Research Output

1997

Monoclonal antibody to the HLA class I α3 domain inhibits T cell activation and prolongs cardiac allograft survival in HLA- transgenic mice

Woo, J., Cornejo, M. C., Gao, L., Taurog, J. D., Hammer, R. E. & Buelow, R., Jun 1997, In : Transplant Immunology. 5, 2, p. 112-121 10 p.

Research output: Contribution to journalArticle

1 Scopus citations

Novel HY peptide antigens presented by HLA-B271

Simmons, W. A., Summerfield, S. G., Roopenian, D. C., Slaughter, C. A., Zuberi, A. R., Gaskell, S. J., Bordoli, R. S., Hoyes, J., Moomaw, C. R., Colbert, R. A., Leong, L. Y. W., Butcher, G. W., Hammer, R. E. & Taurog, J. D., Dec 1 1997, In : Journal of Immunology. 159, 6, p. 2750-2759 10 p.

Research output: Contribution to journalArticle

26 Scopus citations

PDZ domain proteins: Scaffolds for signaling complexes

Ranganathan, R. & Ross, E. M., Dec 1 1997, In : Current Biology. 7, 12, p. R770-R773

Research output: Contribution to journalReview article

Open Access
131 Scopus citations

Photophysics of photosynthesis. Structure and spectroscopy of reaction centers of purple bacteria

Hoff, A. J. & Deisenhofer, J., Aug 1997, In : Physics Report. 287, 1-2, p. 1-247 247 p.

Research output: Contribution to journalReview article

287 Scopus citations

Proteins

Brändén, C. I. & Deisenhofer, J., Dec 1997, In : Current Opinion in Structural Biology. 7, 6, p. 819-820 2 p.

Research output: Contribution to journalEditorial

Structural adaptations in the specialized bacteriophage T4 co- chaperonin Gp31 expand the size of the anfinsen cage

Hunt, J. F., Van der Vies, S. M., Henry, L. & Deisenhofer, J., Jul 25 1997, In : Cell. 90, 2, p. 361-371 11 p.

Research output: Contribution to journalArticle

88 Scopus citations

Structural and functional analysis of the mitotic rotamase Pin1 suggests substrate recognition is phosphorylation dependent

Ranganathan, R., Lu, K. P., Hunter, T. & Noel, J. P., Jun 13 1997, In : Cell. 89, 6, p. 875-886 12 p.

Research output: Contribution to journalArticle

Open Access
563 Scopus citations

The 3-D structure of the cytochrome bel complex from bovine heart

Deisenhofer, J., Xia, D., Kim, H., Yu, C. A., Xia, L. Z., Kachurin, A. & Yu, L., Dec 1 1997, In : FASEB Journal. 11, 9, p. A1277

Research output: Contribution to journalArticle

1 Scopus citations

The QSAR research of pyrrolobenzothiazepinones and pyrrolobenzo- xazepinones - Novel and specific non-nucleoside HIV-1 reverse transcriptase inhibitors

Wang, J. M., Hou, T. J., Li, Y. Y. & Xu, X. J., Dec 1 1997, In : Chinese Chemical Letters. 8, 10, p. 889-892 4 p.

Research output: Contribution to journalArticle

1 Scopus citations

The transcriptional regulatory strategy of the rat tissue kallikrein gene family.

Kroon, E., MacDonald, R. J. & Hammer, R. E., Dec 1997, In : Genes and function. 1, 5-6, p. 309-319 11 p.

Research output: Contribution to journalArticle

7 Scopus citations

Transgenic mice expressing human ApoB95 and ApoB97. Evidence that sequences within the carboxyl-terminal portion of human apoB100 are important for the assembly of lipoprotein(a)

McCormick, S. P. A., Ng, J. K., Cham, C. M., Taylor, S., Marcovina, S. M., Segrest, J. P., Hammer, R. E. & Young, S. G., Sep 19 1997, In : Journal of Biological Chemistry. 272, 38, p. 23616-23622 7 p.

