Research Output

1989

The Photosynthetic Reaction Center from the Purple Bacterium Rhodopseudomonas viridis (Nobel Lecture)

Deisenhofer, J. & Michel, H., Jul 1989, In : Angewandte Chemie International Edition in English. 28, 7, p. 829-847 19 p.

Research output: Contribution to journalReview article

284 Scopus citations

The photosynthetic reaction centre from the purple bacterium

Deisenhofer, J. & Michel, H., Dec 1 1989, In : Bioscience reports. 9, 6, 1 p.

Research output: Contribution to journalComment/debate

The photosynthetic reaction centre from the purple bacterium Rhodopseudomonas viridis

Deisenhofer, J. & Michel, H., Aug 1 1989, In : Bioscience reports. 9, 4, p. 383-419 37 p.

Research output: Contribution to journalArticle

11 Scopus citations

Three-dimensional structure of photosynthetic reaction center from purple bacteria

Miki, K., Deisenhofer, J. & Michel, H., May 1 1989, In : Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme. 34, 6, p. 726-740 15 p.

Research output: Contribution to journalArticle

1 Scopus citations
1990

A truncation mutation in the avian β-adrenergic receptor causes agonist-induced internalization and GTP-sensitive agonist binding characteristic of mammalian receptors

Hertel, C., Nunnally, M. H., Wong, S. K. F., Murphy, E. A., Ross, E. M. & Perkins, J. P., Nov 12 1990, In : Journal of Biological Chemistry. 265, 29, p. 17988-17994 7 p.

Research output: Contribution to journalArticle

41 Scopus citations

Chimeric muscarinic cholinergic:β-adrenergic receptors that activate G(s) in response to muscarinic agonists

Wong, S. K. F., Parker, E. M. & Ross, E. M., May 16 1990, In : Journal of Biological Chemistry. 265, 11, p. 6219-6224 6 p.

Research output: Contribution to journalArticle

176 Scopus citations

Diet-induced hypercholesterolemia in mice: Prevention by overexpression of LDL receptors

Yokode, M., Hammer, R. E., Ishibashi, S., Brown, M. S. & Goldstein, J. L., Jan 1 1990, In : Science. 250, 4985, p. 1273-1275 3 p.

Research output: Contribution to journalArticle

140 Scopus citations

Effect of the expression of a hepatocyte-specific MHC molecule in transgenic mice on T cell tolerance

Jones-Youngblood, S. L., Wieties, K., Forman D.M.D/Ph.D., J. M. & Hammer, R. E., Jan 1 1990, In : Journal of Immunology. 144, 4, p. 1187-1195 9 p.

Research output: Contribution to journalArticle

31 Scopus citations

Expression and performance in transgenic pigs.

Pursel, V. G., Bolt, D. J., Miller, K. F., Pinkert, C. A., Hammer, R. E., Palmiter, R. D. & Brinster, R. L., 1990, In : Journal of reproduction and fertility. Supplement. 40, p. 235-245 11 p.

Research output: Contribution to journalReview article

75 Scopus citations

G Protein-Coupled Receptors: Structure and Function of Signal-Transducing Proteins

Parker, E. M. & Ross, E. M., Jan 1 1990, In : Current Topics in Membranes and Transport. 36, C, p. 131-144 14 p.

Research output: Contribution to journalArticle

4 Scopus citations

Inhibition of FKBP rotamase activity by immunosuppressant FK506: Twisted amide surrogate

Rosen, M. K., Standaert, R. F., Galat, A., Nakatsuka, M. & Schreiber, S. L., Jan 1 1990, In : Science. 248, 4957, p. 863-866 4 p.

Research output: Contribution to journalArticle

178 Scopus citations

Insertion, expression and physiology of growth-regulating genes in ruminants.

Rexroad, C. E., Hammer, R. E., Behringer, R. R., Palmiter, R. D. & Brinster, R. L., 1990, In : Journal of reproduction and fertility. Supplement. 41, p. 119-124 6 p.

