Research Output

1993

GAP-43 augments G protein-coupled receptor transduction in Xenopus laevis oocytes

Strittmatter, S. M., Cannon, S. C., Ross, E. M., Higashijima, T. & Fishman, M. C., Jan 1 1993, In : Proceedings of the National Academy of Sciences of the United States of America. 90, 11, p. 5327-5331 5 p.

Research output: Contribution to journalArticle

Open Access
63 Scopus citations
Open Access
1148 Scopus citations

Rats transgenic for HLA-B27 and human β-2 microglobulin: A model for human spondyloarthropathies

Breban, M. A., Hammer, R. E. & Taurog, J. D., Jan 1 1993, In : Revue du Rhumatisme (English Edition). 60, 3, p. 149-153 5 p.

Research output: Contribution to journalEditorial

1 Scopus citations

Rats transgéniques pour le HLA-B27 et la beta 2-microglobuline humaine: un modèle de spondylo-arthropathie.

Translated title of the contribution: Transgenic rats for HLA-B27 and human beta 2 microglobulin: a model of spondyloarthritisBreban, M. A., Hammer, R. E. & Taurog, J. D., Mar 1 1993, In : Revue du rhumatisme (Ed. francaise : 1993). 60, 3, p. 181-186 6 p.

Research output: Contribution to journalEditorial

Regulation of the M1 muscarinic receptor-Gg-phospholipase C-β pathway by nucleotide exchange and GTP hydrolysis

Ross, E. M. & Berstein, G., 1993, In : Life Sciences. 52, 5-6, p. 413-419 7 p.

Research output: Contribution to journalArticle

9 Scopus citations

Sequential Assignment and Structure Determination of Spider Toxin ω-Aga-IVB

Yu, H., Rosen, M. K., Saccomano, N. A., Phillips, D., Volkmann, R. A. & Schreiber, S. L., 1993, In : Biochemistry. 32, 48, p. 13123-13129 7 p.

Research output: Contribution to journalArticle

53 Scopus citations

Sharing of an HLA-B27-restricted H-Y antigen between rat and mouse

Simmons, W. A., Taurog, J. D., Hammer, R. E. & Breban, M., Jul 1 1993, In : Immunogenetics. 38, 5, p. 351-358 8 p.

Research output: Contribution to journalArticle

9 Scopus citations

Short-term synaptic plasticity is altered in mice lacking synapsin I

Rosahl, T. W., Geppert, M., Spillane, D., Herz, J., Hammer, R. E., Malenka, R. C. & Südhof, T. C., Nov 19 1993, In : Cell. 75, 4, p. 661-670 10 p.

Research output: Contribution to journalArticle

271 Scopus citations

Susceptibility to inflammatory disease in HLA-B27 transgenic rat lines correlates with the level of B27 expression

Taurog, J. D., Maika, S. D., Simmons, W. A., Breban, M. & Hammer, R. E., Jan 1 1993, In : Journal of Immunology. 150, 9, p. 4168-4178 11 p.

Research output: Contribution to journalArticle

196 Scopus citations

Transfer of the inflammatory disease of HLA-B27 transgenic rats by bone marrow engraftment

Breban, M., Hammer, R. E., Richardson, J. A. & Taurog, J. D., Nov 1 1993, In : Journal of Experimental Medicine. 178, 5, p. 1607-1616 10 p.

Research output: Contribution to journalArticle

Open Access
124 Scopus citations

Transgenic mice expressing high plasma concentrations of human apolipoprotein B100 and lipoprotein (a)

Linton, M. F., Farese, R. V., Chiesa, G., Grass, D. S., Chin, P., Hammer, R. E., Hobbs, H. H. & Young, S. G., Dec 1993, In : Journal of Clinical Investigation. 92, 6, p. 3029-3037 9 p.

Research output: Contribution to journalArticle

Open Access
203 Scopus citations
1992

Atherogenesis in transgenic mice expressing human apolipoprotein(a)

Lawn, R. M., Wade, D. P., Hammer, R. E., Chiesa, G., Verstuyft, J. G. & Rubin, E. M., Jan 1 1992, In : Nature. 360, 6405, p. 670-672 3 p.

