Research Output

The structure of the photosynthetic reaction centre from Rhodopseudomonas viridis

Michel, H. & Deisenhofer, J., Jan 1 1988, In : Bulletin de l'Institut Pasteur. 86, 1, p. 37-45 9 p.

Research output: Contribution to journalArticle

Unidirectionality of charge separation in reaction centers of photosynthetic bacteria

Michel-Beyerle, M. E., Plato, M., Deisenhofer, J., Michel, H., Bixon, M. & Jortner, J., 1988, In : BBA - Bioenergetics. 932, C, p. 52-70 19 p.

Research output: Contribution to journalArticle

182 Scopus citations

β-Adrenergic receptors display intramolecular disulfide bridges in situ: Analysis by immunoblotting and functional reconstitution

Moxham, C. P., Ross, E. M., George, S. T. & Malbon, C. C., Jan 1 1988, In : Molecular Pharmacology. 33, 5, p. 486-492 7 p.

Research output: Contribution to journalArticle

21 Scopus citations
1987

A chicken transferrin gene in transgenic mice escapes X-chromosome inactivation

Goldman, M. A., Stokes, K. R., Idzerda, R. L., McKnight, G. S., Hammer, R. E., Brinster, R. L. & Gartler, S. M., Jan 1 1987, In : Science. 236, 4801, p. 593-595 3 p.

Research output: Contribution to journalArticle

34 Scopus citations

Comparison of two highly refined structures of bovine pancreatic trypsin inhibitor

Wlodawer, A., Deisenhofer, J. & Huber, R., Jan 5 1987, In : Journal of Molecular Biology. 193, 1, p. 145-156 12 p.

Research output: Contribution to journalArticle

211 Scopus citations

Diversity of Alpha-Fetoprotein gene expression in mice is generated by a combination of separate enhancer elements

Hammer, R. E., Krumlauf, R., Camper, S. A., Brinster, R. L. & Tilghman, S. M., Jan 1 1987, In : Science. 235, 4784, p. 53-58 6 p.

Research output: Contribution to journalArticle

169 Scopus citations

Growth allometry of the organs in giant transgenic mice

Shea, B. T., Hammer, R. E. & Brinster, R. L., Dec 1 1987, In : Endocrinology. 121, 6, p. 1924-1930 7 p.

Research output: Contribution to journalArticle

104 Scopus citations

Multiple sequences regulate human beta-globin gene expression in transgenic mice.

Townes, T. M., Behringer, R. R., Hammer, R. E., Brinster, R. L. & Palmiter, R. D., 1987, In : Progress in clinical and biological research. 251, p. 323-343 21 p.

Research output: Contribution to journalArticle

Pancreatic neoplasia induced by SV40 T-antigen expression in acinar cells of transgenic mice

Ornitz, D. M., Hammer, R. E., Messing, A., Palmiter, R. D. & Brinster, R. L., Jan 1 1987, In : Science. 238, 4824, p. 188-193 6 p.

Research output: Contribution to journalArticle

179 Scopus citations

Progress on gene transfer in farm animals

Pursel, V. G., Rexroad, C. E., Bolt, D. J., Miller, K. F., Wall, R. J., Hammer, R. E., Pinkert, C. A., Palmiter, R. D. & Brinster, R. L., Dec 1987, In : Veterinary Immunology and Immunopathology. 17, 1-4, p. 303-312 10 p.

Research output: Contribution to journalArticle

59 Scopus citations

Promoter and enhancer elements from the rat elastase I gene function independently of each other and of heterologous enhancers.

Ornitz, D. M., Hammer, R. E., Davison, B. L., Brinster, R. L. & Palmiter, R. D., Oct 1987, In : Molecular and cellular biology. 7, 10, p. 3466-3472 7 p.

Research output: Contribution to journalArticle

Open Access
21 Scopus citations

Role of growth hormone in regulating T‐Dependent immune events in aged, nude, and transgenic rodents

Davila, D. R., Brief, S., Simon, J., Hammer, R. E., Brinster, R. L. & Kelley, K. W., 1987, In : Journal of Neuroscience Research. 18, 1, p. 108-116 9 p.

