Research Output

2003

dHAND-Cre transgenic mice reveal specific potential functions of dHAND during craniofacial development

Ruest, L. B., Dager, M., Yanagisawa, H., Charité, J., Hammer, R. E., Olson, E. N., Yanagisawa, M. & Clouthier, D. E., May 15 2003, In : Developmental Biology. 257, 2, p. 263-277 15 p.

Research output: Contribution to journalArticle

34 Scopus citations

Distinct narcolepsy syndromes in orexin receptor-2 and orexin null mice: Molecular genetic dissection of non-REM and REM sleep regulatory processes

Willie, J. T., Chemelli, R. M., Sinton, C. M., Tokita, S., Williams, S. C., Kisanuki, Y. Y., Marcus, J. N., Lee, C., Elmquist, J. K., Kohlmeier, K. A., Leonard, C. S., Richardson, J. A., Hammer, R. E. & Yanagisawa, M., Jun 5 2003, In : Neuron. 38, 5, p. 715-730 16 p.

Research output: Contribution to journalArticle

472 Scopus citations

Dlx5/6-Enhancer Directed Expression of Cre Recombinase in the Pharyngeal Arches and Brain

Ruest, L. B., Hammer, R. E., Yanagisawa, M. & Clouthier, D. E., Dec 1 2003, In : Genesis. 37, 4, p. 188-194 7 p.

Research output: Contribution to journalArticle

22 Scopus citations

Erratum: Evolutionarily conserved networks of residues mediate allosteric communication in proteins (Nature Structural Biology (2003) 10 (59-69))

Süel, G. M., Lockless, S. W., Wall, M. A. & Ranganathan, R., Mar 1 2003, In : Nature Structural Biology. 10, 3, 1 p.

Research output: Contribution to journalComment/debate

12 Scopus citations

Evolutionarily conserved networks of residues mediate allosteric communication in proteins

Süel, G. M., Lockless, S. W., Wall, M. A. & Ranganathan, R., Jan 1 2003, In : Nature Structural Biology. 10, 1, p. 59-69 11 p.

Research output: Contribution to journalArticle

582 Scopus citations

Homer 2 tunes G protein-coupled receptors stimulus intensity by regulating RGS proteins and PLCβ GAP activities

Shin, D. M., Dehoff, M., Luo, X., Kang, S. H., Tu, J., Nayak, S. K., Ross, E. M., Worley, P. E. & Muallem, S., Jul 21 2003, In : Journal of Cell Biology. 162, 2, p. 293-303 11 p.

Research output: Contribution to journalArticle

74 Scopus citations

Hyperactivated sperm motility driven by CatSper2 is required for fertilization

Quill, T. A., Sugden, S. A., Rossi, K. L., Doolittle, L. K., Hammer, R. E. & Garbers, D. L., Dec 9 2003, In : Proceedings of the National Academy of Sciences of the United States of America. 100, 25, p. 14869-14874 6 p.

Research output: Contribution to journalArticle

242 Scopus citations

Induction of hepatocyte proliferation and death by modulation of T-antigen expression

Comerford, S. A., Clouthier, D. E., Hinnant, E. A. & Hammer, R. E., Apr 24 2003, In : Oncogene. 22, 16, p. 2515-2530 16 p.

Research output: Contribution to journalArticle

6 Scopus citations

Itk functions to control actin polymerization at the immune synapse through localized activation of Cdc42 and WASP

Labno, C. M., Lewis, C. M., You, D., Leung, D. W., Takesono, A., Kamberos, N., Seth, A., Finkelstein, L. D., Rosen, M. K., Schwartzberg, P. L. & Burkhardt, J. K., Sep 16 2003, In : Current Biology. 13, 18, p. 1619-1624 6 p.

Research output: Contribution to journalArticle

104 Scopus citations

'MAD'ly phasing the extracellular domain of the LDL receptor: A medium-sized protein, large tungsten clusters and multiple non-isomorphous crystals

Rudenko, G., Henry, L., Vonrhein, C., Bricogne, G. & Deisenhofer, J., Nov 1 2003, In : Acta Crystallographica - Section D Biological Crystallography. 59, 11, p. 1978-1986 9 p.

