Research Output

2011

WNK1 promotes PIP2 synthesis to coordinate growth factor and GPCR-Gq signaling

An, S. W., Cha, S. K., Yoon, J., Chang, S., Ross, E. M. & Huang, C. L., Dec 6 2011, In : Current Biology. 21, 23, p. 1979-1987 9 p.

Research output: Contribution to journalArticle

22 Scopus citations
2010

Activating WASP mutations associated with X-linked neutropenia result in enhanced actin polymerization, altered cytoskeletal responses, and genomic instability in lymphocytes

Westerberg, L. S., Meelu, P., Baptista, M., Eston, M. A., Adamovich, D. A., Cotta-de-Almeida, V., Seed, B., Rosen, M. K., Vandenberghe, P., Thrasher, A. J., Klein, C., Alt, F. W. & Snapper, S. B., Jun 7 2010, In : Journal of Experimental Medicine. 207, 6, p. 1145-1152 8 p.

Research output: Contribution to journalArticle

38 Scopus citations

A heterodimeric complex of the LRR proteins LRIM1 and APL1C regulates complement-like immunity in Anopheles gambiae

Baxter, R. H. G., Steinert, S., Chelliah, Y., Volohonsky, G., Levashina, E. A. & Deisenhofer, J., Sep 28 2010, In : Proceedings of the National Academy of Sciences of the United States of America. 107, 39, p. 16817-16822 6 p.

Research output: Contribution to journalArticle

38 Scopus citations

A mesoscopic description of contractile cytoskeletal meshworks

Doubrovinski, K., Polyakov, O. & Kaschube, M., Oct 1 2010, In : European Physical Journal E. 33, 2, p. 105-110 6 p.

Research output: Contribution to journalArticle

An interdomain sector mediating allostery in Hsp70 molecular chaperones

Smock, R. G., Rivoire, O., Russ, W. P., Swain, J. F., Leibler, S., Ranganathan, R. & Gierasch, L. M., Oct 6 2010, In : Molecular Systems Biology. 6, 414.

Research output: Contribution to journalArticle

90 Scopus citations

Assessment of linear finite-difference poisson-boltzmann solvers

Wang, J. U. N. & Luo, R. A. Y., Jun 1 2010, In : Journal of Computational Chemistry. 31, 8, p. 1689-1698 10 p.

Research output: Contribution to journalArticle

57 Scopus citations

Autophagy: Snapshot of the network

Levine, B. & Ranganathan, R., Jul 1 2010, In : Nature. 466, 7302, p. 38-40 3 p.

Research output: Contribution to journalShort survey

19 Scopus citations

CDK5RAP2 regulates centriole engagement and cohesion in mice

Barrera, J. A., Kao, L. R., Hammer, R. E., Seemann, J., Fuchs, J. L. & Megraw, T. L., Mar 16 2010, In : Developmental cell. 18, 6, p. 913-926 14 p.