Research output: Contribution to journalReview article

25 Scopus citations

Integration, expression and germ-line transmission of growth-related genes in pigs.

Pursel, V. G., Hammer, R. E., Bolt, D. J., Palmiter, R. D. & Brinster, R. L., 1990, In : Journal of reproduction and fertility. Supplement. 41, p. 77-87 11 p.

Research output: Contribution to journalReview article

48 Scopus citations
Open Access
144 Scopus citations
38 Scopus citations

Regulation of G(i) and G(o) by mastoparan, related amphiphilic peptides, and hydrophobic amines. Mechanism and structural determinants of activity

Higashijima, T., Burnier, J. & Ross, E. M., Sep 10 1990, In : Journal of Biological Chemistry. 265, 24, p. 14176-14186 11 p.

Research output: Contribution to journalArticle

519 Scopus citations

Relative growth of the skull and postcranium in giant transgenic mice

Shea, B. T., Hammer, R. E., Brinster, R. L. & Ravosa, M. R., Aug 1990, In : Genetical Research. 56, 1, p. 21-34 14 p.

Research output: Contribution to journalArticle

39 Scopus citations

Spontaneous inflammatory disease in transgenic rats expressing HLA-B27 and human β2m: An animal model of HLA-B27-associated human disorders

Hammer, R. E., Maika, S. D., Richardson, J. A., Tang, J. P. & Taurog, J. D., Nov 30 1990, In : Cell. 63, 5, p. 1099-1112 14 p.

Research output: Contribution to journalArticle

765 Scopus citations

The expression of influenza virus hemagglutinin in the pancreatic β cells of transgenic mice results in autoimmune diabetes

Roman, L. M., Simons, L. F., Hammer, R. E., Sambrook, J. F. & Gething, M. J. H., May 4 1990, In : Cell. 61, 3, p. 383-396 14 p.

Research output: Contribution to journalArticle

66 Scopus citations
34 Scopus citations

Tissue-specific sorting of the human LDL receptor in polarized epithelia of transgenic mice

Pathak, R. K., Yokode, M., Hammer, R. E., Hofmann, S. L., Brown, M. S., Goldstein, J. L. & Anderson, R. G. W., Aug 1990, In : Journal of Cell Biology. 111, 2, p. 347-359 13 p.

Research output: Contribution to journalArticle

Open Access
70 Scopus citations

Viral hijack of receptors

Ross, E. M., Jan 1 1990, In : Nature. 344, 6268, p. 707-708 2 p.

Research output: Contribution to journalShort survey

5 Scopus citations
1991

A Drosophila mutant defective in extracellular calcium-dependent photoreceptor deactivation and rapid desensitization

Ranganathan, R., Harris, G. L., Stevens, C. F. & Zuker, C. S., Jan 1 1991, In : Nature. 354, 6350, p. 230-232 3 p.

Research output: Contribution to journalArticle

158 Scopus citations

ATP-dependent regulation of flagellar adenylylcyclase in gametes of Chlamydomonas reinhardtii

Zhang, Y., Ross, E. M. & Snell, W. J., Dec 1 1991, In : Journal of Biological Chemistry. 266, 34, p. 22954-22959 6 p.

Research output: Contribution to journalArticle

27 Scopus citations

FK506 and Rapamycin Binding to FKBP: Common Elements in Immunophilin-Ligand Complexation

Wandless, T. J., Michnick, S. W., Rosen, M. K., Karplus, M. & Schreiber, S. L., Jan 1 1991, In : Journal of the American Chemical Society. 113, 6, p. 2339-2341 3 p.

Research output: Contribution to journalArticle

32 Scopus citations

Germ-line intrachromosomal recombination restores fertility in transgenic MyK-103 male mice

Wilkie, T. M., Braun, R. E., Ehrman, W. J., Palmiter, R. D. & Hammer, R. E., Jan 1 1991, In : Genes and Development. 5, 1, p. 38-48 11 p.