Research output: Contribution to journalArticle

241 Scopus citations

Cell-specific expression of cytosolic phosphoenolpyruvate carboxykinase in transgenic mice

Beale, E. G., Clouthier, D. E. & Hammer, R. E., Dec 1 1992, In : FASEB Journal. 6, 15, p. 3330-3337 8 p.

Research output: Contribution to journalReview article

41 Scopus citations

Chromophore-protein interactions and the function of the photosynthetic reaction center: A molecular dynamics study

Treutlein, H., Schulten, K., Brünger, A. T., Karplus, M., Deisenhofer, J. & Michel, H., Jan 1 1992, In : Proceedings of the National Academy of Sciences of the United States of America. 89, 1, p. 75-79 5 p.

Research output: Contribution to journalArticle

Open Access
102 Scopus citations
Open Access
58 Scopus citations

Cytoplasmic sequence required for basolateral targeting of LDL receptor in livers of transgenic mice

Yokode, M., Pathak, R. K., Hammer, R. E., Brown, M. S., Goldstein, J. L. & Anderson, R. G. W., May 11 1992, In : Journal of Cell Biology. 117, 1, p. 39-46 8 p.

Research output: Contribution to journalArticle

Open Access
63 Scopus citations

Dramatic growth of mice that develop from eggs microinjected with metallothionein-growth hormone fusion genes. 1982.

Palmiter, R. D., Brinster, R. L., Hammer, R. E., Trumbauer, M. E., Rosenfeld, M. G., Birnberg, N. C. & Evans, R. M., Jan 1 1992, In : Biotechnology (Reading, Mass.). 24, p. 429-433 5 p.

Research output: Contribution to journalArticle

15 Scopus citations

Electron microscopy of thin-sectioned three-dimensional crystals of SecA protein from Escherichia coli: Structure in projection at 40 Å resolution

Weaver, A. J., McDowall, A. W., Oliver, D. B. & Deisenhofer, J., Jan 1 1992, In : Journal of Structural Biology. 109, 2, p. 87-96 10 p.

Research output: Contribution to journalArticle

15 Scopus citations

High-resolution crystal structures of bacterial photosynthetic reaction centers

Deisenhofer, J. & Michel, H., Jan 1 1992, In : New Comprehensive Biochemistry. 23, C, p. 103-120 18 p.

Research output: Contribution to journalArticle

6 Scopus citations

LDL receptor-related protein internalizes and degrades uPA-PAI-1 complexes and is essential for embryo implantation

Herz, J., Clouthier, D. E. & Hammer, R. E., Oct 30 1992, In : Cell. 71, 3, p. 411-421 11 p.

Research output: Contribution to journalArticle

471 Scopus citations

Molecular Recognition of Immunophilins and Immunophilin-Ligand Complexes

Schreiber, S. L., Lui, J., Albers, M. W., Rosen, M. K., Standaert, R. F., Wandless, T. J. & Somers, P. K., Mar 27 1992, In : Tetrahedron. 48, 13, p. 2545-2558 14 p.

Research output: Contribution to journalArticle

44 Scopus citations

Natural Products as Probes of Cellular Function: Studies of Immunophilins

Rosen, M. K. & Schreiber, S. L., Apr 1992, In : Angewandte Chemie International Edition in English. 31, 4, p. 384-400 17 p.

Research output: Contribution to journalReview article

173 Scopus citations

Phospholipase C-β1 is a GTPase-activating protein for Gq/11, its physiologic regulator

Berstein, G., Blank, J. L., Jhon, D. Y., Exton, J. H., Rhee, S. G. & Ross, E. M., Aug 7 1992, In : Cell. 70, 3, p. 411-418 8 p.

Research output: Contribution to journalArticle

335 Scopus citations

Reconstitution of agonist-stimulated phosphatidylinositol 4,5-bisphosphate hydrolysis using purified m1 muscarinic receptor, G(q/11), and phospholipase C-β1

Berstein, G., Blank, J. L., Smrcka, A. V., Higashijima, T., Sternweis, P. C., Exton, J. H. & Ross, E. M., Jan 1 1992, In : Journal of Biological Chemistry. 267, 12, p. 8081-8088 8 p.