Research output: Contribution to journalArticle

97 Scopus citations

Climate change and the integrity of science

Sills, J., Gleick, P. H., Adams, R. M., Amasino, R. M., Anders, E., Anderson, D. J., Anderson, W. W., Anselin, L. E., Arroyo, M. K., Asfaw, B., Ayala, F. J., Bax, A., Bebbington, A. J., Bell, G., Bennett, M. V. L., Bennetzen, J. L., Berenbaum, M. R., Berlin, O. B., Bjorkman, P. J., Blackburn, E. & 236 others, Blamont, J. E., Botchan, M. R., Boyer, J. S., Boyle, E. A., Branton, D., Briggs, S. P., Briggs, W. R., Brill, W. J., Britten, R. J., Broecker, W. S., Brown, J. H., Brown, P. O., Brunger, A. T., Cairns, J., Canfield, D. E., Carpenter, S. R., Carrington, J. C., Cashmore, A. R., Castilla, J. C., Cazenave, A., Chapin, F. S., Ciechanover, A. J., Clapham, D. E., Clark, W. C., Clayton, R. N., Coe, M. D., Conwell, E. M., Cowling, E. B., Cowling, R. M., Cox, C. S., Croteau, R. B., Crothers, D. M., Crutzen, P. J., Daily, G. C., Dalrymple, G. B., Dangl, J. L., Darst, S. A., Davies, D. R., Davis, M. B., De Camilli, P. V., Dean, C., Defries, R. S., Deisenhofer, J., Delmer, D. P., Delong, E. F., Derosier, D. J., Diener, T. O., Dirzo, R., Dixon, J. E., Donoghue, M. J., Doolittle, R. F., Dunne, T., Ehrlich, P. R., Eisenstadt, S. N., Eisner, T., Emanuel, K. A., Englander, S. W., Ernst, W. G., Falkowski, P. G., Feher, G., Ferejohn, J. A., Fersht, A., Fischer, E. H., Fischer, R., Flannery, K. V., Frank, J., Frey, P. A., Fridovich, I., Frieden, C., Futuyma, D. J., Gardner, W. R., Garrett, C. J. R., Gilbert, W., Goldberg, R. B., Goodenough, W. H., Goodman, C. S., Goodman, M., Greengard, P., Hake, S., Hammel, G., Hanson, S., Harrison, S. C., Hart, S. R., Hartl, D. L., Haselkorn, R., Hawkes, K., Hayes, J. M., Hille, B., Hökfelt, T., House, J. S., Hout, M., Hunten, D. M., Izquierdo, I. A., Jagendorf, A. T., Janzen, D. H., Jeanloz, R., Jencks, C. S., Jury, W. A., Kaback, H. R., Kailath, T., Kay, P., Kay, S. A., Kennedy, D., Kerr, A., Kessler, R. C., Khush, G. S., Kieffer, S. W., Kirch, P. V., Kirk, K., Kivelson, M. G., Klinman, J. P., Klug, A., Knopoff, L., Kornberg, H., Kutzbach, J. E., Lagarias, J. C., Lambeck, K., Landy, A., Langmuir, C. H., Larkins, B. A., Pichon, X. T. L. E., Lenski, R. E., Leopold, E. B., Levin, S. A., Levitt, M., Likens, G. E., Lippincott-Schwartz, J., Lorand, L., Lovejoy, C. O., Lynch, M., Mabogunje, A. L., Malone, T. F., Manabe, S., Marcus, J., Massey, D. S., Mcwilliams, J. C., Medina, E., Melosh, H. J., Meltzer, D. J., Michener, C. D., Miles, E. L., Mooney, H. A., Moore, P. B., Morel, F. M. M., Mosley-Thompson, E. S., Moss, B., Munk, W. H., Myers, N., Nair, G. B., Nathans, J., Nester, E. W., Nicoll, R. A., Novick, R. P., O'Connell, J. F., Olsen, P. E., Opdyke, N. D., Oster, G. F., Ostrom, E., Pace, N. R., Paine, R. T., Palmiter, R. D., Pedlosky, J., Petsko, G. A., Pettengill, G. H., Philander, S. G., Piperno, D. R., Pollard, T. D., Price, P. B., Reichard, P. A., Reskin, B. F., Ricklefs, R. E., Rivest, R. L., Roberts, J. D., Romney, A. K., Rossmann, M. G., Russell, D. W., Rutter, W. J., Sabloff, J. A., Sagdeev, R. Z., Sahlins, M. D., Salmond, A., Sanes, J. R., Schekman, R., Schellnhuber, J., Schindler, D. W., Schmitt, J., Schneider, S. H., Schramm, V. L., Sederoff, R. R., Shatz, C. J., Sherman, F., Sidman, R. L., Sieh, K., Simons, E. L., Singer, B. H., Singer, M. F., Skyrms, B., Sleep, N. H., Smith, B. D., Snyder, S. H., Sokal, R. R., Spencer, C. S., Steitz, T. A., Strier, K. B., Südhof, T. C., Taylor, S. S., Terborgh, J., Thomas, D. H., Thompson, L. G., Tjian, R. T., Turner, M. G., Uyeda, S., Valentine, J. W., Valentine, J. S., Van Etten, J. L., Van Holde, K. E., Vaughan, M., Verba, S., Von Hippel, P. H., Wake, D. B., Walker, A., Walker, J. E., Watson, E. B., Watson, P. J., Weigel, D., Wessler, S. R., West-Eberhard, M. J., White, T. D., Wilson, W. J., Wolfenden, R. V., Wood, J. A., Woodwell, G. M., Wright, H. E., Wu, C., Wunsch, C. & Zoback, M. L., May 7 2010, In : Science. 328, 5979, p. 689-690 2 p.

