Research Output

Article

Functional dissection of Reelin signaling by site-directed disruption of disabled-1 adaptor binding to apolipoprotein E receptor 2: Distinct roles in development and synaptic plasticity

Beffert, U., Durudas, A., Weeber, E. J., Stolt, P. C., Giehl, K. M., Sweatt, J. D., Hammer, R. E. & Herz, J., Feb 15 2006, In : Journal of Neuroscience. 26, 7, p. 2041-2052 12 p.

Research output: Contribution to journalArticle

93 Scopus citations

Functional divergence caused by mutations in an energetic hotspot in ERK2

Taylor, C. A., Cormier, K. W., Keenan, S. E., Earnest, S., Stippec, S., Wichaidit, C., Juang, Y. C., Wang, J., Shvartsman, S. Y., Goldsmith, E. J. & Cobb, M. H., Jul 30 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 31, p. 15514-15523 10 p.

Research output: Contribution to journalArticle

Open Access
6 Scopus citations

Functional domains in the β-adrenergic receptor

Ross, E. M., Wong, S. K. F., Rubenstein, R. C. & Higashijima, T., 1988, In : Cold Spring Harbor symposia on quantitative biology. 53, 1, p. 499-506 8 p.

Research output: Contribution to journalArticle

8 Scopus citations
Open Access
238 Scopus citations

Functional importance of the amino terminus of G

Hepler, J. R., Biddlecome, G. H., Kleuss, C., Camp, L. A., Hofmann, S. L., Ross, E. M. & Gilman, A. G., Jan 5 1996, In : Journal of Biological Chemistry. 271, 1, p. 496-504 9 p.

Research output: Contribution to journalArticle

Open Access
95 Scopus citations
Open Access
57 Scopus citations

Fusion von Wirbelkörpern und dem Sakroiliakalgelenk durch Knorpelgewebe in HLA-B27-transgenen Ratten.

Translated title of the contribution: Fusion of vertebrae and the sacroiliac joint by cartilaginous tissue in HLA-B27 transgenic ratsKriegsmann, J., Franklin, B. N., Gay, R. E., Taurog, J. D., Hammer, R. E., Bräuer, R., Katenkamp, D. & Gay, S., 1996, In : Verhandlungen der Deutschen Gesellschaft für Pathologie. 80, 1 p.

Research output: Contribution to journalArticle

3 Scopus citations

G(s) regulation of endosome fusion suggests a role for signal transduction pathways in endocytosis

Colombo, M. I., Mayorga, L. S., Nishimoto, I., Ross, E. M. & Stahl, P. D., Jan 1 1994, In : Journal of Biological Chemistry. 269, 21, p. 14919-14923 5 p.

Research output: Contribution to journalArticle

51 Scopus citations

GAP-43 augments G protein-coupled receptor transduction in Xenopus laevis oocytes

Strittmatter, S. M., Cannon, S. C., Ross, E. M., Higashijima, T. & Fishman, M. C., Jan 1 1993, In : Proceedings of the National Academy of Sciences of the United States of America. 90, 11, p. 5327-5331 5 p.

Research output: Contribution to journalArticle

Open Access
63 Scopus citations

Gas-Phase Stability of G-quadruplex DNA Determined by Electrospray Ionization Tandem Mass Spectrometry and Molecular Dynamics Simulations

Mazzitelli, C. L., Wang, J., Smith, S. I. & Brodbelt, J. S., Oct 1 2007, In : Journal of the American Society for Mass Spectrometry. 18, 10, p. 1760-1773 14 p.

Research output: Contribution to journalArticle

29 Scopus citations

Generation and cycloaddition of semi-stabilized 2-azaallyllithiums viaelectrocyclic ring-opening or cycloreversion reactions

Pearson, W. H., Walters, M. A., Rosen, M. K. & Harter, W. G., Dec 1 2002, In : Arkivoc. 2002, 8, p. 91-111 21 p.