Research output: Contribution to journalArticle

272 Scopus citations

Reconstitution of lipoprotein(a) by infusion of human low density lipoprotein into transgenic mice expressing human apolipoprotein(a)

Chiesa, G., Hobbs, H. H., Koschinsky, M. L., Lawn, R. M., Maika, S. D. & Hammer, R. E., Jan 1 1992, In : Journal of Biological Chemistry. 267, 34, p. 24369-24374 6 p.

Research output: Contribution to journalArticle

145 Scopus citations

Selective expression of trypsin fusion genes in acinar cells of the pancreas and stomach of transgenic mice

Davis, B. P., Hammer, R. E., Messing, A. & MacDonald, R. J., Dec 1 1992, In : Journal of Biological Chemistry. 267, 36, p. 26070-26077 8 p.

Research output: Contribution to journalArticle

15 Scopus citations

Solution structure of the SH3 domain of Src and identification of its ligand-binding site

Yu, H., Rosen, M. K., Shin, T. B., Seidel-Dugan, C., Brugge, J. S. & Schreiber, S. L., Jan 1 1992, In : Science. 258, 5088, p. 1665-1668 4 p.

Research output: Contribution to journalArticle

277 Scopus citations
8 Scopus citations

Tissue-Specific, Developmental, Hormonal, and Dietary Regulation of Rat Phosphoenolpyruvate Carboxykinase-Human Growth Hormone Fusion Genes in Transgenic Mice

Short, M. K., Clouthier, D. E., Schaefer, I. M., Hammer, R. E., Magnuson, M. A. & Beale, E. G., Mar 1992, In : Molecular and cellular biology. 12, 3, p. 1007-1020 14 p.

Research output: Contribution to journalArticle

Open Access
94 Scopus citations

Tissue-Specific Expression of Kallikrein Family Transgenes in Mice and Rats

Smith, M. S., Lechago, J., Wines, D. R., MacDonald, R. J. & Hammer, R. E., Jun 1992, In : DNA and Cell Biology. 11, 5, p. 345-358 14 p.

Research output: Contribution to journalArticle

21 Scopus citations

Twists and turns on G-protein signalling pathways

Ross, E. M., Oct 1992, In : Current Biology. 2, 10, p. 517-519 3 p.

Research output: Contribution to journalArticle

5 Scopus citations
1991

A Drosophila mutant defective in extracellular calcium-dependent photoreceptor deactivation and rapid desensitization

Ranganathan, R., Harris, G. L., Stevens, C. F. & Zuker, C. S., Jan 1 1991, In : Nature. 354, 6350, p. 230-232 3 p.

Research output: Contribution to journalArticle

158 Scopus citations

ATP-dependent regulation of flagellar adenylylcyclase in gametes of Chlamydomonas reinhardtii

Zhang, Y., Ross, E. M. & Snell, W. J., Dec 1 1991, In : Journal of Biological Chemistry. 266, 34, p. 22954-22959 6 p.

Research output: Contribution to journalArticle

27 Scopus citations

FK506 and Rapamycin Binding to FKBP: Common Elements in Immunophilin-Ligand Complexation

Wandless, T. J., Michnick, S. W., Rosen, M. K., Karplus, M. & Schreiber, S. L., Jan 1 1991, In : Journal of the American Chemical Society. 113, 6, p. 2339-2341 3 p.

Research output: Contribution to journalArticle

32 Scopus citations

Germ-line intrachromosomal recombination restores fertility in transgenic MyK-103 male mice

Wilkie, T. M., Braun, R. E., Ehrman, W. J., Palmiter, R. D. & Hammer, R. E., Jan 1 1991, In : Genes and Development. 5, 1, p. 38-48 11 p.

Research output: Contribution to journalArticle

Open Access
23 Scopus citations

High-resolution structures of photosynthetic reaction centers

Deisenhofer, J. & Michel, H., Jan 1 1991, In : Annual review of biophysics and biophysical chemistry. 20, p. 247-266 20 p.

Research output: Contribution to journalReview article

91 Scopus citations

Immunologic mapping of the amino- and carboxy-termini of the turkey erythrocyte β-adrenergic receptor; Selective proteolysis of both domains

Luxembourg, A., Hekman, M. & Ross, E. M., May 20 1991, In : FEBS Letters. 283, 1, p. 155-158 4 p.

