Research Output

1991

Tolerance to Liver‐Specific Antigens

Forman D.M.D/Ph.D., J. M., Wieties, K. & Hammer, R. E., Aug 1991, In : Immunological Reviews. 122, 1, p. 33-46 14 p.

Research output: Contribution to journalArticle

3 Scopus citations
48 Scopus citations
1990

A truncation mutation in the avian β-adrenergic receptor causes agonist-induced internalization and GTP-sensitive agonist binding characteristic of mammalian receptors

Hertel, C., Nunnally, M. H., Wong, S. K. F., Murphy, E. A., Ross, E. M. & Perkins, J. P., Nov 12 1990, In : Journal of Biological Chemistry. 265, 29, p. 17988-17994 7 p.

Research output: Contribution to journalArticle

41 Scopus citations

Chimeric muscarinic cholinergic:β-adrenergic receptors that activate G(s) in response to muscarinic agonists

Wong, S. K. F., Parker, E. M. & Ross, E. M., May 16 1990, In : Journal of Biological Chemistry. 265, 11, p. 6219-6224 6 p.

Research output: Contribution to journalArticle

176 Scopus citations

Diet-induced hypercholesterolemia in mice: Prevention by overexpression of LDL receptors

Yokode, M., Hammer, R. E., Ishibashi, S., Brown, M. S. & Goldstein, J. L., Jan 1 1990, In : Science. 250, 4985, p. 1273-1275 3 p.

Research output: Contribution to journalArticle

140 Scopus citations

Effect of the expression of a hepatocyte-specific MHC molecule in transgenic mice on T cell tolerance

Jones-Youngblood, S. L., Wieties, K., Forman D.M.D/Ph.D., J. M. & Hammer, R. E., Jan 1 1990, In : Journal of Immunology. 144, 4, p. 1187-1195 9 p.

Research output: Contribution to journalArticle

31 Scopus citations

Expression and performance in transgenic pigs.

Pursel, V. G., Bolt, D. J., Miller, K. F., Pinkert, C. A., Hammer, R. E., Palmiter, R. D. & Brinster, R. L., 1990, In : Journal of reproduction and fertility. Supplement. 40, p. 235-245 11 p.

Research output: Contribution to journalReview article

75 Scopus citations

G Protein-Coupled Receptors: Structure and Function of Signal-Transducing Proteins

Parker, E. M. & Ross, E. M., Jan 1 1990, In : Current Topics in Membranes and Transport. 36, C, p. 131-144 14 p.

Research output: Contribution to journalArticle

4 Scopus citations

Inhibition of FKBP rotamase activity by immunosuppressant FK506: Twisted amide surrogate

Rosen, M. K., Standaert, R. F., Galat, A., Nakatsuka, M. & Schreiber, S. L., Jan 1 1990, In : Science. 248, 4957, p. 863-866 4 p.

Research output: Contribution to journalArticle

178 Scopus citations

Insertion, expression and physiology of growth-regulating genes in ruminants.

Rexroad, C. E., Hammer, R. E., Behringer, R. R., Palmiter, R. D. & Brinster, R. L., 1990, In : Journal of reproduction and fertility. Supplement. 41, p. 119-124 6 p.

Research output: Contribution to journalReview article

25 Scopus citations

Integration, expression and germ-line transmission of growth-related genes in pigs.

Pursel, V. G., Hammer, R. E., Bolt, D. J., Palmiter, R. D. & Brinster, R. L., 1990, In : Journal of reproduction and fertility. Supplement. 41, p. 77-87 11 p.

Research output: Contribution to journalReview article

48 Scopus citations
Open Access
144 Scopus citations
38 Scopus citations

Regulation of G(i) and G(o) by mastoparan, related amphiphilic peptides, and hydrophobic amines. Mechanism and structural determinants of activity

Higashijima, T., Burnier, J. & Ross, E. M., Sep 10 1990, In : Journal of Biological Chemistry. 265, 24, p. 14176-14186 11 p.

Research output: Contribution to journalArticle

519 Scopus citations

Relative growth of the skull and postcranium in giant transgenic mice

Shea, B. T., Hammer, R. E., Brinster, R. L. & Ravosa, M. R., Aug 1990, In : Genetical Research. 56, 1, p. 21-34 14 p.

Research output: Contribution to journalArticle

39 Scopus citations

Spontaneous inflammatory disease in transgenic rats expressing HLA-B27 and human β2m: An animal model of HLA-B27-associated human disorders

Hammer, R. E., Maika, S. D., Richardson, J. A., Tang, J. P. & Taurog, J. D., Nov 30 1990, In : Cell. 63, 5, p. 1099-1112 14 p.

Research output: Contribution to journalArticle

765 Scopus citations

The expression of influenza virus hemagglutinin in the pancreatic β cells of transgenic mice results in autoimmune diabetes

Roman, L. M., Simons, L. F., Hammer, R. E., Sambrook, J. F. & Gething, M. J. H., May 4 1990, In : Cell. 61, 3, p. 383-396 14 p.

