Research Output

Article

Mutation effects predicted from sequence co-variation

Hopf, T. A., Ingraham, J. B., Poelwijk, F. J., Schärfe, C. P. I., Springer, M., Sander, C. & Marks, D. S., Feb 1 2017, In : Nature Biotechnology. 35, 2, p. 128-135 8 p.

Research output: Contribution to journalArticle

120 Scopus citations

Mutation of β-glucosidase 2 causes glycolipid storage disease and impaired male fertility

Yildiz, Y., Matern, H., Thompson, B., Allegood, J. C., Warren, R. L., Ramirez, D. M. O., Hammer, R. E., Hamra, F. K., Matern, S. & Russell, D. W., Nov 1 2006, In : Journal of Clinical Investigation. 116, 11, p. 2985-2994 10 p.

Research output: Contribution to journalArticle

165 Scopus citations

Mutations in the carboxyl-terminal domain of phospholipase C-β1 delineate the dimer interface and a potential Gαq interaction site

Ilkaeva, O., Kinch, L. N., Paulssen, R. H. & Ross, E. M., Feb 8 2002, In : Journal of Biological Chemistry. 277, 6, p. 4294-4300 7 p.

Research output: Contribution to journalArticle

50 Scopus citations

MYC promotes tryptophan uptake and metabolism by the kynurenine pathway in colon cancer

Venkateswaran, N., Lafita-Navarro, M. C., Hao, Y. H., Kilgore, J. A., Perez-Castro, L., Braverman, J., Borenstein-Auerbach, N., Kim, M., Lesner, N. P., Mishra, P., Brabletz, T., Shay, J. W., DeBerardinis, R. J., Williams, N. S., Yilmaz, O. H. & Conacci-Sorrell, M., Sep 1 2019, In : Genes and Development. 33, 17-18, p. 1236-1251 16 p.

Research output: Contribution to journalArticle

Open Access
9 Scopus citations

Myosin VI undergoes a 180° power stroke implying an uncoupling of the front lever arm

Reifenberger, J. G., Toprak, E., Kim, H., Safer, D., Sweeney, H. L. & Selvin, P. R., Dec 4 2009, In : Proceedings of the National Academy of Sciences of the United States of America. 106, 43, p. 18255-18260 6 p.

Research output: Contribution to journalArticle

30 Scopus citations

Narcolepsy in orexin knockout mice: Molecular genetics of sleep regulation

Chemelli, R. M., Willie, J. T., Sinton, C. M., Elmquist, J. K., Scammell, T., Lee, C., Richardson, J. A., Clay Williams, S., Xiong, Y., Kisanuki, Y., Fitch, T. E., Nakazato, M., Hammer, R. E., Saper, C. B. & Yanagisawa, M., Aug 20 1999, In : Cell. 98, 4, p. 437-451 15 p.

Research output: Contribution to journalArticle

2379 Scopus citations

Natural-like function in artificial WW domains

Russ, W. P., Lowery, D. M., Mishra, P., Yaffe, M. B. & Ranganathan, R., Sep 22 2005, In : Nature. 437, 7058, p. 579-583 5 p.

Research output: Contribution to journalArticle

176 Scopus citations

Negative and positive selection of antigen-specific cytotoxic T lymphocytes affected by the α3 domain of MHC I molecules

Aldrich, C. J., Hammer, R. E., Jones-Youngblood, S., Koszinowski, U., Hood, L., Stroynowski, I. T. & Forman D.M.D/Ph.D., J. M., 1991, In : Nature. 352, 6337, p. 718-721 4 p.

Research output: Contribution to journalArticle

75 Scopus citations

Neurexin Iα is a major α-latrotoxin receptor that cooperates in α- latrotoxin action

Geppert, M., Khvotchev, M., Krasnoperov, V., Goda, Y., Missler, M., Hammer, R. E., Ichtchenko, K., Petrenko, A. G. & Südhof, T. C., Jan 16 1998, In : Journal of Biological Chemistry. 273, 3, p. 1705-1710 6 p.

Research output: Contribution to journalArticle

80 Scopus citations

Neurexophilin binding to α-neurexins. A single LNS domain functions as an independently folding ligand-binding unit

Missler, M., Hammer, R. E. & Südhof, T. C., Dec 25 1998, In : Journal of Biological Chemistry. 273, 52, p. 34716-34723 8 p.