Research output: Contribution to journalArticle

9 Scopus citations

Genetic algorithm-optimized QSPR models for bioavailability, protein binding, and urinary excretion

Wang, J., Krudy, G., Xie, X. Q., Wu, C. & Holland, G., Nov 1 2006, In : Journal of Chemical Information and Modeling. 46, 6, p. 2674-2683 10 p.

Research output: Contribution to journalArticle

58 Scopus citations

Genetically encoded photoswitching of actin assembly through the Cdc42-WASP-Arp2/3 complex pathway

Leung, D. W., Otomo, C., Chory, J. & Rosen, M. K., Sep 2 2008, In : Proceedings of the National Academy of Sciences of the United States of America. 105, 35, p. 12797-12802 6 p.

Research output: Contribution to journalArticle

78 Scopus citations

Genetic analysis of Mint/X11 proteins: Essential presynaptic functions of a neuronal adaptor protein family

Ho, A., Morishita, W., Atasoy, D., Liu, X., Tabuchi, K., Hammer, R. E., Malenka, R. C. & Südhof, T. C., Dec 13 2006, In : Journal of Neuroscience. 26, 50, p. 13089-13101 13 p.

Research output: Contribution to journalArticle

65 Scopus citations

Genetic dissection of the amyloid precursor protein in developmental function and amyloid pathogenesis

Li, H., Wang, Z., Wang, B., Guo, Q., Dolios, G., Tabuchi, K., Hammer, R. E., Südhof, T. C., Wang, R. & Zheng, H., Oct 1 2010, In : Journal of Biological Chemistry. 285, 40, p. 30598-30605 8 p.

Research output: Contribution to journalArticle

33 Scopus citations

Genetic engineering of livestock

Pursel, V. G., Pinkert, C. A., Miller, K. F., Bolt, D. J., Campbell, R. G., Palmiter, R. D., Brinster, R. L. & Hammer, R. E., Jan 1 1989, In : Science. 244, 4910, p. 1281-1288 8 p.

Research output: Contribution to journalArticle

308 Scopus citations

Genetic engineering of mammalian embryos.

Hammer, R. E., Pursel, V. G., Rexroad, C. E., Wall, R. J., Bolt, D. J., Palmiter, R. D. & Brinster, R. L., Jul 1986, In : Journal of animal science. 63, 1, p. 269-278 10 p.

Research output: Contribution to journalArticle

37 Scopus citations

Genetic interaction between hap1/ref-1 and p53

Meira, L. B., Cheo, D. L., Hammer, R. E., Burns, D. K., Reis, A. & Friedberg, E. C., Oct 1997, In : Nature genetics. 17, 2, 1 p.

Research output: Contribution to journalArticle

52 Scopus citations

Germ-line intrachromosomal recombination restores fertility in transgenic MyK-103 male mice

Wilkie, T. M., Braun, R. E., Ehrman, W. J., Palmiter, R. D. & Hammer, R. E., Jan 1 1991, In : Genes and Development. 5, 1, p. 38-48 11 p.

Research output: Contribution to journalArticle

Open Access
23 Scopus citations

Global disruption of the WASP autoinhibited structure on Cdc42 binding. Ligand displacement as a novel method for monitoring amide hydrogen exchange

Buck, M., Xu, W. & Rosen, M. K., Nov 27 2001, In : Biochemistry. 40, 47, p. 14115-14122 8 p.

Research output: Contribution to journalArticle

18 Scopus citations

Global folds of highly deuterated, methyl-protonated proteins by multidimensional NMR

Gardner, K. H., Rosen, M. K. & Kay, L. E., Feb 11 1997, In : Biochemistry. 36, 6, p. 1389-1401 13 p.

Research output: Contribution to journalArticle

233 Scopus citations
3 Scopus citations

Glucocorticoid regulation of metallothionein during murine development

Quaife, C., Hammer, R. E., Mottet, N. K. & Palmiter, R. D., Dec 1986, In : Developmental Biology. 118, 2, p. 549-555 7 p.