Research output: Contribution to journalArticle

23 Scopus citations

X-ray crystallographic studies on an inhibitor-induced conformational change of the iron-sulfur protein in mitochondrial BC1 complex

Kim, H., Xia, D., Deisenhofer, J., Yu, C. A., Kachurin, A., Zhang, L. & Yu, L., Dec 1 1997, In : FASEB Journal. 11, 9, p. A1083

Research output: Contribution to journalArticle

6 Scopus citations
1996
76 Scopus citations

A potential SH3 domain-binding site in the Crk SH2 domain

Anafi, M., Rosen, M. K., Gish, G. D., Kay, L. E. & Pawson, T., Sep 16 1996, In : Journal of Biological Chemistry. 271, 35, p. 21365-21374 10 p.

Research output: Contribution to journalArticle

47 Scopus citations

Carboxyl-terminal fragments of phospholipase C-β1 with intrinsic G(q) GTPase-activating protein (GAP) activity

Paulssen, R. H., Woodson, J., Liu, Z. & Ross, E. M., Nov 6 1996, In : Journal of Biological Chemistry. 271, 43, p. 26622-26629 8 p.

Research output: Contribution to journalArticle

58 Scopus citations

Crystallization and preliminary structure of beef heart mitochondrial cytochrome-bc1 complex

Yu, C. A., Xia, J. Z., Kachurin, A. M., Yu, L., Xia, D., Kim, H. & Deisenhofer, J., Jul 18 1996, In : Biochimica et Biophysica Acta - Bioenergetics. 1275, 1-2, p. 47-53 7 p.

Research output: Contribution to journalArticle

83 Scopus citations

Crystal structure of the MHC class Ib molecule H2-M3

Wang, C. R., Fischer Lindahl, K. & Deisenhofer, J., Jan 1 1996, In : Research in Immunology. 147, 5, p. 313-321 9 p.

Research output: Contribution to journalArticle

9 Scopus citations

Defective forebrain development in mice lacking gp330/megalin

Willnow, T. E., Hilpert, J., Armstrong, S. A., Rohlmann, A., Hammer, R. E., Burns, D. K. & Herz, J., Aug 6 1996, In : Proceedings of the National Academy of Sciences of the United States of America. 93, 16, p. 8460-8464 5 p.

Research output: Contribution to journalArticle

383 Scopus citations

Determining the secondary structure and orientation of EmrE, a multi-drug transporter, indicates a transmembrane four-helix bundle

Arkin, I. T., Russ, W. P., Lebendiker, M. & Schuldiner, S., Jun 4 1996, In : Biochemistry. 35, 22, p. 7235-7238 4 p.

Research output: Contribution to journalArticle

98 Scopus citations

Experimental spondyloarthropathy in HLA-B27 transgenic rats

Taurog, J. D. & Hammer, R. E., 1996, In : Clinical Rheumatology. 15, SUPPL. 1, p. 22-27 6 p.

Research output: Contribution to journalArticle

19 Scopus citations

Functional importance of the amino terminus of G

Hepler, J. R., Biddlecome, G. H., Kleuss, C., Camp, L. A., Hofmann, S. L., Ross, E. M. & Gilman, A. G., Jan 5 1996, In : Journal of Biological Chemistry. 271, 1, p. 496-504 9 p.

Research output: Contribution to journalArticle

Open Access
95 Scopus citations

Fusion von Wirbelkörpern und dem Sakroiliakalgelenk durch Knorpelgewebe in HLA-B27-transgenen Ratten.

Translated title of the contribution: Fusion of vertebrae and the sacroiliac joint by cartilaginous tissue in HLA-B27 transgenic ratsKriegsmann, J., Franklin, B. N., Gay, R. E., Taurog, J. D., Hammer, R. E., Bräuer, R., Katenkamp, D. & Gay, S., 1996, In : Verhandlungen der Deutschen Gesellschaft für Pathologie. 80, 1 p.

Research output: Contribution to journalArticle

3 Scopus citations

Generation of transgenic mice from yeast artificial chromosome DNA that has been modified by gene targeting

McCormick, S. P. A., Peterson, K. R., Hammer, R. E., Clegg, C. H. & Young, S. G., Jan 1996, In : Trends in Cardiovascular Medicine. 6, 1, p. 16-24 9 p.