Research output: Contribution to journalArticle

88 Scopus citations

Neurite branching on deformable substrates

Flanagan, L. A., Ju, Y. E., Marg, B., Osterfield, M. & Janmey, P. A., Dec 20 2002, In : NeuroReport. 13, 18, p. 2411-2415 5 p.

Research output: Contribution to journalArticle

530 Scopus citations

Neuropeptide B-deficient mice demonstrate hyperalgesia in response to inflammatory pain

Kelly, M. A., Beuckmann, C. T., Williams, S. C., Sinton, C. M., Motoike, T., Richardson, J. A., Hammer, R. E., Garry, M. G. & Yanagisawa, M., Jul 12 2005, In : Proceedings of the National Academy of Sciences of the United States of America. 102, 28, p. 9942-9947 6 p.

Research output: Contribution to journalArticle

45 Scopus citations

New-generation Amber united-atom force field

Yang, L., Tan, C. H., Hsieh, M. J., Wang, J., Duan, Y., Cieplak, P., Caldwell, J., Kollman, P. A. & Luo, R., Jul 6 2006, In : Journal of Physical Chemistry B. 110, 26, p. 13166-13176 11 p.

Research output: Contribution to journalArticle

151 Scopus citations

Nicotine Reduces Embryo Growth, Delays Implantation, and Retards Parturition in Rats

Hammer, R. E. & Mitchell, J. A., Nov 1979, In : Proceedings of the Society for Experimental Biology and Medicine. 162, 2, p. 333-336 4 p.

Research output: Contribution to journalArticle

15 Scopus citations

Nkx2-5 transactivates the Ets-related protein 71 gene and specifies an endothelial/endocardial fate in the developing embryo

Ferdous, A., Caprioli, A., Iacovino, M., Martin, C. M., Morris, J., Richardson, J. A., Latif, S., Hammer, R. E., Harvey, R. P., Olson, E. N., Kyba, M. & Garry, D. J., Jan 20 2009, In : Proceedings of the National Academy of Sciences of the United States of America. 106, 3, p. 814-819 6 p.

Research output: Contribution to journalArticle

129 Scopus citations

NMR analyses of the activation of the Arp2/3 complex by neuronal Wiskott-Aldrich syndrome protein

Kreishman-Deitrick, M., Goley, E. D., Burdine, L., Denison, C., Egile, C., Li, R., Murali, N., Kodadek, T. J., Welch, M. D. & Rosen, M. K., Nov 22 2005, In : Biochemistry. 44, 46, p. 15247-15256 10 p.

Research output: Contribution to journalArticle

39 Scopus citations

NMR analysis of methyl groups at 100-500 kDa: Model systems and Arp2/3 complex

Kreishman-Deitrick, M., Egile, C., Hoyt, D. W., Ford, J. J., Li, R. & Rosen, M. K., Jul 22 2003, In : Biochemistry. 42, 28, p. 8579-8586 8 p.

Research output: Contribution to journalArticle

20 Scopus citations

NMR detection of side chain-side chain hydrogen bonding interactions in 13C/15N-labeled proteins

Liu, A., Hu, W., Majumdar, A., Rosen, M. K. & Patel, D. J., 2000, In : Journal of biomolecular NMR. 17, 4, p. 305-310 6 p.

Research output: Contribution to journalArticle

22 Scopus citations

NMR structures of the selenoproteins Sep15 and SelM reveal redox activity of a new thioredoxin-like family

Ferguson, A. D., Labunskyy, V. M., Fomenko, D. E., Araç, D., Chelliah, Y., Amezcua, C. A., Rizo-Rey, J., Gladyshev, V. N. & Deisenhofer, J., Feb 10 2006, In : Journal of Biological Chemistry. 281, 6, p. 3536-3543 8 p.

Research output: Contribution to journalArticle

142 Scopus citations

Noise resistance in the spindle assembly checkpoint

Doncic, A., Ben-Jacob, E. & Barkai, N., May 16 2006, In : Molecular Systems Biology. 2, p. 2006.0027 msb4100070.