Research output: Contribution to journalArticle

18 Scopus citations

Mesoscopic reaction-diffusion in intracellular signaling

Elf, J., Dončić, A. & Ehrenberg, M., Sep 19 2003, In : Proceedings of SPIE - The International Society for Optical Engineering. 5110, p. 114-124 11 p.

Research output: Contribution to journalConference article

75 Scopus citations

NMR analysis of methyl groups at 100-500 kDa: Model systems and Arp2/3 complex

Kreishman-Deitrick, M., Egile, C., Hoyt, D. W., Ford, J. J., Li, R. & Rosen, M. K., Jul 22 2003, In : Biochemistry. 42, 28, p. 8579-8586 8 p.

Research output: Contribution to journalArticle

20 Scopus citations
73 Scopus citations
149 Scopus citations

Phosphorylation-regulated Inhibition of the Gz GTPase-activating Protein Activity of RGS Proteins by Synapsin I

Tu, Y., Nayak, S. K., Woodson, J. & Ross, E. M., Dec 26 2003, In : Journal of Biological Chemistry. 278, 52, p. 52273-52281 9 p.

Research output: Contribution to journalArticle

16 Scopus citations
5 Scopus citations

Rational design of genetically encoded fluorescence resonance energy transfer-based sensors of cellular Cdc42 signaling

Seth, A., Otomo, T., Yin, H. L. & Rosen, M. K., Apr 15 2003, In : Biochemistry. 42, 14, p. 3997-4008 12 p.

Research output: Contribution to journalArticle

45 Scopus citations

Regulation of cytosolic phosphoenolpyruvate carboxykinase gene expression in adipocytes

Beale, E. G., Forest, C. & Hammer, R. E., Dec 2003, In : Biochimie. 85, 12, p. 1207-1211 5 p.

Research output: Contribution to journalArticle

22 Scopus citations

RNA Amplification and Transcriptional Profiling for Analysis of Stem Cell Populations

Gallardo, T. D., Hammer, R. E. & Garry, D. J., Oct 1 2003, In : Genesis. 37, 2, p. 57-63 7 p.

Research output: Contribution to journalArticle

27 Scopus citations

Structure of Cdc42 in a complex with the GTPase-binding domain of the cell polarity protein, Par6

Garrard, S. M., Capaldo, C. T., Gao, L., Rosen, M. K., Macara, I. G. & Tomchick, D. R., Mar 3 2003, In : EMBO Journal. 22, 5, p. 1125-1133 9 p.

Research output: Contribution to journalArticle

117 Scopus citations

The Erythropoietin Receptor Transmembrane Domain Mediates Complex Formation with Viral Anemic and Polycythemic gp55 Proteins

Constantinescu, S. N., Keren, T., Russ, W. P., Ubarretxena-Belandia, I., Malka, Y., Kubatzky, K. F., Engelman, D. M., Lodish, H. F. & Henis, Y. I., Oct 31 2003, In : Journal of Biological Chemistry. 278, 44, p. 43755-43763 9 p.

Research output: Contribution to journalArticle

24 Scopus citations

The low-density lipoprotein receptor: Ligands, debates and lore

Rudenko, G. & Deisenhofer, J., Dec 2003, In : Current Opinion in Structural Biology. 13, 6, p. 683-689 7 p.

Research output: Contribution to journalReview article

53 Scopus citations

α-neurexins couple Ca 2+ channels to synaptic vesicle exocytosis

Missier, M., Zhang, W., Rohlmann, A., Kattenstroth, G., Hammer, R. E., Gottmann, K. & Südhof, T. C., Jun 26 2003, In : Nature. 423, 6943, p. 939-948 10 p.

