Research Output

1999

Modulation of the affinity and selectivity of RGS protein interaction with Gα subunits by a conserved asparagine/serine residue

Posner, B. A., Mukhopadhyay, S., Tesmer, J. J., Gilman, A. G. & Ross, E. M., Jun 15 1999, In : Biochemistry. 38, 24, p. 7773-7779 7 p.

Research output: Contribution to journalArticle

66 Scopus citations

Narcolepsy in orexin knockout mice: Molecular genetics of sleep regulation

Chemelli, R. M., Willie, J. T., Sinton, C. M., Elmquist, J. K., Scammell, T., Lee, C., Richardson, J. A., Clay Williams, S., Xiong, Y., Kisanuki, Y., Fitch, T. E., Nakazato, M., Hammer, R. E., Saper, C. B. & Yanagisawa, M., Aug 20 1999, In : Cell. 98, 4, p. 437-451 15 p.

Research output: Contribution to journalArticle

2372 Scopus citations

Novel HY peptide antigens presented by HLA-B27.

Taurog, J. D., Hammer, R. E., Moomaw, C. R., Slaughter, C. A., Roopenian, D. C., Zuberi, A. R., Gaskell, S. J., Bordoli, R. S., Colbert, R. A., Butcher, G. W. & Leong, L. Y., Nov 15 1999, In : Journal of Immunology. 163, 10, p. 5741 1 p.

Research output: Contribution to journalArticle

Palmitoylation of a conserved cysteine in the regulator of G protein signaling (RGS) domain modulates the GTPase-activating activity of RGS4 and RGS10

Tu, Y., Popov, S., Slaughter, C. & Ross, E. M., Dec 31 1999, In : Journal of Biological Chemistry. 274, 53, p. 38260-38267 8 p.

Research output: Contribution to journalArticle

85 Scopus citations

Phospholipase C-β1 directly accelerates GTP hydrolysis by Gα(q) and acceleration is inhibited by Gβγ subunits

Chidiac, P. & Ross, E. M., Jul 9 1999, In : Journal of Biological Chemistry. 274, 28, p. 19639-19643 5 p.

Research output: Contribution to journalArticle

80 Scopus citations
146 Scopus citations

Reciprocal signaling between heterotrimeric G proteins and the p21- stimulated protein kinase

Wang, J., Frost, J. A., Cobb, M. H. & Ross, E. M., Oct 29 1999, In : Journal of Biological Chemistry. 274, 44, p. 31641-31647 7 p.

Research output: Contribution to journalArticle

49 Scopus citations

Reeler/disabled-like disruption of neuronal migration in knockout mice lacking the VLDL receptor and ApoE receptor 2

Trommsdorff, M., Gotthardt, M., Hiesberger, T., Shelton, J., Stockinger, W., Nimpf, J., Hammer, R. E., Richardson, J. A. & Herz, J., 1999, In : Cell. 97, 6, p. 689-701 13 p.

Research output: Contribution to journalArticle

1011 Scopus citations

Structural basis of multifunctional bovine mitochondrial cytochrome bc1 complex

Yu, C. A., Tian, H., Zhang, L., Deng, K. P., Shenoy, S. K., Yu, L., Xia, D., Kim, H. & Deisenhofer, J., Jan 1 1999, In : Journal of Bioenergetics and Biomembranes. 31, 3, p. 191-200 10 p.

Research output: Contribution to journalReview article

20 Scopus citations

Structure and reaction mechanisms of multifunctional mitochondrial cytochrome bc1 complex

Yu, C. A., Zhang, L., Deng, K. P., Tian, H., Xia, D., Kim, H., Deisenhofer, J. & Yu, L., Jan 1 1999, In : BioFactors. 9, 2-4, p. 103-109 7 p.

Research output: Contribution to journalReview article

17 Scopus citations

Structure of antimycin A1, a specific electron transfer inhibitor of ubiquinol-cytochrome c oxidoreductase [6]

Kim, H., Esser, L., Hossain, M. B., Xia, D., Yu, C. A., Rizo-Rey, J., Van Der Helm, D. & Deisenhofer, J., May 26 1999, In : Journal of the American Chemical Society. 121, 20, p. 4902-4903 2 p.