Research output: Contribution to journalLetter

Open Access
102 Scopus citations

Crystal structure of Spot 14, a modulator of fatty acid synthesis

Colbert, C. L., Kim, C. W., Moon, Y. A., Henry, L., Palnitkar, M., McKean, W. B., Fitzgerald, K., Deisenhofer, J., Horton, J. D. & Kwon, H. J., Nov 2 2010, In : Proceedings of the National Academy of Sciences of the United States of America. 107, 44, p. 18820-18825 6 p.

Research output: Contribution to journalArticle

39 Scopus citations

Crystal structure of the formin mDIA1 in autoinhibited conformation

Otomo, T., Tomchick, D. R., Otomo, C., Machius, M. & Rosen, M. K., Nov 1 2010, In : PloS one. 5, 9, p. 1-13 13 p., e12896.

Research output: Contribution to journalArticle

29 Scopus citations

Determination of protein complex stoichiometry through multisignal sedimentation velocity experiments

Padrick, S. B., Deka, R. K., Chuang, J. L., Wynn, R. M., Chuang, D. T., Norgard, M. V., Rosen, M. K. & Brautigam, C. A., Dec 2010, In : Analytical biochemistry. 407, 1, p. 89-103 15 p.

Research output: Contribution to journalArticle

31 Scopus citations

DHHC5 interacts with PDZ domain 3 of post-synaptic density-95 (PSD-95) protein and plays a role in learning and memory

Li, Y., Hu, J., Höfer, K., Wong, A. M. S., Cooper, J. D., Birnbaum, S. G., Hammer, R. E. & Hofmann, S. L., Apr 23 2010, In : Journal of Biological Chemistry. 285, 17, p. 13022-13031 10 p.

Research output: Contribution to journalArticle

50 Scopus citations

Drug and Drug candidate building block analysis

Wang, J. & Hou, T., Jan 25 2010, In : Journal of Chemical Information and Modeling. 50, 1, p. 55-67 13 p.

Research output: Contribution to journalArticle

66 Scopus citations

Filament turnover stabilizes contractile cytoskeletal structures

Guthardt Torres, P., Doubrovinski, K. & Kruse, K., Sep 1 2010, In : EPL. 91, 6, 68003.

Research output: Contribution to journalArticle

10 Scopus citations

Foxj3 transcriptionally activates Mef2c and regulates adult skeletal muscle fiber type identity

Alexander, M. S., Shi, X., Voelker, K. A., Grange, R. W., Garcia, J. A., Hammer, R. E. & Garry, D. J., Jan 15 2010, In : Developmental Biology. 337, 2, p. 396-404 9 p.

Research output: Contribution to journalArticle

22 Scopus citations

Genetic dissection of the amyloid precursor protein in developmental function and amyloid pathogenesis

Li, H., Wang, Z., Wang, B., Guo, Q., Dolios, G., Tabuchi, K., Hammer, R. E., Südhof, T. C., Wang, R. & Zheng, H., Oct 1 2010, In : Journal of Biological Chemistry. 285, 40, p. 30598-30605 8 p.

Research output: Contribution to journalArticle

33 Scopus citations

Low blood pressure in endothelial cell-specific endothelin 1 knockout mice

Kisanuki, Y. Y., Emoto, N., Ohuchi, T., Widyantoro, B., Yagi, K., Nakayama, K., Kedzierski, R. M., Hammer, R. E., Yanagisawa, H., Williams, S. C., Richardson, J. A., Suzuki, T. & Yanagisawa, M., Jul 1 2010, In : Hypertension. 56, 1, p. 121-128 8 p.