Research output: Contribution to journalArticle

444 Scopus citations
2002

Bipartite gating in the outer membrane protein FecA

Van der Helm, D., Chakraborty, R., Ferguson, A. D., Smith, B. S., Esser, L. & Deisenhofer, J., Aug 1 2002, In : Biochemical Society Transactions. 30, 4, p. 708-710 3 p.

Research output: Contribution to journalArticle

10 Scopus citations
464 Scopus citations

Disruption of Abcg5 and Abcg8 in mice reveals their crucial role in biliary cholesterol secretion

Yu, L., Hammer, R. E., Li-Hawkins, J., Von Bergmann, K., Lutjohann, D., Cohen, J. C. & Hobbs, H. H., Dec 10 2002, In : Proceedings of the National Academy of Sciences of the United States of America. 99, 25, p. 16237-16242 6 p.

Research output: Contribution to journalArticle

540 Scopus citations

Experimental control of pancreatic development and maintenance

Holland, A. M., Hale, M. A., Kagami, H., Hammer, R. E. & MacDonald, R. J., Sep 17 2002, In : Proceedings of the National Academy of Sciences of the United States of America. 99, 19, p. 12236-12241 6 p.

Research output: Contribution to journalArticle

168 Scopus citations

Generation and cycloaddition of semi-stabilized 2-azaallyllithiums viaelectrocyclic ring-opening or cycloreversion reactions

Pearson, W. H., Walters, M. A., Rosen, M. K. & Harter, W. G., Dec 1 2002, In : Arkivoc. 2002, 8, p. 91-111 21 p.

Research output: Contribution to journalArticle

9 Scopus citations

Glyceroneogenesis comes of age

Beale, E. G., Hammer, R. E., Antoine, B. & Forest, C., Nov 1 2002, In : FASEB Journal. 16, 13, p. 1695-1696 2 p.

Research output: Contribution to journalReview article

50 Scopus citations

Ignition of a cellular machine

Kreishman-Deltrick, M. & Rosen, M. K., Feb 23 2002, In : Nature Cell Biology. 4, 2, p. E31-E33

Research output: Contribution to journalComment/debate

7 Scopus citations

Knowledge-based potential functions in protein design

Russ, W. P. & Ranganathan, R., Aug 1 2002, In : Current Opinion in Structural Biology. 12, 4, p. 447-452 6 p.

Research output: Contribution to journalReview article

61 Scopus citations

Molecular dynamics and free energy analyses of cathepsin D-inhibitor interactions: Insight into structure-based ligand design

Huo, S., Wang, J., Cieplak, P., Kollman, P. A. & Kuntz, I. D., Mar 28 2002, In : Journal of Medicinal Chemistry. 45, 7, p. 1412-1419 8 p.

Research output: Contribution to journalArticle

162 Scopus citations

Mutations in the carboxyl-terminal domain of phospholipase C-β1 delineate the dimer interface and a potential Gαq interaction site

Ilkaeva, O., Kinch, L. N., Paulssen, R. H. & Ross, E. M., Feb 8 2002, In : Journal of Biological Chemistry. 277, 6, p. 4294-4300 7 p.

Research output: Contribution to journalArticle

50 Scopus citations

Nucleotide control of interdomain interactions in the conformational reaction cycle of SecA

Hunt, J. F., Weinkauf, S., Henry, L., Fak, J. J., McNicholas, P., Oliver, D. B. & Deisenhofer, J., Sep 20 2002, In : Science. 297, 5589, p. 2018-2026 9 p.

Research output: Contribution to journalArticle

228 Scopus citations
Open Access
546 Scopus citations

Overview of the alliance for cellular signaling

Gilman, A. G., Dec 12 2002, In : Nature. 420, 6916, p. 703-706 4 p.

Research output: Contribution to journalReview article

109 Scopus citations

Production of transgenic rats by lentiviral transduction of male germ-line stem cells

Hamra, F. K., Gatlin, J., Chapman, K. M., Grellhesl, D. M., Garcia, J. V., Hammer, R. E. & Garbers, D. L., Nov 12 2002, In : Proceedings of the National Academy of Sciences of the United States of America. 99, 23, p. 14931-14936 6 p.

