Research Output

2003

Cell-autonomous and nonautonomous actions of endothelin-A receptor signaling in craniofacial and cardiovascular development

Clouthier, D. E., Williams, S. C., Hammer, R. E., Richardson, J. A. & Yanagisawa, M., Sep 15 2003, In : Developmental Biology. 261, 2, p. 506-519 14 p.

Research output: Contribution to journalArticle

46 Scopus citations

Conditional expression of mutant M-line titins results in cardiomyopathy with altered sarcomere structure

Gotthardt, M., Hammer, R. E., Hübner, N., Monti, J., Witt, C. C., McNabb, M., Richardson, J. A., Granzier, H., Labeit, S. & Herz, J., Feb 21 2003, In : Journal of Biological Chemistry. 278, 8, p. 6059-6065 7 p.

Research output: Contribution to journalArticle

103 Scopus citations

Contingent phosphorylation/dephosphorylation provides a mechanism of molecular memory in WASP

Torres, E. & Rosen, M. K., May 1 2003, In : Molecular cell. 11, 5, p. 1215-1227 13 p.

Research output: Contribution to journalArticle

132 Scopus citations

dHAND-Cre transgenic mice reveal specific potential functions of dHAND during craniofacial development

Ruest, L. B., Dager, M., Yanagisawa, H., Charité, J., Hammer, R. E., Olson, E. N., Yanagisawa, M. & Clouthier, D. E., May 15 2003, In : Developmental Biology. 257, 2, p. 263-277 15 p.

Research output: Contribution to journalArticle

34 Scopus citations

Distinct narcolepsy syndromes in orexin receptor-2 and orexin null mice: Molecular genetic dissection of non-REM and REM sleep regulatory processes

Willie, J. T., Chemelli, R. M., Sinton, C. M., Tokita, S., Williams, S. C., Kisanuki, Y. Y., Marcus, J. N., Lee, C., Elmquist, J. K., Kohlmeier, K. A., Leonard, C. S., Richardson, J. A., Hammer, R. E. & Yanagisawa, M., Jun 5 2003, In : Neuron. 38, 5, p. 715-730 16 p.

Research output: Contribution to journalArticle

473 Scopus citations

Dlx5/6-Enhancer Directed Expression of Cre Recombinase in the Pharyngeal Arches and Brain

Ruest, L. B., Hammer, R. E., Yanagisawa, M. & Clouthier, D. E., Dec 1 2003, In : Genesis. 37, 4, p. 188-194 7 p.

Research output: Contribution to journalArticle

22 Scopus citations

Erratum: Evolutionarily conserved networks of residues mediate allosteric communication in proteins (Nature Structural Biology (2003) 10 (59-69))

Süel, G. M., Lockless, S. W., Wall, M. A. & Ranganathan, R., Mar 1 2003, In : Nature Structural Biology. 10, 3, 1 p.

Research output: Contribution to journalComment/debate

12 Scopus citations

Evolutionarily conserved networks of residues mediate allosteric communication in proteins

Süel, G. M., Lockless, S. W., Wall, M. A. & Ranganathan, R., Jan 1 2003, In : Nature Structural Biology. 10, 1, p. 59-69 11 p.

Research output: Contribution to journalArticle

593 Scopus citations

Homer 2 tunes G protein-coupled receptors stimulus intensity by regulating RGS proteins and PLCβ GAP activities

Shin, D. M., Dehoff, M., Luo, X., Kang, S. H., Tu, J., Nayak, S. K., Ross, E. M., Worley, P. E. & Muallem, S., Jul 21 2003, In : Journal of Cell Biology. 162, 2, p. 293-303 11 p.

Research output: Contribution to journalArticle

74 Scopus citations

Hyperactivated sperm motility driven by CatSper2 is required for fertilization

Quill, T. A., Sugden, S. A., Rossi, K. L., Doolittle, L. K., Hammer, R. E. & Garbers, D. L., Dec 9 2003, In : Proceedings of the National Academy of Sciences of the United States of America. 100, 25, p. 14869-14874 6 p.

Research output: Contribution to journalArticle

244 Scopus citations

Induction of hepatocyte proliferation and death by modulation of T-antigen expression

Comerford, S. A., Clouthier, D. E., Hinnant, E. A. & Hammer, R. E., Apr 24 2003, In : Oncogene. 22, 16, p. 2515-2530 16 p.