Research output: Contribution to journalArticle

Open Access
23 Scopus citations

High-resolution structures of photosynthetic reaction centers

Deisenhofer, J. & Michel, H., Jan 1 1991, In : Annual review of biophysics and biophysical chemistry. 20, p. 247-266 20 p.

Research output: Contribution to journalReview article

91 Scopus citations

Immunologic mapping of the amino- and carboxy-termini of the turkey erythrocyte β-adrenergic receptor; Selective proteolysis of both domains

Luxembourg, A., Hekman, M. & Ross, E. M., May 20 1991, In : FEBS Letters. 283, 1, p. 155-158 4 p.

Research output: Contribution to journalArticle

10 Scopus citations

Immunophilin-ligand complexes as probes of intracellular signaling pathways

Schreiber, S. L., Liu, J., Albers, M. W., Karmacharya, R., Koh, E., Martin, P. K., Rosen, M. K., Standaert, R. F. & Wandless, T. J., Dec 1 1991, In : Transplantation Proceedings. 23, 6, p. 2839-2844 6 p.

Research output: Contribution to journalArticle

58 Scopus citations

Mapping of the mastoparan-binding site on G proteins: Cross-linking of [125I-Tyr3,Cys11]mastoparan to G(o)

Higashijima, T. & Ross, E. M., Sep 23 1991, In : Journal of Biological Chemistry. 266, 19, p. 12655-12661 7 p.

Research output: Contribution to journalArticle

78 Scopus citations

Negative and positive selection of antigen-specific cytotoxic T lymphocytes affected by the α3 domain of MHC I molecules

Aldrich, C. J., Hammer, R. E., Jones-Youngblood, S., Koszinowski, U., Hood, L., Stroynowski, I. T. & Forman D.M.D/Ph.D., J. M., 1991, In : Nature. 352, 6337, p. 718-721 4 p.

Research output: Contribution to journalArticle

75 Scopus citations

Photoreceptor deactivation and retinal degeneration mediated by a photoreceptor-specific protein kinase C

Smith, D. P., Ranganathan, R., Hardy, R. W., Marx, J., Tsuchida, T. & Zuker, C. S., Jan 1 1991, In : Science. 254, 5037, p. 1478-1484 7 p.

Research output: Contribution to journalArticle

208 Scopus citations

Proton and Nitrogen Sequential Assignments and Secondary Structure Determination of the Human FK5O6 and Rapamycin Binding Protein

Rosen, M. K., Michnick, S. W., Karplus, M. & Schreiber, S. L., May 1 1991, In : Biochemistry. 30, 19, p. 4774-4789 16 p.

Research output: Contribution to journalArticle

46 Scopus citations

Reconstitution of Receptors and G Proteins in Phospholipid Vesicles

Cerione, R. A. & Ross, E. M., Jan 1991, In : Methods in Enzymology. 195, C, p. 329-342 14 p.

Research output: Contribution to journalArticle

27 Scopus citations

Reconstitutively active G protein-coupled receptors purified from baculovirus-infected insect cells

Parker, E. M., Kameyama, K., Higashijima, T. & Ross, E. M., Jan 31 1991, In : Journal of Biological Chemistry. 266, 1, p. 519-527 9 p.

Research output: Contribution to journalArticle

260 Scopus citations

Selectivity of the β-Adrenergic Receptor among Gs, Gi’s, and Go: Assay Using Recombinant α Subunits in Reconstituted Phospholipid Vesicles

Rubenstein, R. C., Linder, M. E. & Ross, E. M., Nov 1 1991, In : Biochemistry. 30, 44, p. 10769-10777 9 p.

Research output: Contribution to journalArticle

54 Scopus citations

Solution structure of FKBP, a rotamase enzyme and receptor for FK506 and rapamycin

Michnick, S. W., Rosen, M. K., Wandless, T. J., Karplus, M. & Schreiber, S. L., May 10 1991, In : Science. 252, 5007, p. 836-839 4 p.