Research output: Contribution to journalLetter

30 Scopus citations

Structure of Cdc42 in complex with the GTPase-binding domain of the 'Wiskott-Aldrich syndrome' protein

Abdul-Manan, N., Aghazadeh, B., Liu, G. A., Majumdar, A., Ouerfelli, O., Simlnovitch, K. A. & Rosen, M. K., May 27 1999, In : Nature. 399, 6734, p. 379-383 5 p.

Research output: Contribution to journalArticle

264 Scopus citations

Studies on Crystal Structure, Conformation Analysis ofa New Designed Hapten Containing Sulfur

Xie, G. Y., Kong, Y. L., Wang, J. M., Xu, X. J. & Jin, S., Jun 10 1999, In : Kao Teng Hsueh Hsiao Hua Heush Hsueh Pao/ Chemical Journal of Chinese Universities. 20, 6, p. 893-894 2 p.

Research output: Contribution to journalArticle

The path to specificity

Zuker, C. S. & Ranganathan, R., Jan 29 1999, In : Science. 283, 5402, p. 650-651 2 p.

Research output: Contribution to journalReview article

26 Scopus citations

The structure of the ligand-binding domain of neurexin Iβ: Regulation of LNS domain function by alternative splicing

Rudenko, G., Nguyen, T., Chelliah, Y., Südhof, T. C. & Deisenhofer, J., Oct 1 1999, In : Cell. 99, 1, p. 93-101 9 p.

Research output: Contribution to journalArticle

110 Scopus citations

TOXCAT: A measure of transmembrane helix association in a biological membrane

Russ, W. P. & Engelman, D. M., Feb 2 1999, In : Proceedings of the National Academy of Sciences of the United States of America. 96, 3, p. 863-868 6 p.

Research output: Contribution to journalArticle

307 Scopus citations

Transgenic mice expressing a human apolipoprotein[a] allele

Acquati, F., Hammer, R. E., Ercoli, B., Mooser, V., Ruixan, T., Rönicke, V., Michalich, A., Chiesa, G., Taramelli, R., Hobbs, H. H. & Müller, H. J., Jun 1 1999, In : Journal of lipid research. 40, 6, p. 994-1006 13 p.

Research output: Contribution to journalArticle

15 Scopus citations
2000

Adult Apaf-1-deficient mice exhibit male infertility

Honarpour, N., Du, C., Richardson, J. A., Hammer, R. E., Wang, X. & Herz, J., Feb 15 2000, In : Developmental Biology. 218, 2, p. 248-258 11 p.

Research output: Contribution to journalArticle

168 Scopus citations

A molecular pathway for light-dependent photoreceptor apoptosis in Drosophila

Kiselev, A., Socolich, M., Vinós, J., Hardy, R. W., Zuker, C. S. & Ranganathan, R., Jan 1 2000, In : Neuron. 28, 1, p. 139-152 14 p.

Research output: Contribution to journalArticle

Open Access
197 Scopus citations

Autoinhibition and activation mechanisms of the Wiskott-Aldrich syndrome protein

Kim, A. S., Kakalis, L. T., Abdul-Manan, N., Liu, G. A. & Rosen, M. K., Mar 9 2000, In : Nature. 404, 6774, p. 151-158 8 p.

Research output: Contribution to journalArticle

562 Scopus citations

Cloning and characterization of the Dictyostelium discoideum cycloartenol synthase cDNA

Godzina, S. M., Lovato, M. A., Meyer, M. M., Foster, K. A., Wilson, W. K., Gu, W., De Hostos, E. L. & Matsuda, S. P. T., Jan 1 2000, In : Lipids. 35, 3, p. 249-255 7 p.

Research output: Contribution to journalArticle

24 Scopus citations

Crystal structure of Rab geranylgeranyltransferase at 2.0 Å resolution

Zhang, H., Seabra, M. C. & Deisenhofer, J., Mar 1 2000, In : Structure. 8, 3, p. 241-251 11 p.

Research output: Contribution to journalArticle

94 Scopus citations

Crystal structure of the catalytic portion of human HMG-CoA reductase: Insights into regulation of activity and catalysis

Istvan, E. S., Palnitkar, M., Buchanan, S. K. & Deisenhofer, J., Mar 1 2000, In : EMBO Journal. 19, 5, p. 819-830 12 p.