Research output: Contribution to journalArticle

6 Scopus citations

Itk functions to control actin polymerization at the immune synapse through localized activation of Cdc42 and WASP

Labno, C. M., Lewis, C. M., You, D., Leung, D. W., Takesono, A., Kamberos, N., Seth, A., Finkelstein, L. D., Rosen, M. K., Schwartzberg, P. L. & Burkhardt, J. K., Sep 16 2003, In : Current Biology. 13, 18, p. 1619-1624 6 p.

Research output: Contribution to journalArticle

104 Scopus citations

'MAD'ly phasing the extracellular domain of the LDL receptor: A medium-sized protein, large tungsten clusters and multiple non-isomorphous crystals

Rudenko, G., Henry, L., Vonrhein, C., Bricogne, G. & Deisenhofer, J., Nov 1 2003, In : Acta Crystallographica - Section D Biological Crystallography. 59, 11, p. 1978-1986 9 p.

Research output: Contribution to journalArticle

18 Scopus citations

Mesoscopic reaction-diffusion in intracellular signaling

Elf, J., Dončić, A. & Ehrenberg, M., Sep 19 2003, In : Proceedings of SPIE - The International Society for Optical Engineering. 5110, p. 114-124 11 p.

Research output: Contribution to journalConference article

75 Scopus citations

NMR analysis of methyl groups at 100-500 kDa: Model systems and Arp2/3 complex

Kreishman-Deitrick, M., Egile, C., Hoyt, D. W., Ford, J. J., Li, R. & Rosen, M. K., Jul 22 2003, In : Biochemistry. 42, 28, p. 8579-8586 8 p.

Research output: Contribution to journalArticle

20 Scopus citations
73 Scopus citations
149 Scopus citations

Phosphorylation-regulated Inhibition of the Gz GTPase-activating Protein Activity of RGS Proteins by Synapsin I

Tu, Y., Nayak, S. K., Woodson, J. & Ross, E. M., Dec 26 2003, In : Journal of Biological Chemistry. 278, 52, p. 52273-52281 9 p.

Research output: Contribution to journalArticle

16 Scopus citations
5 Scopus citations

Rational design of genetically encoded fluorescence resonance energy transfer-based sensors of cellular Cdc42 signaling

Seth, A., Otomo, T., Yin, H. L. & Rosen, M. K., Apr 15 2003, In : Biochemistry. 42, 14, p. 3997-4008 12 p.

Research output: Contribution to journalArticle

45 Scopus citations

Regulation of cytosolic phosphoenolpyruvate carboxykinase gene expression in adipocytes

Beale, E. G., Forest, C. & Hammer, R. E., Dec 2003, In : Biochimie. 85, 12, p. 1207-1211 5 p.

Research output: Contribution to journalArticle

22 Scopus citations

RNA Amplification and Transcriptional Profiling for Analysis of Stem Cell Populations

Gallardo, T. D., Hammer, R. E. & Garry, D. J., Oct 1 2003, In : Genesis. 37, 2, p. 57-63 7 p.

Research output: Contribution to journalArticle

27 Scopus citations

Structure of Cdc42 in a complex with the GTPase-binding domain of the cell polarity protein, Par6

Garrard, S. M., Capaldo, C. T., Gao, L., Rosen, M. K., Macara, I. G. & Tomchick, D. R., Mar 3 2003, In : EMBO Journal. 22, 5, p. 1125-1133 9 p.

Research output: Contribution to journalArticle

117 Scopus citations

The Erythropoietin Receptor Transmembrane Domain Mediates Complex Formation with Viral Anemic and Polycythemic gp55 Proteins

Constantinescu, S. N., Keren, T., Russ, W. P., Ubarretxena-Belandia, I., Malka, Y., Kubatzky, K. F., Engelman, D. M., Lodish, H. F. & Henis, Y. I., Oct 31 2003, In : Journal of Biological Chemistry. 278, 44, p. 43755-43763 9 p.

Research output: Contribution to journalArticle

24 Scopus citations

The low-density lipoprotein receptor: Ligands, debates and lore

Rudenko, G. & Deisenhofer, J., Dec 2003, In : Current Opinion in Structural Biology. 13, 6, p. 683-689 7 p.

Research output: Contribution to journalReview article

53 Scopus citations

α-neurexins couple Ca 2+ channels to synaptic vesicle exocytosis

Missier, M., Zhang, W., Rohlmann, A., Kattenstroth, G., Hammer, R. E., Gottmann, K. & Südhof, T. C., Jun 26 2003, In : Nature. 423, 6943, p. 939-948 10 p.