Research output: Contribution to journalShort survey

13 Scopus citations
168 Scopus citations

Normal luminal bacteria, especially bacteroides species, mediate chronic colitis, gastritis, and arthritis in HLA-B27/human β2 microglobulin transgenic rats

Rath, H. C., Herfarth, H. H., Ikeda, J. S., Grenther, W. B., Hamm, T. E., Balish, E., Taurog, J. D., Hammer, R. E., Wilson, K. H. & Sartor, R. B., Aug 15 1996, In : Journal of Clinical Investigation. 98, 4, p. 945-953 9 p.

Research output: Contribution to journalArticle

Open Access
620 Scopus citations
Open Access
664 Scopus citations

Purification and characterization of phospholipase C-β1 mutants expressed in E. coli

Meij, J. T. A. & Ross, E. M., Aug 23 1996, In : Biochemical and Biophysical Research Communications. 225, 3, p. 705-711 7 p.

Research output: Contribution to journalArticle

5 Scopus citations

RAP, a specialized chaperone, prevents ligand-induced ER retention and degradation of LDL receptor-related endocytic receptors

Willnow, T. E., Rohlmann, A., Norton, J., Otani, H., Braun, J. R., Hammer, R. E. & Herz, J., 1996, In : EMBO Journal. 15, 11, p. 2632-2639 8 p.

Research output: Contribution to journalArticle

227 Scopus citations

Rat MHC-linked peptide transporter alleles strongly influence peptide binding by HLA-B27 but not B27-associated inflammatory disease

Simmons, W. A., Leong, L. Y. W., Satumtira, N., Butcher, G. W., Howard, J. C., Richardson, J. A., Slaughter, C. A., Hammer, R. E. & Taurog, J. D., Feb 15 1996, In : Journal of Immunology. 156, 4, p. 1661-1667 7 p.

Research output: Contribution to journalArticle

24 Scopus citations

Rat spermatogenesis in mouse testis

Clouthier, D. E., Avarbock, M. R., Maika, S. D., Hammer, R. E. & Brinster, R. L., Jun 10 1996, In : Nature. 381, 6581, p. 418-421 4 p.

Research output: Contribution to journalArticle

317 Scopus citations
Open Access
203 Scopus citations

Selective methyl group protonation of perdeuterated proteins

Rosen, M. K., Gardner, K. H., Willis, R. C., Parris, W. E., Pawson, T. & Kay, L. E., Nov 15 1996, In : Journal of Molecular Biology. 263, 5, p. 627-636 10 p.

Research output: Contribution to journalEditorial

246 Scopus citations

Spatial localization of the K+ channel selectivity filter by mutant cycle-based structure analysis

Ranganathan, R., Lewis, J. H. & MacKinnon, R., Jan 1996, In : Neuron. 16, 1, p. 131-139 9 p.

Research output: Contribution to journalArticle

260 Scopus citations

Sustained somatic gene inactivation by viral transfer of cre recombinase

Rohlmann, A., Gotthardt, M., Willnow, T. E., Hammer, R. E. & Herz, J., Nov 1996, In : Nature biotechnology. 14, 11, p. 1562-1565 4 p.

Research output: Contribution to journalArticle

101 Scopus citations

Synaptophysin, a major synaptic vesicle protein, is not essential for neurotransmitter release

Mcmahon, H. T., Bolshakov, V. Y., Janz, R., Hammer, R. E., Siegelbaum, S. A. & Südhof, T. C., May 14 1996, In : Proceedings of the National Academy of Sciences of the United States of America. 93, 10, p. 4760-4764 5 p.

Research output: Contribution to journalArticle

192 Scopus citations

Synergistic interactions between XPC and p53 mutations in double-mutant mice: Neural tube abnormalities and accelerated UV radiation-induced skin cancer

Cheo, D. L., Meira, L. B., Hammer, R. E., Burns, D. K., Doughty, A. T. B. & Friedberg, E. C., Dec 1996, In : Current Biology. 6, 12, p. 1691-1694 4 p.

Research output: Contribution to journalArticle

Open Access
61 Scopus citations

T cells, but not thymic exposure to HLA-B27, are required for the inflammatory disease of HLA-B27 transgenic rats

Breban, M., Fernández-Sueiro, J. L., Richardson, J. A., Hadavand, R. R., Maika, S. D., Hammer, R. E. & Taurog, J. D., Jan 15 1996, In : Journal of Immunology. 156, 2, p. 794-803 10 p.

