Breast Cancer Cells

Moore, R., Ooi, H. K., Kang, T., Bleris, L. & Ma, L., 2015, In : PLoS Computational Biology. 11, 12, e1004653.

Research output: Contribution to journalArticle

23 Scopus citations

MiR-26 suppresses adipocyte progenitor differentiation and fat production by targeting Fbxl19

Acharya, A., Berry, D. C., Zhang, H., Jiang, Y., Jones, B. T., Hammer, R. E., Graff, J. M. & Mendell, J. T., Oct 1 2019, In : Genes and Development. 33, 19-20, p. 1367-1380 14 p.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

MIRO-1 Determines Mitochondrial Shape Transition upon GPCR Activation and Ca2+ Stress

Nemani, N., Carvalho, E., Tomar, D., Dong, Z., Ketschek, A., Breves, S. L., Jaña, F., Worth, A. M., Heffler, J., Palaniappan, P., Tripathi, A., Subbiah, R., Riitano, M. F., Seelam, A., Manfred, T., Itoh, K., Meng, S., Sesaki, H., Craigen, W. J., Rajan, S. & 9 others, Shanmughapriya, S., Caplan, J., Prosser, B. L., Gill, D. L., Stathopulos, P. B., Gallo, G., Chan, D. C., Mishra, P. & Madesh, M., Apr 24 2018, In : Cell Reports. 23, 4, p. 1005-1019 15 p.

Research output: Contribution to journalArticle

18 Scopus citations

Mitochondrial Dynamics Is a Distinguishing Feature of Skeletal Muscle Fiber Types and Regulates Organellar Compartmentalization

Mishra, P., Varuzhanyan, G., Pham, A. H. & Chan, D. C., Jan 1 2015, In : Cell Metabolism. 22, 6, p. 1033-1044 12 p.

Research output: Contribution to journalArticle

70 Scopus citations

Modeling compound-target interaction network of traditional chinese medicines for type II diabetes mellitus: Insight for polypharmacology and drug design

Tian, S., Li, Y., Li, D., Xu, X., Wang, J., Zhang, Q. & Hou, T., Jul 22 2013, In : Journal of Chemical Information and Modeling. 53, 7, p. 1787-1803 17 p.

Research output: Contribution to journalArticle

30 Scopus citations

Modeling heterogeneous responsiveness of intrinsic apoptosis pathway

Ooi, H. K. & Ma, L., Jul 23 2013, In : BMC Systems Biology. 7, 65.

Research output: Contribution to journalArticle

13 Scopus citations

Modeling renal cell carcinoma in mice: Bap1 and Pbrm1 inactivation drive tumor grade

Gu, Y. F., Cohn, S., Christie, A., McKenzie, T., Wolff, N., Do, Q. N., Madhuranthakam, A. J., Pedrosa, I., Wang, T., Dey, A., Busslinger, M., Xie, X-J., Hammer, R. E., McKay, R. M., Kapur, P. & Brugarolas, J. B., 2017, In : Cancer Discovery. 7, 8, p. 900-917 18 p.

Research output: Contribution to journalArticle

39 Scopus citations

Model of human low-density lipoprotein and bound receptor based on CryoEM

Ren, G., Rudenko, G., Ludtke, S. J., Deisenhofer, J., Chiu, W. & Pownall, H. J., Jan 19 2010, In : Proceedings of the National Academy of Sciences of the United States of America. 107, 3, p. 1059-1064 6 p.

Research output: Contribution to journalArticle

56 Scopus citations

Modulation of mutant krasG12D-driven lung tumorigenesis in vivo by gain or loss of PCDH7 function

Zhou, X., Padanad, M. S., Evers, B. M., Smith, B., Novaresi, N., Suresh, S., Richardson, J. A., Stein, E., Zhu, J., Hammer, R. E. & O'Donnell, K. A., Feb 2019, In : Molecular Cancer Research. 17, 2, p. 594-603 10 p.

Research output: Contribution to journalArticle

3 Scopus citations

Modulation of synaptic plasticity and memory by Reelin involves differential splicing of the lipoprotein receptor Apoer2

Beffert, U., Weeber, E. J., Durudas, A., Qiu, S., Masiulis, I., Sweatt, J. D., Li, W. P., Adelmann, G., Frotscher, M., Hammer, R. E. & Herz, J., Aug 18 2005, In : Neuron. 47, 4, p. 567-579 13 p.

Research output: Contribution to journalArticle

321 Scopus citations

Modulation of the affinity and selectivity of RGS protein interaction with Gα subunits by a conserved asparagine/serine residue

Posner, B. A., Mukhopadhyay, S., Tesmer, J. J., Gilman, A. G. & Ross, E. M., Jun 15 1999, In : Biochemistry. 38, 24, p. 7773-7779 7 p.