Research output: Contribution to journalArticle

66 Scopus citations
34 Scopus citations

Tissue-specific sorting of the human LDL receptor in polarized epithelia of transgenic mice

Pathak, R. K., Yokode, M., Hammer, R. E., Hofmann, S. L., Brown, M. S., Goldstein, J. L. & Anderson, R. G. W., Aug 1990, In : Journal of Cell Biology. 111, 2, p. 347-359 13 p.

Research output: Contribution to journalArticle

Open Access
70 Scopus citations

Viral hijack of receptors

Ross, E. M., Jan 1 1990, In : Nature. 344, 6268, p. 707-708 2 p.

Research output: Contribution to journalShort survey

5 Scopus citations
1989

Detergent structure in crystals of a bacterial photosynthetic reaction centre

Roth, M., Lewit-Bentley, A., Michel, H., Deisenhofer, J., Huber, R. & Oesterhelt, D., Jan 1 1989, In : Nature. 340, 6235, p. 659-662 4 p.

Research output: Contribution to journalArticle

183 Scopus citations
Open Access
44 Scopus citations

Expression of human or bovine growth hormone gene with a mouse metallothionein-1 promoter in transgenic swine alters the secretion of porcine growth hormone and insulin-like growth factor-I

Miller, K. F., Bolt, D. J., Pursel, V. G., Hammer, R. E., Pinkert, C. A., Palmiter, R. D. & Brinster, R. L., 1989, In : Journal of Endocrinology. 120, 3, p. 481-488 8 p.

Research output: Contribution to journalArticle

28 Scopus citations

Genetic engineering of livestock

Pursel, V. G., Pinkert, C. A., Miller, K. F., Bolt, D. J., Campbell, R. G., Palmiter, R. D., Brinster, R. L. & Hammer, R. E., Jan 1 1989, In : Science. 244, 4910, p. 1281-1288 8 p.

Research output: Contribution to journalArticle

308 Scopus citations

Histopathology associated with elevated levels of growth hormone and insulin-like growth factor i in transgenic mice

Quaife, C. J., Mathews, L. S., Pinkert, C. A., Hammer, R. E., Brinster, R. L. & Palmiter, R. D., Jan 1989, In : Endocrinology. 124, 1, p. 40-48 9 p.

Research output: Contribution to journalArticle

203 Scopus citations

Immunoglobulin κ gene expression after stable integration. II. Role of the intronic MAR and enhancer in transgenic mice

Xu, M., Hammer, R. E., Blasquez, V. C., Jones, S. L. & Garrard, W. T., Dec 1 1989, In : Journal of Biological Chemistry. 264, 35, p. 21190-21195 6 p.

Research output: Contribution to journalArticle

77 Scopus citations

Metallothionein-vasopressin fusion gene expression in transgenic mice. Nephrogenic diabetes insipidus and brain transcripts localized to magnocellular neurons

Habener, J. F., Cwikel, B. J., Hermann, H., Hammer, R. E., Oalmiter, R. D. & Brinster, R. L., Jan 1 1989, In : Journal of Biological Chemistry. 264, 31, p. 18844-18852 9 p.

Research output: Contribution to journalArticle

37 Scopus citations

Nobel lecture. The photosynthetic reaction centre from the purple bacterium Rhodopseudomonas viridis.

Deisenhofer, J. & Michel, H., Aug 1989, In : The EMBO journal. 8, 8, p. 2149-2170 22 p.

Research output: Contribution to journalReview article

546 Scopus citations

Production of transgenic sheep with growth‐regulating genes

Rexroad, C. E., Hammer, R. E., Bolt, D. J., Mayo, K. E., Frohman, L. A., Palmitter, R. D. & Brinster, R. L., 1989, In : Molecular Reproduction and Development. 1, 3, p. 164-169 6 p.

Research output: Contribution to journalArticle

53 Scopus citations

Signal sorting and amplification through G protein-coupled receptors

Ross, E. M., Aug 1989, In : Neuron. 3, 2, p. 141-152 12 p.

Research output: Contribution to journalReview article

254 Scopus citations

The photosynthetic reaction center from the purple bacterium Rhodopseudomonas viridis

Deisenhofer, J. & Michel, H., 1989, In : Science. 245, 4925, p. 1463-1473 11 p.

Research output: Contribution to journalArticle

481 Scopus citations

The Photosynthetic Reaction Center from the Purple Bacterium Rhodopseudomonas viridis (Nobel Lecture)

Deisenhofer, J. & Michel, H., Jul 1989, In : Angewandte Chemie International Edition in English. 28, 7, p. 829-847 19 p.

Research output: Contribution to journalReview article

284 Scopus citations

The photosynthetic reaction centre from the purple bacterium

Deisenhofer, J. & Michel, H., Dec 1 1989, In : Bioscience reports. 9, 6, 1 p.