Research output: Contribution to journalArticle

77 Scopus citations

Model of human low-density lipoprotein and bound receptor based on CryoEM

Ren, G., Rudenko, G., Ludtke, S. J., Deisenhofer, J., Chiu, W. & Pownall, H. J., Jan 19 2010, In : Proceedings of the National Academy of Sciences of the United States of America. 107, 3, p. 1059-1064 6 p.

Research output: Contribution to journalArticle

56 Scopus citations

Photon-induced near-field electron microscopy (PINEM): Theoretical and experimental

Park, S. T., Lin, M. & Zewail, A. H., Dec 2010, In : New Journal of Physics. 12, 123028.

Research output: Contribution to journalArticle

119 Scopus citations

Physical mechanisms of signal integration by WASP family proteins

Padrick, S. B. & Rosen, M. K., Jul 7 2010, In : Annual Review of Biochemistry. 79, p. 707-735 29 p.

Research output: Contribution to journalReview article

163 Scopus citations

Rationally improving LOV domainĝ€"based photoswitches

Strickland, D., Yao, X., Gawlak, G., Rosen, M. K., Gardner, K. H. & Sosnick, T. R., Aug 1 2010, In : Nature methods. 7, 8, p. 623-626 4 p.

Research output: Contribution to journalArticle

128 Scopus citations

Reply to Sun et al. Myosin VI movement: Wiggly or straight?

Reifenberger, J. G., Toprak, E., Kim, H., Safer, D., Sweeney, H. & Selvin, P. R., Apr 20 2010, In : Proceedings of the National Academy of Sciences of the United States of America. 107, 16, p. E64

Research output: Contribution to journalLetter

Self-organization in systems of treadmilling filaments

Doubrovinski, K. & Kruse, K., Jan 1 2010, In : European Physical Journal E. 31, 1, p. 95-104 10 p.

Research output: Contribution to journalArticle

10 Scopus citations

Soluble amyloid precursor protein (APP) regulates transthyretin and Klotho gene expression without rescuing the essential function of APP

Li, H., Wang, B., Wang, Z., Guo, Q., Tabuchi, K., Hammer, R. E., Südhof, T. C. & Zheng, H., Oct 5 2010, In : Proceedings of the National Academy of Sciences of the United States of America. 107, 40, p. 17362-17367 6 p.

Research output: Contribution to journalArticle

89 Scopus citations

Structural and Energetic Mechanisms of Cooperative Autoinhibition and Activation of Vav1

Yu, B., Martins, I. R. S., Li, P., Amarasinghe, G. K., Umetani, J., Fernandez-Zapico, M. E., Billadeau, D. D., Machius, M., Tomchick, D. R. & Rosen, M. K., Jan 22 2010, In : Cell. 140, 2, p. 246-256 11 p.

Research output: Contribution to journalArticle

94 Scopus citations

Structure and control of the actin regulatory WAVE complex

Chen, Z., Borek, D., Padrick, S. B., Gomez, T. S., Metlagel, Z., Ismail, A. M., Umetani, J., Billadeau, D. D., Otwinowski, Z. & Rosen, M. K., Nov 25 2010, In : Nature. 468, 7323, p. 533-538 6 p.

Research output: Contribution to journalArticle

240 Scopus citations

Structure and Modeling of GPCRs: Implications for Drug Discovery

Reynolds, K. A., Katritch, V. & Abagyan, R., Jul 15 2010, GPCR Molecular Pharmacology and Drug Targeting: Shifting Paradigms and New Directions. John Wiley and Sons, p. 385-433 49 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

5 Scopus citations

Super-Accuracy and Super-Resolution. Getting Around the Diffraction Limit.

Toprak, E., Kural, C. & Selvin, P. R., 2010, C ed. Unknown Publisher. 26 p. (Methods in Enzymology; vol. 475, no. C)

Research output: Book/ReportBook

11 Scopus citations

Synergistic activation of phospholipase C-β3 by Gαq and Gβγ describes a simple two-state coincidence detector

Philip, F., Kadamur, G., Silos, R. G., Woodson, J. & Ross, E. M., Aug 10 2010, In : Current Biology. 20, 15, p. 1327-1335 9 p.