Research output: Contribution to journalArticle

13 Scopus citations

Non-antibiotic Small-Molecule Regulation of DHFR-Based Destabilizing Domains In Vivo

Peng, H., Chau, V. Q., Phetsang, W., Sebastian, R. M., Stone, M. R. L., Datta, S., Renwick, M., Tamer, Y. T., Toprak, E., Koh, A. Y., Blaskovich, M. A. T. & Hulleman, J. D., Dec 13 2019, In : Molecular Therapy - Methods and Clinical Development. 15, p. 27-39 13 p.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Nonclassical binding of formylated peptide in crystal structure of the MHC class lb molecule H2-M3

Wang, C. R., Castaño, A. R., Peterson, P. A., Slaughter, C., Fischer Lindahl, K. & Deisenhofer, J., Aug 25 1995, In : Cell. 82, 4, p. 655-664 10 p.

Research output: Contribution to journalArticle

133 Scopus citations

Nonequilibrium atomistic molecular dynamics simulation of tubular nanomotor propelled by bubble propulsion

Man, V. H., Li, M. S., Wang, J., Derreumaux, P. & Nguyen, P. H., Jul 14 2019, In : Journal of Chemical Physics. 151, 2, 024103.

Research output: Contribution to journalArticle

1 Scopus citations

Normal Development and Fertility of Knockout Mice Lacking the Tumor Suppressor Gene LRP1b Suggest Functional Compensation by LRP1

Marschang, P., Brich, J., Weeber, E. J., Sweatt, J. D., Shelton, J. M., Richardson, J. A., Hammer, R. E. & Herz, J., May 2004, In : Molecular and cellular biology. 24, 9, p. 3782-3793 12 p.

Research output: Contribution to journalArticle

45 Scopus citations

Normal luminal bacteria, especially bacteroides species, mediate chronic colitis, gastritis, and arthritis in HLA-B27/human β2 microglobulin transgenic rats

Rath, H. C., Herfarth, H. H., Ikeda, J. S., Grenther, W. B., Hamm, T. E., Balish, E., Taurog, J. D., Hammer, R. E., Wilson, K. H. & Sartor, R. B., Aug 15 1996, In : Journal of Clinical Investigation. 98, 4, p. 945-953 9 p.

Research output: Contribution to journalArticle

Open Access
622 Scopus citations
73 Scopus citations

Novel developmental specificity in the nervous system of transgenic animals expressing growth hormone fusion genes

Swanson, L. W., Simmons, D. M., Arriza, J., Hammer, R. E., Brinster, R., Rosenfeld, M. G. & Evans, R. M., Dec 1 1985, In : Nature. 317, 6035, p. 363-366 4 p.

Research output: Contribution to journalArticle

78 Scopus citations

Novel HY peptide antigens presented by HLA-B27.

Taurog, J. D., Hammer, R. E., Moomaw, C. R., Slaughter, C. A., Roopenian, D. C., Zuberi, A. R., Gaskell, S. J., Bordoli, R. S., Colbert, R. A., Butcher, G. W. & Leong, L. Y., Nov 15 1999, In : Journal of Immunology. 163, 10, p. 5741 1 p.

Research output: Contribution to journalArticle

Novel HY peptide antigens presented by HLA-B271

Simmons, W. A., Summerfield, S. G., Roopenian, D. C., Slaughter, C. A., Zuberi, A. R., Gaskell, S. J., Bordoli, R. S., Hoyes, J., Moomaw, C. R., Colbert, R. A., Leong, L. Y. W., Butcher, G. W., Hammer, R. E. & Taurog, J. D., 1997, In : Journal of Immunology. 159, 6, p. 2750-2759 10 p.

Research output: Contribution to journalArticle

26 Scopus citations
Open Access
1 Scopus citations

Nuclear Import Receptor Inhibits Phase Separation of FUS through Binding to Multiple Sites

Yoshizawa, T., Ali, R., Jiou, J., Fung, H. Y. J., Burke, K. A., Kim, S. J., Lin, Y., Peeples, W. B., Saltzberg, D., Soniat, M., Baumhardt, J. M., Oldenbourg, R., Sali, A., Fawzi, N. L., Rosen, M. K. & Chook, Y. M., Jan 1 2018, (Accepted/In press) In : Cell.

Research output: Contribution to journalArticle

72 Scopus citations

Nucleotide control of interdomain interactions in the conformational reaction cycle of SecA

Hunt, J. F., Weinkauf, S., Henry, L., Fak, J. J., McNicholas, P., Oliver, D. B. & Deisenhofer, J., Sep 20 2002, In : Science. 297, 5589, p. 2018-2026 9 p.