Research output: Contribution to journalArticle

64 Scopus citations

Gonadotroph-specific expression of metallothionein fusion genes in pituitaries of transgenic mice

Low, M. J., Lechan, R. M., Hammer, R. E., Brinster, R. L., Habener, J. F., Mandel, G. & Goodman, R. H., Jan 1 1986, In : Science. 231, 4741, p. 1002-1004 3 p.

Research output: Contribution to journalArticle

30 Scopus citations

GPCR structure-based virtual screening approach for CB2 antagonist search

Chen, J. Z., Wang, J. & Xie, X. Q., Jul 1 2007, In : Journal of Chemical Information and Modeling. 47, 4, p. 1626-1637 12 p.

Research output: Contribution to journalArticle

87 Scopus citations

G Protein-Coupled Receptors: Structure and Function of Signal-Transducing Proteins

Parker, E. M. & Ross, E. M., Jan 1 1990, In : Current Topics in Membranes and Transport. 36, C, p. 131-144 14 p.

Research output: Contribution to journalArticle

4 Scopus citations
42 Scopus citations

Growth allometry of the organs in giant transgenic mice

Shea, B. T., Hammer, R. E. & Brinster, R. L., Dec 1 1987, In : Endocrinology. 121, 6, p. 1924-1930 7 p.

Research output: Contribution to journalArticle

104 Scopus citations

Growth enhancement of transgenic mice expressing human insulin-like growth factor I

Mathews, L. S., Hammer, R. E., Behringer, R. R., D'Ercole, A. J., Bell, G. I., Brinster, R. L. & Palmiter, R. D., Dec 1988, In : Endocrinology. 123, 6, p. 2827-2833 7 p.

Research output: Contribution to journalArticle

353 Scopus citations
91 Scopus citations

Guanosine Triphosphatase-Activating Proteins for Heterotrimeric G-Proteins

Ross, E. M., Wang, J., Tu, Y. & Biddlecome, G. H., 1997, In : Advances in Pharmacology. 42, C, p. 458-461 4 p.

Research output: Contribution to journalArticle

2 Scopus citations

Gβγinhibits Gα GTPase-activating proteins by inhibition of Gα-GTP binding during stimulation by receptor

Tang, W., Tu, Y., Nayak, S. K., Woodson, J., Jehl, M. & Ross, E. M., Feb 24 2006, In : Journal of Biological Chemistry. 281, 8, p. 4746-4753 8 p.

Research output: Contribution to journalArticle

23 Scopus citations

Helix-to-coil transitions in proteins: Helicity resonance in ultrafast electron diffraction

Lin, M. M., Shorokhov, D. & Zewail, A. H., Mar 10 2006, In : Chemical Physics Letters. 420, 1-3, p. 1-7 7 p.

Research output: Contribution to journalArticle

15 Scopus citations

Hepatic fibrosis, glomerulosclerosis, and a lipodystrophy-like syndrome in PEPCK-TGF-β1 transgenic mice

Clouthier, D. E., Comerford, S. A. & Hammer, R. E., Dec 1 1997, In : Journal of Clinical Investigation. 100, 11, p. 2697-2713 17 p.

Research output: Contribution to journalArticle

Open Access
233 Scopus citations

Heritable and stable gene knockdown in rats

Dann, C. T., Alvarado, A. L., Hammer, R. E. & Garbers, D. L., Jul 25 2006, In : Proceedings of the National Academy of Sciences of the United States of America. 103, 30, p. 11246-11251 6 p.

Research output: Contribution to journalArticle

63 Scopus citations

Heterozygosity for the mouse Apex gene results in phenotypes associated with oxidative stress

Meira, L. B., Devaraj, S., Kisby, G. E., Burns, D. K., Daniel, R. L., Hammer, R. E., Grundy, S. M., Jialal, I. & Friedberg, E. C., Jul 15 2001, In : Cancer Research. 61, 14, p. 5552-5557 6 p.

Research output: Contribution to journalArticle

141 Scopus citations

Hierarchical database screenings for HIV-1 reverse transcriptase using a pharmacophore model, rigid docking, solvation docking, and MM-PB/SA

Wang, J., Kang, X., Kuntz, I. D. & Kollman, P. A., Apr 7 2005, In : Journal of Medicinal Chemistry. 48, 7, p. 2432-2444 13 p.