Research output: Contribution to journalArticle

196 Scopus citations

Quantifying robustness of biochemical network models

Ma, L. & Iglesias, P. A., Dec 13 2002, In : BMC Bioinformatics. 3, 38.

Research output: Contribution to journalArticle

102 Scopus citations

Robustness analysis of a self-oscillating molecular network in Dictyostelium Discoideum

Ma, L. & Iglesias, P., 2002, Proceedings of the IEEE Conference on Decision and Control. Vol. 3. p. 2538-2543 6 p.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

4 Scopus citations

Smooth muscle-selective deletion of guanylyl cyclase-A prevents the acute but not chronic effects of ANP on blood pressure

Holtwick, R., Gotthardt, M., Skryabin, B., Steinmetz, M., Potthast, R., Zetsche, B., Hammer, R. E., Herz, J. & Kuhn, M., May 14 2002, In : Proceedings of the National Academy of Sciences of the United States of America. 99, 10, p. 7142-7147 6 p.

Research output: Contribution to journalArticle

216 Scopus citations

Solvation model based on weighted solvent accessible surface area

Kollman, P. A., Wang, J., Wang, W., Huo, S. & Lee, M., May 31 2002, In : Journal of Physical Chemistry B. 105, 21, p. 5055-5067 13 p.

Research output: Contribution to journalArticle

103 Scopus citations

Speckle experiments in random lasers

Van Soest, G., Poelwijk, F. J. & Lagendijk, A., Apr 1 2002, In : Physical Review E - Statistical, Nonlinear, and Soft Matter Physics. 65, 4, p. 046603/1-046603/5 046603.

Research output: Contribution to journalArticle

13 Scopus citations

Structural basis of gating by the outer membrane transporter FecA

Ferguson, A. D., Chakraborty, R., Smith, B. S., Esser, L., Van Der Helm, D. & Deisenhofer, J., Mar 1 2002, In : Science. 295, 5560, p. 1715-1719 5 p.

Research output: Contribution to journalArticle

287 Scopus citations
163 Scopus citations

Structure of the LDL receptor extracellular domain at endosomal pH

Rudenko, G., Henry, L., Henderson, K., Ichtchenko, K., Brown, M. S., Goldstein, J. L. & Deisenhofer, J., Dec 20 2002, In : Science. 298, 5602, p. 2353-2358 6 p.

Research output: Contribution to journalArticle

336 Scopus citations

TonB-dependent receptors - Structural perspectives

Ferguson, A. D. & Deisenhofer, J., Oct 11 2002, In : Biochimica et Biophysica Acta - Biomembranes. 1565, 2, p. 318-332 15 p.

Research output: Contribution to journalReview article

98 Scopus citations

Uncoupling Kapβ2 substrate dissociation and ran binding

Chook, Y. M., Jung, A., Rosen, M. K. & Blobel, G., Jun 4 2002, In : Biochemistry. 41, 22, p. 6955-6966 12 p.

Research output: Contribution to journalArticle

43 Scopus citations
2001

An analysis of the interactions between the Sem-5 SH3 domain and its ligands using molecular dynamics, free energy calculations, and sequence analysis

Wang, W., Lim, W. A., Jakalian, A., Wang, J., Wang, J., Luo, R., Bayly, C. I. & Kollman, P. A., Oct 8 2001, In : Journal of the American Chemical Society. 123, 17, p. 3986-3994 9 p.

Research output: Contribution to journalArticle

119 Scopus citations

APC2 cullin protein and APC11 RING protein comprise the minimal ubiquitin ligase module of the anaphase-promoting complex

Tang, Z., Li, B., Bharadwaj, R., Zhu, H., Özkan, E., Hakala, K., Deisenhofer, J. & Yu, H., Jan 1 2001, In : Molecular biology of the cell. 12, 12, p. 3839-3851 13 p.

Research output: Contribution to journalArticle

136 Scopus citations