Research output: Contribution to journalArticle

231 Scopus citations

OPA1 Isoforms in the Hierarchical Organization of Mitochondrial Functions

Del Dotto, V., Mishra, P., Vidoni, S., Fogazza, M., Maresca, A., Caporali, L., McCaffery, J. M., Cappelletti, M., Baruffini, E., Lenaers, G., Chan, D., Rugolo, M., Carelli, V. & Zanna, C., Jun 20 2017, In : Cell Reports. 19, 12, p. 2557-2571 15 p.

Research output: Contribution to journalArticle

54 Scopus citations

Optimality and evolution of transcriptionally regulated gene expression

Poelwijk, F. J., Heyning, P. D., de Vos, M. G. J., Kiviet, D. J. & Tans, S. J., Aug 16 2011, In : BMC Systems Biology. 5, 128.

Research output: Contribution to journalArticle

19 Scopus citations

Organization of Chromatin by Intrinsic and Regulated Phase Separation

Gibson, B. A., Doolittle, L. K., Schneider, M. W. G., Jensen, L. E., Gamarra, N., Henry, L., Gerlich, D. W., Redding, S. & Rosen, M. K., Oct 3 2019, In : Cell. 179, 2, p. 470-484.e21

Research output: Contribution to journalArticle

50 Scopus citations

Origins of Allostery and Evolvability in Proteins: A Case Study

Raman, A. S., White, K. I. & Ranganathan, R., Jul 14 2016, In : Cell. 166, 2, p. 468-480 13 p.

Research output: Contribution to journalArticle

46 Scopus citations
Open Access
553 Scopus citations
Open Access
144 Scopus citations
Open Access
195 Scopus citations
79 Scopus citations
149 Scopus citations
Open Access
665 Scopus citations

p53 genes function to restrain mobile elements

Wylie, A., Jones, A. E., D’Brot, A., Lu, W. J., Kurtz, P., Moran, J. V., Rakheja, D., Chen, K., Hammer, R. E., Comerford, S. A., Amatruda, J. F. & Abrams, J. M., Jan 1 2016, In : Genes and Development. 30, 1, p. 64-77 14 p.

Research output: Contribution to journalArticle

73 Scopus citations

p53-Mdm2 loop controlled by a balance of its feedback strength and effective dampening using ATM and delayed feedback

Wagner, J., Ma, L., Rice, J. J., Hu, W., Levine, A. J. & Stolovitzky, G. A., Sep 1 2005, In : IEE Proceedings Systems Biology. 152, 3, p. 109-117 9 p.

Research output: Contribution to journalArticle

70 Scopus citations

Palmitoylation of a conserved cysteine in the regulator of G protein signaling (RGS) domain modulates the GTPase-activating activity of RGS4 and RGS10

Tu, Y., Popov, S., Slaughter, C. & Ross, E. M., Dec 31 1999, In : Journal of Biological Chemistry. 274, 53, p. 38260-38267 8 p.

Research output: Contribution to journalArticle

85 Scopus citations

Pancreatic neoplasia induced by SV40 T-antigen expression in acinar cells of transgenic mice

Ornitz, D. M., Hammer, R. E., Messing, A., Palmiter, R. D. & Brinster, R. L., Jan 1 1987, In : Science. 238, 4824, p. 188-193 6 p.

Research output: Contribution to journalArticle

179 Scopus citations

Paradigms for computational nucleic acid design

Dirks, R. M., Lin, M., Winfree, E. & Pierce, N. A., Jul 14 2004, In : Nucleic acids research. 32, 4, p. 1392-1403 12 p.

Research output: Contribution to journalArticle

142 Scopus citations

Partial correction of murine hereditary growth disorder by germ-line incorporation of a new gene

Hammer, R. E., Palmiter, R. D. & Brinster, R. L., Dec 1 1984, In : Nature. 311, 5981, p. 65-67 3 p.

Research output: Contribution to journalArticle

102 Scopus citations

Pathogenesis of autosomal dominant hereditary spastic paraplegia (SPG6) revealed by a rat model.

Watanabe, F., Arnold, W. D., Hammer, R. E., Ghodsizadeh, O., Moti, H., Schumer, M., Hashmi, A., Hernandez, A., Sneh, A., Sahenk, Z. & Kisanuki, Y. Y., Nov 2013, In : Journal of neuropathology and experimental neurology. 72, 11, p. 1016-1028 13 p.

Research output: Contribution to journalArticle

Open Access
10 Scopus citations
38 Scopus citations