Research output: Contribution to journalArticle

65 Scopus citations

Hierarchical Organization Endows the Kinase Domain with Regulatory Plasticity

Creixell, P., Pandey, J. P., Palmeri, A., Bhattacharyya, M., Creixell, M., Ranganathan, R., Pincus, D. & Yaffe, M. B., Oct 24 2018, In : Cell Systems. 7, 4, p. 371-383.e4

Research output: Contribution to journalArticle

7 Scopus citations

Hierarchical Regulation of WASP/WAVE Proteins

Padrick, S. B., Cheng, H. C., Ismail, A. M., Panchal, S. C., Doolittle, L. K., Kim, S., Skehan, B. M., Umetani, J., Brautigam, C. A., Leong, J. M. & Rosen, M. K., Nov 7 2008, In : Molecular cell. 32, 3, p. 426-438 13 p.

Research output: Contribution to journalArticle

138 Scopus citations

High-level rearrangement and transcription of yeast artificial chromosome-based mouse Igκ transgenes containing distal regions of the contig

Li, S., Hammer, R. E., George-Raizen, J. B., Meyers, K. C. & Garrard, W. T., Jan 15 2000, In : Journal of Immunology. 164, 2, p. 812-824 13 p.

Research output: Contribution to journalArticle

8 Scopus citations

High-order epistasis in catalytic power of dihydrofolate reductase gives rise to a rugged fitness landscape in the presence of trimethoprim selection

Tamer, Y. T., Gaszek, I. K., Abdizadeh, H., Batur, T. A., Reynolds, K. A., Atilgan, A. R., Atilgan, C. & Toprak, E., 2019, In : Molecular biology and evolution. 36, 7, p. 1533-1550 18 p.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

High plasma levels of immunoreactive somatostatin in transgenic mice expressing a metallothionein-somatostatin fusion gene.

Low, M. J., Goodman, R. H., Brinster, R. L., Palmiter, R. D., Hammer, R. E. & Habener, J. F., Dec 1 1984, In : Transactions of the Association of American Physicians. 97, p. 205-209 5 p.

Research output: Contribution to journalArticle

27 Scopus citations

High-resolution crystal structure of the human CB1 cannabinoid receptor

Shao, Z., Yin, J., Chapman, K., Grzemska, M., Clark, L., Wang, J. & Rosenbaum, D. M., Dec 22 2016, In : Nature. 540, 7634, p. 602-606 5 p.

Research output: Contribution to journalArticle

153 Scopus citations

High-resolution crystal structures of bacterial photosynthetic reaction centers

Deisenhofer, J. & Michel, H., Jan 1 1992, In : New Comprehensive Biochemistry. 23, C, p. 103-120 18 p.

Research output: Contribution to journalArticle

6 Scopus citations

Histopathology associated with elevated levels of growth hormone and insulin-like growth factor i in transgenic mice

Quaife, C. J., Mathews, L. S., Pinkert, C. A., Hammer, R. E., Brinster, R. L. & Palmiter, R. D., Jan 1989, In : Endocrinology. 124, 1, p. 40-48 9 p.

Research output: Contribution to journalArticle

203 Scopus citations
50 Scopus citations

Homer 2 tunes G protein-coupled receptors stimulus intensity by regulating RGS proteins and PLCβ GAP activities

Shin, D. M., Dehoff, M., Luo, X., Kang, S. H., Tu, J., Nayak, S. K., Ross, E. M., Worley, P. E. & Muallem, S., Jul 21 2003, In : Journal of Cell Biology. 162, 2, p. 293-303 11 p.

Research output: Contribution to journalArticle

74 Scopus citations

Hormone receptors uncoupled from adenylate cyclase (AC) in a variant S49 lymphoma cell clone

Ross, E. M., Raga, T. & Gilman, A. G., Jan 1 1977, In : Federation Proceedings. 36, 3, p. no.259

Research output: Contribution to journalArticle