Research output: Contribution to journalArticle

99 Scopus citations

Targeted expression of cloned genes in transgenic mice

MacDonald, R. J., Swift, G. H., Hammer, R. E., Ornitz, D. M., Davis, B. P., Brinster, R. L. & Palmiter, R. D., Jan 1987, In : Progress in Brain Research. 71, C, p. 3-12 10 p.

Research output: Contribution to journalArticle

3 Scopus citations

The effect of activating ligands on the intrinsic fluorescence of guanine nucleotide-binding regulatory proteins

Higashijima, T., Ferguson, K. M., Sternweis, P. C., Ross, E. M., Smigel, M. D. & Gilman, A. G., Mar 26 1987, In : Journal of Biological Chemistry. 262, 2, p. 752-756 5 p.

Research output: Contribution to journalArticle

130 Scopus citations

The hydrophobic tryptic core of the β-adrenergic receptor retains G(s) regulatory activity in response to agonists and thiols

Rubenstein, R. C., Wong, S. K. F. & Ross, E. M., Dec 1 1987, In : Journal of Biological Chemistry. 262, 34, p. 16655-16662 8 p.

Research output: Contribution to journalArticle

50 Scopus citations

The rat elastase I regulatory element is an enhancer that directs correct cell specificity and developmental onset of expression in transgenic mice.

Hammer, R. E., Swift, G. H., Ornitz, D. M., Quaife, C. J., Palmiter, R. D., Brinster, R. L. & MacDonald, R. J., Aug 1987, In : Molecular and cellular biology. 7, 8, p. 2956-2967 12 p.

Research output: Contribution to journalArticle

Open Access
52 Scopus citations

Two 3' sequences direct adult erythroid-specific expression of human β-globulin genes in transgenic mice

Behringer, R. R., Hammer, R. E., Brinster, R. L., Palmiter, R. D. & Townes, T. M., Jan 1 1987, In : Proceedings of the National Academy of Sciences of the United States of America. 84, 20, p. 7056-7060 5 p.

Research output: Contribution to journalArticle

Open Access
103 Scopus citations
1986
142 Scopus citations

Differential expression of α-fetoprotein genes on the inactive X chromosome in extraembryonic and somatic tissues of a transgenic mouse line

Krumlauf, R., Chapman, V. M., Hammer, R. E., Brinster, R. & Tilghman, S. M., Dec 1 1986, In : Nature. 319, 6050, p. 224-226 3 p.

Research output: Contribution to journalArticle

42 Scopus citations

Effect of Al3+ plus F- on the Catecholamine-Stimulated GTPase Activity of Purified and Reconstituted Gs

Brandt, D. R. & Ross, E. M., Nov 1986, In : Biochemistry. 25, 22, p. 7036-7041 6 p.

Research output: Contribution to journalArticle

8 Scopus citations

Estrogen regulation of the avian transferrin gene in transgenic mice

Hammer, R. E., Idzerda, R. L., Brinster, R. L. & McKnight, G. S., Jan 1 1986, In : Molecular and cellular biology. 6, 4, p. 1010-1014 5 p.

Research output: Contribution to journalArticle

Open Access
11 Scopus citations

Genetic engineering of mammalian embryos.

Hammer, R. E., Pursel, V. G., Rexroad, C. E., Wall, R. J., Bolt, D. J., Palmiter, R. D. & Brinster, R. L., Jul 1986, In : Journal of animal science. 63, 1, p. 269-278 10 p.

Research output: Contribution to journalArticle

37 Scopus citations

Glucocorticoid regulation of metallothionein during murine development

Quaife, C., Hammer, R. E., Mottet, N. K. & Palmiter, R. D., Dec 1986, In : Developmental Biology. 118, 2, p. 549-555 7 p.

Research output: Contribution to journalArticle

64 Scopus citations

Gonadotroph-specific expression of metallothionein fusion genes in pituitaries of transgenic mice

Low, M. J., Lechan, R. M., Hammer, R. E., Brinster, R. L., Habener, J. F., Mandel, G. & Goodman, R. H., Jan 1 1986, In : Science. 231, 4741, p. 1002-1004 3 p.

