Research Output

2000

Structural basis for relief of autoinhibition of the Dbl homology domain of proto-oncogene Vav by tyrosine phosphorylation

Aghazadeh, B., Lowry, W. E., Huang, X. Y. & Rosen, M. K., Sep 1 2000, In : Cell. 102, 5, p. 625-633 9 p.

Research output: Contribution to journalArticle

Open Access
302 Scopus citations

Synaptic assembly of the brain in the absence of neurotransmitter secretion

Verhage, M., Maia, A. S., Plomp, J. J., Brussaard, A. B., Heeroma, J. H., Vermeer, H., Toonen, R. F., Hammer, R. E., Van Den Berg, T. K., Missler, M., Geuze, H. J. & Südhof, T. C., Feb 4 2000, In : Science. 287, 5454, p. 864-869 6 p.

Research output: Contribution to journalArticle

889 Scopus citations

The GxxxG motif: A framework for transmembrane helix-helix association

Russ, W. P. & Engelman, D. M., Feb 25 2000, In : Journal of Molecular Biology. 296, 3, p. 911-919 9 p.

Research output: Contribution to journalArticle

695 Scopus citations

The structural basis for red fluorescence in the tetrameric GFP homolog DsRed

Wall, M. A., Socolich, M. & Ranganathan, R., Dec 23 2000, In : Nature Structural Biology. 7, 12, p. 1133-1138 6 p.

Research output: Contribution to journalArticle

292 Scopus citations

The structure of the catalytic portion of human HMG-CoA reductase

Istvan, E. S. & Deisenhofer, J., Dec 15 2000, In : Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids. 1529, 1-3, p. 9-18 10 p.

Research output: Contribution to journalReview article

100 Scopus citations
1999

A Comparison of Three Heuristic Algorithms for Molecular Docking

Hou, T. J., Wang, J. M. & Xu, X. J., Jul 1 1999, In : Chinese Chemical Letters. 10, 7, p. 615-618 4 p.

Research output: Contribution to journalArticle

12 Scopus citations

Adipose expression of the phosphoenolpyruvate carboxykinase promoter requires peroxisome proliferator-activated receptor γ and 9-cis-retinoic acid receptor binding to an adipocyte-specific enhancer in vivo

Devine, J. H., Eubank, D. W., Clouthier, D. E., Tontonoz, P., Spiegelman, B. M., Hammer, R. E. & Beale, E. G., May 7 1999, In : Journal of Biological Chemistry. 274, 19, p. 13604-13612 9 p.

Research output: Contribution to journalArticle

75 Scopus citations

Analysis of genomic regions involved in regulation of the rabbit surfactant protein A gene in transgenic mice

Alcorn, J. L., Hammer, R. E., Graves, K. R., Smith, M. E., Maika, S. D., Michael, L. F., Gao, E., Wang, Y. & Mendelson, C. R., Aug 1 1999, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 277, 2 21-2, p. L349-L361

Research output: Contribution to journalArticle

26 Scopus citations

Analysis of SCAMP1 function in secretory vesicle exocytosis by means of gene targeting in mice

Fernández-Chacón, R., De Toledo, G. A., Hammer, R. E. & Südhof, T. C., Nov 12 1999, In : Journal of Biological Chemistry. 274, 46, p. 32551-32554 4 p.

Research output: Contribution to journalArticle

45 Scopus citations

A new MHC locus that influences class I peptide presentation.

Taurog, J. D., Lindahl, K. F., Hammer, R. E., Slaughter, C. A., Maika, S. D., Zhou, M., Roopenian, D. C., Christianson, G. J., Gaskell, S. J., Jones, R. C., Bordoli, R., Ploegh, H. L., Galocha, B. & Summerfield, S. G., Oct 1999, In : Immunity. 11, 4, 1 p.

Research output: Contribution to journalComment/debate

Open Access

A phospho-switch controls the dynamic association of synapsins with synaptic vesicles

Hosaka, M., Hammer, R. E. & Südhof, T. C., Oct 1999, In : Neuron. 24, 2, p. 377-387 11 p.

Research output: Contribution to journalArticle

199 Scopus citations
34 Scopus citations

Applications of genetic algorithms on the structure - Activity relationship analysis of some cinnamamides

Hou, T. J., Wang, J. M., Liao, N. & Xu, X. J., Jan 1 1999, In : Journal of Chemical Information and Computer Sciences. 39, 5, p. 775-781 7 p.