Research output: Contribution to journalComment/debate

The photosynthetic reaction centre from the purple bacterium Rhodopseudomonas viridis

Deisenhofer, J. & Michel, H., Aug 1 1989, In : Bioscience reports. 9, 4, p. 383-419 37 p.

Research output: Contribution to journalArticle

11 Scopus citations

Three-dimensional structure of photosynthetic reaction center from purple bacteria

Miki, K., Deisenhofer, J. & Michel, H., May 1 1989, In : Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme. 34, 6, p. 726-740 15 p.

Research output: Contribution to journalArticle

1 Scopus citations
1988

A mutant human proinsulin is secreted from islets of Langerhans in increased amounts via an unregulated pathway

Carroll, R. J., Hammer, R. E., Chan, S. J., Swift, H. H., Rubenstein, A. H. & Steiner, D. F., Jan 1 1988, In : Proceedings of the National Academy of Sciences of the United States of America. 85, 23, p. 8943-8947 5 p.

Research output: Contribution to journalArticle

Open Access
109 Scopus citations

Dramatic pituitary hyperplasia in transgenic mice expressing a human growth hormone-releasing factor gene

Mayo, K. E., Hammer, R. E., Swanson, L. W., Brinster, R. L., Rosenfeld, M. G. & Evans, R. M., Jul 1988, In : Molecular Endocrinology. 2, 7, p. 606-612 7 p.

Research output: Contribution to journalArticle

Open Access
159 Scopus citations

Expression of a metallothionein-vasopressin fusion gene in transgenic mice produces hypervasopressinemia and manifestations of nephrogenic diabetes insipidus.

Habener, J. F., Cwikel, B., Hermann, H., Hammer, R. E., Palmiter, R. D. & Brinster, R. L., Dec 1 1988, In : Transactions of the Association of American Physicians. 101, p. 155-162 8 p.

Research output: Contribution to journalArticle

5 Scopus citations

Expression of insulin-like growth factor i in transgenic mice with elevated levels of growth hormone is correlated with growth

Mathews, L. S., Hammer, R. E., Brinster, R. L. & Palmiter, R. D., Jul 1 1988, In : Endocrinology. 123, 1, p. 433-437 5 p.

Research output: Contribution to journalArticle

138 Scopus citations

Functional domains in the β-adrenergic receptor

Ross, E. M., Wong, S. K. F., Rubenstein, R. C. & Higashijima, T., 1988, In : Cold Spring Harbor symposia on quantitative biology. 53, 1, p. 499-506 8 p.

Research output: Contribution to journalArticle

8 Scopus citations

Growth enhancement of transgenic mice expressing human insulin-like growth factor I

Mathews, L. S., Hammer, R. E., Behringer, R. R., D'Ercole, A. J., Bell, G. I., Brinster, R. L. & Palmiter, R. D., Dec 1988, In : Endocrinology. 123, 6, p. 2827-2833 7 p.

Research output: Contribution to journalArticle

353 Scopus citations
50 Scopus citations

Mastoparan, a peptide toxin from wasp venom, mimics receptors by activating GTP-binding regulatory proteins (G proteins)

Higashijima, T., Uzu, S., Nakajima, T. & Ross, E. M., Jan 1 1988, In : Journal of Biological Chemistry. 263, 14, p. 6491-6494 4 p.

Research output: Contribution to journalArticle

561 Scopus citations
79 Scopus citations
17 Scopus citations

Receptor-G protein-effector: The design of a biochemical switchboard

Ross, E. M., Dec 1 1988, In : Journal Of Chemical Education. 65, 11, p. 937-942 6 p.

Research output: Contribution to journalArticle

4 Scopus citations

Relevance of the Photosynthetic Reaction Center from Purple Bacteria to the Structure of Photosystem II

Michel, H. & Deisenhofer, J., Jan 1 1988, In : Biochemistry. 27, 1, p. 1-7 7 p.

Research output: Contribution to journalArticle

626 Scopus citations

Structure and function of the photosynthetic reaction center from Rhodopseudomonas viridis

Michel, H. & Deisenhofer, J., Jan 1 1988, In : Pure and Applied Chemistry. 60, 7, p. 953-958 6 p.

Research output: Contribution to journalArticle

13 Scopus citations

Studies of HLA-B27-associated disease

Taurog, J. D., Durand, J. P., El-Zaatari, F. A. K. & Hammer, R. E., Dec 23 1988, In : The American Journal of Medicine. 85, 6 SUPPL. 1, p. 59-60 2 p.

Research output: Contribution to journalArticle

3 Scopus citations

The catecholamine binding site of the β-adrenergic receptor is formed by juxtaposed membrane-spanning domains

Wong, S. K. F., Slaughter, C., Ruoho, A. E. & Ross, E. M., Jan 1 1988, In : Journal of Biological Chemistry. 263, 17, p. 7925-7928 4 p.

Research output: Contribution to journalArticle

85 Scopus citations