Research output: Contribution to journalArticle

38 Scopus citations

WASH and WAVE actin regulators of the Wiskott-Aldrich syndrome protein (WASP) family are controlled by analogous structurally related complexes

Jia, D., Gomez, T. S., Metlagel, Z., Umetani, J., Otwinowski, Z., Rosen, M. K. & Billadeau, D. D., Jun 8 2010, In : Proceedings of the National Academy of Sciences of the United States of America. 107, 23, p. 10442-10447 6 p.

Research output: Contribution to journalArticle

130 Scopus citations
2009

A large kindred with X-linked neutropenia with an I294T mutation of the Wiskott-Aldrich syndrome gene

Beel, K., Cotter, M. M., Blatny, J., Bond, J., Lucas, G., Green, F., Vanduppen, V., Leung, D. W., Rooney, S., Smith, O. P., Rosen, M. K. & Vandenberghe, P., Jan 1 2009, In : British Journal of Haematology. 144, 1, p. 120-126 7 p.

Research output: Contribution to journalArticle

64 Scopus citations

Analysis of full and partial agonists binding to β2- adrenergic receptor suggests a role of transmembrane helix v in agonist-specific conformational changes

Katritch, V., Reynolds, K. A., Cherezov, V., Hanson, M. A., Roth, C. B., Yeager, M. & Abagyan, R., Jul 1 2009, In : Journal of Molecular Recognition. 22, 4, p. 307-318 12 p.

Research output: Contribution to journalArticle

94 Scopus citations

Aqueous solubility prediction based on weighted atom type counts and solvent accessible surface areas

Wang, J., Hou, T. & Xu, X., Mar 23 2009, In : Journal of Chemical Information and Modeling. 49, 3, p. 571-581 11 p.

Research output: Contribution to journalArticle

44 Scopus citations

Chapter 5 Recent Advances on in silico ADME Modeling

Wang, J. & Hou, T., 2009, In : Annual Reports in Computational Chemistry. 5, p. 101-127 27 p.

Research output: Contribution to journalArticle

26 Scopus citations

Characterization of a Dazl-GFP germ cell-specific reporter

Nicholas, C. R., Xu, E. Y., Banani, S. F., Hammer, R. E., Hamra, F. K. & Reijo Pera, R. A., Jul 1 2009, In : Genesis. 47, 2, p. 74-84 11 p.

Research output: Contribution to journalArticle

26 Scopus citations

Conformations and coherences in structure determination by ultrafast electron diffraction

Lin, M. M., Shorokhov, D. & Zewail, A. H., Apr 23 2009, In : Journal of Physical Chemistry A. 113, 16, p. 4075-4093 19 p.

Research output: Contribution to journalArticle

14 Scopus citations

Deletion of ELOVL5 leads to fatty liver through activation of SREBP-1c in mice

Moon, Y. A., Hammer, R. E. & Horton, J. D., Apr 1 2009, In : Journal of lipid research. 50, 3, p. 412-423 12 p.

Research output: Contribution to journalArticle

109 Scopus citations

Dependence of Mouse Embryonic Stem Cells on Threonine Catabolism

Wang, J., Alexander, P., Wu, L., Hammer, R. E., Cleaver, O. & McKnight, S. L., Jul 24 2009, In : Science. 325, 5939, p. 435-439 5 p.

Research output: Contribution to journalArticle

215 Scopus citations

Examination of the effect of the annealing cation on higher order structures containing guanine or isoguanine repeats

Pierce, S. E., Wang, J., Jayawickramarajah, J., Hamilton, A. D. & Brodbelt, J. S., Oct 26 2009, In : Chemistry - A European Journal. 15, 42, p. 11244-11255 12 p.