Research output: Contribution to journalArticle

10 Scopus citations

Immunophilin-ligand complexes as probes of intracellular signaling pathways

Schreiber, S. L., Liu, J., Albers, M. W., Karmacharya, R., Koh, E., Martin, P. K., Rosen, M. K., Standaert, R. F. & Wandless, T. J., Dec 1 1991, In : Transplantation Proceedings. 23, 6, p. 2839-2844 6 p.

Research output: Contribution to journalArticle

58 Scopus citations

Mapping of the mastoparan-binding site on G proteins: Cross-linking of [125I-Tyr3,Cys11]mastoparan to G(o)

Higashijima, T. & Ross, E. M., Sep 23 1991, In : Journal of Biological Chemistry. 266, 19, p. 12655-12661 7 p.

Research output: Contribution to journalArticle

78 Scopus citations

Negative and positive selection of antigen-specific cytotoxic T lymphocytes affected by the α3 domain of MHC I molecules

Aldrich, C. J., Hammer, R. E., Jones-Youngblood, S., Koszinowski, U., Hood, L., Stroynowski, I. T. & Forman D.M.D/Ph.D., J. M., 1991, In : Nature. 352, 6337, p. 718-721 4 p.

Research output: Contribution to journalArticle

75 Scopus citations

Photoreceptor deactivation and retinal degeneration mediated by a photoreceptor-specific protein kinase C

Smith, D. P., Ranganathan, R., Hardy, R. W., Marx, J., Tsuchida, T. & Zuker, C. S., Jan 1 1991, In : Science. 254, 5037, p. 1478-1484 7 p.

Research output: Contribution to journalArticle

208 Scopus citations

Proton and Nitrogen Sequential Assignments and Secondary Structure Determination of the Human FK5O6 and Rapamycin Binding Protein

Rosen, M. K., Michnick, S. W., Karplus, M. & Schreiber, S. L., May 1 1991, In : Biochemistry. 30, 19, p. 4774-4789 16 p.

Research output: Contribution to journalArticle

46 Scopus citations

Reconstitution of Receptors and G Proteins in Phospholipid Vesicles

Cerione, R. A. & Ross, E. M., Jan 1991, In : Methods in Enzymology. 195, C, p. 329-342 14 p.

Research output: Contribution to journalArticle

27 Scopus citations

Reconstitutively active G protein-coupled receptors purified from baculovirus-infected insect cells

Parker, E. M., Kameyama, K., Higashijima, T. & Ross, E. M., Jan 31 1991, In : Journal of Biological Chemistry. 266, 1, p. 519-527 9 p.

Research output: Contribution to journalArticle

260 Scopus citations

Selectivity of the β-Adrenergic Receptor among Gs, Gi’s, and Go: Assay Using Recombinant α Subunits in Reconstituted Phospholipid Vesicles

Rubenstein, R. C., Linder, M. E. & Ross, E. M., Nov 1 1991, In : Biochemistry. 30, 44, p. 10769-10777 9 p.

Research output: Contribution to journalArticle

54 Scopus citations

Solution structure of FKBP, a rotamase enzyme and receptor for FK506 and rapamycin

Michnick, S. W., Rosen, M. K., Wandless, T. J., Karplus, M. & Schreiber, S. L., May 10 1991, In : Science. 252, 5007, p. 836-839 4 p.

Research output: Contribution to journalArticle

260 Scopus citations

Structures of bacterial photosynthetic reaction centers

Deisenhofer, J. & Michel, H., Jan 1 1991, In : Annual review of cell biology. 7, p. 1-23 23 p.

Research output: Contribution to journalReview article

55 Scopus citations

Study of Receptor-Ligand Interactions through Receptor Labeling and Isotope-Edited NMR

Rosen, M. K., Michnick, S. W., Wandless, T. J. & Schreiber, S. L., Oct 1 1991, In : Journal of Organic Chemistry. 56, 22, p. 6262-6264 3 p.

Research output: Contribution to journalArticle

7 Scopus citations

The molecular genetics of invertebrate phototransduction

Ranganathan, R., Harris, W. A. & Zuker, C. S., Nov 1991, In : Trends in Neurosciences. 14, 11, p. 486-493 8 p.

Research output: Contribution to journalReview article

46 Scopus citations