Research output: Contribution to journalArticle

447 Scopus citations
2004

A Drosophila pattern recognition receptor contains a peptidoglycan docking groove and unusual L,D-carboxypeptidase activity

Chang, C. I., Pili-Floury, S., Hervé, M., Parquet, C., Chelliah, Y., Lemaitre, B., Mengin-Lecreulx, D. & Deisenhofer, J., Sep 2004, In : PLoS biology. 2, 9

Research output: Contribution to journalArticle

76 Scopus citations

A two-state allosteric model for autoinhibition rationalizes WASP signal integration and targeting

Buck, M., Xu, W. & Rosen, M. K., Apr 23 2004, In : Journal of Molecular Biology. 338, 2, p. 271-285 15 p.

Research output: Contribution to journalArticle

44 Scopus citations

Chemical inhibition of N-WASP by stabilization of a native autoinhibited conformation

Peterson, J. R., Bickford, L. C., Morgan, D., Kim, A. S., Ouerfelli, O., Kirschner, M. W. & Rosen, M. K., Aug 1 2004, In : Nature Structural and Molecular Biology. 11, 8, p. 747-755 9 p.

Research output: Contribution to journalArticle

138 Scopus citations

Chemoattractant-induced phosphatidylinositol 3,4,5-trisphosphate accumulation is spatially amplified and adapts, independent of the actin cytoskeleton

Janetopoulos, C., Ma, L., Devreotes, P. N. & Iglesias, P. A., Jun 15 2004, In : Proceedings of the National Academy of Sciences of the United States of America. 101, 24, p. 8951-8956 6 p.

Research output: Contribution to journalArticle

177 Scopus citations

Critical roles of the guanylyl cyclase B receptor in endochondral ossification and development of female reproductive organs

Tamura, N., Doolittle, L. K., Hammer, R. E., Shelton, J. M., Richardson, J. A. & Garbers, D. L., Dec 7 2004, In : Proceedings of the National Academy of Sciences of the United States of America. 101, 49, p. 17300-17305 6 p.

Research output: Contribution to journalArticle

196 Scopus citations

Defining the spermatogonial stem cell

Hamra, F. K., Schultz, N., Chapman, K. M., Grellhesl, D. M., Cronkhite, J. T., Hammer, R. E. & Garbers, D. L., May 15 2004, In : Developmental Biology. 269, 2, p. 393-410 18 p.

Research output: Contribution to journalArticle

115 Scopus citations

Development and testing of a general Amber force field

Wang, J., Wolf, R. M., Caldwell, J. W., Kollman, P. A. & Case, D. A., Jul 15 2004, In : Journal of Computational Chemistry. 25, 9, p. 1157-1174 18 p.

Research output: Contribution to journalArticle

8039 Scopus citations

Discovery, Modeling, and Human Pharmacokinetics of N-(2-Acetyl-4,6-dimethylphenyl)-3-(3,4-dimethylisoxazol-5-ylsulfamoyl) -thiophene-2-carboxamide (TBC3711), a Second Generation, ETA Selective, and Orally Bioavailable Endothelin Antagonist

Wu, C., Decker, E. R., Blok, N., Bui, H., You, T. J., Wang, J., Bourgoyne, A. R., Knowles, V., Berens, K. L., Holland, G. W., Brock, T. A. & Dixon, R. A. F., Apr 8 2004, In : Journal of Medicinal Chemistry. 47, 8, p. 1969-1986 18 p.

Research output: Contribution to journalArticle

94 Scopus citations

Disregulated glyceroneogenesis: PCK1 as a candidate diabetes and obesity gene

Beale, E. G., Hammer, R. E., Antoine, B. & Forest, C., Apr 2004, In : Trends in Endocrinology and Metabolism. 15, 3, p. 129-135 7 p.

Research output: Contribution to journalReview article

80 Scopus citations

Double-knockout mice for α- and β-synucleins: Effect on synaptic functions

Chandra, S., Fornai, F., Kwon, H. B., Yazdani, U., Atasoy, D., Liu, X., Hammer, R. E., Battaglia, G., German, D. C., Castillo, P. E. & Südhof, T. C., Oct 12 2004, In : Proceedings of the National Academy of Sciences of the United States of America. 101, 41, p. 14966-14971 6 p.

Research output: Contribution to journalArticle

289 Scopus citations

Expression of a Poly-Glutamine-Ataxin-3 Transgene in Orexin Neurons Induces Narcolepsy-Cataplexy in the Rat

Beuckmann, C. T., Sinton, C. M., Williams, S. C., Richardson, J. A., Hammer, R. E., Sakurai, T. & Yanagisawa, M., May 5 2004, In : Journal of Neuroscience. 24, 18, p. 4469-4477 9 p.