Research output: Contribution to journalArticle

260 Scopus citations

Structures of bacterial photosynthetic reaction centers

Deisenhofer, J. & Michel, H., Jan 1 1991, In : Annual review of cell biology. 7, p. 1-23 23 p.

Research output: Contribution to journalReview article

55 Scopus citations

Study of Receptor-Ligand Interactions through Receptor Labeling and Isotope-Edited NMR

Rosen, M. K., Michnick, S. W., Wandless, T. J. & Schreiber, S. L., Oct 1 1991, In : Journal of Organic Chemistry. 56, 22, p. 6262-6264 3 p.

Research output: Contribution to journalArticle

7 Scopus citations

The molecular genetics of invertebrate phototransduction

Ranganathan, R., Harris, W. A. & Zuker, C. S., Nov 1991, In : Trends in Neurosciences. 14, 11, p. 486-493 8 p.

Research output: Contribution to journalReview article

46 Scopus citations

Tolerance to Liver‐Specific Antigens

Forman D.M.D/Ph.D., J. M., Wieties, K. & Hammer, R. E., Aug 1991, In : Immunological Reviews. 122, 1, p. 33-46 14 p.

Research output: Contribution to journalArticle

3 Scopus citations
48 Scopus citations
1992

Atherogenesis in transgenic mice expressing human apolipoprotein(a)

Lawn, R. M., Wade, D. P., Hammer, R. E., Chiesa, G., Verstuyft, J. G. & Rubin, E. M., Jan 1 1992, In : Nature. 360, 6405, p. 670-672 3 p.

Research output: Contribution to journalArticle

241 Scopus citations

Cell-specific expression of cytosolic phosphoenolpyruvate carboxykinase in transgenic mice

Beale, E. G., Clouthier, D. E. & Hammer, R. E., Dec 1 1992, In : FASEB Journal. 6, 15, p. 3330-3337 8 p.

Research output: Contribution to journalReview article

41 Scopus citations

Chromophore-protein interactions and the function of the photosynthetic reaction center: A molecular dynamics study

Treutlein, H., Schulten, K., Brünger, A. T., Karplus, M., Deisenhofer, J. & Michel, H., Jan 1 1992, In : Proceedings of the National Academy of Sciences of the United States of America. 89, 1, p. 75-79 5 p.

Research output: Contribution to journalArticle

Open Access
102 Scopus citations
Open Access
58 Scopus citations

Cytoplasmic sequence required for basolateral targeting of LDL receptor in livers of transgenic mice

Yokode, M., Pathak, R. K., Hammer, R. E., Brown, M. S., Goldstein, J. L. & Anderson, R. G. W., May 11 1992, In : Journal of Cell Biology. 117, 1, p. 39-46 8 p.

Research output: Contribution to journalArticle

Open Access
63 Scopus citations

Dramatic growth of mice that develop from eggs microinjected with metallothionein-growth hormone fusion genes. 1982.

Palmiter, R. D., Brinster, R. L., Hammer, R. E., Trumbauer, M. E., Rosenfeld, M. G., Birnberg, N. C. & Evans, R. M., Jan 1 1992, In : Biotechnology (Reading, Mass.). 24, p. 429-433 5 p.

Research output: Contribution to journalArticle

15 Scopus citations

Electron microscopy of thin-sectioned three-dimensional crystals of SecA protein from Escherichia coli: Structure in projection at 40 Å resolution

Weaver, A. J., McDowall, A. W., Oliver, D. B. & Deisenhofer, J., Jan 1 1992, In : Journal of Structural Biology. 109, 2, p. 87-96 10 p.

Research output: Contribution to journalArticle

15 Scopus citations

High-resolution crystal structures of bacterial photosynthetic reaction centers

Deisenhofer, J. & Michel, H., Jan 1 1992, In : New Comprehensive Biochemistry. 23, C, p. 103-120 18 p.

Research output: Contribution to journalArticle

6 Scopus citations