Research output: Contribution to journalArticle

68 Scopus citations

Automated docking of peptides and proteins by genetic algorithm

Wang, J., Hou, T., Chen, L. & Xu, X., Jan 18 1999, In : Chemometrics and Intelligent Laboratory Systems. 45, 1-2, p. 281-286 6 p.

Research output: Contribution to journalArticle

19 Scopus citations

Automated docking of peptides and proteins by using a genetic algorithm combined with a tabu search

Hou, T., Wang, J., Chen, L. & Xu, X., Jan 1 1999, In : Protein Engineering. 12, 8, p. 639-647 9 p.

Research output: Contribution to journalArticle

61 Scopus citations

Conformational analysis of peptides using Monte Carlo simulations combined with the genetic algorithm

Wang, J., Hou, T., Chen, L. & Xu, X., Jan 18 1999, In : Chemometrics and Intelligent Laboratory Systems. 45, 1-2, p. 347-351 5 p.

Research output: Contribution to journalArticle

21 Scopus citations

Crystal structure of the DNA nucleotide excision repair enzyme UvrB from Thermus thermophilus

Machius, M., Henry, L., Palnitkar, M. & Deisenhofer, J., Oct 12 1999, In : Proceedings of the National Academy of Sciences of the United States of America. 96, 21, p. 11717-11722 6 p.

Research output: Contribution to journalArticle

90 Scopus citations

Crystal structure of the outer membrane active transporter FepA from Escherichia coli

Buchanan, S. K., Smith, B. S., Venkatramani, L., Xia, D., Esser, L., Palnitkar, M., Chakraborty, R., Van Der Helm, D. & Deisenhofer, J., May 27 1999, In : Nature Structural Biology. 6, 1, p. 56-63 8 p.

Research output: Contribution to journalArticle

458 Scopus citations

Erratum: Rat MHC-linked peptide transporter alleles strongly influence peptide binding by HLA-B27 but not B-27-associated inflammatory disease (Journal of Immunology (1996) 156 (1661-1667))

Taurog, J. D., Hammer, R. E., Richardson, J. A., Satumtira, N., Slaughter, C. A., Butcher, G. W., Howard, J. C. & Leong, L. Y. W., Nov 15 1999, In : Journal of Immunology. 163, 10, 1 p.

Research output: Contribution to journalComment/debate

2 Scopus citations

Erratum: A new MHC locus that influences class I peptide presentation (Immunity (1997) 7 (641-651))

Taurog, J. D., Lindahl, K. F., Hammer, R. E., Slaughter, C. A., Maika, S. D., Zhou, M., Roopenian, D. C., Christianson, G. J., Gaskell, S. J., Jones, R. C., Bordoli, R., Ploegh, H. L., Galocha, B. & Summerfield, S. G., Jan 1 1999, In : Immunity. 11, 4, p. x

Research output: Contribution to journalComment/debate

Erratum: Novel HY peptide antigens presented by HLA-B27 (Journal of Immunology (1997) 159 (2750-2759))

Taurog, J. D., Hammer, R. E., Moomaw, C. R., Slaughter, C. A., Roopenian, D. C., Zuberi, A. R., Gaskell, S. J., Bordoli, R. S., Hoyes, J., Colbert, R. A., Butcher, G. W. & Leong L.Y.-, W., Nov 15 1999, In : Journal of Immunology. 163, 10, 1 p.

Research output: Contribution to journalComment/debate

Essential roles in synaptic plasticity for synaptogyrin I and synaptophysin I

Janz, R., Südhof, T. C., Hammer, R. E., Unni, V., Siegelbaum, S. A. & Bolshakov, V. Y., Nov 1999, In : Neuron. 24, 3, p. 687-700 14 p.

Research output: Contribution to journalArticle

Open Access
226 Scopus citations

Evolutionarily conserved pathways of energetic connectivity in protein families

Lockless, S. W. & Ranganathan, R., Oct 8 1999, In : Science. 286, 5438, p. 295-299 5 p.

Research output: Contribution to journalArticle

923 Scopus citations
3 Scopus citations

Inflammatory disease in HLA-B27 transgenic rats

Taurog, J. D., Maika, S. D., Satumtira, N., Dorris, M. L., McLean, I. L., Yanagisawa, H., Sayad, A., Stagg, A. J., Fox, G. M., O'Brien, A. L., Rehman, M., Zhou, M., Weiner, A. L., Splawski, J. B., Richardson, J. A. & Hammer, R. E., Jul 29 1999, In : Immunological Reviews. 169, p. 209-223 15 p.