Research output: Contribution to journalArticle

66 Scopus citations

Modulation of the protein components of β-adrenergic adenylate cyclase (AC) during maturation of rat reticulocytes

Larner, A. C. & Ross, E. M., Jan 1 1981, In : Federation Proceedings. 40, 3 I, p. No. 2421

Research output: Contribution to journalArticle

Molecular basis for LDL receptor recognition by PCSK9

Hyock, J. K., Lagace, T. A., McNutt, M. C., Horton, J. D. & Deisenhofer, J., Feb 12 2008, In : Proceedings of the National Academy of Sciences of the United States of America. 105, 6, p. 1820-1825 6 p.

Research output: Contribution to journalArticle

254 Scopus citations

Molecular dynamics and free energy analyses of cathepsin D-inhibitor interactions: Insight into structure-based ligand design

Huo, S., Wang, J., Cieplak, P., Kollman, P. A. & Kuntz, I. D., Mar 28 2002, In : Journal of Medicinal Chemistry. 45, 7, p. 1412-1419 8 p.

Research output: Contribution to journalArticle

162 Scopus citations

Molecular Dynamics Simulations Revealed the Regulation of Ligands to the Interactions between Androgen Receptor and Its Coactivator

Liu, N., Zhou, W., Guo, Y., Wang, J., Fu, W., Sun, H., Li, D., Duan, M. & Hou, T., Aug 27 2018, In : Journal of Chemical Information and Modeling. 58, 8, p. 1652-1661 10 p.

Research output: Contribution to journalArticle

14 Scopus citations

Molecular Mechanism and Kinetics of Amyloid-β42 Aggregate Formation: A Simulation Study

Man, V. H., He, X., Ji, B., Liu, S., Xie, X. Q. & Wang, J., Nov 20 2019, In : ACS Chemical Neuroscience. 10, 11, p. 4643-4658 16 p.

Research output: Contribution to journalArticle

2 Scopus citations

Molecular Mechanisms of Hepatic Steatosis and Insulin Resistance in the AGPAT2-Deficient Mouse Model of Congenital Generalized Lipodystrophy

Cortés, V. A., Curtis, D. E., Sukumaran, S., Shao, X., Parameswara, V., Rashid, S., Smith, A. R., Ren, J., Esser, V., Hammer, R. E., Agarwal, A. K., Horton, J. D. & Garg, A., Feb 4 2009, In : Cell Metabolism. 9, 2, p. 165-176 12 p.

Research output: Contribution to journalArticle

151 Scopus citations

Molecular Recognition of Immunophilins and Immunophilin-Ligand Complexes

Schreiber, S. L., Lui, J., Albers, M. W., Rosen, M. K., Standaert, R. F., Wandless, T. J. & Somers, P. K., Mar 27 1992, In : Tetrahedron. 48, 13, p. 2545-2558 14 p.

Research output: Contribution to journalArticle

44 Scopus citations

Monoclonal antibody to the HLA class I α3 domain inhibits T cell activation and prolongs cardiac allograft survival in HLA- transgenic mice

Woo, J., Cornejo, M. C., Gao, L., Taurog, J. D., Hammer, R. E. & Buelow, R., Jun 1997, In : Transplant Immunology. 5, 2, p. 112-121 10 p.

Research output: Contribution to journalArticle

1 Scopus citations

MORT: A powerful foundational library for computational biology and CADD

Zhang, Q., Zhang, W., Li, Y., Wang, J., Zhang, J. & Hou, T., Jun 27 2014, In : Journal of Cheminformatics. 6, 1, 36.

Research output: Contribution to journalArticle

3 Scopus citations

Multiple repeat elements within the FAM21 tail link the WASH actin regulatory complex to the retromer

Jia, D., Gomez, T. S., Billadeau, D. D. & Rosen, M. K., Jun 15 2012, In : Molecular biology of the cell. 23, 12, p. 2352-2361 10 p.

Research output: Contribution to journalArticle

90 Scopus citations

Multiple sequences regulate human beta-globin gene expression in transgenic mice.

Townes, T. M., Behringer, R. R., Hammer, R. E., Brinster, R. L. & Palmiter, R. D., 1987, In : Progress in clinical and biological research. 251, p. 323-343 21 p.

Research output: Contribution to journalArticle

Mutagenesis of the human apolipoprotein B gene in a yeast artificial chromosome reveals the site of attachment for apolipoprotein(a)

Mccormick, S. P. A., Ng, J. K., Taylor, S., Flynn, L. M., Hammer, R. E. & Young, S. G., Oct 24 1995, In : Proceedings of the National Academy of Sciences of the United States of America. 92, 22, p. 10147-10151 5 p.

Research output: Contribution to journalArticle

75 Scopus citations