Research output: Contribution to journalArticle

30 Scopus citations

Somatostatin is targeted to the regulated secretory pathway of gonadotrophs in transgenic mice expressing a metallothionein-somatostatin gene

Low, M. J., Stork, P. J., Hammer, R. E., Brinster, R. L., Warhol, M. J., Mandel, G. & Goodman, R. H., Dec 1 1986, In : Journal of Biological Chemistry. 261, 34, p. 16260-16263 4 p.

Research output: Contribution to journalArticle

6 Scopus citations

Stimulation of growth hormone synthesis by glucose in islets of langerhans isolated from transgenic mice

Welsh, M., Hammer, R. E., Brinster, R. L. & Steiner, D. F., Dec 1 1986, In : Journal of Biological Chemistry. 261, 28, p. 12915-12917 3 p.

Research output: Contribution to journalArticle

7 Scopus citations

Structural homology of reaction centers from Rhodopseudomonas sphaeroides and Rhodopseudomonas viridis as determined by x-ray diffraction

Allen, J. P., Feher, G., Yeates, T. O., Rees, D. C., Deisenhofer, J., Michel, H. & Huber, R., Dec 1 1986, In : Proceedings of the National Academy of Sciences of the United States of America. 83, 22, p. 8589-8593 5 p.

Research output: Contribution to journalArticle

312 Scopus citations

The regulation of α-foetoprotein minigene expression in the germline of mice

Hammer, R. E., Krumlauf, R., Camper, S., Brinster, R. L. & Tilghman, S. M., Dec 1 1986, In : Journal of Embryology and Experimental Morphology. 97, SUPPL., p. 257-262 6 p.

Research output: Contribution to journalArticle

1 Scopus citations

Tissue‐specific Expression of Pancreatic Genes in Transgenic Mice

MacDonald, R. J., Hammer, R. E., Swift, G. H., Ornitz, D. M., Davis, B. P., Palmiter, R. D. & Brinster, R. L., Oct 1986, In : Annals of the New York Academy of Sciences. 478, 1, p. 131-146 16 p.

Research output: Contribution to journalArticle

14 Scopus citations

Transgenic Progeny Inherit Tissue-Specific Expression of Rat Elastase I Genes

MacDonald, R. J., Hammer, R. E., Swift, G. H., Davis, B. P. & Brinster, R. L., Oct 1986, In : DNA. 5, 5, p. 393-401 9 p.

Research output: Contribution to journalArticle

5 Scopus citations
1985

A rapid whole-mount staining procedure for nuclei of mammalian embryos

Pursel, V. G., Wall, R. J., Rexroad, C. E., Hammer, R. E. & Brinster, R. L., Dec 1985, In : Theriogenology. 24, 6, p. 687-691 5 p.

Research output: Contribution to journalArticle

147 Scopus citations

A simple method for counting nuclei in the preimplantation mouse embryo

Ebert, K. M., Hammer, R. E. & Papaioannou, V. E., Sep 1 1985, In : Experientia. 41, 9, p. 1207-1209 3 p.

Research output: Contribution to journalArticle

50 Scopus citations

beta-Adrenergic receptors and regulatory GTP-binding proteins: reconstitution of coupling in phospholipid vesicles.

Asano, T., Brandt, D. R., Pedersen, S. E. & Ross, E. M., Jan 1 1985, In : Advances in cyclic nucleotide and protein phosphorylation research. 19, p. 47-56 10 p.

Research output: Contribution to journalArticle

8 Scopus citations

Cleavage of pig embryos after labeling with fluorescent dyes

Pursel, V. G., Wall, R. J., Hammer, R. E. & Brinster, R. L., Dec 1985, In : Theriogenology. 24, 6, p. 693-700 8 p.

Research output: Contribution to journalArticle

3 Scopus citations

Correlation of structural and spectroscopic properties of a photosynthetic reaction center

Zinth, W., Knapp, E. W., Fischer, S. F., Kaiser, W., Deisenhofer, J. & Michel, H., Aug 23 1985, In : Chemical Physics Letters. 119, 1, p. 1-4 4 p.