Research output: Contribution to journalReview article

174 Scopus citations

Kinetic control of guanine nucleotide binding to soluble Gα(q)

Markin, V. S. & Ross, E. M., Jul 1 1999, In : Biochemical Pharmacology. 58, 1, p. 39-48 10 p.

Research output: Contribution to journalArticle

43 Scopus citations

Leptin reverses insulin resistance and diabetes mellitus in mice with congenital lipodystrophy

Shimomura, I., Hammer, R. E., Ikemoto, S., Brown, M. S. & Goldstein, J. L., Sep 2 1999, In : Nature. 401, 6748, p. 73-76 4 p.

Research output: Contribution to journalArticle

804 Scopus citations

Ligand recognition by SH3 and WW domains: The role of N-alkylation in PPII helices

Aghazadeh, B. & Rosen, M. K., Sep 1999, In : Chemistry and Biology. 6, 9, p. R241-R246

Research output: Contribution to journalReview article

16 Scopus citations

Modulation of the affinity and selectivity of RGS protein interaction with Gα subunits by a conserved asparagine/serine residue

Posner, B. A., Mukhopadhyay, S., Tesmer, J. J., Gilman, A. G. & Ross, E. M., Jun 15 1999, In : Biochemistry. 38, 24, p. 7773-7779 7 p.

Research output: Contribution to journalArticle

66 Scopus citations

Narcolepsy in orexin knockout mice: Molecular genetics of sleep regulation

Chemelli, R. M., Willie, J. T., Sinton, C. M., Elmquist, J. K., Scammell, T., Lee, C., Richardson, J. A., Clay Williams, S., Xiong, Y., Kisanuki, Y., Fitch, T. E., Nakazato, M., Hammer, R. E., Saper, C. B. & Yanagisawa, M., Aug 20 1999, In : Cell. 98, 4, p. 437-451 15 p.

Research output: Contribution to journalArticle

2367 Scopus citations

Novel HY peptide antigens presented by HLA-B27.

Taurog, J. D., Hammer, R. E., Moomaw, C. R., Slaughter, C. A., Roopenian, D. C., Zuberi, A. R., Gaskell, S. J., Bordoli, R. S., Colbert, R. A., Butcher, G. W. & Leong, L. Y., Nov 15 1999, In : Journal of Immunology. 163, 10, p. 5741 1 p.

Research output: Contribution to journalArticle

Palmitoylation of a conserved cysteine in the regulator of G protein signaling (RGS) domain modulates the GTPase-activating activity of RGS4 and RGS10

Tu, Y., Popov, S., Slaughter, C. & Ross, E. M., Dec 31 1999, In : Journal of Biological Chemistry. 274, 53, p. 38260-38267 8 p.

Research output: Contribution to journalArticle

85 Scopus citations

Phospholipase C-β1 directly accelerates GTP hydrolysis by Gα(q) and acceleration is inhibited by Gβγ subunits

Chidiac, P. & Ross, E. M., Jul 9 1999, In : Journal of Biological Chemistry. 274, 28, p. 19639-19643 5 p.

Research output: Contribution to journalArticle

80 Scopus citations
146 Scopus citations

Reciprocal signaling between heterotrimeric G proteins and the p21- stimulated protein kinase

Wang, J., Frost, J. A., Cobb, M. H. & Ross, E. M., Oct 29 1999, In : Journal of Biological Chemistry. 274, 44, p. 31641-31647 7 p.

Research output: Contribution to journalArticle

48 Scopus citations

Reeler/disabled-like disruption of neuronal migration in knockout mice lacking the VLDL receptor and ApoE receptor 2

Trommsdorff, M., Gotthardt, M., Hiesberger, T., Shelton, J., Stockinger, W., Nimpf, J., Hammer, R. E., Richardson, J. A. & Herz, J., 1999, In : Cell. 97, 6, p. 689-701 13 p.

Research output: Contribution to journalArticle

1006 Scopus citations

Structural basis of multifunctional bovine mitochondrial cytochrome bc1 complex

Yu, C. A., Tian, H., Zhang, L., Deng, K. P., Shenoy, S. K., Yu, L., Xia, D., Kim, H. & Deisenhofer, J., Jan 1 1999, In : Journal of Bioenergetics and Biomembranes. 31, 3, p. 191-200 10 p.