Research output: Contribution to journalArticle

211 Scopus citations

Decreased IRS-2 and increased SREBP-1c lead to mixed insulin resistance and sensitivity in livers of lipodystrophic and ob/ob mice

Shimomura, I., Matsuda, M., Hammer, R. E., Bashmakov, Y., Brown, M. S. & Goldstein, J. L., Jan 1 2000, In : Molecular cell. 6, 1, p. 77-86 10 p.

Research output: Contribution to journalArticle

Open Access
651 Scopus citations

Detection of very weak side chain-main chain hydrogen bonding interactions in medium-size 13C/15N-labeled proteins by sensitivity- enhanced NMR spectroscopy

Liu, A., Hu, W., Majumdar, A., Rosen, M. K. & Patel, D. J., Jan 1 2000, In : Journal of Biomolecular NMR. 17, 1, p. 79-82 4 p.

Research output: Contribution to journalArticle

14 Scopus citations

Disruption of ECE-1 and ECE-2 reveals a role for endothelin-converting enzyme-2 in murine cardiac development

Yanagisawa, H., Hammer, R. E., Richardson, J. A., Emoto, N., Clay Williams, S., Takeda, S. I., Clouthier, D. E. & Yanagisawa, M., May 2000, In : Journal of Clinical Investigation. 105, 10, p. 1373-1382 10 p.

Research output: Contribution to journalArticle

Open Access
163 Scopus citations

DNA photolyases and cryptochromes

Deisenhofer, J., Aug 30 2000, In : Mutation Research - DNA Repair. 460, 3-4, p. 143-149 7 p.

Research output: Contribution to journalArticle

64 Scopus citations
861 Scopus citations

High-level rearrangement and transcription of yeast artificial chromosome-based mouse Igκ transgenes containing distal regions of the contig

Li, S., Hammer, R. E., George-Raizen, J. B., Meyers, K. C. & Garrard, W. T., Jan 15 2000, In : Journal of Immunology. 164, 2, p. 812-824 13 p.

Research output: Contribution to journalArticle

8 Scopus citations
3117 Scopus citations

Interhelical hydrogen bonding drives strong interactions in membrane proteins

Zhou, F. X., Cocco, M. J., Russ, W. P., Brunger, A. T. & Engelman, D. M., Feb 1 2000, In : Nature Structural Biology. 7, 2, p. 154-160 7 p.

Research output: Contribution to journalArticle

340 Scopus citations

Mechanistic studies of affinity modulation

Rosen, M. K., Amos, C. D. & Wandless, T. J., Dec 6 2000, In : Journal of the American Chemical Society. 122, 48, p. 11979-11982 4 p.

Research output: Contribution to journalArticle

6 Scopus citations

NMR detection of side chain-side chain hydrogen bonding interactions in 13C/15N-labeled proteins

Liu, A., Hu, W., Majumdar, A., Rosen, M. K. & Patel, D. J., Jan 1 2000, In : Journal of biomolecular NMR. 17, 4, p. 305-310 6 p.

Research output: Contribution to journalArticle

22 Scopus citations

Photon correlation spectroscopy: X rays versus visible light

Riese, D. O., Vos, W. L., Wegdam, G. H., Poelwijk, F. J., Abernathy, D. L. & Grübel, G., Jan 1 2000, In : Physical Review E - Statistical Physics, Plasmas, Fluids, and Related Interdisciplinary Topics. 61, 2, p. 1676-1680 5 p.

Research output: Contribution to journalArticle

41 Scopus citations

Retraction: Sharing of an HLA-B27-restricted male H-Y antigen between rat and mouse (Immunogenetics (1993) 38 (351-358))

Simmons, W. A., Taurog, J. D., Hammer, R. E. & Breban, M., Jan 1 2000, In : Immunogenetics. 51, 1, 1 p.

Research output: Contribution to journalComment/debate

Sharing of an HLA-B27-restricted H-Y antigen between rat and mouse.

Taurog, J. D., Hammer, R. E. & Breban, M., Jan 1 2000, In : Immunogenetics. 51, 1, 1 p.

Research output: Contribution to journalComment/debate

Structural basis for relief of autoinhibition of the Dbl homology domain of proto-oncogene Vav by tyrosine phosphorylation

Aghazadeh, B., Lowry, W. E., Huang, X. Y. & Rosen, M. K., Sep 1 2000, In : Cell. 102, 5, p. 625-633 9 p.