Research output: Contribution to journalArticle

18 Scopus citations

Fasting-Induced Hypothermia and Reduced Energy Production in Mice Lacking Acetyl-CoA Synthetase 2

Sakakibara, I., Fujino, T., Ishii, M., Tanaka, T., Shimosawa, T., Miura, S., Zhang, W., Tokutake, Y., Yamamoto, J., Awano, M., Iwasaki, S., Motoike, T., Okamura, M., Inagaki, T., Kita, K., Ezaki, O., Naito, M., Kuwaki, T., Chohnan, S., Yamamoto, T. T. & 4 others, Hammer, R. E., Kodama, T., Yanagisawa, M. & Sakai, J., Feb 4 2009, In : Cell Metabolism. 9, 2, p. 191-202 12 p.

Research output: Contribution to journalArticle

55 Scopus citations
55 Scopus citations

Insights into pilus assembly and secretion from the structure and functional characterization of usher PapC

Huang, Y., Smith, B. S., Chen, L. X., Baxter, R. H. G. & Deisenhofer, J., May 5 2009, In : Proceedings of the National Academy of Sciences of the United States of America. 106, 18, p. 7403-7407 5 p.

Research output: Contribution to journalArticle

49 Scopus citations

Insulin receptor tyrosine kinase substrate links the E. coli O157:H7 actin assembly effectors Tir and EspF U during pedestal formation

Vingadassalom, D., Kazlauskas, A., Skehan, B., Cheng, H. C., Magoun, L., Robbins, D., Rosen, M. K., Saksela, K. & Leong, J. M., Apr 21 2009, In : Proceedings of the National Academy of Sciences of the United States of America. 106, 16, p. 6754-6759 6 p.

Research output: Contribution to journalArticle

86 Scopus citations

Molecular Mechanisms of Hepatic Steatosis and Insulin Resistance in the AGPAT2-Deficient Mouse Model of Congenital Generalized Lipodystrophy

Cortés, V. A., Curtis, D. E., Sukumaran, S., Shao, X., Parameswara, V., Rashid, S., Smith, A. R., Ren, J., Esser, V., Hammer, R. E., Agarwal, A. K., Horton, J. D. & Garg, A., Feb 4 2009, In : Cell Metabolism. 9, 2, p. 165-176 12 p.

Research output: Contribution to journalArticle

151 Scopus citations

Myosin VI undergoes a 180° power stroke implying an uncoupling of the front lever arm

Reifenberger, J. G., Toprak, E., Kim, H., Safer, D., Sweeney, H. L. & Selvin, P. R., Dec 4 2009, In : Proceedings of the National Academy of Sciences of the United States of America. 106, 43, p. 18255-18260 6 p.

Research output: Contribution to journalArticle

30 Scopus citations

Nkx2-5 transactivates the Ets-related protein 71 gene and specifies an endothelial/endocardial fate in the developing embryo

Ferdous, A., Caprioli, A., Iacovino, M., Martin, C. M., Morris, J., Richardson, J. A., Latif, S., Hammer, R. E., Harvey, R. P., Olson, E. N., Kyba, M. & Garry, D. J., Jan 20 2009, In : Proceedings of the National Academy of Sciences of the United States of America. 106, 3, p. 814-819 6 p.

Research output: Contribution to journalArticle

129 Scopus citations

Polarization effects in molecular mechanical force fields

Cieplak, P., Dupradeau, F. Y., Duan, Y. & Wang, J., Sep 21 2009, In : Journal of Physics Condensed Matter. 21, 33, 333102.

Research output: Contribution to journalReview article

205 Scopus citations

Primary peptide folding dynamics observed with ultrafast temperature jump

Mohammed, O. F., Jas, G. S., Lin, M. M. & Zewail, A. H., Jul 20 2009, In : Angewandte Chemie - International Edition. 48, 31, p. 5628-5632 5 p.

Research output: Contribution to journalArticle

35 Scopus citations

Protein Sectors: Evolutionary Units of Three-Dimensional Structure

Halabi, N., Rivoire, O., Leibler, S. & Ranganathan, R., Aug 21 2009, In : Cell. 138, 4, p. 774-786 13 p.

Research output: Contribution to journalArticle

406 Scopus citations