Research output: Contribution to journalReview article

20 Scopus citations

Structure and reaction mechanisms of multifunctional mitochondrial cytochrome bc1 complex

Yu, C. A., Zhang, L., Deng, K. P., Tian, H., Xia, D., Kim, H., Deisenhofer, J. & Yu, L., Jan 1 1999, In : BioFactors. 9, 2-4, p. 103-109 7 p.

Research output: Contribution to journalReview article

17 Scopus citations

Structure of antimycin A1, a specific electron transfer inhibitor of ubiquinol-cytochrome c oxidoreductase [6]

Kim, H., Esser, L., Hossain, M. B., Xia, D., Yu, C. A., Rizo-Rey, J., Van Der Helm, D. & Deisenhofer, J., May 26 1999, In : Journal of the American Chemical Society. 121, 20, p. 4902-4903 2 p.

Research output: Contribution to journalLetter

30 Scopus citations

Structure of Cdc42 in complex with the GTPase-binding domain of the 'Wiskott-Aldrich syndrome' protein

Abdul-Manan, N., Aghazadeh, B., Liu, G. A., Majumdar, A., Ouerfelli, O., Simlnovitch, K. A. & Rosen, M. K., May 27 1999, In : Nature. 399, 6734, p. 379-383 5 p.

Research output: Contribution to journalArticle

264 Scopus citations

Studies on Crystal Structure, Conformation Analysis ofa New Designed Hapten Containing Sulfur

Xie, G. Y., Kong, Y. L., Wang, J. M., Xu, X. J. & Jin, S., Jun 10 1999, In : Kao Teng Hsueh Hsiao Hua Heush Hsueh Pao/ Chemical Journal of Chinese Universities. 20, 6, p. 893-894 2 p.

Research output: Contribution to journalArticle

The path to specificity

Zuker, C. S. & Ranganathan, R., Jan 29 1999, In : Science. 283, 5402, p. 650-651 2 p.

Research output: Contribution to journalReview article

26 Scopus citations

The structure of the ligand-binding domain of neurexin Iβ: Regulation of LNS domain function by alternative splicing

Rudenko, G., Nguyen, T., Chelliah, Y., Südhof, T. C. & Deisenhofer, J., Oct 1 1999, In : Cell. 99, 1, p. 93-101 9 p.

Research output: Contribution to journalArticle

110 Scopus citations

TOXCAT: A measure of transmembrane helix association in a biological membrane

Russ, W. P. & Engelman, D. M., Feb 2 1999, In : Proceedings of the National Academy of Sciences of the United States of America. 96, 3, p. 863-868 6 p.

Research output: Contribution to journalArticle

306 Scopus citations

Transgenic mice expressing a human apolipoprotein[a] allele

Acquati, F., Hammer, R. E., Ercoli, B., Mooser, V., Ruixan, T., Rönicke, V., Michalich, A., Chiesa, G., Taramelli, R., Hobbs, H. H. & Müller, H. J., Jun 1 1999, In : Journal of lipid research. 40, 6, p. 994-1006 13 p.

Research output: Contribution to journalArticle

15 Scopus citations
1998

Accurate quantification of expression of transgenes marked with restriction endonuclease site polymorphisms by RT-PCR

Li, S., George-Raizen, J. B., Hammer, R. E. & Garrard, W. T., Oct 21 1998, In : BioTechniques. 25, 4, p. 558-562 5 p.

Research output: Contribution to journalArticle

2 Scopus citations

Activation of a matrix processing peptidase from the crystalline cytochrome complex of bovine heart mitochondria

Deng, K., Zhang, L., Kachurin, A. M., Yu, L., Xia, D., Kim, H., Deisenhofer, J. & Yu, C. A., Aug 14 1998, In : Journal of Biological Chemistry. 273, 33, p. 20752-20757 6 p.

Research output: Contribution to journalArticle

32 Scopus citations
526 Scopus citations

A novel electron transfer mechanism suggested by crystallographic studies of mitochondrial cytochrome bc1 complex

Xia, D., Kim, H., Yu, C. A., Yu, L., Kachurin, A., Zhang, L. & Deisenhofer, J., Dec 1 1998, In : Biochemistry and Cell Biology. 76, 5, p. 673-679 7 p.

Research output: Contribution to journalArticle

11 Scopus citations
9 Scopus citations