Research output: Contribution to journalArticle

Open Access
302 Scopus citations

Synaptic assembly of the brain in the absence of neurotransmitter secretion

Verhage, M., Maia, A. S., Plomp, J. J., Brussaard, A. B., Heeroma, J. H., Vermeer, H., Toonen, R. F., Hammer, R. E., Van Den Berg, T. K., Missler, M., Geuze, H. J. & Südhof, T. C., Feb 4 2000, In : Science. 287, 5454, p. 864-869 6 p.

Research output: Contribution to journalArticle

891 Scopus citations

The GxxxG motif: A framework for transmembrane helix-helix association

Russ, W. P. & Engelman, D. M., Feb 25 2000, In : Journal of Molecular Biology. 296, 3, p. 911-919 9 p.

Research output: Contribution to journalArticle

699 Scopus citations

The structural basis for red fluorescence in the tetrameric GFP homolog DsRed

Wall, M. A., Socolich, M. & Ranganathan, R., Dec 23 2000, In : Nature Structural Biology. 7, 12, p. 1133-1138 6 p.

Research output: Contribution to journalArticle

293 Scopus citations

The structure of the catalytic portion of human HMG-CoA reductase

Istvan, E. S. & Deisenhofer, J., Dec 15 2000, In : Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids. 1529, 1-3, p. 9-18 10 p.

Research output: Contribution to journalReview article

100 Scopus citations
2001

An analysis of the interactions between the Sem-5 SH3 domain and its ligands using molecular dynamics, free energy calculations, and sequence analysis

Wang, W., Lim, W. A., Jakalian, A., Wang, J., Wang, J., Luo, R., Bayly, C. I. & Kollman, P. A., Oct 8 2001, In : Journal of the American Chemical Society. 123, 17, p. 3986-3994 9 p.

Research output: Contribution to journalArticle

121 Scopus citations

APC2 cullin protein and APC11 RING protein comprise the minimal ubiquitin ligase module of the anaphase-promoting complex

Tang, Z., Li, B., Bharadwaj, R., Zhu, H., Özkan, E., Hakala, K., Deisenhofer, J. & Yu, H., 2001, In : Molecular biology of the cell. 12, 12, p. 3839-3851 13 p.

Research output: Contribution to journalArticle

136 Scopus citations

Automatic parameterization of force field by systematic search and genetic algorithms

Wang, J. & Kollman, P. A., Sep 1 2001, In : Journal of Computational Chemistry. 22, 12, p. 1219-1228 10 p.

Research output: Contribution to journalArticle

93 Scopus citations
51 Scopus citations

Conformational stabilization and crystallization of the SecA translocation ATPase from Bacillus subtilis

Weinkauf, S., Hunt, J. F., Scheuring, J., Henry, L., Fak, J., Oliver, D. B. & Deisenhofer, J., Apr 25 2001, In : Acta Crystallographica Section D: Biological Crystallography. 57, 4, p. 559-565 7 p.

Research output: Contribution to journalArticle

16 Scopus citations

Constitutively activating mutation in WASP causes X-linked severe congenital neutropenia

Devriendt, K., Kim, A. S., Mathijs, G., Frints, S. G. M., Schwartz, M., Van Den Oord, J. J., Verhoef, G. E. G., Boogaerts, M. A., Fryns, J. P., You, D., Rosen, M. K. & Vandenberghe, P., Mar 20 2001, In : Nature genetics. 27, 3, p. 313-317 5 p.

Research output: Contribution to journalArticle

319 Scopus citations

Crystal structure of a T cell receptor Vα11 (AV11S5) domain: New canonical forms for the first and second complementarity determining regions

Machius, M., Cianga, P., Deisenhofer, J. & Ward, E. S., Jul 20 2001, In : Journal of Molecular Biology. 310, 4, p. 689-698 10 p.

Research output: Contribution to journalArticle

11 Scopus citations

Crystal structures of mitochondrial processing peptidase reveal the mode for specific cleavage of import signal sequences

Taylor, A. B., Smith, B. S., Kitada, S., Kojima, K., Miyaura, H., Otwinowski, Z., Ito, A. & Deisenhofer, J., Aug 11 2001, In : Structure. 9, 7, p. 615-625 11 p.

Research output: Contribution to journalArticle

164 Scopus citations
176 Scopus citations