Research output: Contribution to journalArticle

53 Scopus citations

Developmental regulation of α-fetoprotein genes in transgenic mice

Krumlauf, R., Hammer, R. E., Tilghman, S. M. & Brinster, R. L., 1985, In : Molecular and cellular biology. 5, 7, p. 1639-1648 10 p.

Research output: Contribution to journalArticle

Open Access
76 Scopus citations

Development of porcine ova that were centrifuged to permit visualization of pronuclei and nuclei.

Wall, R. J., Pursel, V. G., Hammer, R. E. & Brinster, R. L., Apr 1985, In : Biology of reproduction. 32, 3, p. 645-651 7 p.

Research output: Contribution to journalArticle

Open Access
100 Scopus citations

Effects of nicotine on oviducal blood flow and embryo development in the rat

Mitchell, J. A. & Hammer, R. E., Jan 1 1985, In : Journal of Reproduction and Fertility. 74, 1, p. 71-76 6 p.

Research output: Contribution to journalArticle

Open Access
35 Scopus citations

Elastase I promoter directs expression of human growth hormone and SV40 T antigen genes to pancreatic acinar cells in transgenic mice

Ornitz, D. M., Palmiter, R. D., Messing, A., Hammer, R. E., Pinkert, C. A. & Brinster, R. L., Jan 1 1985, In : Cold Spring Harbor symposia on quantitative biology. VOL. 50, p. 399-409 11 p.

Research output: Contribution to journalArticle

60 Scopus citations

Experience with various techniques for the refinement of protein structures

Deisenhofer, J., Remington, S. J. & Steigemann, W., Jan 1 1985, In : Methods in Enzymology. 115, C, p. 303-323 21 p.

Research output: Contribution to journalArticle

19 Scopus citations

Expression of human growth hormone-releasing factor in transgenic mice results in increased somatic growth

Hammer, R. E., Brinster, R. L., Rosenfeld, M. G., Evans, R. M. & Mayo, K. E., Dec 1 1985, In : Nature. 315, 6018, p. 413-416 4 p.

Research output: Contribution to journalArticle

174 Scopus citations

Functional activation of β-adrenergic receptors by thiols in the presence or absence of agonists

Pedersen, S. E. & Ross, E. M., Dec 1 1985, In : Journal of Biological Chemistry. 260, 26, p. 14150-14157 8 p.

Research output: Contribution to journalArticle

63 Scopus citations
91 Scopus citations

Novel developmental specificity in the nervous system of transgenic animals expressing growth hormone fusion genes

Swanson, L. W., Simmons, D. M., Arriza, J., Hammer, R. E., Brinster, R., Rosenfeld, M. G. & Evans, R. M., Dec 1 1985, In : Nature. 317, 6035, p. 363-366 4 p.

Research output: Contribution to journalArticle

78 Scopus citations

Production of transgenic rabbits, sheep and pigs by microinjection

Hammer, R. E., Pursel, V. G., Rexroad, C. E., Wall, R. J., Bolt, D. J., Ebert, K. M., Palmiter, R. D. & Brinster, R. L., Dec 1 1985, In : Nature. 315, 6021, p. 680-683 4 p.

Research output: Contribution to journalArticle

702 Scopus citations

Reconstitution of catecholamine-stimulated adenylate cyclase activity using three purified proteins

May, D. C., Ross, E. M., Gilman, A. G. & Smigel, M. D., Dec 1 1985, In : Journal of Biological Chemistry. 260, 29, p. 15829-15833 5 p.

Research output: Contribution to journalArticle

105 Scopus citations

Regulated expression of α-fetoprotein genes in transgenic mice

Krumlauf, R., Hammer, R. E. & Brinster, R., 1985, In : Cold Spring Harbor symposia on quantitative biology. VOL. 50, p. 371-378 8 p.

Research output: Contribution to journalArticle

16 Scopus citations

Specific expression of an elastase-human growth hormone fusion gene in pancreatic acinar cells of transgenic mice

Ornitz, D. M., Palmiter, R. D., Hammer, R. E., Brinster, R. L., Swift, G. H. & MacDonald, R. J., Dec 1 1985, In : Nature. 313, 6003, p. 600-602 3 p.

Research output: Contribution to journalArticle

110 Scopus citations