Research output: Contribution to journalArticle

167 Scopus citations

The crystal structure of the bifunctional enzyme 6-phosphofructo-2- kinase/fructose-2,6-bisphosphatase reveals distinct domain homologies

Hasemann, C. A., Istvan, E. S., Uyeda, K. & Deisenhofer, J., Sep 15 1996, In : Structure. 4, 9, p. 1017-1029 13 p.

Research output: Contribution to journalArticle

114 Scopus citations

The crystal structure of the GroES co-chaperonin at 2.8 Å resolution

Hunt, J. F., Weaver, A. J., Landry, S. J., Gierasch, L. & Deisenhofer, J., Jan 4 1996, In : Nature. 379, 6560, p. 37-45 9 p.

Research output: Contribution to journalArticle

387 Scopus citations
1995

Arrestin binding determines the rate of inactivation of the G protein-coupled receptor rhodopsin in vivo

Ranganathan, R. & Stevens, C. F., Jun 16 1995, In : Cell. 81, 6, p. 841-848 8 p.

Research output: Contribution to journalArticle

45 Scopus citations

A structural basis of the interactions between leucine-rich repeats and protein ligands

Kobe, B. & Deisenhofer, J., Jan 1 1995, In : Nature. 374, 6518, p. 183-186 4 p.

Research output: Contribution to journalArticle

547 Scopus citations

A transgene coding for a human insulin analog has a mitogenic effect on murine embryonic β cells

Vincent, M. T., Carroll, R. J., Hammer, R. E., Chan, S. J., Guz, Y., Steiner, D. F. & Teitelman, G., Jul 3 1995, In : Proceedings of the National Academy of Sciences of the United States of America. 92, 14, p. 6239-6243 5 p.

Research output: Contribution to journalArticle

18 Scopus citations

Carboxyl-terminal domains in the avian β1-adrenergic receptor that regulate agonist-promoted endocytosis

Parker, E. M., Swigart, P., Nunnally, M. H., Perkins, J. P. & Ross, E. M., Jan 1 1995, In : Journal of Biological Chemistry. 270, 12, p. 6482-6487 6 p.

Research output: Contribution to journalArticle

29 Scopus citations

Characterization of psoriasiform and alopecic skin lesions in HLA-B27 transgenic rats

Yanagisawa, H., Richardson, J. A., Taurog, J. D. & Hammer, R. E., Jan 1 1995, In : American Journal of Pathology. 147, 4, p. 955-964 10 p.

Research output: Contribution to journalArticle

24 Scopus citations

Cooperation between elements of an organ-specific transcriptional enhancer in animals

Kruse, F., Rose, S. D., Swift, G. H., Hammer, R. E. & MacDonald, R. J., Aug 1995, In : Molecular and cellular biology. 15, 8, p. 4385-4394 10 p.

Research output: Contribution to journalArticle

Open Access
33 Scopus citations

Crystallization and preliminary X‐ray analysis of fructose 6‐phosphate, 2‐kinase:fructose 2,6‐bisphosphatase

Istvan, E. S., Hasemann, C. A., Kurumbail, R. G., Uyeda, K. & Deisenhofer, J., Nov 1995, In : Protein Science. 4, 11, p. 2439-2441 3 p.

Research output: Contribution to journalArticle

6 Scopus citations

Crystallographic refinement at 2.3 Å resolution and refined model of the photosynthetic reaction centre from Rhodopseudomonas viridis

Deisenhofer, J., Epp, O., Sinning, I. & Michel, H., Feb 24 1995, In : Journal of Molecular Biology. 246, 3, p. 429-457 29 p.

Research output: Contribution to journalArticle

543 Scopus citations

Crystal structure of DNA photolyase from Escherichia coli

Park, H. W., Kim, S. T., Sancar, A. & Deisenhofer, J., Jan 1 1995, In : Science. 268, 5219, p. 1866-1872 7 p.

Research output: Contribution to journalArticle

453 Scopus citations