Research output: Contribution to journalArticle

140 Scopus citations

Expression of the poly-glutamine-ataxin-3 transgene causes loss of orexin expression: A rat model of narcolepsy

Beuckmann, C. T., Sinton, C. M., Williams, S. C., Richardson, J. A., Hammer, R. E., Sakurai, T. & Yanagisawa, M., May 1 2004, In : Sleep and Biological Rhythms. 2, SUPPL. 1, p. S44

Research output: Contribution to journalArticle

Local complexity of amino acid interactions in a protein core

Jain, R. K. & Ranganathan, R., Jan 1 2004, In : Proceedings of the National Academy of Sciences of the United States of America. 101, 1, p. 111-116 6 p.

Research output: Contribution to journalArticle

35 Scopus citations

Loss-of-Function Analysis of EphA Receptors in Retinotectal Mapping

Feldheim, D. A., Nakamoto, M., Osterfield, M., Gale, N. W., DeChiara, T. M., Rohatgi, R., Yancopoulos, G. D. & Flanagan, J. G., Mar 10 2004, In : Journal of Neuroscience. 24, 10, p. 2542-2550 9 p.

Research output: Contribution to journalArticle

Open Access
116 Scopus citations

Metal Import through Microbial Membranes

Ferguson, A. D. & Deisenhofer, J., Jan 9 2004, In : Cell. 116, 1, p. 15-24 10 p.

Research output: Contribution to journalReview article

101 Scopus citations

Normal Development and Fertility of Knockout Mice Lacking the Tumor Suppressor Gene LRP1b Suggest Functional Compensation by LRP1

Marschang, P., Brich, J., Weeber, E. J., Sweatt, J. D., Shelton, J. M., Richardson, J. A., Hammer, R. E. & Herz, J., May 2004, In : Molecular and cellular biology. 24, 9, p. 3782-3793 12 p.

Research output: Contribution to journalArticle

45 Scopus citations
Open Access
195 Scopus citations

Paradigms for computational nucleic acid design

Dirks, R. M., Lin, M., Winfree, E. & Pierce, N. A., Jul 14 2004, In : Nucleic acids research. 32, 4, p. 1392-1403 12 p.

Research output: Contribution to journalArticle

142 Scopus citations

Responding to Directional Cues: A Tale of Two Cells

Paliwal, S., Ma, L., Krishnan, J., Levchenko, A. & Iglesias, P. A., Aug 2004, In : IEEE Control Systems. 24, 4, p. 77-90 14 p.

Research output: Contribution to journalArticle

9 Scopus citations

Structural determinants of allosteric ligand activation in RXR heterodimers

Shulman, A. I., Larson, C., Mangelsdorf, D. J. & Ranganathan, R., Feb 6 2004, In : Cell. 116, 3, p. 417-429 13 p.

Research output: Contribution to journalArticle

254 Scopus citations

Structure of the photolyase-like domain of cryptochrome 1 from Arabidopsis thaliana

Brautigam, C. A., Smith, B. S., Ma, Z., Palnitkar, M., Tomchick, D. R., Machius, M. & Deisenhofer, J., Aug 17 2004, In : Proceedings of the National Academy of Sciences of the United States of America. 101, 33, p. 12142-12147 6 p.

Research output: Contribution to journalArticle

216 Scopus citations

Tetramerization and ATP Binding by a Protein Comprising the A, B, and C Domains of Rat Synapsin I

Brautigam, C. A., Chelliah, Y. & Deisenhofer, J., Mar 19 2004, In : Journal of Biological Chemistry. 279, 12, p. 11948-11956 9 p.

Research output: Contribution to journalArticle

22 Scopus citations

Two complementary, local excitation, global inhibition mechanisms acting in parallel can explain the chemoattractant-induced regulation of PI(3,4,5)P 3 response in Dictyostelium cells

Ma, L., Janetopoulos, C., Yang, L., Devreotes, P. N. & Iglesias, P. A., Dec 2004, In : Biophysical journal. 87, 6, p. 3764-3774 11 p.

Research output: Contribution to journalArticle

115 Scopus citations

Uncoupling conformational change from GTP hydrolysis in a heterotrimetric G protein α-subunit

Thomas, C. J., Du, X., Li, P., Wang, Y., Ross, E. M. & Sprang, S. R., May 18 2004, In : Proceedings of the National Academy of Sciences of the United States of America. 101, 20, p. 7560-7565 6 p.

Research output: Contribution to journalArticle

23 Scopus citations